检索结果-南通市图书馆

Sino - US Cultural Exchange： How： to Tell a Good Story of China

在线全文

学校读者我要写书评

暂无评论

China & The World Cultural Exchange 2017年第5期83卷 45-46页

作者： LiLiYan guo wenmei

Reccntl.x. Cultural Counselor Li *** and Consul guo wenmei of the Chinese Consulate General in New York published a signed article Sino-US Cultural Exchanges：How to Tell a Good Story of China,in China Culture Daily.

关键词：

The spin-isospin decomposition of the nuclear symmetry energy from low to high density

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Physics C 2020年第5期44卷 114-118页

作者： wenmei guo M.Colonna V.Greco U.Lombardo H.-JSchulze Department of Physics Anhui Normal UniversityWuhu 241000China Laboratori Nazionali del Sud(INFN) Via S.Sofia 6295123 CataniaItaly Dipartimento di Fisica e Astronomia Via S.Sofia 6495123 CataniaItaly INFN Sezione di CataniaVia S.Sofia 6295123 CataniaItaly

The energy per particle BA in nuclear matter is calculated up to high baryon density in the whole isospin asymmetry range from symmetric matter to pure neutron *** results,obtained in the framework of the Brueckner-Hartree-Fock approximation with two-and three-body forces,confirm the well-known parabolic dependence on the asymmetry parameterβ=(N?Z)/A(β^2 law)that is valid in a wide density *** investigate the extent to which this behavior can be traced back to the properties of the underlying interaction,aside from the mean field approximation,the spin-isospin decomposition of BA is *** indications suggest that theβ^2 law could be violated at higher densities as a consequence of the three-body *** raises the problem that the symmetry energy,calculated according to theβ^2 law as a difference between BA in pure neutron matter and symmetric nuclear matter,cannot be applied to neutron *** should return to the proper definition of the nuclear symmetry energy as a response of the nuclear system to small isospin imbalance from the Z=N nuclei and pure neutron matter.

关键词： symmetry energy nuclear interaction spin-isospin decomposition nuclear matter

Single-cell mass spectrometry studies of drug metabolism heterogeneity and primary resistance to gefitinib in non-small cell lung cancer cells

在线全文

学校读者我要写书评

暂无评论

Chinese Chemical Letters 2024年第2期35卷 436-440页

作者： Guizhen Zhu Yaoyao Zhao wenmei Zhang Yuanyuan Wu Yuanxing Liu Guangsheng guo Xiayan Wang Zhihong Liu Center of Excellence for Environmental Safety and Biological Effects Beijing Key Laboratory for Green Catalysis and SeparationDepartment of ChemistryBeijing University of TechnologyBeijing 100124China Minzu University of China Beijing 100081China Key Laboratory for the Synthesis and Application of Organic Functional Molecules College of Health Science and EngineeringHubei UniversityWuhan 430062China

Patients with epidermal growth factor receptor(EGFR)wild-type non-small cell lung cancer(NSCLC)often show primary resistance to gefitinib *** is thus necessary to study the metabolism of gefitinib in NSCLC cells to comprehensively reveal the reasons for the primary resistance of ***,we develop a platform for studying drug metabolism heterogeneity based on single-cell mass spectrometry(sDMH-scMS)by integrating living-cell electrolaunching ionization MS(ILCEI-MS)and high-performance liquid chromatography-MS(HPLC-MS)analysis,and the primary resistance of NSCLC cells to gefitinib was studied using this *** ILCEI-MS analysis showed that approximately 11.9%of NSCLC single cells contained the gefitinib metabolite M11;HPLC-MS detection diluted the intensity of M11 in subpopulations and concealed the heterogeneity of drug metabolism in tumor single *** intensity of gefitinib in EGFR wild-type A549 cells was markedly lower than in mutant PC9 cells,and the intensity of gefitinib metabolites was significantly higher than in PC9 cells,suggesting that the primary resistance of NSCLC cells is related to gefitinib ***,the combination of gefitinib and the drug-metabolizing enzyme inhibitorα-naphthoflavone was shown to overcome the primary resistance of the NSCLC ***,the results of this study are expected to be applicable for clinical drug resistance diagnosis and treatment at the single-cell level.

关键词： Single-cell mass spectrometry Drug metabolism Non-small cell lung cancer Gefitinib Primary resistance

Silencing of the long non-coding RNA LINC00265 triggers autophagy and apoptosis in lung cancer by reducing protein stability of SIN3A oncogene

在线全文

学校读者我要写书评

暂无评论

Oncology Research 2024年第7期32卷 1185-1195页

作者： XIAOBI HUANG CHUNYUAN CHEN YONGYANG CHEN HONGLIAN ZHOU YONGHUA CHEN ZHONG HUANG YULIU XIE BAIYANG LIU YUDONG guo ZHIXIONG YANG GUANGHUA CHEN wenmei SU Department of Pulmonary Oncology Affiliated Hospital of Guangdong Medical UniversityZhanjiang524001China Department of Thoracic Surgery Affiliated Hospital of Guangdong Medical UniversityZhanjiang524001China Department of Orthopedics Affiliated Hospital of Guangdong Medical UniversityZhanjiang524001China Guangdong Provincial Key Laboratory of Autophagy and Major Chronic Non-Communicable Diseases Affiliated Hospital of Guangdong Medical UniversityZhanjiang524001China

Background:Long non-coding RNAs are important regulators in cancer biology and function either as tumor suppressors or as *** dysregulation has been closely associated with ***00265 is upregulated in lung adenocarcinoma and is a prognostic biomarker of this ***,the mechanism underlying its function in cancer progression remains poorly ***:Here,the regulatory role of LINC00265 in lung adenocarcinoma was examined using lung cancer cell lines,clinical samples,and ***:We found that high levels of LINC00265 expression were associated with shorter overall survival rate of patients,whereas knockdown of LINC00265 inhibited proliferation of cancer cell lines and tumor growth in *** blot andﬂow cytometry analyses indicated that silencing of LINC00265 induced autophagy and ***,we showed that LINC00265 interacted with and stabilized the transcriptional co-repressor Switch-independent 3a(SIN3A),which is a scaffold protein functioning either as a tumor repressor or as an oncogene in a context-dependent *** of SIN3A also reduced proliferation of lung cancer cells,which was correlated with the induction of *** observations raise the possibility that LINC00265 functions to promote the oncogenic activity of SIN3A in lung ***:Ourﬁndings thus identify SIN3A as a LINC00265-associated protein and should help to understand the mechanism underlying LINC00265-mediated oncogenesis.

关键词： LINC00265 Autophagy Lung adenocarcinoma(LUAD) Cancer progression Switch-independent 3a(SIN3A)

建国60年中国农村学校体育研究内容体系及存在的问题

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

沈阳体育学院学报 2010年第5期29卷 16-19页

作者：郭文梅周口师范学院公体部河南周口466001

主要采用文献研究、数理统计、逻辑分析等方法对建国60年来的中国农村学校体育相关研究进行梳理,从研究的时间与数量分布、研究的类型与内容体系,以及研究存在的主要问题等几个方面进行评述。结果显示:中国农村学校体育的研究起源于20世... 详细信息

主要采用文献研究、数理统计、逻辑分析等方法对建国60年来的中国农村学校体育相关研究进行梳理,从研究的时间与数量分布、研究的类型与内容体系,以及研究存在的主要问题等几个方面进行评述。结果显示:中国农村学校体育的研究起源于20世纪60年代,研究数量直到80年代才开始迅猛增长。研究的类型包括理论探讨、现状调查、经验总结、对策建议和新闻报道类五大类,且存在着概念界定不够清晰、严谨性和规范性不够、以偏概全现象突出等问题。本研究旨在为新时期更好地发展农村学校体育工作提供理论参考,为后续研究提供基础数据。

关键词：中国农村学校体育研究内容

基于modified-HBT干涉仪的压缩态光场光子统计特性的理论和实验研究

在线全文

学校读者我要写书评

暂无评论

光学学报 2020年第22期40卷 180-187页

作者：韩亚帅吴道华郭文梅安徽师范大学物理与电子信息学院安徽芜湖241000 安徽师范大学光电材料科学与技术安徽省重点实验室安徽芜湖241000 安徽工程大学电气工程学院安徽芜湖241000 安徽工程大学高端装备先进感知与智能控制教育部重点实验室安徽芜湖241000

用一对平衡零拍探测器分别替代HBT(Hanbury-Brown-Twiss)实验中的单光子探测器,构成了一个modified-HBT干涉仪。介绍了基于modified-HBT干涉仪的光场二阶关联函数测量原理以及步骤,着重讨论了测量过程中对暗噪声的处理。基于理论分析,... 详细信息

用一对平衡零拍探测器分别替代HBT(Hanbury-Brown-Twiss)实验中的单光子探测器,构成了一个modified-HBT干涉仪。介绍了基于modified-HBT干涉仪的光场二阶关联函数测量原理以及步骤,着重讨论了测量过程中对暗噪声的处理。基于理论分析,利用此干涉仪同时记录和统计了光场两空间分离模式的正交分量信息,实现了对光学参量振荡器输出的平移压缩态光场二阶关联函数的测量以及光子统计特性的表征。对于振幅压缩光,在特定的平移参量下,其二阶关联函数值小于1,表明光子呈现反聚束效应;而相位压缩光的二阶关联函数值总是大于1,光子呈现聚束效应。利用双光子干涉理论对测量到的平移压缩态光场的光子统计特性进行了解释,为理解压缩光的光子统计特性提供了参考。

关键词：量子光学压缩态二阶关联函数平衡零拍探测双光子干涉

我院儿童抗感冒复方制剂说明书及不合理用药处方分析

在线全文

学校读者我要写书评

暂无评论

中国药房 2016年第29期27卷 4053-4057页

作者：李根郭文玫梁华王玉兰成都市妇女儿童中心医院药学部成都610091

目的:了解儿童抗感冒复方制剂现状,为临床合理用药提供参考。方法:收集我院使用的儿童抗感冒复方制剂说明书,对其组分、规格、剂型、用量等进行统计;同时列举2015年6-12月典型的不合理用药处方进行分析。结果与结论:我院共有40种儿童抗... 详细信息

目的:了解儿童抗感冒复方制剂现状,为临床合理用药提供参考。方法:收集我院使用的儿童抗感冒复方制剂说明书,对其组分、规格、剂型、用量等进行统计;同时列举2015年6-12月典型的不合理用药处方进行分析。结果与结论:我院共有40种儿童抗感冒药在用,包括14种化学药和26种中成药,其中15种药品说明书中未标明儿童用量,占37.5%。抗感冒复方制剂种类多,规格、用量差异大,相同年龄/体质量儿童按照说明书服用不同药品,同一组分含量相差较大,表明说明书中儿童用法用量需进一步完善。我院尚存在重复用药、配伍禁忌、用量不适宜等不合理用药现象。

关键词：儿童抗感冒药复方制剂说明书

在线全文

学校读者我要写书评

暂无评论

老年糖尿病视网膜病变病人报告结局研究进展

护理研究 2022年第16期36卷 2954-2957页

作者：郭文梅罗羽卞薇钟竹中国人民解放军陆军军医大学第一附属医院重庆400038

综述老年糖尿病视网膜病变病人生存质量、症状负担及信息化测评工具,以期为国内学者选择适宜的评估工具提供指导,从而为研发适合我国文化背景的老年糖尿病视网膜病变病人报告结局工具提供科学的参考依据。

关键词：糖尿病视网膜病变病人报告结局评估工具:老年人综述

年龄相关性黄斑变性患者营养干预决策辅助方案的构建及应用

在线全文

学校读者我要写书评

暂无评论

中华护理杂志 2022年第23期57卷 2870-2876页

作者：万君丽张凤郭文梅吴雪梅卞薇陆军军医大学第一附属医院眼科重庆市400038

目的探讨营养干预决策辅助方案在年龄相关性黄斑变性患者中的应用效果。方法通过参考国内外文献、专家函询、课题小组讨论以及预试验,基于共同决策三阶段会谈模型构建年龄相关性黄斑变性患者营养干预决策辅助方案,包括团队会谈、选择会... 详细信息

目的探讨营养干预决策辅助方案在年龄相关性黄斑变性患者中的应用效果。方法通过参考国内外文献、专家函询、课题小组讨论以及预试验,基于共同决策三阶段会谈模型构建年龄相关性黄斑变性患者营养干预决策辅助方案,包括团队会谈、选择会谈、决策会谈3个步骤。2021年3月—12月便利选取重庆市某三级甲等综合医院眼科110例年龄相关性黄斑变性患者,采用随机数字表法分为试验组和对照组各55例。试验组在常规健康教育的基础上实施决策辅助方案,对照组给予常规健康教育。干预后分别使用年龄相关性黄斑变性营养相关知识测评问卷、决策准备量表、决策自我效能量表、决策困境量表、综合医院焦虑/抑郁情绪测定表对两组进行评估。结果试验组干预后营养相关知识测评问卷得分高于对照组(P<0.001),决策准备量表得分高于对照组(P<0.001);决策自我效能量表得分高于对照组(P<0.001),决策困境量表得分低于对照组(P<0.001);试验组焦虑/抑郁情绪测定表得分低于对照组(P<0.05)。结论应用该研究制订的患者决策辅助方案,可提高患者营养干预相关知识水平,提高患者的决策准备度和决策自我效能,降低患者决策困境水平,改善患者焦虑/抑郁情绪。

关键词：年龄相关性黄斑变性营养疗法决策支持系统临床护理