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改善睡眠热环境可提高睡眠质量

科学通报 2020年第7期65卷 533-534页

作者：兰丽连之伟上海交通大学设计学院建筑学系上海200240

人的一生大约有1/3的时间在睡眠中度过.睡眠是人的一种重要生理现象,可使人体的精力和体力得以恢复.睡眠是影响人们是否会得阿尔茨海默病(也称老年痴呆症)的最主要生活方式因素[1].2019年11月发表在Science杂志的一项最新研究表明,深睡... 详细信息

人的一生大约有1/3的时间在睡眠中度过.睡眠是人的一种重要生理现象,可使人体的精力和体力得以恢复.睡眠是影响人们是否会得阿尔茨海默病(也称老年痴呆症)的最主要生活方式因素[1].2019年11月发表在Science杂志的一项最新研究表明,深睡(慢波睡眠)时脑脊液会对大脑进行清洗,清除脑内毒素(包括导致阿尔茨海默病的β淀粉样蛋白)[2].每天少睡1 h,就会显著改变人体血糖水平,使人体免疫系统受损,增加患心脏病的概率.此外,失眠还与大多数精神疾病相关.

关键词：阿尔茨海默病老年痴呆症慢波睡眠睡眠质量 β淀粉样蛋白改善睡眠内毒素脑脊液

锗硅烯与CH_3OH加成反应机理及区域选择性

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物理化学学报 2015年第9期31卷 1699-1707页

作者：曾小兰王岩信阳师范学院化学化工学院河南信阳464000

采用密度泛函理论方法,在B3LYP/6-311++G(d,p)水平,研究了几种锗硅烯与CH3OH的加成反应的微观机理和势能剖面,分析了锗硅烯中Si=Ge双键的极性对加成反应区域选择性的影响.研究结果表明,锗硅烯可分别与CH3OH的单聚体或二聚体发生加成反应... 详细信息

采用密度泛函理论方法,在B3LYP/6-311++G(d,p)水平,研究了几种锗硅烯与CH3OH的加成反应的微观机理和势能剖面,分析了锗硅烯中Si=Ge双键的极性对加成反应区域选择性的影响.研究结果表明,锗硅烯可分别与CH3OH的单聚体或二聚体发生加成反应.所有加成反应均从初始亲核或亲电复合物的形成开始.母体锗硅烯H2Si=Ge H2与CH3OH二聚体的加成反应比其与CH3OH单聚体的相应反应在动力学上更容易些,但在其它锗硅烯与CH3OH的反应中情况则相反.用Ph或Si Me3基团取代H2Si=Ge H2中的H原子在动力学上使反应变得不利且Si Me3基团的影响更显著.加成反应的区域选择性与锗硅烯中Si=Ge双键的极性以及Si-O(Ge-H)和Ge-O(Si-H)键的相对强弱都有关.

关键词：锗硅烯加成反应反应机理密度泛函理论区域选择性

Driver at 10 MJ and 1 shot/30 min for inertial confinement fusion at high gain:Efficient,compact,low-cost,low laser-plasma instabilities,beam color selectable from 2ω/3ω/4ω,applicable to multiple laser fusion schemes

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Matter and Radiation at Extremes 2024年第4期9卷 4-7页

作者：隋展蓝可 Shanghai Institute of Laser Plasma China Academy of Engineering PhysicsShanghai 201800China Instituteof Applied Physics and Computational Mathematics Beijing 100094China

The achievement of ignition at the National Ignition Facility(NIF)has prompted a global wave of further research on inertial fusion energy(IFE).However,IFE requires a target gain G of 30-100,and it is hard to achieve fusion at such high gain with the energy,configuration,and technical approach of the ***,we present a conceptual design for a next-generation laser driver that is applicable to multiple laser fusion schemes and provides 10 MJ,2-3 PW at 3ω(or 2ω,in which case the energy and power can be higher),and one shot per 30 min,with the aim of achieving G>*** is also efficient,compact,and low in cost,and it has low susceptibility to laser-plasma instabilities.

关键词： applicable compact instabilities

Exosomes as mediators of tumor immune escape and immunotherapy in hepatocellular carcinoma

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Liver Research 2022年第3期6卷 132-138页

作者： Ming-Cheng Guan Ming-Da Wang Wan-Yin Wang Chao Li lan-Qing Yao Hong Zhu Tian Yang Department of Medical Oncology The First Affiliated Hospital of Soochow UniversitySuzhouJiangsuChina Department of Hepatobiliary Surgery Eastern Hepatobiliary Surgery HospitalSecond Military Medical University(Navy Medical University)ShanghaiChina Eastern Hepatobiliary Clinical Research Institute Third Affiliated Hospital of Navy Medical UniversityShanghaiChina School of Clinical Medicine Hangzhou Medical CollegeHangzhouZhejiangChina

Hepatocellular carcinoma(HCC),a typical inflammatory-related cancer,mainly occurs in patients with chronic liver ***,the liver is an immunologically privileged apparatus with multiple immunosuppressive cell *** long process of inflammation-mediated carcinogenesis turns the HCC tumor microenvironment(TME)into one with strong immunosuppression,facilitating the immune escape of HCC *** data have manifested that tumor-associated cell-derived exosomes carry diverse molecular cargoes(e.g.,proteins and nucleic acids)for mediating cell-to-cell communication and are implicated in TME remodeling to promote tumor-infiltrating immune cell reprogramming,ultimately creating a tumor-friendly *** by several intrinsic attributes,such as good stability(bilayer-like structure)and high biocompatibility(cell secretion),exosomes can be modified or engineered as nanocarriers to deliver tumor-specific antigens or antitumor drugs to targeted cells or organs,thus effectively triggering the HCC cell elimination by the immune *** review aimed to highlight the pivotal role of exosomes in regulating immune escape mechanisms in HCC and recent advances in exosome-mediated immunotherapy for HCC.

关键词： Hepatocellular carcinoma(HCC) Exosomes Tumor immune escape Immunotherapy Tumor microenvironment(TME) Tumor immune microenvironment

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健身俱乐部会员体育健身需求的动态分析

成都体育学院学报 2008年第8期34卷 26-27,54页

作者：黄梅兰兰广西大学体育教学部广西南宁530004 广西中医学院体育教学部广西南宁530001

不同时期,健身俱乐部会员体育健身需求表现出不同特征。通过对1999年和2007年两年中南宁市7家健身俱乐部的1000名健身会员到健身俱乐部体育健身的目的和对各种体育健身项目的喜好进行调查、对比与分析,结果表明:健身俱乐部会员体育健身... 详细信息

不同时期,健身俱乐部会员体育健身需求表现出不同特征。通过对1999年和2007年两年中南宁市7家健身俱乐部的1000名健身会员到健身俱乐部体育健身的目的和对各种体育健身项目的喜好进行调查、对比与分析,结果表明:健身俱乐部会员体育健身的目的由普遍追求改善体型转向追求健康与情感需要,对体育健身项目的需求也由相对集中转向多样化与个性化。现时,有氧器械类个体练习最受男会员青眯,而健身舞类和瑜伽最受女会员喜爱。

关键词：健身俱乐部会员体育健身目的体育项目需求动态分析

Protective effect of ginsenoside Rg1 on 661W cells exposed to oxygen-glucose deprivation/reperfusion via keap1/nrf2 pathway

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International Journal of Ophthalmology(English edition) 2023年第7期16卷 1026-1033页

作者： Ming Zhou Xin-Qi Ma Yi-Yu Xie Jia-Bei Zhou Xie-lan Kuang Huang-Xuan Shen Chong-De Long State Key Laboratory of Ophthalmology Zhongshan Ophthalmic CenterSun Yat-sen UniversityGuangdong Provincial Key Laboratory of Ophthalmology and Visual ScienceGuangzhou 510060China

AIM:To construct an in vitro model of oxygen-glucose deprivation/reperfusion(OGD/R)induced injury to the optic nerve and to study the oxidative damage mechanism of ischemia-reperfusion(I/R)injury in 661W cells and the protective effect of ginsenoside ***:The 661W cells were treated with different concentrations of Na2S2O4 to establish OGD/R model in ***,intracellular reactive oxygen species(ROS)levels and superoxide dismutase(SOD)levels were measured at different time points during the reperfusion injury *** injury model was pretreated with graded concentrations of ginsenoside ***-time polymerase chain reaction(PCR)was used to measure the expression levels of cytochrome C(cyt C)/B-cell lymphoma-2(Bcl2)/Bcl2 associated protein X(Bax),heme oxygenase-1(HO-1),caspase9,nuclear factor erythroid 2-related factor 2(nrf2),kelch-like ECH-associated protein 1(keap1)and other *** blot was used to detect the expression of nrf2,phosphorylated nrf2(pnrf2)and keap1 protein ***:Compared to the untreated group,the cell activity of 661W cells treated with Na2S2O4 for 6 and 8h decreased(P<0.01).Additionally,the ROS content increased and SOD levels decreased significantly(P<0.01).In contrast,treatment with ginsenoside Rg1 reversed the cell viability and SOD levels in comparison to the Na_(2)S_(2)O_(4)treated group(P<0.01).Moreover,Rg1 reduced the levels of caspase3,caspase9,and cyt C,while increasing the Bcl2/Bax *** differences were all statistically significant(P<0.05).Western blot analysis showed no significant difference in the protein expression levels of keap1 and nrf2 with Rg1 treatment,however,Rg1 significantly increased the ratio of pnrf2/nrf2 protein expression compared to the Na_(2)S_(2)O_(4)treated group(P<0.001).CONCLUSION:The OGD/R process is induced in 661W cells using Na_(2)S_(2)O_(4).Rg1 inhibits OGD/R-induced oxidative damage and alleviates the extent of apoptosis in 661W cells through the keap1/nrf2 pathway

关键词： oxygen-glucose deprivation/reoxygenation ginsenoside Rg1 oxidative stress phosphorylated nrf2

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DVR网络共享技术的研究与实现

计算机工程 2006年第1期32卷 136-138页

作者：詹玲兰洋华中科技大学计算机学院信息存储系统重点实验室武汉430074 信阳师范学院信阳464000

针对DVR文件存储和访问的特点,该文将它同TCP/IP网络以及iSCSI协议相结合,设计了支持网络数据块共享的DVR网络共享系统,详细介绍了这种网络共享系统的设计方案,并进行了相应的试验测试和性能分析。

关键词：数字影像录像系统 TCP/IP iSCSI

黄土地层大规模地震液化滑移的机理与风险评估

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岩土工程学报 2020年第1期42卷 1-19页

作者：王兰民中国地震局(甘肃省)黄土地震工程重点实验室中国地震局兰州地震研究所

2018年印度尼西亚帕卢7.4级地震造成的低角度饱和土层大规模滑移灾难对黄土地区地震造成的土层大规模低角度滑动灾害研究具有重要的警示意义。为了研究黄土地层大规模地震液化滑移机理,通过对国内外强震触发的典型黄土地震液化灾害进行... 详细信息

2018年印度尼西亚帕卢7.4级地震造成的低角度饱和土层大规模滑移灾难对黄土地区地震造成的土层大规模低角度滑动灾害研究具有重要的警示意义。为了研究黄土地层大规模地震液化滑移机理,通过对国内外强震触发的典型黄土地震液化灾害进行深入的调查分析,基于现场大型探槽和钻孔勘探、室内动三轴试验、现场剪切波速测试、SPT测试、土体微结构测试和数值模拟分析,揭示了饱和黄土液化的特征和机理,提出了饱和黄土场地液化的初判与详判方法,研究了黄土大规模地层液化滑移的滑动条件、运动学及动力学特征,论述了黄土地层大规模地震液化滑移的机制,构建了滑距和致灾范围预测模型;提出了液化滑移灾害的概率风险评估方法,给出了不同超越概率下黄土地层大规模地震液化灾害风险区划图;并从主动防控、被动防控和综合监测预警3个方面提出了黄土地层大规模液化滑移灾害的防控途径及措施。研究结果可为黄土地层大规模液化滑移灾害风险评估与防治提供理论依据。

关键词：黄土地层液化判别滑移机理滑距和致灾范围风险评估

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韧带和肌腱损伤康复与再生的新概念(英文)

体育科学 2008年第9期28卷 17-18页

作者： Sarvo lan-Yuan Woo Rui Liang University of Pittsburgh

The nonlinear biomechanical properties of ligaments and tendons are well designed to guide synovial joints to move easily and smoothly,to transfer the large forces generated by muscles tobones and alsotolimit excessive bone to bone displacement when the external applied loads are higher in order to protect other soft tissues in and around the joints from *** such,these tissues experience large,repetitive forces during sports and work-related activities and are injured frequently,especially those of the knee and shoulder joints.

关键词：韧带损伤腱外伤治疗方法护理方法