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Hyaluronic acid derivative-modified nano-structured lipid carrier for cancer targeting and therapy

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2020年第7期21卷 571-580页

作者： Xiao LIU Hai LIU Su-lan WANG Jing-wen LIU Department of Pharmacy Sir Run Run Shaw HospitalSchool of MedicineZhejiang UniversityHangzhou 310016China Department of Radiotherapy Sir Run Run Shaw HospitalSchool of MedicineZhejiang UniversityHangzhou 310016China Department of Pharmacological and Pharmaceutical Sciences College of PharmacyUniversity of HoustonHangzhou 310016China

To reduce the problems of poor solubility,high in vivo dosage requirement,and weak targeting ability of paclitaxel(PTX),a hyaluronic acid-octadecylamine(HA-ODA)-modified nano-structured lipid carrier(HA-NLC)was ***-ODA conjugates were synthesized by an amide reaction between HA and *** hydrophobic chain of HA-ODA can be embedded in the lipid core of the NLC to obtain *** HA-NLC displayed strong internalization in cluster determinant 44(CD44)highly expressed MCF-7 cells,and endocytosis mediated by the CD44 receptor was *** HA-NLC had an encapsulation efficiency of PTX of 72.0%.The cytotoxicity of the PTXloaded nanoparticle HA-NLC/PTX in MCF-7 cells was much stronger than that of the commercial preparation *** vivo,the HA-NLC exhibited strong tumor targeting *** distribution of the NLCs to the liver and spleen was reduced after HA modification,while more nanoparticles were aggregated to the tumor *** results suggest that HA-NLC has excellent properties as a nano drug carrier and potential for in vivo targeting.

关键词： Paclitaxel(PTX) Hyaluronic acid-octadecylamine(HA-ODA) Nano-structured lipid carrier(NLC) Tumor targeting In vivo distribution

Relationship between age of pregnant women with gestational diabetes mellitus and mode of delivery and neonatal Apgar score

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World Journal of Diabetes 2022年第9期13卷 776-785页

作者： lan Gao Cun-Ren Chen Fei Wang Qun Ji Kai-Ning Chen Yang Yang Hai-Wei Liu Department of Endocrinology Hainan General Hospital/Hainan Affiliated Hospital of Hainan Medical UniversityHaikou 570311Hainan ProvinceChina Department of Obstetrics and Gynecology Hainan General Hospital/Hainan Affiliated Hospital of Hainan Medical UniversityHaikou 570311Hainan ProvinceChina

BACKGROUND Gestational diabetes mellitus(GDM)refers to abnormal glucose tolerance during pregnancy,and it is often accompanied by obvious changes in glucose and lipid metabolism,and associated with adverse pregnancy *** incidence of fetal distress,polyhydramnios,puerperal infection,premature delivery,and macrosomia in pregnant women with GDM are higher than in those without *** To analyze the relationship between age of pregnant women with GDM and mode of delivery and neonatal Apgar *** A total of 583 pregnant women with GDM who delivered in the Department of Obstetrics at our hospital between March 2019 and March 2022 were *** them,377 aged35 years were selected as the older *** clinical data of the two groups were collected,and the relationship between age of the pregnant women with GDM and mode of delivery,maternal and neonatal outcomes,and neonatal Apgar score were *** the older group,159 women were classed as the adverse outcome group and 47 as the good outcome group according to whether they had adverse maternal and infant *** related factors of adverse maternal and infant outcomes were analyzed through logistic *** The number of women with assisted pregnancy,≤37 wk gestation,≥2 pregnancies,one or more deliveries,and no pre-pregnancy blood glucose screening in the older group were all higher than those in the right age group(P0.05).The right age group had higher Ap

关键词： Gestational diabetes mellitus Age Mode of delivery Neonatal Apgar score

基于深度欺骗策略的网络积极防御系统的设计与实现

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高技术通讯 2007年第8期17卷 798-802页

作者：姚兰钟力西安电子科技大学综合业务网理论及关键技术（ISN）国家重点实验室西安710071 解放军信息安全测评认证中心北京100016

为解决网络欺骗的安全性、欺骗性和交互性问题,提出了一个基于深度欺骗策略的五重欺骗与控制架构,在此基础上,建立了可实际应用的网络积极防御系统.该系统将防护、欺骗、监视、控制与审计整合为一体,在安全的条件下,通过网络服务欺骗、... 详细信息

为解决网络欺骗的安全性、欺骗性和交互性问题,提出了一个基于深度欺骗策略的五重欺骗与控制架构,在此基础上,建立了可实际应用的网络积极防御系统.该系统将防护、欺骗、监视、控制与审计整合为一体,在安全的条件下,通过网络服务欺骗、安全漏洞伪造、操作行为控制、文件系统欺骗和信息欺骗,实现了对整个网络入侵过程的欺骗与控制.其完整的欺骗与控制框架不仅仅针对某一攻击过程,还确保了系统不会轻易被识别,使欺骗程度和安全性大大提高.

关键词：深度欺骗积极防御网络服务仿真安全漏洞伪造操作行为控制

Protective effects of Longhu Rendan on chronic liver injury and fibrosis in mice

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Liver Research 2022年第2期6卷 93-102页

作者： Guizhi Yang Shengwen Li Jiahua Jin Yuanyuan Xuan Liqin Ding Minxia Huang Jun Liu Biye Wang Tian lan Guangdong Pharmaceutical University GuangzhouGuangdongChina Shanghai Zhonghua Pharmaceutical Co. Ltd.ShanghaiChina

Background and aim:Liver fibrosis resulting from persistent liver injury represents a major healthcare problem *** Chinese medicine has played an essential role in the treatment of liver fibrosis in recent ***,this study aims to assess the effect of Longhu Rendan(LHRD),a Chinese traditional patent medicine,on liver fibrosis and its potential ***:The liver fibrosis in mice was induced via the intraperitoneal injection of carbon tetrachloride(CCl4)for 6 weeks or bile duct ligation for 15 *** methods were used to judge the therapeutic effect of ***:LHRD significantly suppressed the activity of serum index of abnormal liver function,liver cell apoptosis,and necrosis,attenuating liver ***,LHRD treatment alleviated liver fibrotic features,such as the reduction of collagen deposition and hepatic stellate cell activation as well as profibrotic gene ***,LHRD treatment inhibited nuclear transcription factorkappa B signaling and inflammatory gene expression and diminished the production of reactive oxygen species and 4-hydroxynonenal,along with the downregulation of NADPH oxidase ***:Overall,the present study demonstrates that LHRD ameliorates liver injury and fibrosis via the inhibition of inflammation and oxidative stress in mice,indicating that LHRD is a potential medicine for the treatment of liver fibrosis.

关键词： Longhu Rendan(LHRD) Liver injury Liver fibrosis Oxidative stress Inflammation

3D conformal radiotherapy combined with transcatheter arterial chemoembolization for hepatocellular carcinoma

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World Journal of Gastroenterology 2014年第45期20卷 17227-17234页

作者： Li-Qun Zou Bing-lan Zhang Qing Chang Fu-Ping Zhu Yan-Yan Li Yu-Quan Wei Yong-Song Guan Department of Oncology Cancer Center State Key Laboratory of Biotherapy West China Hospital Sichuan University Department of Hepatobiliary Surgery The Ninth People’s Hospital of Chongqing

AIM: To compare transcatheter arterial chemoembolization (TACE) and 3D conformal radiotherapy (3D-CRT) with TACE monotherapy in hepatocellular carcinoma (HCC). METHODS: We searched all the eligible studies from the Cochrane Library, PubMed, Medline, Embase, and CNKI. The meta-analysis was performed to assess the survival benefit, tumor response, and the decline in alpha-fetoprotein (AFP) level. According to the heterogeneity of the studies, pooled OR with 95% CI were calculated using the fixed-effects or random-effects model. An observed OR > 1 indicated that the addition of 3D-CRT to TACE offered survival benefits to patients that could be considered statistically significant. Statistical analyses were performed using Review Manager Software. RESULTS: Ten studies met the criteria to perform a meta-analysis including 908 HCC participants, with 400 patients in the TACE/3D-CRT combination group and 508 in the TACE alone group. TACE combined with 3D-CRT significantly improved 1-, 2- and 3-year overall survival compared with TACE monotherapy (OR = 1.87, 95% CI: 1.37-2.55, P < 0.0001), (OR = 2.38, 95% CI: 1.78-3.17, P < 0.00001) and (OR = 2.97, 95% CI: 2.10-4.21, P < 0.00001). In addition, TACE plus 3DCRT was associated with a higher tumor response (complete remission and partial remission) (OR = 3.81; 95% CI: 2.70-5.37; P < 0.00001), and decline rates of AFP level (OR = 3.24, 95% CI: 2.09-5.02, P < 0.00001). CONCLUSION: This meta-analysis demonstrated that TACE combined with 3D-CRT was better than TACE monotherapy for patients with HCC, which needs to be confirmed by large multicenter trials. (C) 2014 Baishideng Publishing Group Inc. All rights reserved.

关键词： Hepatocellular carcinoma Chemoembolization Three-dimensional conformal radiotherapy Meta-analysis

Mineralogical and Geochemical Constraints on the Origin of the Ultramafic Rocks from Wuwamen Ophiolite at the Southern Margin of Middle Tianshan, Xinjiang

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Acta Geologica Sinica(English Edition) 2015年第A2期89卷 70-71页

作者： NIU Xiaolu YANG Jingsui LIU Fei FENG Guangying .TIAN Yazhou ZHANG lan GAO Jian ZHAO Yijue CARMA State Key Laboratory of Continental Tectonics and Dynamics Institute of Geology Chinese Academy ofGeological Sciences Beijing 100037 School of Earth Sciences and Mineral Resources China University of Geosciences Beijing 100083

Wuwamen ophiolite is located at the southern margin of Middle Tianshan, Xinjiang Province. In this paper, petrology, mineralogy and geochemistry of the ultramafic rocks from Wuwamen ophiolite were studied to constrain their origin and tectonic setting. The studies will be helpful in interpreting the evolution process of the South Tianshan Ocean.

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Arbitrary linear THz wave polarization converter with cracked cross meta-surface

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Chinese Optics Letters 2019年第4期17卷 80-83页

作者： Han Sun lan Wang Yaxin Zhang Shixiong Liang Jiaguang Han Feng lan Xinlan Zhou Ziqiang Yang Terahertz Science and Technology Research Center University of Electronic Science and Technology of China National Key Laboratory of Application Specific Integrated Circuit Hebei Semiconductor Research Institute Center for Terahertz Waves College of Precision Instrument and Optoelectronics Engineering Tianjin UniversityKey Laboratory of Optoelectronic Information Technology Ministry of Education

This Letter presents a double-layer structure combining a cracked cross meta-surface and grating surface to realize arbitrary incident linear terahertz(THz) wave polarization conversion. The arbitrary incident linear polarization THz wave will be induced with the same resonant modes in the unit cell, which results in polarization conversion insensitive to the linear polarization angle. Moreover, the zigzag-shaped resonant surface current leads to a strong magnetic resonance between the meta-surface and gratings, which enhances the conversion efficiency. The experimental results show that a more than 70% conversion rate can be achieved under arbitrary linear polarization within a wide frequency band. Moreover, around 0.89 THz nearly perfect polarization conversion is realized.

关键词： Letter presents structure combining polarization conversion

Multi-agent evaluation for energy management by practically scalingα-rank

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Frontiers of Information Technology & Electronic Engineering 2024年第7期25卷 1003-1016页

作者： Yiyun SUN Senlin ZHANG Meiqin LIU Ronghao ZHENG Shanling DONG Xuguang lan National Key Laboratory of Industrial Control Technology Zhejiang UniversityHangzhou 310027China College of Electrical Engineering Zhejiang UniversityHangzhou 310027China National Key Laboratory of Human–Machine Hybrid Augmented Intelligence Xi’an Jiaotong UniversityXi’an 710049China

Currently,decarbonization has become an emerging trend in the power system ***,the increasing number of photovoltaic units distributed into a distribution network may result in voltage issues,providing challenges for voltage regulation across a large-scale power grid *** learning based intelligent control of smart inverters and other smart building energy management(EM)systems can be leveraged to alleviate these *** achieve the best EM strategy for building microgrids in a power system,this paper presents two large-scale multi-agent strategy evaluation methods to preserve building occupants’comfort while pursuing systemlevel *** EM problem is formulated as a general-sum game to optimize the benefits at both the system and building ***α-rank algorithm can solve the general-sum game and guarantee the ranking theoretically,but it is limited by the interaction complexity and hardly applies to the practical power system.A new evaluation algorithm(TcEval)is proposed by practically scaling theα-rank algorithm through a tensor complement to reduce the interaction ***,considering the noise prevalent in practice,a noise processing model with domain knowledge is built to calculate the strategy payoffs,and thus the TcEval-AS algorithm is proposed when noise *** evaluation algorithms developed in this paper greatly reduce the interaction complexity compared with existing approaches,including ResponseGraphUCB(RG-UCB)andαInformationGain(α-IG).Finally,the effectiveness of the proposed algorithms is verified in the EM case with realistic data.

关键词： Energy management Multi-agent deep reinforcement learning Strategy evaluation Power grid system

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动态网络空间中的k-NN查询

电子学报 2011年第2期39卷 389-394页

作者：殷晓岚中国科学院软件研究所软件工程技术研发中心北京100190 中国科学院研究生院北京100049

随着无线通讯应用的持续增长和定位技术的发展,如何有效率的应答大量移动对象的查询请求以及基于位置的服务(location-based services LBS)变得越来越重要,k-NN查询是其中的重要服务功能.本文提出了一种解决动态网络中静态对象k-NN查询... 详细信息

随着无线通讯应用的持续增长和定位技术的发展,如何有效率的应答大量移动对象的查询请求以及基于位置的服务(location-based services LBS)变得越来越重要,k-NN查询是其中的重要服务功能.本文提出了一种解决动态网络中静态对象k-NN查询算法,该算法先将网络以目标对象为中心进行网络划分,通过定位原始对象在网络上的位置来计算位置相关查询.同时还分析了算法的复杂性,给出了实验比较.

关键词：移动对象空间数据网络库距离索引 k-NN