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Endovascular embolization by a magnetic microfiberbot

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National Science Review 2024年第5期11卷 95-96页

作者： Shuning Zhang wenlong yang Junbo Ge Department of Cardiology Zhongshan HospitalFudan University Shanghai Institute of Cardiovascular Diseases Key Laboratory of Viral Heart Diseases National Health Commission Key Laboratory of Viral Heart Diseases Chinese Academy of Medical Sciences National Clinical Research Center for Interventional Medicine Institutes of Biomedical Sciences Fudan University

The evolving landscape of embolization therapy for treating cerebral aneurysms and brain tumors represents a pivotal stride towards enhancing the efficacy and safety of minimally invasive treatments [1]. Conventional endovascular embolization methods [2], characterized by the manual maneuvering of catheters through the vascular system, present notable limitations in steerability and precision, compounded by the potential health risks associated with prolonged exposure to radiation for surgeons.

关键词： embolization endovascular magnetic microfiberbot

Surface cleaned Cu_(x)Pd_(y)alloy:Synthesis and their superior performances in hydrogen evolution reaction and biosensor

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Nano Research 2023年第5期16卷 7941-7949页

作者： Xinmei Liu Xue Li wenlong yang Gang Liu Yu Wang Yuhang Zuo Harbin University of Science and Technology Harbin 150001China Jiangsu Zhongsheng Gaoke Environment Co. Ltd.Wuxi 214244China

High cost and restricted activity of electrocatalysis are the major challenges for hydrogen generation and *** this work,we provided a one-pot synthesis of Cu_(x)Pd_(y)alloy nanoparticles(NPs)with controllable atomic ratio and“clean surface”.Benefiting from the preferable d-band structure,the Cu_(62)Pd_(38)NPs exhibited a lower overpotentials in the hydrogen evolution reaction(HER)over the full pH *** the acidic media,Cu_(62)Pd_(38)NPs achieved a low overpotential of 28.12 mV for HER,which was 25.73%of Pd *** the neutral solution,the overpotential by Cu_(62)Pd_(38)NPs is only 41.71%for that by uncleaned CuPd *** alkaline media,the overpotential by Cu_(62)Pd_(38)NPs was declined from 38.01 to 20.20 mV after 720 min yielding hydrogen,which was only 53.14%for the initial *** applied in biosensor,the synergistic effect of Cu and Pd accelerated the kinetics of electrocatalytic process,resulting in an enhanced *** glucose sensor constructed by Cu_(67)Pd_(33)exhibited a wider detection range up to 100.0 *** the sensitivity is 379.4μA/(mM·cm^(2)),which is ca.4.63 and 14.09 folds for that by pure Cu NPs and Pd NPs,*** optimal atomic percent would be conducive to optimize electrocatalytic activity of Cu_(x)Pd_(y)*** volcano plots for Cu_(x)Pd_(y)would open up a new avenue for designing electrocatalysis with rationalized cost and optimized performance.

关键词： alloy biosensor hydrogen evolution reaction overpotential detection range

Effect of Interfacial Strength on the Flexural Behavior of Glass Fiber Reinforced Polymer(GFRP) Reinforced Concrete Beam

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Journal of Wuhan University of Technology(Materials Science) 2015年第5期30卷 1001-1007页

作者：张亚芳 yang wenlong LIU Hao CHEN Peiran LIU Feng Faculty of Civil Engineering Guangzhou University

The reinforcement/matrix interfacial strength has been considered as the key factor when glass fiber reinforced polymer(GFRP) bar is mixed with concrete. In this paper, based on micromechanics, fourpoint bending numerical models with and without glass fiber of different interfacial strength have been set up to simulate the damage process of GFRP reinforced concrete beam. The results show that the higher the interfacial strength is, the higher the ultimate bearing capacity of beams, and the less the opening width and height of cracks will be reached. Furthermore, mixing of glass fibers has less influence on the damage process when the interfacial strength is weak, however, it can help to improve the ultimate bearing capacity of the beams, retard the expansion of cracks and improve the toughness when the interfacial strength is high.

关键词： interfacial strength GFRP damage process debonding numerical simulation

Biocompatibility of iron carbide and detection of metals ions signaling proteomic analysis via HPLC/ESl-Orbitrap

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Nano Research 2017年第6期10卷 1912-1923页

作者： Murtaza Hasan wenlong yang Yanmin Ju Xin Chu Yun Wang Yulin Deng Nasir Mahmood yanglong Hou Department of Materials Science and Engineering College of Engineering Peking University Beijing 700871 China School of Life Sciences Beijing Institu te of Technology Beijing 100081 China

Recently, magnetic nanopartides （NPs） have been extensively used in food industry and biomedical treatments. However, the biocompatibility mechanism on expression proteomics, before consideration of magnetic NPs for clinical application, has not yet been fully elucidated. Therefore, this study was undertaken to identify potential biomarkers of metal ion signaling proteins in human cervical cancer cell line （HeLa） cells. Here, we report the in vitro investigations of the cell cycle response and significant changes in protein abundance of HeLa cells when exposed to self-tailored hydrophilic Fe2C NPs. The comparative proteomic approach based on 180 labeling coupled with high performance liquid chromatography/ electrospray ionization with ion trap mass analyzer （HPLC/ESI-Orbitrap） was applied, and 394 proteins were identified. There were 46 significantly differentiated proteins based on the specific metal ion signaling response. Among them, 60S ribosomal protein L37a, serine/arginine-rich splicing factor 7, calmodulin, and calumenin were downregulated, whereas transketolase was overexpressed. Functional interaction network of Fe2C-regulated proteins was successfully created by the STRING algorithm to show the strong interactions between proteins. This work will not only help to understand the molecular mechanism of metal ion signaling proteins that can potentially be used to develop therapeutic protocols for diagnosis of diseases but also give direction for tailoring biocompatible magnetic NPs.

关键词： biocompatibility,^18O labeling magnetic nanoparticles proteomic analysis

A green method for synthesizing novel nanoparticles and their application in flexible conductive patterns

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Journal of Materiomics 2020年第2期6卷 300-307页

作者： Wei Li Qiongying Cen Wenjiang Li Zihan Zhao wenlong yang Yuqian Li Minfang Chen Guang yang Jinjun yang School of Materials Science and Engineering Tianjin Key Lab for Photoelectric Materials&DevicesNational Demonstration Center for Experimental Function Materials EducationTianjin University of TechnologyTianjin300384China Tianjin Key Laboratory of Hazardous Waste Safety Disposal and Recycling Technology School of Environmental Science and Safety EngineeringTianjin University of TechnologyTianjin300384China

A general and unified approach to synthesize Ag,Cu and Au nanoparticles(NPs)is developed at room temperature in air atmosphere under ultrasonication in poly(N-vinylpyrrolidone)(PVP)solutions with ascorbic acid and glucose as the reducing and nucleation agents,***,TEM,and HR-TEM analysis of the Ag,Cu,and Au NPs confirm purity and average diameters of 15.5±2.0 nm,50±3.0 nm,and 10±1.0 nm,*** ultrasonic-assisted mechanism,wherein reduction occurs readily and produces anti-oxidation particles,is proposed and *** infrared sintering was used to avoid damaging the substrate of conductive patterns whose resistivity at 10 W(~50℃)sintering power for less than 6 min reached up to 10±0.5 μΩ cm,40±3.0 μΩ cm,and 280±5 μΩ cm for Ag,Cu,and Au patterns,***-based electrodes were produced successfully and exhibited excellent flexibility and good *** potential of this method for large scale production is discussed.

关键词： Novel nanoparticles Conductivity Ultrasonic-assisted Infrared sintering

Filament growth dynamics in solid electrolyte-based resistive memories revealed by in situ TEM

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Nano Research 2014年第7期7卷 1065-1072页

作者： Xuezeng Tian Lifen Wang Jiake Wei Shize yang wenlong Wang Zhi Xu Xuedong Bai Beijing National Laboratory for Condensed Matter Physics Institute of Physics Chinese Academy of Sciences Beijing 7 O0190 China

Solid electrolyte based-resistive memories have been considered to be a potential candidate for future information technology with applications in non-volatile memory, logic circuits and neuromorphic computing. A conductive filament model has been generally accepted to be the underlying mechanism for the resistive switching. However, the growth dynamics of such conductive filaments is still not fully understood. Here, we explore the controllability of filament growth by correlating observations of the filament growth with the electric field distribution and several other factors. The filament growth behavior has been recorded using in situ transmission electron microscopy. By studying the real- time recorded filament growth behavior and morphologies, we have been able to simulate the electric field distribution in accordance with our observations. Other factors have also been shown to affect the filament growth, such as Joule heating and electrolyte infrastructure. This work provides insight into the controllable growth of conductive filaments and will help guide research into further functionalities of nanoionic resistive memories.

关键词： resistive switching conductive filaments in situ transmissionelectron microscope real-time observation computer simulation

Defect engineering of BCZT-based piezoelectric ceramics with high piezoelectric properties

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Journal of Advanced Ceramics 2022年第1期11卷 184-195页

作者： Xinjian WANG Yu HUAN Yixuan ZHU Peng ZHANG wenlong yang Peng LI Tao WEI Longtu LI Xiaohui WANG School of Material Science and Engineering University of JinanJinan 250022China School of Materials Science and Engineering Liaocheng UniversityLiaocheng 252000China State Key Laboratory of New Ceramics and Fine Processing School of Materials Science and EngineeringTsinghua UniversityBeijing 100084China

The intrinsic conduction mechanism and optimal sintering atmosphere of(Ba_(0.85)Ca_(0.15))(Zr_(0.1)Ti_(0.9))O_(3)(BCZT)ceramics were regulated by Mn-doping element in this *** Hall and impedance analysis,the undoped BCZT ceramics exhibit a typical n-type conduction mechanism,and the electron concentration decreases with the increasing oxygen partial ***,the undoped ceramics exhibit best electrical properties(piezoelectrical constant<733=585 pC·N^(-1),electro-mechanical coupling factor k_(p)=56%)in O_(2).A handful of Mn-doping element would transfer the conduction mechanism from n-type into *** the hole concentration reduces with the decreasing oxygen partial pressure for Mn-doped BCZT ***,the Mn-doped ceramics sintered in N_(2)have the highest insulation resistance and best piezoelectric properties(d_(33)=505 pC·N^(-1),k_(p)=50%).The experimental results demonstrate that the Mn-doping element can effectively adjust the intrinsic conduction mechanism and then predict the optimal atmosphere.

关键词： BCZT ceramics Mn-doping different sintering atmosphere p/n-type conduction mechanism defect engineering

Large-scale population structure and genetic architecture of agronomic traits of garlic

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Horticulture Research 2023年第4期10卷 187-199页

作者： Huixia Jia Qing Zhao Jiangping Song Xiaohui Zhang wenlong yang Zhenzhen Du Yue Zhu Haiping Wang State Key Laboratory of Vegetable Biobreeding Institute of Vegetables and FlowersChinese Academy of Agricultural SciencesBeijing 100081China

Garlic,an asexually propagated crop,is the second important bulb crop after the onion and is used as a vegetable and medicinal *** and diverse garlic resources have been formed over thousands of years of ***,genome variation,population structure and genetic architecture of garlic agronomic traits were still not well ***,1100258 single nucleotide polymorphisms(SNPs)were identified using genotyping-by-sequencing in 606 garlic accessions collected from43 *** structure,principal component and phylogenetic analysis showed that these accessions were divided into five *** agronomic traits,including above-ground growth traits,bulb-related and bolt-related traits in two consecutive years were implemented in a genome-wide association *** total,542 SNPs were associated with these agronomic traits,among which 188 SNPs were repeatedly associated with more than two *** SNP(chr6:1896135972)was repeatedly associated with ten *** associated SNPs were located within or near 858 genes,56 of which were transcription ***,one non-synonymous SNP(Chr4:166524085)in ribosomal protein S5 was repeatedly associated with above-ground growth and bulb-related ***,gene ontology enrichment analysis of candidate genes for genomic selection regions between complete-bolting and non-bolting accessions showed that these genes were significantly enriched in‘vegetative to reproductive phase transition of meristem’,‘shoot system development’,‘reproductive process’,*** results provide valuable information for the reliable and efficient selection of candidate genes to achieve garlic genetic improvement and superior varieties.

关键词： agronomic traits repeatedly

基于经筋理论探讨针刀恢刺法治疗紧张型头痛伴帽状腱膜挛缩的应用

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中医康复 2025年第1期2卷 66-70页

作者：李艳菲刘方铭尹聪杨文龙刘治镇山东中医药大学山东济南250355 山东第一医科大学第一附属医院山东济南250014

紧张型头痛是临床最常见的慢性头痛之一,主要表现为双侧轻中度压迫样或紧箍样头痛,发病多与生活中应激事件相关,其病因病理与肌筋膜激痛点有着密切联系。但当前临床研究主要以其伴随的情绪障碍症状为主,较少涉及局部腱膜组织病理改变方... 详细信息

紧张型头痛是临床最常见的慢性头痛之一,主要表现为双侧轻中度压迫样或紧箍样头痛,发病多与生活中应激事件相关,其病因病理与肌筋膜激痛点有着密切联系。但当前临床研究主要以其伴随的情绪障碍症状为主,较少涉及局部腱膜组织病理改变方向。在临床实践中,发现部分明显筋结点的患者亦伴发有帽状腱膜挛缩症状。在经筋学说中“结筋病灶点”理论指导下,松解百会次、目窗次、率谷次等穴位,并结合局部筋结治疗点治疗,达到了舒筋解结、祛邪通痹的良好疗效。现基于经筋理论探讨其理论机制,为紧张性头痛的治疗提供新思路。

关键词：经筋理论针刀恢刺法头痛紧张型头痛帽状腱膜挛缩