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Effect of early enteral nutrition on postoperative nutritional status and immune function in elderly patients with esophageal cancer or cardiac cancer

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Chinese Journal of Cancer Research 2013年第3期25卷 299-305页

作者： Guiping Yu Guoqiang Chen Bin Huang wenlong shao Guangqiao Zeng Department of Cardiothoracic Surgery The Affiliated Jiangyin Hospital Southeast University Medical College Department of Cardiothoracic Surgery The First Affiliated Hospital Guangzhou Medical University Guangzhou Institute of Respiratory Disease (GIRD) and China State Key Laboratory of Respiratory Disease The First Affiliated Hospital Guangzhou Medical University

To explore the effect of early enteral nutrition （EN） on postoperative nutritional status, intestinal permeability, and immune 6anction in elderly patients with esophageal cancer or cardiac cancer. Methods： A total of 96 patients with esophageal cancer or cardiac cancer who underwent surgical treatment in our hospital from June 2007 to December 2010 were enrolled in this study. They were divided into EN group （n=50） and parenteral nutrition （PN） group （n=46） based on the nutrition support modes. The body weight, time to first flatus/defecation, average hospital stay, complications and mortality after the surgery as well as the liver function indicators were recorded and analyzed. Peripheral blood samples were collected on the days 1, 4 and 7 after surgery. The plasma diamine oxidase （DAO） activity and D-lactate level were determined to assess the intestinal permeability. The plasma endotoxin levels were determined using dynamic turbidimetric assay to assess the protective effect of EN on intestinal mucosal barrier. The postoperative blood levels of inflammatory cytokines and immunoglobulins were determined using enzyme- linked immunosorbent assay （ELISA）. Results： After the surgery, the time to first flatus/defecation, average hospital stay, and complications were significantly less in the EN group than those in the PN group （P〈0.05）, whereas the EN group had significantly higher albumin levels than the PN group （P〈0.05）. On the 7th postoperative day, the DAO activity, D-lactate level and endotoxin contents were significantly lower in the EN group than those in the PN group （all P〈0.05）. In addition, the EN group had significantly higher IgA, IgG, IgM, and CD4 levels than the PN group （P〈0.05） but significantly lower IL-2, IL-6, and TNF-a levels （P〈0.05）. Conclusions： In elderly patients with esophageal cancer or cardiac cancer, early EN after surgery can effectively improve the nutritional status, protect intestinal mucosal barrier （by reducing plasma endoxins）, an

关键词： Enteral nutrition nutritional status intestinal permeability endotoxin immune function

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Carbon spheres with rational designed surface and secondary particle-piled structures for fast and stable sodium storage

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Journal of Energy Chemistry 2021年第3期30卷 368-376页

作者： wenlong shao Fangyuan Hu Siyang Liu Tianpeng Zhang Ce Song Zhihuan Weng Jinyan Wang Xigao Jian State Key Laboratory of Fine Chemicals Department of Polymer Materials&EngineeringLiaoning Province Engineering Research Centre of High Performance ResinsDalian University of TechnologyDalian 116024LiaoningChina School of Materials Science and Engineering Key Laboratory of Energy Materials and Devices(Liaoning Province)State Key Laboratory of Fine ChemicalsLiaoning Province Engineering Centre of High Performance ResinsDalian University of TechnologyDalian 116024LiaoningChina School of Mathematical Sciences Dalian University of TechnologyDalian 116024LiaoningChina

The electrochemical performance of hard carbon in sodium storage is still limited by its poor cycling stability and rate capability because of the sluggish kinetics *** this study,we use a simple and effective method to accelerate the kinetics process by engineering the structure of the electrode to promote its surface and near-surface *** goal is realized by the use of slightly aggregated ultra-small carbon *** large specific surface area formed by the small spheres can provide abundant active sites for electrochemical *** abundant mesopores and macropores derived from the secondary particle piled structure of the carbon spheres could facilitate the transport of electrolytes,shorten the diffusion distance of Na^(+)and accommodate the volume expansion during *** from these unique structure features,PG700-3(carbon spheres with the diameters of 40-60 nm carbonized at 700℃)exhibits high performance for sodium storage.A high reversible capacity of 163 mAh g^(-1) could be delivered at a current density of 1.0 A g^(-1) after 100 ***,at a current density of 10.0 A g^(-1),the specific capacity of PG700-3 gradually increases to 140 mAh g^(-1) after 10000 cycles,corresponding to a capacity retention of 112%.Given the enhanced kinetics of SIBs reactions,PG700-3 exhibits an excellent rate capability,i.e.,230 and 138 mAh g^(-1) at 0.1 and 5.0 A g^(-1),*** study provides a facile method to attain high performance anode materials for *** design strategy and improvement mechanism could be extended to other materials for high rate applications.

关键词： Sodium ion batteries Anode Carbon spheres High rate capability Surface reactions

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A flexible design strategy to modify Ti3C2Tx MXene surface terminations via nucleophilic substitution for long-life Li-S batteries

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Journal of Energy Chemistry 2022年第11期31卷 349-358,I0010页

作者： Tianpeng Zhang wenlong shao Siyang Liu Zihui Song Runyue Mao Xin Jin Xigao Jian Fangyuan Hu School of Materials Science and Engineering State Key Laboratory of Fine ChemicalsKey Laboratory of Energy Materials and Devices(Liaoning Province)Dalian University of TechnologyDalian 116024LiaoningChina State Key Laboratory of Fine Chemicals Department of Polymer Science&MaterialsLiaoning Province Engineering Research Centre of High Performances ResinsDalian University of TechnologyDalian 116024LiaoningChina

MXene-based materials have gained considerable attention for lithium-sulfur(Li-S)batteries cathode materials due to their superior electric conductivity and high affinitive to ***,there are still challenges in modifying the surface functional groups of MXene to further improve the electrochemical performance and increase the structure variety for MXene-based sulfur ***,we report an efficient and flexible nucleophilic substitution(S_(N))strategy to modify the Ti_(3)C_(2)T_(x) surface terminations and purposefully designed Magnolol-modified Ti_(3)C_(2)T_(x)(M-Ti_(3)C_(2)T_(x))as powerful cathode host *** from more C-Ti-O bonds forming and diallyl groups terminations reducing after the dehalogenation and nucleophilic addition reactions,the given M-Ti_(3)C_(2)T_(x) electrode could effectively suppress the lithium polysulfides shuttling via chemisorption and C—S covalent bond ***,the Magnolol-modified Ti_(3)C_(2)T_(x) significantly accelerates polysulfide redox reaction and reduces the activation energy of Li_(2) S *** a result,the as-prepared M-Ti_(3)C_(2)T_(x) electrode displays an excellent rate capability and a high reversible capacity of 7.68 mAh cm^(-2)even under 7.2 mg cm^(-2)S-loaded with a low decay rate of 0.07%(from 2 nd cycle).This flexible surface-modified strategy for MXene terminations is expected to be extended to other diverse MXene applications.

关键词： Lithium-sulfur batteries Nucleophilic substitution Magnolol-modified Ti3C2Tx Multifunctional sulfur host Long-cycle life

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A lightweight nitrogen/oxygen dual-doping carbon nanofiber interlayer with meso-/micropores for high-performance lithium-sulfur batteries

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Journal of Energy Chemistry 2021年第7期30卷 115-123页

作者： Fangyuan Hu Hao Peng Tianpeng Zhang wenlong shao Siyang Liu Jinyan Wang Chenghao Wang Xigao Jian School of Materials Science and Engineering State Key Laboratory of Fine ChemicalsKey Laboratory of Energy Materials and Devices(Liaoning Province).Dalian University of TechnologyDalian 116024LiaoningChina State Key Laboratory of Fine Chemicals Liaoning Province Engineering Research Centre of High Performance Resins.Dalian University of TechnologyDalian 116024LiaoningChina School of Mathematical Sciences Dalian University of TechnologyDalian 116024LiaoningChina

Lithium-sulfur(Li-S) batteries are promising energy-storage devices for future generations of portable electronics and electric vehicles because of the outstanding energy density,low cost,and nontoxic nature of *** the past decades,various novel electrodes and electrolytes have been studied to improve the performance of Li-S ***,the very limited lifespan and rate performance of Li-S batteries originating from the dissolution and diffusion of long-chain polysulfides in liquid electrolytes,and the intrinsic poor conductivity of S severely hinder their practical ***,an electrospinning method was developed to fabricate a thin conductive interlayer consisting of meso-/microporous N/O dual-doping carbon nanofiber(CNF).The freestanding 3 D interwoven structure with conductive pathways for electrons and ions can enhance the contact between polysulfides and N/O atoms to realize the highly robust trapping of polysulfides via the extremely polar ***,combining the meso-microporous N/O dual-doping CNF interlayer with a monodispersed S nanoparticle cathode results in a superior electrochemical performance of 862.5 mAh/g after 200 cycles at 0.2 C and a cycle decay as low as 0.08% per *** area specific capacity of 5.22 mAh/cm^(2) can be obtained after 100 cycles at 0.1 C with a high S loading of 7.5 mg/cm^(2).

关键词： Lithium-sulfur batteries Cathode interlayer Electrospinning Nitrogen/oxygen dual-doped carbon nanofibers Meso-micropore structure

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High and ultra-stable energy storage from all-carbon sodium-ion capacitor with 3D framework carbon as cathode and carbon nanosheet as anode

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Journal of Energy Chemistry 2021年第4期30卷 304-312页

作者： Fangyuan Hu Siyang Liu Shengming Li Cheng Liu Guipeng Yu Ce Song wenlong shao Tianpeng Zhang Xigao Jian School of Materials Science and Engineering State Key Laboratory of Fine ChemicalsLiaoning Province Engineering Centre of High Performance ResinsDalian University of TechnologyDalian 116024LiaoningChina School of Innovation and Entrepreneurship Dalian University of TechnologyDalian 116024LiaoningChina State Key Laboratory of Fine Chemicals Liaoning Province Engineering Research Centre of High Performance ResinsDalian University of TechnologyDalian 116024LiaoningChina School of Chemistry and Chemical Engineering Central South UniversityChangsha 410083HunanChina School of Mathematical Sciences Dalian University of TechnologyDalian 116024LiaoningChina

Sodium-ion capacitors(SICs)are extremely promising due to the combined merits of high energy-power characteristics and considerable price ***,it is still difficult to achieve high energypower outputs and cycle stability in a typical configuration of the metal-based battery-type anode and activated carbon capacitor-type cathode due to the kinetic *** this work,a carbon nanosheet(PSCS-600)with large interlayer spacing of 0.41 nm derived from the bio-waste pine cone shell was ***,the covalent triazine framework derived carbon(OPDN-CTF-A)was obtained through ionothermal synthesis strategy,exhibiting beneficial hierarchical pores(0.5-6 nm)and high heteroatoms(5.6 at%N,6.6 at%O).On this basis,the all-carbon SICs were fabricated by the integration of PSCS-600 anode and OPDN-CTF-A *** device delivered high energy density 111 Wh kg^(-1),high power output of 14,200 W kg^(-1) and ultra-stable cycling life(~90.7%capacitance retention after 10,000 cycles).This work provides new ideas in fabricating carbon-carbon architectural SICs with high energy storage for practical application.

关键词： All-carbon capacitor Sodium-ion storage Cycle stability Carbon Electrode design

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Nonintubated thoracoscopic lobectomy plus lymph node dissection following segmentectomy for central type pulmonary masses

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Chinese Journal of Cancer Research 2013年第1期25卷 124-127页

作者： wenlong shao Wei Wang Weiqiang Yin Zhihua Guo Guilin Peng Ying Chen Jianxing He Department of Thoracic Surgery the First Affiliated Hospital of Guangzhou Medical College Guangzhou Research Institute of Respiratory Disease China State Key Laboratory of Respiratory Disease

Lung cancer is the most common cancer worldwide. In the United States, it causes more cancer-related deaths than the next four causes （breast cancer, prostate cancer, colon cancer, and pancreatic cancer） of cancer-related mortality combined （1）. About 30% of people have already progressed to stage III lung cancer and 40% to stage IV at the time they are diagnosed （2）. Although chest X-ray and sputum cytology, when applied in health check-ups, can identify some relatively small tumors, they are not able to lower the overall mortality （3）. More recently,

关键词： node VATS Nonintubated thoracoscopic lobectomy plus lymph node dissection following segmentectomy for central type pulmonary masses lung

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High-Performance and Flexible Co-Planar Integrated Microsystem of Carbon-Based All-Solid-State Micro-Supercapacitor and Real-Time Temperature Sensor

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Energy & Environmental Materials 2023年第6期6卷 291-296页

作者： Dongming Liu Jiaxin Ma Shuanghao Zheng wenlong shao Tianpeng Zhang Siyang Liu Xigao Jian Zhongshuai Wu Fangyuan Hu School of Materials Science and Engineering State Key Laboratory of Fine ChemicalsSchool of Polymer MaterialsDalian University of TechnologyDalian 116024China State Key Laboratory of Catalysis Dalian Institute of Chemical PhysicsChinese Academy of SciencesDalian 116023China University of Chinese Academy of Sciences Beijing 100049China Dalian National Laboratory for Clean Energy Chinese Academy of SciencesDalian 116023China

With the rapid development of flexible and portable microelectronics,the extreme demand for miniaturized,mechanically flexible,and integrated microsystems are strongly ***,biomass-derived carbons(BDCs)are prepared by KOH activation using Qamgur precursor,exhibiting three-dimensional(3D)hierarchical porous *** from unobstructed 3D hierarchical porous structure,BDCs provide an excellent specific capacitance of 433 F g^(-1)and prominent cyclability without capacitance degradation after 50000 cycles at 50 A g^(-1).Furthermore,BDC-based planar micro-supercapacitors(MSCs)without metal collector,prepared by mask-assisted coating,exhibit outstanding areal-specific capacitance of 84 mF cm^(-2)and areal energy density of 10.6μWh cm^(-2),exceeding most of the previous carbon-based ***,the MSCs disclose extraordinary flexibility with capacitance retention of almost 100%under extreme bending *** importantly,a flexible planar integrated system composed of the MSC and temperature sensor is assembled to efficiently monitor the temperature variation,providing a feasible route for flexible MSC-based functional micro-devices.

关键词： 3D hierarchical porous carbon biomass-derived carbon integrated microsystem micro-supercapacitors temperature sensor

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A Novel Strategy of In Situ Trimerization of Cyano Groups Between the Ti3C2Tx(MXene) Interlayers for High-Energy and High-Power Sodium-Ion Capacitors

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Nano-Micro Letters 2020年第10期12卷 177-191页

作者： Siyang Liu Fangyuan Hu wenlong shao Wenshu Zhang Tianpeng Zhang Ce Song Man Yao Hao Huang Xigao Jian School of Materials Science and Engineering State Key Laboratory of Fine ChemicalsKey Laboratory of Energy Materials and Devices(Liaoning Province)Dalian University of TechnologyDalian 116024People’s Republic of China State Key Laboratory of Fine Chemicals Department of Polymer Science and EngineeringDalian University of TechnologyDalian 116024People’s Republic of China School of Mathematical Sciences Dalian University of TechnologyDalian 116024People’s Republic of China

2D MXenes are attractive for energy storage applications because of their high electronic ***,it is still highly challenging for improving the sluggish sodium(Na)-ion transport kinetics within the MXenes ***,a novel nitrogen-doped Ti3C2Tx MXene was synthesized by introducing the in situ polymeric sodium dicyanamide(Na-dca)to tune the complex terminations and then utilized as intercalation-type pseudocapacitive anode of Na-ion capacitors(NICs).The Na-dca can intercalate into the interlayers of Ti3C2 Tx nanosheets and simultaneously form sodium tricyanomelaminate(Na3TCM)by the catalyst-free *** as-prepared Ti3C2Tx/Na3TCM exhibits a high N-doping of 5.6 at.%in the form of strong Ti-N bonding and stabilized triazine ring ***,coupling Ti3C2Tx/Na3 TCM anode with different mass of activated carbon cathodes,the asymmetric MXene//carbon NICs are *** is able to deliver high energy density(97.6 Wh kg-1),high power output(16.5 kW kg-1),and excellent cycling stability(≈82.6%capacitance retention after 8000 cycles).

关键词： Sodium-ion capacitors MXene Fast kinetics Triazine polymerization Nitrogen doping

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Nonintubated uniportal video-assisted thoracoscopic surgery for primary spontaneous pneumothorax

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Chinese Journal of Cancer Research 2015年第2期27卷 197-202页

作者： Shuben Li Fei Cui Jun Liu Xin Xu wenlong shao Weiqiang Yin Hanzhang Chen Jianxing He The First Clinical College Southern Medical University Department of Cardiothoracic Surgery The First Affiliated Hospital of Guangzhou Medical University

Objective： The objective of the current study was to evaluate the feasibility and safety of nonintubated nniportal video-assisted thoracoscopic surgery （VATS） for the management of primary spontaneous pneumothorax （PSP）. Methods： From November 2011 to June 2013, 32 consecutive patients with PSP were treated by nonintubated uniportal thoracoscopic bullectomy using epidnral anaesthesia and sedation without endotracheal intubation. An incision 2 cm in length was made at the 6th intercostal space in the median axillary line. The pleural space was entered by blunt dissection for placement of a soft incision protector. Instruments were then inserted through the incision protector to perform thoracoscopic bullectomy. Data were collected within a minimum follow-up period of 10 months. Results： The average time of surgery was 49.0 rain （range, 33-65 rain）. No complications were recorded. The postoperative feeding time was 6 h. The mean postoperative chest tube drainage and hospital stay were 19.3 h and 41.6 h, respectively. The postoperative pain was mild for 30 patients （93.75%） and moderate for two patients （6.25%）. No recurrences ofpneumothorax were observed at follow-up. Conclusions： The initial results indicated that nonintubated uniportal video-assisted thoracoscopic operations are not only technically feasible, but may also be a safe and less invasive alternative for select patients in the management of PSP. This is the first report to include the use of a nonintubated uniportal technique in VATS for such a large number of PSP cases. Further work and development of instruments are needed to define the applications and advantages of this technique.

关键词： Uniportal video-assisted thoracoscopic surgery (VATS) spontaneous pneumothorax

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Safety and feasibility of video-assisted thoracoscopic surgery for stage IIIA lung cancer

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Chinese Journal of Cancer Research 2014年第4期26卷 418-422页

作者： wenlong shao Jun Liu Wehua Liang Hanzhang Chen Shuben Li Weiqiang Yin Xin Zhang Jianxing He Department of Thoracic Surgery The First Affiliated Hospital of Guangzhou Medical University Department of Thoracic Surgery Guangzhou Institute of Respiratory Diseases Key cite of National Clinical Research Center for Respiratory Diseases

Objective： The current study was prospectively designed to explore the application of video-assisted thoracoscopic surgery （VATS） radical treatment for patients with stage ⅢA lung cancer, with the primary endpoints being the safety and feasibility of this operation and the second endpoints being the survival and complications after the surgery. Methods： A total of 51 patients with radiologically or mediastinoscopically confirmed stage ⅢA lung cancer underwent VATS radical treatment, during which the standard pulmonary lobectomy and mediastinal lymph node dissection were performed after pre-operative assessment. The operative time, intraoperative blood loss/ complications, postoperative recovery, postoperative complications, and lymph node dissection were recorded and analyzed. This study was regarded as successful if the surgical success rate reached 90% or higher. Results： A total of 51 patients with non-small cell lung cancer （NSCLC） were enrolled in this study from March 2009 to February 2010. The median post-operative follow-up duration was 50.5 months. Of these 51 patients, 41 （80.4%） had N2 lymph node metastases. All patients underwent the thoracoscopic surgeries, among whom 50 （98%） received pulmonary lobectomy and mediastinal lymph node dissection completely under the thoracoscope, 6 had their incisions extended to about 6 cm due to larger tumor sizes, and 1 had his surgery performed using a 12 cm small incision for handling the adhesions between lymph nodes and blood vessels. No patient was converted to conventional open thoracotomy. No perioperative death was noted. One patient received a second surgery on the second post-operative day due to large drainage （〉1,000 mL）, and the postoperative recovery was satisfactory. Up to 45 patients （88.2%） did not suffer from any perioperative complication, and 6 （11.8%） experienced one or more complications. Conclusions： VATS radical treatment is a safe and feasible treatment for stage ⅢA lung cancer.

关键词： Lung cancer video-assisted thoracoscopic surgery (VATS) systematic node dissection (SND)

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