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Metabolomic characteristics of spontaneously hypertensive rats under chronic stress and the treatment effect of Danzhi Xiaoyao Powder, a traditional Chinese medicine formula

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Journal of Integrative Medicine 2022年第1期20卷 73-82页

作者： Shuai Chen Jin Hu Deng-cheng Lu Hong-yi liu shan-shan Wei College of Basic Medical Sciences Yunnan University of Chinese MedicineKunming 650500Yunnan ProvinceChina Department of Endocrinology Yunnan Provincial Hospital of Traditional Chinese MedicineKunming 650021Yunnan ProvinceChina Key Laboratory of Syndrome Micro-Differentiation of Yunnan Province Kunming 650500Yunnan ProvinceChina

Objective: Numerous studies have demonstrated the close relationship between chronic stress and blood pressure(BP). Hypertensive subjects exhibit exaggerated reactions to stress, especially higher BP. The mechanisms by which stress affects pre-existing hypertension still need to be explored. Danzhi Xiaoyao Powder(DP), a historical traditional Chinese medicine formula, is a promising treatment for BP control in hypertensive patients under stress. The present study investigated the metabolomic disruption caused by chronic stress and the treatment effect and mechanism of ***: Spontaneously hypertensive rats(SHRs) were subjected to chronic restraint stress(CRS) for 4 weeks. BP was measured via the tail-cuff method, and anxiety-like behavior was quantified using the elevated-plus-maze test. Meanwhile, DP was administered intragastrically, and its effects were observed. Global metabolomic analysis was performed using ultra-high-performance liquid chromatography-quadrupole time-of-flight mass spectrometry, followed by multivariate statistical analysis to detect differential metabolites and ***: DP alleviated the CRS-induced increase in BP and anxiety-like behavior. Systematic metabolic differences were found among the three study groups. A total of 29 differential plasma metabolites were identified in both positive-and negative-ion modes. These metabolites were involved in triglyceride metabolism, amino acid(phenylalanine, tryptophan, and glycine) metabolism, and steroid hormone ***: These findings expose the metabolomic disturbances induced by chronic stress in SHRs and suggest an innovative treatment for this disorder.

关键词： Hypertension Stress Metabolomics Danzhi Xiaoyao Powder

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Joint Detection of Serum Vitamin D,Body Mass Index,and Tumor Necrosis Factor Alpha for the Diagnosis of Crohn’s Disease

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当代医学科学(英文) 2023年第3期43卷 496-504页

作者： Ying ZHEng Jing-hong li shan-ying liAO Yi-ming FU Yan-jun ZHAng Jun-long liN Xin-bin CHEN Wei-hong SHA Shi-xue DAI Wen-jun MA Department of Nutrition Guangdong Provincial People's HospitalGuangdong Academy of Medical SciencesSouthern Medical UniversityGuangzhou510080China The Second School of Clinical Medicine Southern Medical UniversityGuangzhou 510080China Department of Gastroenterology Guangdong Provincial People's HospitalGuangdong Academy of Medical SciencesSouthern Medical UniversityGuangzhou 510080China The First School of Clinical Medicine&Nanfang Hospital Southern Medical UniversityGuangzhou 510080China Department of Gastroenterology Guangdong Provincial Geriatrics InstituteNational Key Clinical SpecialtyGuangdong Provincial People's HospitalGuangdong Academy of Medical SciencesSouthern Medical UniversityGuangzhou 510080China

Objective Vitamin D(VD)deficiency was reported to contribute to the progression of Crohn’s disease(CD)and affect the prognosis of CD *** study investigated the role of serum VD,body mass index(BMI),and tumor necrosis factor alpha(TNF-α)in the diagnosis of Crohn’s *** CD patients(n=76)and healthy subjects(n=76)were enrolled between May 2019 and December *** serum 25-hydroxyvitamin D[25(OH)D]levels,BMI,and TNF-αlevels,together with other biochemical parameters,were assessed before *** diagnostic efficacy of the single and joint detection of serum 25(OH)D,BMI,and TNF-αwas determined using receiver operating characteristic(ROC)*** The levels of 25(OH)D,BMI,and nutritional indicators,including hemoglobin,total protein,albumin,and high-density lipoprotein cholesterol,were much lower,and the TNF-αlevels were much higher in the CD patients than in the healthy subjects(Pngle detection of 25(OH)D,BMI,and TNF-αwere 0.887,0.896,and 0.838,respectively,with the optimal cutoff values being 20.64 ng/mL,19.77 kg/m^(2),and 6.85 fmol/mL,*** diagnostic efficacy of the joint detection of 25(OH)D,BMI,and TNF-αwas the highest,with an area under the ROC curve of 0.988(95%CI:0.968–1.000).Conclusion The joint detection of 25(OH)D,TNF-α,and BMI showed high sensitivity,specificity,and accuracy in CD diagnosis;thus,it would be effective for the diagnosis of CD in clinical practice.

关键词： Crohn’s disease vitamin D body mass index tumor necrosis factor alpha

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某露天矿边坡稳定性及优化研究

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价值工程 2024年第16期43卷 97-100页

作者：杨一豪李学锋黄绪兴肖武宁杜瀚段善达杨谦广西大学资源环境与材料学院南宁530004

文章以广西某露天矿山高陡边坡为研究对象,通过现场调查及室内岩石力学试验,结合矿山地质资料,采用RQD和RMR方法进行岩体质量评价,采用RocLab软件确定岩体力学参数,采用极限平衡法并基于Slide软件进行边坡稳定性及优化研究。研究结果表... 详细信息

文章以广西某露天矿山高陡边坡为研究对象,通过现场调查及室内岩石力学试验,结合矿山地质资料,采用RQD和RMR方法进行岩体质量评价,采用RocLab软件确定岩体力学参数,采用极限平衡法并基于Slide软件进行边坡稳定性及优化研究。研究结果表明:使用推荐的优化参数可使现状边坡的安全性和经济性之间达到最佳平衡,采场边坡参数的选取可作为同类矿山参考之依据。

关键词：露天矿岩体质量评价边坡稳定性滑坡治理

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“医养康护一体化”——在中国老龄化社会下发展海南“候鸟”式养老的现状与思考

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海南医学 2024年第6期35卷 873-875页

作者：吴天宇江山北京体育大学北京100000 联勤保障部队三亚康复疗养中心海南三亚572000 中日友好医院康复医学科北京100029

国内“候鸟”老人前往海南养老的重要因素是其舒适的气候环境。受医疗服务体系以及相关养老服务人才的影响,落后的海南省“候鸟”式养老产业和渴望前往海南省的“候鸟”数量形成巨大反差。在老龄化现象日益严重的中国,针对“候鸟”老人... 详细信息

国内“候鸟”老人前往海南养老的重要因素是其舒适的气候环境。受医疗服务体系以及相关养老服务人才的影响,落后的海南省“候鸟”式养老产业和渴望前往海南省的“候鸟”数量形成巨大反差。在老龄化现象日益严重的中国,针对“候鸟”老人的身体状况,合理推动和发展海南省特有的“医养康护一体化”养老服务体系,是海南省“候鸟”式养老服务未来发展的必然趋势。

关键词：海南候鸟养老医养康护一体化现状

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On pancreatic cancer screening by magnetic resonance imaging with the recent evidence by Del Chiaro and colleagues

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Chinese Journal of Cancer Research 2015年第4期27卷 417-422页

作者： Yì-Xiáng J.Wáng Jing-shan Gong Romaric Loffroy Department of Imaging and Interventional Radiology Faculty of Medicine The Chinese University of Hong Kong Prince of Wales Hospital Department of Radiology Shenzhen People’s Hospital Second Clinical Medicine College of Jinan University Department of Vascular Oncologic and Interventional Radiology Le2i UMR CNRS 6306 University of Dijon School of Medicine Bocage Teaching Hospital

Pancreatic cancer is a lethal disease because incidence and mortality rates are nearly *** 5-year survival rate in Western countries is 4%,the lowest among all types of cancer（1）.In China,pancreatic cancer is the sixth leading cause of death from malignant disease,with an overall cumulative 5-year survival rate of 1%to 3%（2,3）.

关键词： screening mortality intraductal cumulative lethal identical mucinous incidence familial pancreas

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Recyclable Carbon Nitride Nanosheet-Photocatalyzed Aminomethylation of Imidazo[1,2-a]pyridines in Green Solvent

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Chinese Journal of Chemistry 2022年第1期40卷 97-103页

作者： Tao Shi Yu-Ting liu shan-shan Wang Qi-Yan Lv Bing Yu School of Biology College of ChemistryZhengzhou UniversityZhengzhouHenan 450001China Institute of Chemistry Henan Academy of SciencesZhengzhouHenan 450002China Beijing Institute of Technology Analysis&Testing Center Beijing Institute of TechnologyBeijing 100081China

An efficient and eco-friendly carbon nitride nanosheet(NM-g-C3N4)-catalyzed decarboxylative coupling reaction of imidazo-fused heterocycles(i.e.,imidazo[1,2-a]pyridines,benzo[d]imidazo[2,1-b]thiazole)with N-phenylglycines in dimethyl carbonate(DMC)has been *** toxic solvents,external oxidants,and restricted reaction conditions could be effectively avoided in this powerful and sustainable ***,NM-g-C3N4 could be straightforwardly recovered by simple centrifugation and recycled and reused at least 7 times without an obvious decrease in catalytic activity.

关键词： Photocatalysis Heterogeneous catalysis Carbon nitride Decarboxylative coupling Green chemistry

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Therapeutic effects of combined oxaliplatin and S-1 in older patients with advanced gastric cardiac adenocarcinoma

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World Journal of Gastroenterology 2011年第47期17卷 5221-5226页

作者： She-Gan Gao Rui-Nuo Jia Xiao-shan Feng Xuan-Hu Xie Tan-You shan li-Xian Pan Na-Sha Song Yu-Feng Wang Kai-li Ding li-Dong Wang Department of Oncology First-Affiliated HospitalCancer Institute Henan University of Science and TechnologyLuoyang 471003 Henan Province China Henan Key Laboratory for Esophageal Can-cer Laboratory for Cancer Research Basic Medical CollegeZhengzhou University Zhengzhou 450052 Henan ProvinceChina

AIM:To evaluate the effects and safety of combination chemotherapy with oxaliplatin (L-OHP) and S-1 (SOX regimen) in older patients with advanced gastric cardiac adenocarcinoma (GCA). METHODS: Seventy patients with advanced GCA were classified according to age into an older group (≥ 75 years) and a control group (ng was 78.1% (25/32) in the older group and 76.3% (29/38) in the control group (χ2 = 0.032 and P = 0.857). Effi cacy was 68.8% (22/32) in the older group and 65.8% (25/38) in the control group (χ2 = 0.069 and P = 0.793). Toxicities were reversible and similar in both groups (P > 0.05). CONCLUSION: The SOX regimen is an effective, safe and well-tolerated regimen for older patients with advanced GCA.

关键词：胃的心脏的腺癌 Oxaliplatin S-1 治疗效果

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益智游戏促进幼儿专注力发展的策略研究

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齐齐哈尔高等师范专科学校学报 2024年第2期 13-15,74页

作者：张婷婷孙山四川轻化工大学四川自贡643000

益智游戏对幼儿专注力训练、专注水平提升、专注行为发展具有重要的实践价值。目前,益智游戏存在环境中无关刺激干扰、材料不满足幼儿的兴趣和需要、教师观察与指导不到位、“被合作”和忽略评价等问题。为了促进幼儿专注力发展,应该创... 详细信息

益智游戏对幼儿专注力训练、专注水平提升、专注行为发展具有重要的实践价值。目前,益智游戏存在环境中无关刺激干扰、材料不满足幼儿的兴趣和需要、教师观察与指导不到位、“被合作”和忽略评价等问题。为了促进幼儿专注力发展,应该创设安静有序的游戏环境、提供幼儿感兴趣和需要的游戏材料、提高教师的游戏观察与指导能力、强化益智游戏的合作性、关注幼儿益智游戏表现评价和提升家长教育能力,家园共育幼儿专注力。

关键词：益智游戏专注力策略

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The Potential Distribution Prediction of Oncomelania hupensis Based on Newly Emerging and Reemergent Habitats-China,2015−2019

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China CDC weekly 2021年第5期3卷 90-93,I0001,I0002页

作者： Yanfeng Gong Yinlong li lijuan Zhang shan Lv Jing Xu Shizhu li National Institute of Parasitic Diseases Chinese Center for Disease Control and PreventionChinese Center for Tropical Diseases ResearchWHO Collaborating Centre for Tropical DiseasesNational Center for International Research on Tropical DiseasesMinistry of Science and TechnologyKey Laboratory of Parasite and Vector BiologyNational Health Commission of ChinaShanghaiChina

What is already known about this topic?Oncomelania hupensis(***)is the only intermediate host of Schistosoma *** distribution of *** is affected by a series of climate,geographical,sand ocioeconomic factors,which reflect the risk areas of *** is added by this report?There were certain geographical aggregations in the potential high distribution areas of ***,which were mainly distributed in Poyang Lake area,Dongting Lake area,and the middle and the lower reaches of the Yangtze *** are the implications for public health practice?Monitoring and forecasting the distribution of *** is conducive to improving the early warning capabilities of the potential risk of schistosomiasis transmission and progressively promoting the elimination of schistosomiasis nationwide.

关键词： Schistosoma schistosomiasis pens

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铜管在羧酸环境下的腐蚀行为和腐蚀机理研究

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铜业工程 2024年第1期 29-37页

作者：李海红秦世腾王忠琦李德山刘晓王松伟烟台大学核装备与核工程学院山东烟台264005 烟台先进材料与绿色制造山东省实验室山东烟台265500 中国科学院金属研究所辽宁沈阳110016

铜管是空调及制冷行业用热交换器的核心部件,在服役过程中常由于蚁穴腐蚀导致设备提前失效。本文采用蒸气腐蚀、电化学腐蚀方法研究了铜管在羧酸环境下的腐蚀行为,通过金相显微镜(OM)、扫描电镜(SEM)、X射线粉末衍射仪(XRD)观察和分析... 详细信息

铜管是空调及制冷行业用热交换器的核心部件,在服役过程中常由于蚁穴腐蚀导致设备提前失效。本文采用蒸气腐蚀、电化学腐蚀方法研究了铜管在羧酸环境下的腐蚀行为,通过金相显微镜(OM)、扫描电镜(SEM)、X射线粉末衍射仪(XRD)观察和分析了表面腐蚀形貌和腐蚀产物的结构,通过接触角测量仪研究了羧酸与铜管的界面行为。结果表明,与CH_(3)COOH蒸气腐蚀相比,铜管在HCOOH蒸气环境下的腐蚀速度慢,腐蚀产物更致密。在HCOOH蒸气环境下,铜管容易出现蚁穴腐蚀。铜管表面的腐蚀产物主要由羧酸铜和氧化亚铜组成。蚁穴腐蚀属于电化学腐蚀,腐蚀机理复杂。腐蚀初期,表面氧化膜被聚集在铜管表面的羧酸溶解,暴露的铜基体作为微观阳极,之后,腐蚀坑内产生的微裂纹的尖端作为微观阳极,使腐蚀加速,直至贯穿管壁。

关键词：铜管羧酸蚁穴腐蚀电化学腐蚀金相组织

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