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DPB3 and DPB4 proteins regulate Medicago flowering and leaf anthocyanin biosynthesis

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Journal of Genetics and Genomics 2023年第6期50卷 450-453页

作者： Yingying Meng Chongnan Wang Qiqi Li wenkai ji jiangqi Wen Kirankumar S.Mysore Yanxi Pei Lifang Niu Hao Lin Biotechnology Research Institute Chinese Academy of Agricultural SciencesBeijing 100081China College of Life Science Shanxi UniversityTaiyuanShanxi 030006China Department of Plant and Soil Sciences Institute for Agricultural BiosciencesOklahoma State UniversityArdmoreOK 73401USA Department of Biochemistry and Molecular Biology Institute for Agricultural BiosciencesOklahoma State UniversityArdmoreOK 73401USA

As important subunits of the leading-strand DNA polymerase epsilon,chromatin remodeling,and histone acetylation complexes,the H2A/H2B-like histone-fold domain-containing proteins DNA PO-LYMERASE II SUBUNIT B3(DPB3)and DPB4 play key roles in nucleosome assembly and heterochromatin maintenance during DNA replication in yeast,Drosophila,and mammals(He et al.,2017;Bellelli et al.,2018;Yu et al.,2018;Casari et al.,2021).

关键词： mammals nucleosome complexes

Trace water triggers high-efficiency photocatalytic hydrogen peroxide production

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Journal of Energy Chemistry 2022年第1期31卷 47-54,I0003页

作者： Zaixiang Xu Yang Li Yongyong Cao Renfeng Du Zhikang Bao Shijie Zhang Fangjun Shao wenkai ji jun Yang Guilin Zhuang Shengwei Deng Zhongzhe Wei Zihao Yao Xing Zhong jianguo Wang Institute of Industrial Catalysis College of Chemical EngineeringState Key Laboratory Breeding Base of Green-Chemical Synthesis TechnologyZhejiang University of TechnologyHangzhou 310032ZhejiangChina Department of Chemistry Zhejiang UniversityHangzhou 310027ZhejiangChina

Photocatalytic production of hydrogen peroxide(H_(2)O_(2))has attracted much attentions as a promising method for sustainable solar ***,we demonstrate that trace water can drastically boost highefficiency photocatalytic production of H_(2)O_(2) with a record-high concentration of 113 mmol L^(-1) using alkali-assisted C_(3)N_(4) as photocatalyst in water/alcohol mixture *** electron paramagnetic resonance(EPR)measurement,the radical species generated during the photocatalytic process of H_(2)O_(2) are *** propose alcohol is used to provide and stabilize-OOH radicals through hydrogen bond,while trace water could trigger photocatalytic production of H_(2)O_(2) via providing and transferring indispensable free protons to completely consume OOH radicals,which breaks the reaction balance of-OOH radical generation from ***-OOH radicals could be supplied by alcohol continuously to serve as a reservoir for high-efficiency production of H_(2)O_(2).These results pave the way towards photocatalytic method on semiconductor catalysts as an outstanding approach for production of hydrogen peroxide.

关键词： Hydrogen peroxide Photocatalysis Carbon nitride Water Radicals

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文化宣传片对外译介传播的多模态协同重构

外语教学 2021年第5期42卷 82-86页

作者：吉文凯西安外国语大学高级翻译学院陕西西安710128

本研究以Halliday系统功能语法和Kress视觉语法为理论基础,尝试构建文化宣传片对外译介多模态语篇重构分析模式。进而以该模式为基础,以陕西电视台制作的、在国际会议上使用的、彰显陕西文化自信的汉英双语宣传片为研究语料,从多模态语... 详细信息

本研究以Halliday系统功能语法和Kress视觉语法为理论基础,尝试构建文化宣传片对外译介多模态语篇重构分析模式。进而以该模式为基础,以陕西电视台制作的、在国际会议上使用的、彰显陕西文化自信的汉英双语宣传片为研究语料,从多模态语篇分析视角,探讨面对体现蒙太奇拍摄手法、多种模态相互糅合、协同传达信息的文化宣传片时,译者如何对文本模态进行"操纵"才能实现目的语篇多种模态的最优协同,从而助力文化宣传片的目的语文化传播。

关键词：多模态语篇分析文化宣传片译介

The MYB Activator WHITE PETAL1 Associates with MtTT8 and MtWD40-1 to Regulate Carotenoid-Derived Flower Pigmentation in Medicago truncatula

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The MYB Activator WHITE PETAL1 Associates with MtTT8 and MtW...

Brain age estimation:premise,promise,and problems

中国生物工程学会第十三届学术年会暨2019年全国生物技术大会

作者： Yingying Meng Zuoyi Wang Yiqin Wang Chongnan Wang Butuo Zhu Huan Liu wenkai ji jiangqi Wen Chengcai Chu Million Tadege Lifang Niu Hao Lin Biotechnology Research Institute Chinese Academy of Agricultural Sciences The State Key Laboratory of Plant Genomics Institute of Genetics and Developmental Biology Chinese Academy of Sciences Noble Research Institute Department of Plant and Soil Sciences Institute for Agricultural Biosciences Oklahoma State University

Carotenoids are a group of natural tetraterpenoid pigments with indispensable roles in the plant life cycle and the human diet. Although the carotenoid biosynthetic pathway has been well characterized, the regulatory mechanisms that control carotenoid metabolism, especially in floral organs, remain poorly understood. In this study, we identified an anthocyanin-related R2 R3-MYB protein, WHITE PETAL1(WP1), that plays a critical role in regulating floral carotenoid pigmentation in Medicago truncatula. Carotenoid analyses showed that the yellow petals of wild-type M. truncatula contained high concentrations of carotenoids that largely consisted of esterified lutein, and that disruption of WP1 function via Tnt1 insertion led to substantially reduced lutein accumulation. WP1 mainly functions as a transcriptional activator and directly regulates the expression of carotenoid biosynthetic genes including MtLYCe and MtLYCb through its C-terminal acidic activation motif. Further molecular and genetic analyses revealed that WP1 physically interacts with MtTT8 and MtWD40-1 proteins and that this interaction facilitates WP1’s function in the transcriptional activation of both carotenoid and anthocyanin biosynthetic genes. Our findings demonstrate the molecular mechanism of WP1-mediated regulation of floral carotenoid pigmentation and suggest that the conserved MYB-bHLH-WD40 regulatory module functions in carotenoid biosynthesis in M. truncatula, with specificity imposed by the MYB partner.

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Neural Regeneration Research 2025年第8期20卷 2313-2314页

作者： Jarrad Perron ji Hyun Ko Graduate Program in Biomedical Engineering Price Faculty of EngineeringUniversity of ManitobaWinnipegMBCanada PrairieNeuro Research Centre Kleysen Institute for Advanced MedicineHealth Sciences CentreWinnipegMBCanada Department of Human Anatomy and Cell Science Rady Faculty of Health SciencesUniversity of ManitobaWinnipegMBCanada

Premise:The com bined effects of modern healthcare practices which prolong lifespan and declining birthrates have created unprecedented changes in age demographics worldwide that are especially pronounced in Japan,South Korea,Europe,and North *** old age is the most significant predictor of dementia,global healthcare systems must rise to the challenge of providing care for those with neurodegenerative disorders.

关键词： estimation providing birth

Manufacture the conducting polymer with light

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Science China Chemistry 2025年第1期68卷 8-9页

作者： Yang Li Tianyu Li Yan ji Baoguang Liu College of Electronic and Optical Engineering & College of Flexible Electronics (Future Technology) Nanjing University of Posts & Telecommunications

Poly(3,4-ethylenedioxythiophene) (PEDOT), heralded as the “king” of conducting polymers, is esteemed in bioelectronics for its mixed electronic and ionic conductivity, mechanical properties compatible with biological tissues, tunable healing ability and stability in diverse environments [1]. Based on additive manufacturing of three-dimensional structures,PEDOT realizes the implementation in the efficient production of flexible bioelectronics, the construction of intricate electrode-neural implantations, and the development of smart brain-computer-interfaces [2].

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Magneto‑Dielectric Synergy and Multiscale Hierarchical Structure Design Enable Flexible Multipurpose Microwave Absorption and Infrared Stealth Compatibility

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Nano-Micro Letters 2025年第2期17卷 401-416页

作者： Chen Li Leilei Liang Baoshan Zhang Yi Yang Guangbin ji School of Electronic Science and Engineering Nanjing UniversityNanjing 210093People’s Republic of China College of Materials Science and Technology Nanjing University of Aeronautics and AstronauticsNanjing 210016People’s Republic of China

Developing advanced stealth devices to cope with radar-infrared(IR)fusion detection and diverse application scenarios is increasingly demanded,which faces significant challenges due to conflicting microwave and IR cloaking mechanisms and functional integration ***,we propose a multiscale hierarchical structure design,integrating wrinkled MXene IR shielding layer and flexible Fe_(3)O_(4)@C/PDMS microwave absorption *** top wrinkled MXene layer induces the intensive diffuse reflection effect,shielding IR radiation signals while allowing microwave to pass ***,the permeable microwaves are assimilated into the bottom Fe_(3)O_(4)@C/PDMS layer via strong magneto-electric *** theoretical and experimental optimization,the assembled stealth devices realize a near-perfect stealth capability in both X-band(8–12 GHz)and long-wave infrared(8–14μm)wavelength ***,it delivers a radar cross-section reduction of−20 dB m^(2),a large apparent temperature modulation range(ΔT=70℃),and a low average IR emissivity of ***,the optimal device demonstrates exceptional curved surface conformability,self-cleaning capability(contact angle≈129°),and abrasion resistance(recovery time≈5 s).This design strategy promotes the development of multispectral stealth technology and reinforces its applicability and durability in complex and hostile environments.

关键词： Microwave absorption Radar-infrared compatible stealth Wrinkled MXene Magneto-dielectric synergy Multifunction

新型国产远段打孔覆膜支架治疗Stanford B型主动脉夹层的安全性和有效性

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中华医学杂志 2022年第40期102卷 3207-3212页

作者：季文凯唐夏陈宦君杨瑛纪敏王冀峰朱恩帅张丽琼王家平刘训强昆明医科大学附属延安医院血管外科昆明650051 昆明医科大学附属延安医院超声科昆明650051 昆明医科大学第二附属医院介入科昆明650101

目的评估新型国产远段打孔覆膜支架(Talos支架)治疗Stanford B型主动脉夹层(TBAD)的安全性和有效性。方法选取2018年2月至2019年12月在昆明医科大学附属延安医院使用Talos支架治疗的25例TBAD患者为研究对象。术中血管造影确定释放支架... 详细信息

目的评估新型国产远段打孔覆膜支架(Talos支架)治疗Stanford B型主动脉夹层(TBAD)的安全性和有效性。方法选取2018年2月至2019年12月在昆明医科大学附属延安医院使用Talos支架治疗的25例TBAD患者为研究对象。术中血管造影确定释放支架后保留的分支动脉数;术后第5天通过视觉模拟评分法(VAS)评估患者疼痛情况;比较患者术前和术后6、12个月CT血管造影(CTA)气管分叉水平主动脉直径、真腔直径、假腔直径;在术后1、6、12、24个月进行随访,记录支架相关不良事件发生情况、再次手术情况及存活率。结果纳入患者男19例,女6例,年龄(52.6±11.1)岁。术中血管造影显示保留了4(1,7)条分支动脉,术后第5天VAS评分为1(0,1)分。术前和术后6、12个月气管分叉水平主动脉直径分别为(34.9±1.1)、(34.6±0.9)、(34.8±1.0)mm,差异无统计学意义(P=0.926);术前和术后6、12个月气管分叉水平真腔直径分别为(13.3±1.6)、(21.8±1.0)、(22.3±1.1)mm,术前和术后6、12个月气管分叉水平假腔直径分别为(20.8±2.2)、(4.5±1.5)、(4.6±1.7)mm,术后6、12个月真腔直径和假腔直径与术前比较差异均有统计学意义(均P<0.001)。术后30 d未发生支架相关不良事件;术后12个月未发生二次手术,未发生Ⅰ型和Ⅲ型内漏,无死亡病例与截瘫病例,支架结构、位置保持良好;术后24个月无死亡与截瘫病例,未发生支架相关不良事件。结论使用Talos支架治疗TBAD能够有效帮助主动脉重塑,同时能够保留肋间动脉与脊髓动脉,具有较好的临床效果和安全性。

关键词：动脉瘤,夹层覆膜支架介入治疗治疗结果

Exploring the potential of extrachromosomal DNA as a novel oncogenic driver

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Science China Life Sciences 2025年第1期68卷 144-157页

作者： Huanbo Zhu Longtao Huangfu Junbing Chen jiafu ji Xiaofang Xing Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing) Division of Gastrointestinal Cancer Translational Research LaboratoryPeking University Cancer Hospital & Institute Department of Gastrointestinal Cancer Center Peking University Cancer Hospital & Institute Department of Liver Surgery & Transplantation Liver Cancer InstituteZhongshan HospitalFudan University Key Laboratory of Carcinogenesis and Cancer Invasion Ministry of Education State Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancers Beijing Key Laboratory of Carcinogenesis and Translational ResearchDivision of Gastrointestinal Cancer Translational Research LaboratoryPeking University Cancer Hospital & Institute

Extrachromosomal DNA(ecDNA) is a form of circular DNA mostly found in tumor cells. Unlike the typical chromosomal DNA, ecDNA is circular, self-replicating, and carries complete or partial gene fragments. Although ecDNA occurrence remains a rare event in cancer, recent studies have shown that oncogene amplification on ecDNA is widespread throughout many types of cancer, implying that ecDNA plays a central role in accelerating tumor evolution. ecDNA has also been associated with increased tumor mutation burden, chromosomal instability, and even tumor microenvironment remodeling. ecDNA may be crucial in influencing tumor heterogeneity, drug sensitivity,oncogenic senescence, and tumor immunogenicity, leading to a worsening prognosis for tumor patients. In this way, several clinical trials have been conducted to investigate the importance of ecDNA in clinical treatment. In this review, we summarize the biogenesis, characteristics, and current research methods of ecDNA, discuss the vital role of ecDNA-caused tumor heterogeneity in cancers, and highlight the potential role of ecDNA in cancer therapy.

关键词： extrachromosomal DNA cancer therapy tumor heterogeneity drug resistance tumor evolution