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Early prediction of growth patterns after pediatric kidney transplantation based on height-related single-nucleotide polymorphisms

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Chinese Medical Journal 2024年第10期137卷 1199-1206页

作者： Yi Feng Yonghua Feng Mingyao Hu Hongen Xu Zhigang Wang Shicheng Xu Yongchuang Yan Chenghao Feng Zhou Li Guiwen Feng wenjun Shang Department of Renal Transplantation The First Affiliated Hospital of Zhengzhou UniversityZhengzhouHenan 450052China Precision Medicine Center Academy of Medical ScienceZhengzhou UniversityZhengzhouHenan 450052China

Background:Growth retardation is a common complication of chronic kidney disease in children,which can be partially relieved after renal *** study aimed to develop and validate a predictive model for growth patterns of children with end-stage renal disease(ESRD)after kidney transplantation using machine learning algorithms based on genomic and clinical ***:A retrospective cohort of 110 children who received kidney transplants between May 2013 and September 2021 at the First Affiliated Hospital of Zhengzhou University were recruited for whole-exome sequencing(WES),and another 39 children who underwent transplant from October 2021 to March 2022 were enrolled for external *** on previous studies,we comprehensively collected 729 height-related single-nucleotide polymorphisms(SNPs)in exon *** machine learning algorithms and 10-fold cross-validation analysis were employed for model ***:The 110 children were divided into two groups according to change in height-for-age *** univariate analysis,age and 19 SNPs were incorporated into the model and *** random forest model showed the best prediction efficacy with an accuracy of 0.8125 and an area under curve(AUC)of 0.924,and also performed well in the external validation cohort(accuracy,0.7949;AUC,0.796).Conclusions:A model with good performance for predicting post-transplant growth patterns in children based on SNPs and clinical variables was constructed and validated using machine learning *** model is expected to guide clinicians in the management of children after renal transplantation,including the use of growth hormone,glucocorticoid withdrawal,and nutritional supplementation,to alleviate growth retardation in children with ESRD.

关键词： Growth Machine learning Pediatric kidney transplantation Single-nucleotide polymorphism

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Cl- ions accelerating interface charge transfer in a Si/In2S3 Faradaic junction photocathode for solar seawater splitting

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Science China Chemistry 2024年第9期67卷 2923-2929页

作者： Jun Luo Ruotong Bao Hongzheng Dong Ye Fu Dongjian Jiang Bo Wang Yuzhan Zheng Qiong Wang wenjun Luo Zhigang Zou Eco-materials and Renewable Energy Research Center (ERERC) Jiangsu Key Laboratory for Nano Technology National Laboratory of Solid State Microstructures College of Engineering and Applied Sciences Nanjing University National Laboratory of Solid State Microstructures and Department of Physics Nanjing University

Photoelectrocatalytic seawater splitting is a promising low-cost method to produce green hydrogen in a large scale. The effects of Cl-ions in seawater on the performance of a photoanode have been reported in previous studies. However, few researches have been done on the roles of Cl-ions in a photocathode. Herein, for the first time, we find that Cl-ions in the electrolyte improve the photocurrent of a Si/In2S3photocathode by 50% at-0.6 VRHE. An in-situ X-ray photoelectron spectroscopy（XPS） characterization combined with the time-of-flight secondary-ion mass spectrometry by simulating photoelectrochemical conditions was used to investigate the interface charge transfer mechanism. The results suggest that there is an In2+3S3–x（OH）2xlayer on the surface of In2S3in the phosphate buffer solution（PBS） electrolyte, which plays a role as an interface charge transfer mediator in the Si/In2S3photocathode. The In2+3S3–x（OH）2xsurface layer becomes In2+3S3–x（Cl）2xin the PBS electrolyte with NaCl and accelerates the charge transfer rate at the In2S3/electrolyte interface. These results offer a new concept of regulating interface charge transfer mediator to enhance the performance of photoelectrocatalytic seawater splitting for hydrogen production.

关键词： solar hydrogen production interface charge transfer mechanism coupled electron and ion transfer in-situ XPS characterization In2+3S3–x(OH)2x surface layer

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Effects of surface chlorine atoms on charge distribution and reaction barriers for photocatalytic CO_(2)reduction

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Nano Materials Science 2024年第2期6卷 235-243页

作者： Wendong Zhang wenjun Ma Yuerui Ma Peng Chen Qingqing Ye Yi Wang Zhongwei Jiang Yingqing Ou Fan Dong Chongqing Key Laboratory of Green Synthesis and Application&Chongqing Key Laboratory of Inorganic Functional Materials College of ChemistryChongqing Normal UniversityChongqing401331China Suzhou Industrial Technology Research Institute of Zhejiang University Jiangsu215000China Department of Chemistry Faculty of ScienceNational University of SingaporeSingapore117543Singapore Yangtze Delta Region Institute(Huzhou)&Institute of Fundamental and Frontier Sciences University of Electronic Science and Technology of ChinaHuzhou313001China

Photocatalytic CO_(2)reduction to produce high value-added carbon-based fuel has been proposed as a promising approach to mitigate global warming ***,the conversion efficiency and product selectivity are still low due to the sluggish dynamics of transfer processes involved in proton-assisted multi-electron *** the formation energy barriers of intermediate products is an effective method to enhance the selectivity and productivity of final *** this study,we aim to regulate the surface electronic structure of Bi_(2)WO_(6)by doping surface chlorine atoms to achieve effective photocatalytic CO_(2)*** Cl atoms can enhance the absorption ability of light,affect its energy band structure and promote charge *** with DFT calculations,it is revealed that surface Cl atoms can not only change the surface charge distribution which affects the competitive adsorption of H_(2)O and CO_(2),but also lower the formation energy barrier of intermediate products to generate more intermediate*COOH,thus facilitating CO ***,this study demonstrates a promising surface halogenation strategy to enhance the photocatalytic CO_(2)reduction activity of a layered structure Bi-based catalyst.

关键词： Surface chlorine atoms Charge distribution Reaction barriers Photocatalytic CO_(2)reduction Bi_(2)WO_(6)

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Understanding the mechanism underlying the anti-inflammatory effect of dietary flavonoids on IBD: a focus on gut microbiota and its metabolites involved in SCFA， bile acid， tryptophan and lipopolysaccharides

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Food Science and Human Wellness 2024年

作者： Huihui Xiong Hui Chen Lingli Chen Kehui Ouyang Suyun Lin wenjun Wang College of Food Science and Engineering Jiangxi Agricultural University College of Animal Science and Technology Jiangxi Agricultural University

Inflammatory bowel disease (IBD) is a chronic gastrointestinal disease with a high incidence. Treatment for IBD includes medications and diet， and common anti-inflammatory medications have limitations like drug resistance and serious adverse effects. Accumulating evidence has demonstrated that dietary flavonoids exhibit an alleviative effect on IBD by influencing gut microbiota. The microbiota-derived metabolites also regulate IBD and maintain intestinal homeostasis. In this review， we investigate the therapeutic effect of gut microbiota and metabolites on IBD by intestinal immune and intestinal barrier function. We demonstrate the underlying mechanism of dietary flavonoids as an anti-inflammatory molecule alleviating IBD by regulating gut microbiota， short chain fatty acid (SCFA)， bile acid (BA)， tryptophan (Trp) metabolism and lipopolysaccharides (LPS)-toll-like receptor 4 (TLR4) signaling pathway. Based on structural differences of flavonoids， we summarize the recent research progress on the role of different dietary flavonoids in alleviating IBD by gut microbiota and metabolites in animal and clinical trials. This review indicates that dietary flavonoids targeting gut microbiota and metabolites provide a promising strategy for the treatment of inflammation and novel insights into the management of IBD.

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3种芽孢杆菌菌剂对望天树苗木生长和光合特性的影响

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热带亚热带植物学报 2022年第2期30卷 213-223页

作者：汪丛啸何福英杨梅戴文君李婷广西大学林学院南宁530004 广西南宁良凤江国家森林公园南宁530004

为加快望天树(Parashorea chinensis)幼苗的生长,采用随机区组试验设计,1.5 a生望天树实生苗分别接种胶质芽孢杆菌(Bacillusmucilaginosus)、侧孢芽孢杆菌(***)和巨大芽孢杆菌(***)菌剂。结果表明,3种芽孢杆菌菌剂处理对苗木的生长、光... 详细信息

为加快望天树(Parashorea chinensis)幼苗的生长,采用随机区组试验设计,1.5 a生望天树实生苗分别接种胶质芽孢杆菌(Bacillusmucilaginosus)、侧孢芽孢杆菌(***)和巨大芽孢杆菌(***)菌剂。结果表明,3种芽孢杆菌菌剂处理对苗木的生长、光合指标均有提高,其中苗高、地径增量分别较对照提高了30.2%~57.2%和5.3%~49.7%,根系活力提高了74.5%~227.4%,净光合速率提高了15.3%~227.6%。6.0×10^(9)cfu/g的巨大芽孢杆菌处理的苗高、地径、生物量、根表面积、根平均直径、叶面积、叶绿素含量及净光合速率、实际光合效率、光化学淬灭系数均表现最好,与苗木质量指数和隶属函数法分析结果一致。因此,6.0×10^(9)cfu/g巨大芽孢杆菌对望天树苗木生长发育的促进作用最大。

关键词：芽孢杆菌菌剂光合作用苗木生长望天树

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基于自适应变惯性权重精英变异粒子群算法的微电网优化调度研究

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长春工业大学学报 2023年第4期44卷 328-334页

作者：戴文俊胡艳丽淮南师范学院机械与电气工程学院安徽淮南232038

为优化并网型微电网经济运行,编制合理的日运行计划,构建含购电费用、燃料费用和环境成本的多目标调度模型。提出一种自适应变惯性权重精英变异粒子群算法求解模型,该算法根据粒子间距动态调整惯性权重并融合精英变异策略以克服早熟收... 详细信息

为优化并网型微电网经济运行,编制合理的日运行计划,构建含购电费用、燃料费用和环境成本的多目标调度模型。提出一种自适应变惯性权重精英变异粒子群算法求解模型,该算法根据粒子间距动态调整惯性权重并融合精英变异策略以克服早熟收敛。通过测试函数和微电网调度运行算例仿真实验表明,该算法具有较高的精度且编制发电计划的费用最低。

关键词：微电网优化调度自适应精英变异粒子群优化算法

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Energy storage optimization of ferroelectric ceramics during phase-transition process of amorphous/nanocrystalline and polycrystalline by using a phaseffeld model for dielectric breakdown

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Journal of Advanced Dielectrics 2024年第1期14卷 33-41页

作者： Suilong Huang Jianwen Chen Zhen Su Xiucai Wang Wenbo Zhu wenjun Chen Xinmei Yu Peng Xiao School of Electronic and Information Engineering Foshan University Foshan 528000P.R.China School of Mechatronic Engineering and Automation Foshan University Foshan 528000P.R.China China-Australia Institute for Advanced Materials and Manufacturing Jiaxing University Jiaxing 314001P.R.China School of Materials Science and Hydrogen Energy Foshan University Foshan 528000P.R.China School of Physics and Optoelectronic Engineering Foshan University Foshan 528000P.R.China

Ferroelectric ceramics have the potential to be widely applied in the modern industry and military power systems due to their ultrafast charging/discharging speed and high energy *** the structural design and electrical properties of ferroelectric capacitor,it is still a challenge to ffnd out the optimal energy storage of ferroelectric ceramics during the phase-transition process of amorphous/nanocrystalline and *** this work,a ffnite element model suitable for the multiphase ceramic system is constructed based on the phase ffeld breakdown *** nonlinear coupling relationship of multiple physical ffelds between multiphase ceramics was taken into account in this *** basic structures of multiphase ceramics are generated by using the Voronoi diagram construction *** speciffed structure of multiphase ceramics in the phase-transition process of amorphous/nanocrystalline and polycrystalline was further obtained through the grain boundary diffusion *** simulation results show that the multiphase ceramics have an optimal energy storage in the process of amorphous polycrystalline transformation,and the energy storage density reaches the maximum when the crystallinity is 13.96%and the volume fraction of grain is 2.08%.It provides a research plan and idea for revealing the correlation between microstructure and breakdown characteristics of multiphase *** simulation model realizes the nonlinear coupling of the multiphase ceramic mesoscopic structure and the phase ffeld *** provides a reference scheme for the structural design and performance optimization of ferroelectric ceramics.

关键词： Ferroelectric ceramics phase transition phase-field model dielectric breakdown energy storage

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Tumor microenvironment-activated theranostic nanoreactor for NIR-II Photoacoustic imaging-guided tumor-specific photothermal therapy

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Fundamental Research 2024年第1期4卷 178-187页

作者： Nan Yang Hui Li Changyu Cao Lei Zhao Xuejiao Song wenjun Wang Wenjing Xu Yewei Zhang Peng Chen Xiaochen Dong Key Laboratory of Flexible Electronics(KLOFE)and Institute of Advanced Materials(IAM) School of Physical and Mathematical SciencesNanjing Tech University(NanjingTech)Nanjing 211816China School of Physical Science and Information Technology Liaocheng UniversityLiaocheng 252059China Department of Hepatobiliary and Pancreatic Surgery the Second Affiliated Hospital of Nanjing Medical UniversityNanjing 210011China School of Chemical and Biomedical Engineering Lee Kong Chian School of MedicineNanyang Technological University62 Nanyang DriveSingapore 637459Singapore

Theranostic agents that can be sensitively and specifically activated by the tumor microenvironment(TME)have recently attracted considerable *** this study,TME-activatable 3,3′,5,5′-tetramethylbenzidine(TMB)-copper peroxide(CuO_(2))@poly(lactic-co-glycolic acid)(PLGA)@red blood cell membrane(RBCM)(TCPR)nanoparticles(NPs)for second near-infrared photoacoustic imaging-guided tumor-specific photothermal therapy were developed by co-loading CuO_(2)NPs and TMB into PLGA camouflaged by *** an efficient H_(2)O_(2)supplier,once exposed to a proton-rich TME,CuO_(2)NPs can generate H_(2)O_(2)and Cu^(2+),which are further reduced to Cu^(+) by endogenous ***,the Cu^(+)-mediated Fenton-like reaction produces cytotoxic·OH to kill the cancer cells and induce TMB-mediated photoacoustic and photothermal *** with the RBCM modification-prolonged blood circulation,TCPR NPs display excellent specificity and efficiency in suppressing tumor growth,paving the way for more accurate,safe,and efficient cancer theranostics.

关键词： Nanoparticles Photoacoustic imaging Second near-infrared region Tumor microenvironment Self-sufficient H_(2)O_(2)

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肺间质病变继发性肺结核患者的高分辨率CT特征

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中国当代医药 2022年第31期29卷 133-135,139页

作者：戴粹新戴文君戴粹民陈武江西省景德镇市第五人民医院影像科江西景德镇333000

目的探讨肺间质病变继发性肺结核患者的高分辨率CT(HRCT)特征。方法选取2018年6月至2021年12月景德镇市第五人民医院收治的68例肺间质病变继发性肺结核患者作为研究对象,分析患者的HRCT检查影像学特征,包括病变部位、分布特点、伴随征... 详细信息

目的探讨肺间质病变继发性肺结核患者的高分辨率CT(HRCT)特征。方法选取2018年6月至2021年12月景德镇市第五人民医院收治的68例肺间质病变继发性肺结核患者作为研究对象,分析患者的HRCT检查影像学特征,包括病变部位、分布特点、伴随征象等。结果HRCT显示肺间质病变继发性肺结核患者病变部位多见于肺上叶,共累及155个肺段,其中左、右肺上叶尖后段病变占比较高,分别为33.55%(52/155)、30.97%(48/155);病变具体部位肺叶段中央及叶间胸膜占比较高,分别为48.39%(75/155)、36.13%(56/155);肺小叶内间质出现异常,其中细微结节及小叶内细网织线样阴影的检出率为100%;痰培养阳性者出现空洞征的占比高于痰培养阴性者,差异有统计学意义(P<0.05)。结论HRCT检查可清晰呈现肺间质病变继发性肺结核患者肺小叶内的细微病变,病灶好发部位、形态学特征可作为该病与其他间质性肺部疾病的鉴别依据,具备较高的诊断价值。

关键词：肺间质继发性肺结核高分辨率CT 影像学特征

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对四川马边地区磷-萤石-铅锌-铜多矿种多空间勘查开发工作的思考

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地质论评 2024年第2期70卷 716-719页

作者：文俊四川省第七地质大队四川乐山614000

马边地区的磷矿资源储量丰富,以往的找矿工作中在沉积型磷矿勘查方面取得了显著的找矿成果。马边地区的磷矿矿业权地块有17处,开采或勘查矿种均为磷矿,只有3处采矿权地块附加开采铅锌矿,1处采矿权地块附加开采萤石矿,马边地区的矿产勘... 详细信息

马边地区的磷矿资源储量丰富,以往的找矿工作中在沉积型磷矿勘查方面取得了显著的找矿成果。马边地区的磷矿矿业权地块有17处,开采或勘查矿种均为磷矿,只有3处采矿权地块附加开采铅锌矿,1处采矿权地块附加开采萤石矿,马边地区的矿产勘查开发呈现出矿种单一、空间狭窄的局面。基于近年来的找矿成果,建议构建马边地区磷—萤石—铅锌—铜多矿种多空间勘查开发新格局,部署以沉积型磷矿、热液型萤石—铅锌矿、砂岩型铜矿为主攻方向的综合找矿工作,主要包括在已有矿山上部及深部开展增储上产勘查工作、空白区的综合找矿工作及相应的科技创新工作,力争为新一轮找矿突破战略行动产出实效,为保障我国关键矿产资源供给安全发挥重要作用。

关键词：磷矿萤石矿铅锌矿铜矿麦地坪组灯影组筇竹寺组马边地区

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