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基于血清代谢组学分析热习服相关代谢产物及通路特征

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海军军医大学学报 2024年第5期45卷 569-577页

作者：张雄宝陈佳晖傅亚婷沈昊胡雪菲常文军海军军医大学(第二军医大学)海军医学系海军环境与劳动卫生学教研室上海200433

目的分析热习服与未习服人员血清中小分子代谢物的差异,揭示人体热习服相关血清小分子代谢物特征。方法选择70例由温到热跨域作业的健康男性为研究对象,以跨域后暴露于自然高温高湿环境作业或人工空调舒适环境作业为标准,分为热习服组(n... 详细信息

目的分析热习服与未习服人员血清中小分子代谢物的差异,揭示人体热习服相关血清小分子代谢物特征。方法选择70例由温到热跨域作业的健康男性为研究对象,以跨域后暴露于自然高温高湿环境作业或人工空调舒适环境作业为标准,分为热习服组(n=40)和未习服组(n=30)。收集所有研究对象跨域后2个月时的清晨空腹血液样本,经标准处理后采用液相色谱-串联质谱法进行代谢组学检测,用Progenesis QI软件和R 1.6.2软件ropls包筛选两组人员的差异小分子代谢物,对差异小分子代谢物进行京都基因与基因组百科全书(KEGG)通路富集分析。结果两组研究对象年龄和BMI差异无统计学意义(均P>0.05)。血清代谢组学检测共发现小分子代谢物1320个,正交偏最小二乘判别分析结果显示,热习服组和未习服组样本表现出良好的组间区分和组内聚集。两组血清样本间浓度差异在1.5倍(P<0.05)以上的小分子代谢物有89个,其中57个在热习服组升高、32个在热习服组降低;KEGG通路富集分析显示,差异小分子代谢物主要富集于氨基酸代谢和甘油磷脂代谢等13条代谢通路,涉及色氨酸、甘氨酸、丝氨酸、苏氨酸、精氨酸和脯氨酸等通路。结论热环境暴露下的热习服训练改变了人体血清小分子代谢物的组学特征,表现为氨基酸代谢水平增强,其可能与热耐力的维护有关。

关键词：热习服热耐力跨域训练血清代谢组氨基酸代谢

Newcastle Disease Virus/HK84:Next Potential Star for Targeted Immunotherapy of Hepatocellular Carcinoma?

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Journal of Clinical and Translational Hepatology 2022年第2期10卷 179-180页

作者： Weiyi Huang wenjun chang Department of Pharmacology Shantou University Medical CollegeShantouGuangdongChina Department of Navy Envi-ronmental and Occupational Health Naval Medical UniversityShanghaiChina

Of all liver cancers,hepatocellular carcinoma(HCC)is reported as the most common globally,with the highest incidence in East Asia.1 Because of the late diagnosis of disease,HCC is one of the top causes of cancer-related mortality,with the poor overall prognosis,the survival rate largely depends on the stage of diagnosis,the extent of cirrhosis,other associated risk factors and the medical treatment.1,2 Therefore,there is urgent need for reliable HCC treatments,which re-quires further investigation and *** addition to traditional cancer therapy,such as surgery and chemotherapy,immunotherapy has recently undergone rapid development and now includes checkpoint inhibitors,inhibiting cytokine blockade,adoptive cellular therapies and vaccines,which are under investigation in preclinical and/or in clinical ***,the currently available immunotherapy regimens for HCC under investigation have shown limited effectiveness in a relatively small number of patients.

关键词： diagnosis Carcinoma mortality

轮船轮机员用新型智能化温控复合降温背心的试制及其降温效果评价

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产业用纺织品 2024年第1期42卷 2-7页

作者：卢浩张洲瀛陈佳晖傅亚婷常文军于旭东上海理工大学健康科学与工程学院上海200433 海军军医大学海医系上海200433 海军特色医学中心特种作战医学研究室上海200433

针对一代降温背心在环境温度40℃以上降温效果不明显的问题,分别对其温控系统主机的核心元件、蓄电池和降温服进行优化,制成新型降温背心———新型智能化温控复合降温背心,以减轻轮船轮机员作业时的热负荷。选择10名受试者在37、41和4... 详细信息

针对一代降温背心在环境温度40℃以上降温效果不明显的问题,分别对其温控系统主机的核心元件、蓄电池和降温服进行优化,制成新型降温背心———新型智能化温控复合降温背心,以减轻轮船轮机员作业时的热负荷。选择10名受试者在37、41和45℃的高温模拟环境下,穿着工作状态和非工作状态的新型智能化温控复合降温背心,测试并评价其降温效果。结果表明:新型智能化温控复合降温背心在40℃以上环境温度中仍有显著的降温效果,且在不同的试验环境温度中,受试者穿着工作状态的新型降温背心的各项生理指标均有显著和非常显著性的降低,主观舒适度评分也明显低于穿着非工作状态新型降温背心的评分(P<0.05),人体舒适度提高。该新型降温背心设计合理,能有效减少人体热应激,具有良好的降温效果。

关键词：降温背心智能化温控高温耐受试验直肠温度降温效果

Regression model for estimation of attribute reliability

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Journal of Control and Decision 2021年第2期8卷 201-212页

作者： Guangyan Lu wenjun chang Department of Operation Management CRRC Qishuyan Institute Co.LtdChangzhouPeople’s Republic of China School of Management Hefei University of TechnologyHefeiBox 270HefeiAnhui 230009People’s Republic of China Key Laboratory of Process Optimization and Intelligent Decision-making Ministry of EducationHefeiAnhui 230009People’s Republic of China Ministry of Education Engineering Research Center for Intelligent Decision Making&Information System Technologies Hefei 230009People’s Republic of China

In this paper,a regression model is developed to estimate attribute reliability in the evidential reasoning(ER)*** analysing the difference between attribute weight and attribute reliability,a general qualitative definition of attribute reliability is *** reliability of an attribute is quantitatively measured in consistence with the qualitative definition in the context of the ER approach.A regression model is then constructed to generate attribute reliabilities by minimising the maximum differences between the real value of attribute reliability and its *** the post-optimal solution space of attribute reliabilities,an optimisation model is constructed to determine the expected utilities of each alternative in order to generate solutions to multiple attribute decision analysis *** place selection problem in Qingyang County of Chizhou in Anhui province of China is analysed using the proposed regression model to demonstrate its detailed implementation process,validity and applicability.

关键词： Multiple attribute decision analysis attribute reliability regression model evidential reasoning rule evidential reasoning approach

Data-driven group decision making for diagnosis of thyroid nodule

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Science China(Information Sciences) 2019年第11期62卷 151-173页

作者： Chao FU wenjun chang Weiyong LIU Shanlin YANG School of Management Hefei University of Technology Key Laboratory of Process Optimization and Intelligent Decision-making Ministry of Education Department of Ultrasound The First Affiliated Hospital of USTC Division of Life Sciences and MedicineUniversity of Science and Technology of China

Emerging information technologies’ integration into various fields has enhanced the development of these fields. Large volumes of data have been accumulated in this process. The accumulated data offer opportunities and challenges for people facing practical problems. On the one hand, it is essential to depend on a group’s capabilities rather than an individual’s capabilities to handle practical problems because the individual may lack sufficient expertise and experience to use data. In this situation, the practical problems can be considered as group decision making(GDM) problems. On the other hand, the accumulated data can help generate quality solutions to GDM problems. To obtain such solutions under the assumption that the accumulated data regarding a specific decision problem are available, this paper proposes a data-driven GDM method. In the method, decision makers’ weights are learned from historical overall assessments and the corresponding gold standards, while criterion weights are learned from historical overall assessments and the corresponding decision matrices. The learned expert weights and criterion weights are used to produce the aggregated assessments, from which alternatives are compared or the overall conclusion is made. In a tertiary hospital located in Hefei, Anhui Province, China, the proposed method is applied to aid radiologists in diagnosing thyroid nodules.

关键词： data-driven group decision making interval number learning of expert weights learning of criterion weights diagnosis of thyroid nodule

Bone tissue engineering scaffold materials: Fundamentals, advances, and challenges

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Chinese Chemical Letters 2024年第2期35卷 176-186页

作者： chang Xu Zhize Liu Xi Chen Yang Gao wenjun Wang Xijing Zhuang Hao Zhang Xufeng Dong Department of Cardiovascular Surgery Central Hospital of Dalian University of TechnologyDalian 116089China School of Materials Science and Engineering Dalian University of TechnologyDalian 116024China Department of Orthopaedics Central Hospital of Dalian University of TechnologyDalian 116089China Department of Dermatology Allergologyand VenereologyUniversity of LübeckLübeck 23562Germany

Bone damage caused by trauma and tumors is a serious problem for human health, therefore, three-dimensional (3D) scaffolding materials that stimulate and promote the regeneration of broken bone tissues have become the focus of current research in the field of bone damage *** this regard, a preferential combination of materials and preparation techniques is considered crucial for the preparation of advanced bone tissue engineering scaffolds to better facilitate the regeneration of broken *** this review, current research advances and challenges in bone tissue engineering scaffolds are discussed and analyzed in ***, we elucidated the structure and self-healing mechanism of bone ***, the main applications of different materials, including inorganic and organic materials, in bone tissue engineering scaffolds are ***, we overview the latest research progress of the mainstream preparation strategies of bone tissue engineering scaffolds, and provide an in-depth analysis of the different advantages of each ***, promising future directions and challenges of bone tissue engineering scaffolds are systematically discussed.

关键词： Biomaterials Bone defects Tissue engineering Scaffolds Osteogenesis

Genome-wide association studies:inherent limitations and future challenges

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Frontiers of Medicine 2012年第4期6卷 444-450页

作者： Yan Du Jiaxin Xie wenjun chang Yifang Han Guangwen Cao Department of Epidemiology Second Military Medical UniversityShanghai 200433China

Genome-wide association studies(GWAS)have achieved great success in identifying genetic variants related to complex human diseases such as cancer and have provided valuable insights into their genetic ***,GWAS is quite the fashion in ***,there are issues related to its *** work needs to be done in the post-GWAS *** sequencing followed by functional studies will be needed to elucidate the underpinning biological mechanisms and further translate GWAS findings into medical *** with pharmacogenomics,the success of GWAS in identifying genetic risk factors and genetic differences in drug response has been gradually enabling personalized *** this article,we used hepatocellular carcinoma(HCC)as an example to demonstrate some of the inherent limitations and summarized future challenges of GWAS.

关键词： genome-wide association studies(GWAS) genetic variant cancer limitation challenge

Interaction of Hepatitis B Virus X Protein with the Pregnane X Receptor Enhances the Synergistic Effects of Aflatoxin B1 and Hepatitis B Virus on Promoting Hepatocarcinogenesis

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Journal of Clinical and Translational Hepatology 2021年第4期9卷 466-476页

作者： Yongdong Niu Shaohua Fan Qin Luo Liming Chen Danmei Huang wenjun chang Wenxin Qin Ganggang Shi Department of Pharmacology Shantou University Medical CollegeShantouGuangdongChina Key Laboratory for Biotechnology on Medicinal Plants of Jiangsu Province School of Life ScienceJiangsu Normal UniversityXuzhouJiangsuChina State Key Laboratory of Oncogenes and Related Genes Shanghai Cancer InstituteRenji HospitalShanghai Jiao Tong University School of MedicineShanghaiChina Department of Oncology First Affiliated Hospital of Shantou University Medical CollegeShantouGuangdongChina Department of Environmental Hygiene Second Military Medical UniversityShanghaiChina

Background and Aims:Hepatitis B virus(HBV)infection has been found to increase hepatocellular sensitivity to carcinogenic xenobiotics,by unknown mechanisms,in the generation of hepatocellular *** pregnane X receptor(PXR)is a key regulator of the body’s defense against xenobiotics,including xenobiotic carcinogens and clinical *** this study,we aimed to investigate the molecular mechanisms of HBV X protein(HBx)-PXR signaling in the synergistic effects of chemical carcinogens in HBV-associated ***:The expression profile of PXR-cytochrome p4503A4(CYP3A4)signaling was determined by PCR,western blotting,and tissue *** viability and aflatoxin B1(AFB1)cytotoxicity were measured using the cell counting kit-8 *** gene expression was evaluated using transient transfection and real *** genotoxicity of AFB1 was assessed in newborn mice with a single dose of ***:HBx enhanced the hepatotoxicity of AFB1 by activating CYP3A4 and reducing glutathione Stransferase Mu 1(GSTM1)in cell *** of PXR by pregnenolone 16α-carbonitrile increased AFB1-induced liver tumor incidence by up-regulating oncogenic KRAS to enhance interleukin(IL)-11:IL-11 receptor subunit alpha-1(IL11RA-1)-mediated inflammation in an HBx transgenic ***:Our finding regarding AFB1 toxicity enhancement by an HBx-PXR-CYP3A4/GSTM1-KRASIL11:IL11RA signaling axis provides a rational explanation for the synergistic effects of chemical carcinogens in HBV infection-associated hepatocarcinogenesis.

关键词： Liver cancer Hepatitis B virus X protein Pregnane X receptor Aflatoxin B1 Hepatotoxicity

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考虑缺失属性的多属性群决策方法

系统科学与数学 2022年第4期42卷 920-934页

作者：付超盛松常文军合肥工业大学管理学院合肥230009 过程优化与智能决策教育部重点实验室合肥230009 智能决策与信息系统技术教育部工程研究中心合肥230009

针对决策者在不完全属性集下进行评价的多属性群决策问题,考虑对缺失属性上的评价进行估计,提出了一种基于决策者相似度的多属性群决策方法.给定决策者在不完全属性集上的评价矩阵,构造同时考虑交叉属性个数和评价值的决策者相似度,基... 详细信息

针对决策者在不完全属性集下进行评价的多属性群决策问题,考虑对缺失属性上的评价进行估计,提出了一种基于决策者相似度的多属性群决策方法.给定决策者在不完全属性集上的评价矩阵,构造同时考虑交叉属性个数和评价值的决策者相似度,基于此相似度对缺失属性评价进行估计,进而利用加权平均法对完整的评价矩阵进行集结得到每个决策者的方案排序.在此基础上,以决策者方案排序与总体方案排序差异最小为目标,构建优化模型以产生最优的总体方案排序.运用所提方法解决江苏省常州市一家高速列车制造企业的战略项目评价问题,验证了该方法的有效性与应用性.

关键词：不完全属性集相似度加权平均法多属性群决策