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肠内营养对结直肠癌患者脱落肿瘤细胞、菌群及免疫的影响

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肿瘤代谢与营养电子杂志 2024年第3期11卷 390-395页

作者：张福杰张文俊于登峰大连大学附属新华医院肿瘤科辽宁大连116000

目的探讨肠内营养对结直肠癌患者腹腔及肠腔内脱落肿瘤细胞、肠道菌群、免疫功能的影响。方法选取2022年3月至2023年3月于大连大学附属新华医院行根治术治疗的300例结直肠癌患者作为研究对象,按照随机数字表法分为试验组(肠内营养)与对... 详细信息

目的探讨肠内营养对结直肠癌患者腹腔及肠腔内脱落肿瘤细胞、肠道菌群、免疫功能的影响。方法选取2022年3月至2023年3月于大连大学附属新华医院行根治术治疗的300例结直肠癌患者作为研究对象,按照随机数字表法分为试验组(肠内营养)与对照组(予以传统肠道准备),各150例。对比腹腔和肠腔内脱落细胞阳性率、肠道耐受性、肠道清洁度;观察术前和术后7 d的肠道菌群(双歧杆菌、乳酸杆菌、大肠埃希菌、肠球菌)、总蛋白(TP)、前清蛋白(PA)、白蛋白(ALB)、CD4~+T细胞百分比、CD8~+T细胞百分比,并计算CD4~+T细胞/CD8~+T细胞比值。结果试验组的腹腔、肠腔内脱落细胞阳性率分别为4.67%、10.67%,显著均低于对照组(P<0.05)。两组整体肠道耐受性(Ⅰ级/Ⅱ级/Ⅲ级)和肠道清洁度(Ⅰ级/Ⅱ级/Ⅲ级/Ⅳ级)比较,差异具有统计学意义(P<0.05)。两组术后7 d每克粪便湿重中双歧杆菌、乳酸杆菌的对数值高于术前,而大肠埃希菌、肠球菌的对数值低于术前(P<0.05)。试验组术后7 d的CD4~+T细胞百分比、CD8~+T细胞百分比、CD4~+T细胞/CD8~+T细胞比值,TP、PA、ALB水平高于术前(P<0.05);试验组术后7 d每克粪便湿重中双歧杆菌、乳酸杆菌、大肠埃希菌、肠球菌的对数值,CD4~+T细胞百分比、CD8~+T细胞百分比,CD4~+T细胞/CD8~+T细胞比值,TP、PA、ALB水平分别为(7.65±0.68)log GFU/g、(6.92±0.71)log GFU/g、(8.56±1.45)log GFU/g、(8.28±0.97)log GFU/g,(41.03±2.21)%、(26.25±2.07)%、(1.92±0.28),(69.52±6.82)g/L、(266.36±9.58)mg/L、(40.01±3.69)g/L,对照组分别为(6.19±0.42)log GFU/g、(6.08±0.43)log GFU/g、(9.31±1.72)log GFU/g、(9.01±1.21)log GFU/g,(30.14±1.48)%、(18.01±1.51)%、(1.50±0.19),(62.01±4.05)g/L、(217.08±8.41)mg/L、(31.82±3.12)g/L,两组比较,试验组每克粪便湿重中双歧杆菌、乳酸杆菌的对数值,CD4~+T细胞百分比、CD8~+T细胞百分比、CD4~+T细胞/CD8~+T细胞,TP、PA、ALB水平更高,大肠埃希菌、肠球菌的对数值更低,差异具有统计学意义(P<0.05)。结论结直肠癌患者术前予以肠内营养有利于减少腹腔及肠腔内脱落肿瘤细胞的阳性率和纠正胃肠道菌群,改善营养状态和免疫功能,对指导临床治疗和改善预后具有重要意义。

关键词：肠内营养传统肠道准备结直肠癌肿瘤细胞肠道菌群

Uplink transmission design for crowded correlated cell-free massive MIMO-OFDM systems

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Science China(Information Sciences) 2021年第8期64卷 127-142页

作者： Junyuan GAO Yongpeng WU Yongjian WANG wenjun zhang Fan WEI The Department of Electronic Engineering Shanghai Jiao Tong University The National Computer Network Emergency Response Technical Team/Coordination Center of China

In cell-free massive multiple-input multiple-output(MIMO) orthogonal frequency division multiplexing(OFDM) systems, user equipments(UEs) are served by many distributed access points(APs),where channels are correlated owing to finite angle-delay spread in realistic outdoor wireless propagation environments. Meanwhile, the number of UEs is growing rapidly for future fully networked society. In this paper, we focus on the uplink transmission design in crowded correlated cell-free massive MIMO-OFDM systems with a limited number of orthogonal pilots. For the pilot transmission phase, we identify active UEs based on non-orthogonal pilot phase shift hopping patterns and non-orthogonal adjustable phase shift pilots(APSP). We derive a closed-form expression of mean square error of channel estimation(MSE-CE) and obtain an optimal condition for minimizing MSE-CE. According to this condition, the APSP set allocation scheme is proposed. Furthermore, for the data transmission, the max-min power control algorithm is devised to maximize the minimum spectral efficiency(SE) lower bound among active UEs. Simulation results indicate significant performance gains in terms of MSE-CE for the proposed APSP set allocation scheme. The proposed power control scheme can further improve the minimum SE among active UEs. Hence, they are crucial for crowded correlated cell-free massive MIMO-OFDM systems.

关键词： APSP set allocation cell-free massive MIMO-OFDM correlated channels crowded scenarios power control

The expression of N-cadherin/catenins/actin complex in human lung normal and carcinoma cells

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Chinese Science Bulletin 1998年第9期43卷 774-779页

作者： wenjun zhang Zhongxiang Lin Zhiqian zhang Ying Hu Beijing Inst Canc Res Dept Cell Biol Beijing 100034 Peoples R China Beijing Med Univ Sch Oncol Beijing 100034 Peoples R China

The difference between human normal and carcinoma lung cells was studied with regard to the protein expression level and localization of the cadherin/catenin/actin complex. Results demonstrated that normal lung cell RF expressed high levels of N-cadherin, β-catenin, α-catenin. These 3 proteins were colocalized at AJs and their submembrane adhesion plaques where they link the Rho-phalloidin-positive actin stress fibers, indicating the existence of N-cadherin/catenin/actin complexes at the AJs. Aberrant expression of AJ proteins and the actin cytoskelecton in carcinoma PG cells was observed: (1) inhibition of N-cadherin and to a degree of inhibition of α-catenin protein expression; (2) varied protein modification of β-catenin in cytoplasm soluble fraction and altered distribution of immunofluorescence: majorly in the cytoplasm and minorly on the membrane; (3) disassembly of actin stress fibers and formation of actin bodies in the cytoplasm. The data suggest that inhibited expression of AJ proteins is correlated with the disruption of the AJ complexes and the actin cytoskeleton in carcinoma PG cells, and responsible for its metastasis behaviors.

关键词： N-cadherin/catenin/actin complex protein expression human lung normal and carcinoma cells.

鄂尔多斯盆地东缘奥陶纪马家沟期边界断层的新认识及其对成钾凹陷的控制

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地球学报 2024年第5期45卷 678-690页

作者：桂宝玲张永生邢恩袁彭渊陈天宇毛亚辉张文君赵海彤蒋苏扬中国地质科学院矿产资源研究所自然资源部盐湖资源与环境重点实验室北京100037 中国地质科学院矿产资源研究所自然资源部成矿作用与资源评价重点实验室北京100037 中国地质科学院自然资源部深地科学与探测技术实验室北京100037 中国石油长庆油田分公司第二采气厂陕西榆林719000 中国石油长庆油田分公司油气工艺研究院陕西西安710018 中国石油华北油田分公司勘探开发研究院河北任丘062552

鄂尔多斯盆地陕北盐盆奥陶系马家沟组具备良好的成钾潜力,然而,当前仅勘探到薄钾石盐矿层和厚层钾石盐矿化段,大规模钾盐矿尚未发现。通过分析鄂尔多斯盆地东缘地震剖面的构造特征,认为盆地东缘晋西挠褶带西部马五6亚段沉积期存在活动... 详细信息

鄂尔多斯盆地陕北盐盆奥陶系马家沟组具备良好的成钾潜力,然而,当前仅勘探到薄钾石盐矿层和厚层钾石盐矿化段,大规模钾盐矿尚未发现。通过分析鄂尔多斯盆地东缘地震剖面的构造特征,认为盆地东缘晋西挠褶带西部马五6亚段沉积期存在活动边界正断层。在该断层作用下,形成东断西超的活动同沉积凹陷,富钾卤水大量汇聚于此。在持续干旱的强蒸发环境下,卤水持续浓缩,成钾窗口出现,钾石盐大规模析出,进而形成整装海相优质固体钾石盐矿床。侏罗纪末期,挤压应力导致成钾凹陷抬升,形成古凹今隆的格局,钾盐层抬升至较浅部位,有利于水溶法经济开采。

关键词：鄂尔多斯盆地东缘晋西挠褶带奥陶系马家沟组海相钾盐构造成钾古凹今隆

Cell surface clustering of Cadherin adhesion complex induced by antibody coated beads

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Chinese Science Bulletin 2000年第16期45卷 1504-1509页

作者： wenjun zhang Zhongxiang Lin Ying Hu Beijing Med Univ Beijing Inst Canc Res Sch Oncol Beijing 100034 Peoples R China

Cadherin receptors mediate cell-cell adhesion, signal transduction and assembly of cytoskeletons. How a single transmembrane molecule Cadherin can be involved in multiple functions through modulating its binding activities with many membrane adhesion molecules and cytoskeletal components is an unanswered question which can be elucidated by clues from bead experiments. Human lung cells expressing N-Cadherin were examined. After co-incubation with anti-N-Cadherin monoclonal antibody coated beads, cell surface clustering of N-Cadherin was induced. Immunofluorescent detection demonstrated that in addition to Cadherin, β-Catenin, α-Catenin, a-Actinin and Actin fluorescence also aggregated respectively at the membrane site of bead attachment. Myosin heavy chain (MHC), another major component of Actin cytoskeleton, did not aggregate at the membrane site of bead attachment. Adhesion unrelated protein Con A and polylysine conjugated beads did not induce the clustering of adhesion molecules. It is indicated

关键词： Latex bead N-Cadherin adherens junction adhesion molecular complex.

Engineered tumor cell-derived vaccines against cancer: The art of combating poison with poison

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Bioactive Materials 2023年第4期22卷 491-517页

作者： Xinyi zhang Hengqing Cui wenjun zhang Zhaoshen Li Jie Gao Changhai Clinical Research Unit Shanghai Changhai HospitalNaval Medical UniversityShanghai200433China Institute of Translational Medicine Shanghai UniversityShanghai200444China Department of Gastroenterology Shanghai Changhai HospitalNaval Medical UniversityShanghai200433China Department of Burns and Plastic Surgery Shanghai Changzheng HospitalShanghai200003China

Tumor vaccination is a promising approach for tumor immunotherapy because it presents high specificity and few side ***,tumor vaccines that contain only a single tumor antigen can allow immune system evasion by tumor *** antigens are complex and heterogeneous,and identifying a single antigen that is uniformly expressed by tumor cells is *** tumor cells can produce comprehensive antigens that trigger extensive tumor-specific immune ***,tumor cells are an ideal source of antigens for tumor vaccines.A better understanding of tumor cell-derived vaccines and their characteristics,along with the development of new technologies for antigen delivery,can help improve vaccine *** this review,we summarize the recent advances in tumor cell-derived vaccines in cancer immunotherapy and highlight the different types of engineered approaches,mechanisms,administration methods,and future *** discuss tumor cell-derived vaccines,including whole tumor cell components,extracellular vesicles,and cell membrane-encapsulated *** cell-derived vaccines contain multiple tumor antigens and can induce extensive and potent tumor immune ***,they should be engineered to overcome limitations such as insufficient immunogenicity and weak *** genetic and chemical engineering of tumor cell-derived vaccines can greatly enhance their targeting,intelligence,and functionality,thereby realizing stronger tumor immunotherapy *** advances in materials science,biomedicine,and oncology can facilitate the clinical translation of tumor cell-derived vaccines.

关键词： Vaccine Cancer Immunotherapy Immunogenicity Engineering Nanotechnology Biomaterials

Distinctive MJO Activity during the Boreal Winter of the 2015/16 Super El Nino in Comparison with Other Super El Nino Events

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Advances in Atmospheric Sciences 2021年第4期38卷 555-568页

作者： Xuben LEI wenjun zhang Pang-Chi HSU Chao LIU Key Laboratory of Meteorological Disaster Ministry of Education/Joint International Research Laboratory of Climate and Environmental Change/Collaborative Innovation Center on Forecast and Evaluation of Meteorological DisastersNanjing University of Information Science&TechnologyNanjing 210044China

Many previous studies have demonstrated that the boreal winters of super El Nino events are usually accompanied by severely suppressed Madden-Julian oscillation(MJO) activity over the western Pacific due to strong descending motion associated with a weakened Walker Circulation. However, the boreal winter of the 2015/16 super El Nino event is concurrent with enhanced MJO activity over the western Pacific despite its sea surface temperature anomaly(SSTA)magnitude over the Nino 3.4 region being comparable to the SSTA magnitudes of the two former super El Nino events(i.e.,1982/83 and 1997/98). This study suggests that the MJO enhanced over western Pacific during the 2015/16 super El Nino event is mainly related to its distinctive SSTA structure and associated background thermodynamic conditions. In comparison with the previous super El Nino events, the warming SSTA center of the 2015/16 super El Nino is located further westward, and a strong cold SSTA is not detected in the western Pacific. Accordingly, the low-level moisture and air temperature(as well as the moist static energy, MSE) tend to increase in the central-western Pacific. In contrast, the low-level moisture and MSE show negative anomalies over the western Pacific during the previous super El Nino *** the MJO-related horizontal wind anomalies contribute to the further westward warm SST-induced positive moisture and MSE anomalies over the western tropical Pacific in the boreal winter of 2015/16, stronger moisture convergence and MSE advection are generated over the western Pacific and lead to the enhancement of MJO convection.

关键词： super El Nino Madden-Julian oscillation moisture diagnosis

“好房子”全过程数字化工程管理创新途径研究

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城市建筑空间 2024年第8期31卷 17-19页

作者：张文俊曹伟员邓浩北京国标建筑科技有限责任公司

随着信息技术飞速发展,数字化工程管理在既有住宅改造中的应用越来越广泛。通过搭建数字化工程管理信息化平台、应用BIM+5G技术,引入人工智能技术,制定数字化管理标准,应用全过程空气质量监控系统、数字化全屋诊断技术,引入装配式技术,... 详细信息

随着信息技术飞速发展,数字化工程管理在既有住宅改造中的应用越来越广泛。通过搭建数字化工程管理信息化平台、应用BIM+5G技术,引入人工智能技术,制定数字化管理标准,应用全过程空气质量监控系统、数字化全屋诊断技术,引入装配式技术,可有效提高工程管理效率,实现资源回收和再利用,减少能源消耗和碳排放,推动绿色装修发展。

关键词：好房子室内装修数字化工程管理

Short review on liquid membrane technology and their applications in biochemical engineering

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Chinese Journal of Chemical Engineering 2022年第9期35卷 21-33页

作者： wenjun zhang Wenshu Ge Min Li Shuangqing Li Minqiang Jiang Xiujuan zhang Gaohong He State Key Laboratory of Fine Chemicals Dalian University of TechnologyDalian 116023China School of Chemical Engineering Dalian University of TechnologyPanjin 124221China

As a branch of membrane separation technology,liquid membrane has attracted great attention and expanded investigations in biological chemical engineering,with life and health concern in *** of membrane solvent and mobile carrier,liquid membrane was acquired of function,performing the facilitated mass transfer across the diffusive solvent,so as for the separation and delivery achievement with *** this review,two types of liquid membrane are mainly focused,respectively on supported liquid membrane(SLM)of membrane solvent supporter in necessity,and on emulsion liquid membrane(ELM)of the required interfacial stabilizers and ***,the transfer mechanism,compositions,structure and features of SLM and ELM are introduced ***,the current investigations of liquid membrane have been discussed,focusing on the improvements of efficacy and stability in separation&detection,encapsulation and delivery,so as to scale up the favorable and efficient application with bio-life ***,this review could provide comprehensive insight into the bio-applications of liquid membrane,and guidelines for the further investigations on the efficacy and long-term applicable stability,in order to realize the industrialization.

关键词： Liquid membrane Membrane separation Membrane encapsulation Delivery vehicle Bio-application