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High-Precision Flow Numerical Simulation and Productivity Evaluation of Shale Oil Considering Stress Sensitivity

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Fluid Dynamics & Materials Processing 2024年第10期20卷 2281-2300页

作者： Mingjing Lu Qin Qian Anhai Zhong Feng Yang wenjun He Min Li Petroleum Engineering Technology Research Institute of Shengli Oilfield SINOPECDongying257000China Postdoctoral Scientific Research Working Station of Shengli Oilfield SINOPECDongying257000China

Continental shale oil reservoirs,characterized by numerous bedding planes and micro-nano scale pores,feature significantly higher stress sensitivity compared to other types of ***,research on suitable stress sensitivity characterization models is still *** this study,three commonly used stress sensitivity models for shale oil reservoirs were considered,and experiments on representative core samples were *** fitting and comparing the data,the“exponential model”was identified as a characterization model that accurately represents stress sensitivity in continental shale oil *** validate the accuracy of the model,a two-phase seepage mathematical model for shale oil reservoirs coupled with the exponential model was *** model was discretely solved using the finite volume method,and its accuracy was verified through the commercial simulator *** study evaluated the productivity of a typical horizontal well under different engineering,geological,and fracture *** results indicate that considering stress sensitivity leads to a 13.57%reduction in production for the same matrix ***,as the fracture half-length and the number of fractures increase,and the bottomhole flowing pressure decreases,the reservoir stress sensitivity becomes higher.

关键词： Shale oil horizontal wells Embedded Discrete Fracture Model(EDFM) stress sensitivity numerical simulation sensitivity analysis

基于MMC直流阻抗重塑的直流故障限流控制策略

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南方电网技术 2022年第9期16卷 8-17页

作者：吴轲郭约法梁伟锋邓文军广东电网有限责任公司东莞供电局广东东莞523008 四川大学电气工程学院成都610065

基于模块化多电平换流器的柔性直流输电系统是一个低惯量、弱阻尼系统,一旦发生直流短路故障,急速上升的故障电流将损坏电力电子设备、破坏电网安全运行。为研究故障限流方法,首先根据功率平衡原理将模块化多电平换流器(modular multi-l... 详细信息

基于模块化多电平换流器的柔性直流输电系统是一个低惯量、弱阻尼系统,一旦发生直流短路故障,急速上升的故障电流将损坏电力电子设备、破坏电网安全运行。为研究故障限流方法,首先根据功率平衡原理将模块化多电平换流器(modular multi-level converter,MMC)等效为受控电流源,计及MMC的子模块投入比例系数分别建立了不同控制模式下的直流阻抗频域模型。然后分析了换流器电路参数和控制参数对故障电流的影响规律,得出了关键影响因素为桥臂电感和子模块投入比例,进而提出了基于直流阻抗重塑的故障限流控制策略,通过自适应减小子模块投入比例抑制故障电流上升。最后,通过仿真验证了所建直流阻抗的准确性和故障限流控制的有效性。

关键词：模块化多电平换流器直流阻抗直流故障故障电流影响因素故障限流控制

Exosomes derived from pulmonary metastatic sites enhance osteosarcoma lung metastasis by transferring the miR-194/215 cluster targeting MARCKS

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Acta Pharmaceutica Sinica B 2024年第5期14卷 2039-2056页

作者： Pei Yu Yubao Han Lulu Meng Yanyuan Tian Zhiwei Jin Jun Luo Chao Han wenjun Xu Lingyi Kong Chao Zhang State Key Laboratory of Natural Medicines Jiangsu Key Laboratory of Bioactive Natural Product ResearchSchool of Traditional Chinese PharmacyChina Pharmaceutical UniversityNanjing 211198China

Osteosarcoma,a prevalent primary malignant bone tumor,often presents with lung metastases,severely impacting patient survival *** vesicles,particularly exosomes,play a pivotal role in the formation and progression of osteosarcoma-related pulmonary ***,the communication between primary osteosarcoma and exosome-mediated pulmonary lesions remains obscure,with the potential impact of pulmonary metastatic foci on osteosarcoma progression largely *** study unveils an innovative mechanism by which exosomes originating from osteosarcoma pulmonary metastatic sites transport the miR-194/215 cluster to the primary tumor *** transportation enhances lung metastatic capability by downregulating myristoylated alanine-rich C-kinase substrate(MARCKS)*** this phenomenon,in this study we employ cationic bovine serum albumin(CBSA)to form nanoparticles(CBSA-anta-194/215)via electrostatic interaction with antagomir-miR-194/*** nanoparticles are loaded into nucleic acid-depleted exosomal membrane vesicles(anta-194/215@Exo)targeting osteosarcoma lung metastatic *** with bioengineered exosome mimetics(anta-194/215@Exo)not only impedes osteosarcoma progression but also significantly prolongs the lifespan of tumor-bearing *** findings suggest that pulmonary metastatic foci-derived exosomes initiate primary osteosarcoma lung metastasis by transferring the miR-194/215 cluster targeting MARCKS,making the miR-194/215 cluster a promising therapeutic target for inhibiting the progression of patients with osteosarcoma lung metastases.

关键词： Lung–bone transmission miR-194/215 cluster Exosome Lung metastasis Epithelial–mesenchymal transition Vasculogenic mimicry Bioengineered exosome mimetics Osteosarcoma

Chemotactic nanomotor for multimodal combined therapy of glioblastoma

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Science China Chemistry 2024年第4期67卷 1277-1288页

作者： Ting Li Lin Chen Yunxin Xue Xiangyu Xiao wenjun Dai Kaiyuan Tan Tiantian Chen Yingfang Tao Chun Mao Jian Shen Mimi Wan National and Local Joint Engineering Research Center of Biomedical Functional Materials School of Chemistry and Materials ScienceNanjing Normal UniversityNanjing 210023China

Glioblastoma(GBM) is the most aggressive malignant brain tumor. Due to the infiltration and heterogeneity of GBM, the obstruction of the blood-brain barrier(BBB) and the unique immunosuppressive mechanism, it is hard to achieve significant effects of GBM treatment. Here, a kind of chemotactic nanomotor that loaded with glucose oxidase(GOx) and carboxylated cisplatin(Pt(IV)) prodrug on the L-arginine-derived polymer is proposed. The nanomotors are driven by catalysis of glucose decomposition and the positive chemotaxis towards the GBM microenvironment where inducible nitric oxide synthase and reactive oxygen species are highly expressed. This facilitates the BBB crossing and GBM targeting of the nanomotors. In addition, the released nitric oxide(NO) during propulsion as well as the loaded GOx and Pt(IV) can exert combined NO/starvation/chemotherapy. Meanwhile, it is able to induce and enhance the immune response through multiple pathways, thus better coping with the complexities of GBM treatment.

关键词： chemotaxis combined therapy glioblastoma nanomotors

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挖补修理复合材料层合板疲劳性能研究进展

高分子材料科学与工程 2024年第2期40卷 164-172页

作者：邓金鑫陈林徐辉黄文俊程小全北京航空航天大学航空科学与工程学院北京100191 北京航空航天大学宁波创新研究院浙江宁波315800 大连长丰实业总公司辽宁大连116038 中国直升机设计研究所江西景德镇333001

随着纤维增强复合材料结构的应用更加广泛,其结构修理问题日渐凸显。挖补修理在复合材料层合板修理中具有重要地位,而修理后结构的疲劳性能是评价结构修理质量的重要依据,因此对复合材料挖补修理层合板疲劳性能的研究意义重大。文中从... 详细信息

随着纤维增强复合材料结构的应用更加广泛,其结构修理问题日渐凸显。挖补修理在复合材料层合板修理中具有重要地位,而修理后结构的疲劳性能是评价结构修理质量的重要依据,因此对复合材料挖补修理层合板疲劳性能的研究意义重大。文中从模型和试验两方面总结了挖补修理复合材料层合板疲劳性能研究现状,指出了当前挖补修理复合材料层合板疲劳性能研究存在的问题,可为复合材料结构挖补修理研究和工程应用提供参考。

关键词：复合材料层合板挖补修理疲劳性能

Multi-User Semantic Fusion for Semantic Communications over Degraded Broadcast Channels

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China Communications 2024年第10期21卷 86-100页

作者： Wu Tong Chen Zhiyong Tao Meixia Xia Bin Zhang wenjun Cooperative Medianet Innovation Center Shanghai Jiao Tong UniversityShanghai 200240China

Degraded broadcast channels(DBC) are a typical multiuser communication scenario, Semantic communications over DBC still lack in-depth research. In this paper, we design a semantic communications approach based on multi-user semantic fusion for wireless image transmission over DBC. The transmitter extracts semantic features for two users separately and then effectively fuses them for broadcasting by leveraging semantic similarity. Unlike traditional allocation of time, power, or bandwidth, the semantic fusion scheme can dynamically control the weight of the semantic features of the two users to balance their performance. Considering the different channel state information(CSI) of both users over DBC,a DBC-Aware method is developed that embeds the CSI of both users into the joint source-channel coding encoder and fusion module to adapt to the *** results show that the proposed system outperforms the traditional broadcasting schemes.

关键词： channel adaptability degraded broadcasting channels semantic communications semantic fusion

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CTA诊断冠状动脉异常起源肺动脉

中国医学影像技术 2017年第9期33卷 1335-1338页

作者：陈艳库雷志熊青峰许娟邓文俊武汉亚洲心脏病医院放射科湖北武汉430022

目的探讨冠状动脉(简称冠脉)异常起源肺动脉(ACAPA)的CTA图像特征。方法回顾性分析本院收治的24例ACAPA的患者资料,分析其CTA表现,并与手术结果对照。结果 24例患者中,发生于左冠脉20例(20/24,83.33%)、右冠脉1例(1/24,4.17%)、前降支1... 详细信息

目的探讨冠状动脉(简称冠脉)异常起源肺动脉(ACAPA)的CTA图像特征。方法回顾性分析本院收治的24例ACAPA的患者资料,分析其CTA表现,并与手术结果对照。结果 24例患者中,发生于左冠脉20例(20/24,83.33%)、右冠脉1例(1/24,4.17%)、前降支1例(1/24,4.17%)、回旋支2例(2/24,8.33%)。冠脉异常起源部位:起源于肺动脉窦或肺动脉主干后壁11例(11/24,45.83%)、左壁7例(7/24,29.17%)、右壁4例(7/24,16.67%),起源于左肺动脉2例(2/24,8.33%)。侧支循环:婴儿型5例,冠脉间未见侧支血管;成人型19例,其中左/右冠脉异常起源16例,前降支异常起源1例,回旋支异常起源2例。合并双前降支和冠脉在升主动脉壁内走行各1例。外科手术19例。术后CTA复查5例,1例人工管道与回旋支吻合口局限性狭窄,1例右心室流出道再狭窄,1例冠脉假性动脉瘤。结论 CTA可清晰显示冠脉异常起源部位、与升主动脉的距离、侧支血管、合并其他冠脉畸形,有助于术前制定手术方式及术后随访。

关键词：冠状血管体层摄影术,X线计算机异常起源肺动脉

Dual-Mode Resonant Sectorial Monopole Antenna with Stable Backfire Gain

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Chinese Journal of Electronics 2024年

作者： Feiyan JI Heng ZHANG Xiuqiong XING wenjun LU Lei ZHU Jiangsu Key Laboratory of Wireless Communications Nanjing University of Posts and Telecommunications Key Laboratory of Wireless Sensor Network & Communication Shanghai Institute of Microsystem and Information TechnologyChinese Academy of Sciences Department of Electrical and Computer Engineering Faculty of Science and Technology University of Macau

A novel design approach to wideband, dual-mode resonant monopole antenna with stable, enhanced backfire gain is advanced. The sectorial monopole evolves from a linear, 0.75-wavelength electric prototype monopole under wideband dual-mode resonant operation. As theoretically predicted by the two resonant modes TE9/5,1and experimentally validated at 2.4-GHz band, the designed antenna exhibits a wide impedance bandwidth over 90.1%(i.e., 2.06-5.44 GHz), in which the stable gain bandwidth in the backfire,-x-direction(θ = 90°, φ = 180°) with peak value of 3.2 dBi and fluctuation less than 3 dB is up to 45.3%(i.e., 3.74-5.44 GHz). It is concluded that the stable wideband backfire gain frequency response should be owing to the high-order resonant mode in the unique sectorial monopole antennas.

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Modification of food protein fibrils: During and after fibrillization

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Food Science and Human Wellness 2024年

作者： Kefan Ouyang Hexiang Xie Hua Xiong Qiang Zhao wenjun Wang State Key Laboratory of Food Science and Resources， Nanchang University Jiangxi Key Laboratory of Natural Products and Functional Food， College of Food Science and Engineering， Jiangxi Agricultural University

Fibrillization endows food proteins with anisotropic nanostructures， significantly enhancing their functional properties. The resultant food protein fibrils (FPFs) have garnered attention for their diverse applications across the food industry. However， the full potential of FPFs is hindered by inherent challenges， particularly their limited stability. This review critically examines the formation of FPFs in food processing， the new protein sources， and on the modification strategies of FPFs， thereby unlocking new avenues for FPF utilization in food processing. In particular， the strategies during and after fibrillization are highlighted. The first strategy is to modify the structure and function of protein fibrils by influencing fibrillization， such as through pretreatment， incubation conditions， nuclei induction， and ingredient interactions. The second strategy is to modify the mature FPFs by regulating their properties and interactions with other components. The review also discusses the potential applications and challenges of FPFs in food systems， such as food preservation， functional food design， and novel delivery carriers.

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