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Interpretation of the Diabetes Prevention and Control Action of the Healthy China Initiative 2019−2030

China CDC weekly 2020年第9期2卷 143-145页

作者： Wenjuan Wang National Center for Chronic and Non-communicable Disease Control and Prevention Chinese Center for Disease Control and PreventionBeijingChina

In the past 30 years,the prevalence of diabetes in China has been increasing,but the awareness rate,treatment rate and control rate of diabetes are relatively low,and the death rate,disability rate,disease burden of diabetes and its complications are constantly increasing,which brings heavy burden to individuals,families and social economy.The Healthy China Initiative(2019-2030)is a roadmap to a healthy China and an innovative public policy system project.The Diabetes Prevention and Control Action is one of the four chronic and noncommunicable diseases prevention and control actions in the Healthy China Initiative(2019-2030).Based on the background,basic principles and key contents of diabetes prevention and control,this paper interpreted the diabetes prevention and control action from five aspects,that is,healthy lifestyle is the foundation,which emphasized that individuals are the first responsibility for their health,and advocates reducing the risk of diabetes by practicing healthy diet,increasing physical activity and maintaining a healthy weight;Early detection and early intervention are key links,which emphasized to pay attention to individual blood glucose level,high risk individuals regularly test blood glucose;Standardize health management is the priority,which emphasized to strengthen the implementation of graded diagnosis and treatment standards,and medical institutions provide guidance on self-management of health for patients with diabetes;The improvement of capacity in primary level is the guarantee,where emphasis is placed on improving the ability of medical personnel to screen,intervention and standardize diagnosis and treatment;And innovative health service models are the key measures which emphasized the use of information technology to improve the efficiency of health management.

关键词： prevention Action guarantee

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Effects of diet shift on the gut microbiota of the critically endangered Siberian Crane

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Avian Research 2023年第3期14卷 443-452页

作者： Wenjuan Wang Yafang wang Qing Chen Huifang Ding School of Ecology and Nature Conservation Beijing Forestry UniversityBeijing100083China Center for East Asian–Australasian Flyway Studies Beijing Forestry UniversityBeijing100083China Jiangxi Province Key Laboratory of Watershed Ecosystem Change and Biodiversity Center for Watershed EcologyInstitute of Life ScienceNanchang UniversityNanchang330031China Jiangxi Poyang Lake Wetland Conservation and Restoration National Permanent Scientific Research Base National Ecosystem Research Station of Jiangxi Poyang Lake WetlandNanchang330031China

Wetlands worldwide have suffered from serious degradation and transformation,leading to waterbirds increasingly dependent on agricultural fields for feeding.Although gut microbiota is an essential component of host health,the impacts of agricultural feeding on gut microbial community and pathogen transmission remain poorly understood.To fill this knowledge gap,we used 16S rRNA sequencing to characterize the fecal bacterial community of the Siberian Crane(Grus leucogeranus),a Critically Endangered species,that recently has shifted its foraging from largely Vallisneria tubers in Poyang Lake natural wetlands to crops(i.e.,rice seeds and lotus rhizomes) in agricultural fields.We compared the bacterial communities between tuber foraging cranes and crop foraging cranes.Our results indicate that diet shift greatly modified the gut microbiota diversity,composition and function.Crop foraging cranes had higher microbiota diversity than tuber foraging cranes.The alteration in microbiota composition and function were correlated with change in food nutrition.Tuber(i.e.,high in fiber)foraging cranes were enriched in Clostridiaceae with fiber digestion ability,and crop(i.e.,high in carbohydrate)foraging cranes were enriched in bacterial taxa and functions related to carbohydrate metabolism.The flexibility of gut microbiota might enhance Siberian Cranes’ ability to adapt to novel diet and environment.However,many enriched families in crop foraging cranes were pathogenic bacteria,which might increase the susceptibility of cranes to pathogenic infection.Special caution should be taken to agricultural feeding waterbirds in Asia,where the widespread poultry-keeping in over-harvested rice fields might increase the transmission probability of pathogenetic bacteria among wild birds,domestic poultry and humans.

关键词： Diet shift Pathogenic bacteria Poyang Lake Siberian Crane Vallisneria tuber Wetland degradation

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Design and validation of a variable camber wing structure

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Chinese Journal of Aeronautics 2024年第2期37卷 1-11页

作者： Xiasheng SUN Jingfeng XUE Jin ZHOU Zhigang wang Wenjuan Wang Mengjie ZHANG Chinese Aeronautical Establishment Beijing 100012China School of Aeronautic Science and Engineering Beihang UniversityBeijing 100191China Aircraft Strength Research Institute of China Xi’an 710065China Graduate School of Chinese Aeronautical Establishment Yangzhou 225002China

Variable camber wing technology is one of the important development trends of green aviation at present.Through smooth,seamless,continuous and adaptive change of wing camber,the aerodynamic performance is improved in achieving increase in lift and reduction in resistance and noise.Based on the aerodynamic validation model CAE-AVM,Chinese Aeronautical Establishment(CAE)has carried out the design and validation of a variable camber wing,proposed an aerodynamic deformation matrix for the leading and trailing edges of aircraft wings in takeoff,landing and cruise conditions.Various structures and driving schemes are compared,and several key technology problems of leading and trailing edge deformation are solved.A full-size leading edge wind tunnel test piece with a span of 2.7 m and a trailing edge ground function test piece are developed.The deformation and shape maintenance capabilities of the leading edge is verified under real wind load conditions,and the load bearing and deformation capabilities of the trailing edge is verified under simulated follow-on load.The results indicate that the leading and trailing edges of the variable camber wing can achieve the required deformation angle and have a certain load-bearing capacity.Our study can provide some insights into the application of variable camber wing technology for civil aircraft.

关键词： Variable camber wing Leading edge Trailing edge Structure Measurement and control Test

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Quantifying phase separation at the nanoscale by dual-color fluorescence cross-correlation spectroscopy(dcFCCS)

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Biophysics Reports 2022年第1期8卷 29-41页

作者： Yirong Yao Wenjuan Wang Chunlai Chen Beijing Frontier Research Center of Biological Structure Tsinghua University Beijing Advanced Innovation Center for Structural Biology School of Life Sciences Technology Center for Protein Sciences Tsinghua University

Liquid–liquid phase separation(LLPS) causes the formation of membraneless condensates, which play important roles in diverse cellular processes. Currently, optical microscopy is the most commonly used method to visualize micron-scale phase-separated condensates. Because the optical spatial resolution is restricted by the diffraction limit(～200 nm), dynamic formation processes from individual biomolecules to micron-scale condensates are still mostly unknown. Herein, we provide a detailed protocol applying dual-color fluorescence cross-correlation spectroscopy(dcFCCS) to detect and quantify condensates at the nanoscale, including their size, growth rate, molecular stoichiometry, and the binding affinity of client molecules within condensates. We expect that the quantitative dcFCCS method can be widely applied to investigate many other important phase separation systems.

关键词： Liquid-liquid phase separation Nanoscale Dual-color fluorescence cross-correlation spectroscopy Molecular stoichiometry Binding affinity

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Insights into the cross-amyloid aggregation of Aβ_(40) and its N-terminal truncated peptide Aβ_(11-40) affected by epigallocatechin gallate

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Chinese Journal of Chemical Engineering 2022年第5期35卷 284-293页

作者： Yue Liang Wenjuan Wang Yan Sun Xiaoyan Dong Department of Biochemical Engineering and Key Laboratory of Systems Bioengineering(Ministry of Education) School of Chemical Engineering and TechnologyTianjin UniversityTianjin 300354China

Inhibition of protein misfolding and aggregation is a great challenge in the field of biochemical and biopharmaceutical engineering.Alzheimer’s disease(AD)is a protein-misfolding disease,and the interactions between 40-amino-acid-residueβ-amyloid peptide(Aβ_(40)) and its N-terminal truncated peptide Aβ_(11-40) demonstrate that Aβ_(11-40) may play an important role in the pathological process of AD.However,the effect of inhibitors on Aβ_(11-40) aggregation and on the cross-amyloid aggregation(coassembly)between Aβ_(40) and Aβ_(11-40) has never been studied.Herein,coaggregation and seeding interactions between Aβ_(40) and Aβ_(11-40) as well as the effect of epigallocatechin gallate(EGCG),a small molecule inhibitor,on the cross-amyloid aggregation have been investigated by extensive analyses.It is found that Aβ_(11-40) participates in the aggregation of Aβ_(40) and leads to the formation of coaggregates that contain lessβ-sheet structures than pure Aβ_(40) aggregates.The aggregation kinetics along with morphologies and secondary structures of the coaggregates are also significantly affected by the Aβ_(40)/Aβ_(11-40) ratio.EGCG accelerates the nucleation of Aβ_(40) but retards that of Aβ_(11-40) by affecting their elongation and secondary nucleation processes in solution and on solid surfaces.Meanwhile,EGCG makes the conformations of the seeding-induced Aβaggregates more compact,especially for the homologous seedings.Isothermal titration calorimetry measurement indicates that hydrophobic interactions mainly contribute to the inhibition of the two Aβisoforms by EGCG.The findings of this research have provided new insights into Aβaggregation and the effect of an important inhibitor and the results would benefit in the development of potent inhibitors against co-assembly of different amyloid proteins.

关键词： Protein Aggregation Kinetics Nucleation Elongation Molecular interactions

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Ag-single atoms modified S_(1.66)-N_(1.91)/TiO_(2-x)for photocatalytic activation of peroxymonosulfate for bisphenol A degradation

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Chinese Chemical Letters 2022年第4期33卷 2121-2124页

作者： Tian wang Jianjun Zhou Wenjuan Wang Yunqing Zhu Junfeng Niu School of Environmental Science and Engineering Shaanxi University of Science and TechnologyXi’an 710021China School of Environment and Civil Engineering Dongguan University of TechnologyDongguan 523808China

In this study,Ag_(0.23)/(S_(1.66)-N_(1.91)/TiO_(2-x))single-atom photocatalyst was synthesized by in-situ photoreducing of silver on S,N-TiO_(2-x) nanocomposite and used to degrade bisphenol A(BPA)through heterogeneous activation of potassium peroxymonosulfate(PMS)under visible-light illumination.The structure,physicochemical property,morphology,and electronic property were evalutated by X-ray diffraction(XRD),Raman spectrum,X-ray photoelectron spectra(XPS),high-resolution transmission electron microscopy(HR-TEM),UV-vis diffuse reflectance spectra(UV-vis DRS),electron paramagnetic resonance(EPR)spectrum.Ag_(0.23)/(S_(1.66)-N_(1.91)/TiO_(2-x))single-atom photocatalyst exhibited 2.4 times higher activity for the synergetic degradation of BPA than that of its counterpart,and 48.73%mineralization rate of BPA also achieved.It was ascribed to the uniformly-dispersed metallic Ag atoms as the active site for accelerating the migration rate of photo-generated carrier for generation of high reactive radicals.The EPR experiments indicated that SO_(4)^(-) and ^(·)OH was jointly involved in BPA degradation.

关键词： Photo-Fenton Single-atomic photocatalyst Sulfate radical Bisphenol A PMS

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Big Data Access Control Mechanism Based on Two-Layer Permission Decision Structure

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Computers, Materials & Continua 2024年第4期79卷 1705-1726页

作者： Aodi Liu Na wang Xuehui Du Dibin Shan Xiangyu Wu Wenjuan Wang He’nan Province Key Laboratory of Information Security Information Engineering UniversityZhengzhou450000China

Big data resources are characterized by large scale, wide sources, and strong dynamics. Existing access controlmechanisms based on manual policy formulation by security experts suffer from drawbacks such as low policymanagement efficiency and difficulty in accurately describing the access control policy. To overcome theseproblems, this paper proposes a big data access control mechanism based on a two-layer permission decisionstructure. This mechanism extends the attribute-based access control (ABAC) model. Business attributes areintroduced in the ABAC model as business constraints between entities. The proposed mechanism implementsa two-layer permission decision structure composed of the inherent attributes of access control entities and thebusiness attributes, which constitute the general permission decision algorithm based on logical calculation andthe business permission decision algorithm based on a bi-directional long short-term memory (BiLSTM) neuralnetwork, respectively. The general permission decision algorithm is used to implement accurate policy decisions,while the business permission decision algorithm implements fuzzy decisions based on the business constraints.The BiLSTM neural network is used to calculate the similarity of the business attributes to realize intelligent,adaptive, and efficient access control permission decisions. Through the two-layer permission decision structure,the complex and diverse big data access control management requirements can be satisfied by considering thesecurity and availability of resources. Experimental results show that the proposed mechanism is effective andreliable. In summary, it can efficiently support the secure sharing of big data resources.

关键词： Big data access control data security BiLSTM

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Extracellular vesicle-carried GTF2I from mesenchymal stem cells promotes the expression of tumor-suppressive FAT1 and inhibits stemness maintenance in thyroid carcinoma

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Frontiers of Medicine 2023年第6期17卷 1186-1203页

作者： Jie Shao Wenjuan Wang Baorui Tao Zihao Cai Haixia Li Jinhong Chen Department of General Surgery Huashan HospitalFudan UniversityShanghai 200040China Department of Pathology Huashan HospitalFudan UniversityShanghai 200040China

Through bioinformatics predictions,we identified that GTF2I and FAT1 were downregulated in thyroid carcinoma(TC).Further,Pearson’s correlation coefficient revealed a positive correlation between GTF2I expression and FAT1 expression.Therefore,we selected them for this present study,where the effects of bone marrow mesenchymal stem cell-derived EVs(BMSDs-EVs)enriched with GTF2I were evaluated on the epithelial–to–mesenchymal transition(EMT)and stemness maintenance in TC.The under-expression of GTF2I and FAT1 was validated in TC cell lines.Ectopically expressed GTF2I and FAT1 were found to augment malignant phenotypes of TC cells,EMT,and stemness maintenance.Mechanistic studies revealed that GTF2I bound to the promoter region of FAT1 and consequently upregulated its expression.MSC-EVs could shuttle GTF2I into TPC-1 cells,where GTF2I inhibited TC malignant phenotypes,EMT,and stemness maintenance by increasing the expression of FAT1 and facilitating the FAT1-mediated CDK4/FOXM1 downregulation.In vivo experiments confirmed that silencing of GTF2I accelerated tumor growth in nude mice.Taken together,our work suggests that GTF2I transferred by MSC-EVs confer antioncogenic effects through the FAT1/CDK4/FOXM1 axis and may be used as a promising biomarker for TC treatment.

关键词： thyroid carcinoma mesenchymal stem cell extracellular vesicle GTF2I FAT1 CDK4

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Tracking translation of single m RNA molecule in live cells

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Science Bulletin 2016年第14期61卷 1071-1073页

作者： Wenjuan Wang Chunlai Chen School of Life Sciences Tsinghua University Technology Center for Protein Sciences Tsinghua University Tsinghua-Peking Joint Center for Life Sciences Tsinghua University Beijing Advanced Innovation Center for Structural Biology Tsinghua University

Proteins are the major players in cellular functions.To produce proteins,genetic information stored in DNA needs to be firstly transcribed into m RNA,which is then translated by the ribosome.No doubt,protein expressio... 详细信息

关键词： mRNA 分子水平实时跟踪活细胞翻译基因转化蛋白质细胞功能

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Ozonation of aromatic monomer compounds in water: factors determining reaction outcomes

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Frontiers of Environmental Science & Engineering 2023年第5期17卷 13-25页

作者： Zhe wang wenjuan Zhang Zhiwei wang Jing Chang School of Environmental Science and Safety Engineering Tianjin University of TechnologyTianjin 300384China School of Environmental and Municipal Engineering Tianjin Key Laboratory of Aquatic Science and TechnologyTianjin Chengjian UniversityTianjin 300384China Tianjin Municipal Engineering Design&Research Institute Co. Ltd.Tianjin 300384China

For aromatic monomer compounds (AMCs), ozonation outcomes were usually predicted by the substituents of the benzene ring based on the electron inductive effect. However, the predicted results were occasionally unreliable for complex substituents, and other factors caused concern. In this study, p-chloronitrobenzene (p-CNB) and ibuprofen (IBP) were selected for ozonation. According to the electron inductive theory, p-CNB should be less oxidizable, but the opposite was true. The higher rates of p-CNB were due to various sources of assistance. First, the hydroxyl radical (•OH) contributed 90 % to p-CNB removal at pH 7.0, while its contribution to IBP removal was 50 %. Other contributions came from molecular O3 oxidation. Second, p-CNB achieved 40 % of the total organic carbon (TOC) removal and fewer by-product types and quantities, when compared to the results for IBP. Third, the oxidation of p-CNB started with hydroxyl substitution reactions on the benzene ring;then, the ring opened. However, IBP was initially oxidized mainly on the butane branched chain, with a chain-shortening process occurring before the ring opened. Finally, the degradation pathway of p-CNB was single and consumed fewer oxidants. However, both branches of IBP were attacked simultaneously, and three degradation pathways that relied on more oxidants were proposed. All of these factors were determinants of the rapid removal of p-CNB.

关键词： Ozonation Aromatic compound Oxidizing specie By-product Initial reaction position Degradation pathway

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