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Bioinspired Tactile Sensation Based on Synergistic Microcrack-Bristle Structure Design toward High Mechanical Sensitivity and Direction-Resolving Capability

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Research 2024年第1期2023卷 611-624页

作者： Yiqun Zhang Qi Liu wenjuan ren Yangyang Song Hua Luo Yangyang Han Liang He Xiaodong Wu Zhuqing Wang School of Mechanical Engineering Sichuan UniversityChengdu 610065China Med+X Center for Manufacturing West China HospitalSichuan UniversityChengdu 610041China State Key Laboratory of Polymer Materials Engineering Polymer Research Institute of Sichuan UniversityChengdu 610065China

Natural tactile sensation is complex,which involves not only contact force intensity detection but also the perception of the force direction,the surface texture,and other mechanical ***,the vast majority of the developed tactile sensors can only detect the normal force,but usually cannot resolve shear force or even distinguish the directions of the ***,we present a new paradigm of bioinspired tactile sensors for resolving both the intensity and the directions of mechanical stimulations via synergistic microcrack-bristle structure design and cross-shaped configuration *** microcrack sensing structure gives high mechanical sensitivity to the tactile sensors,and the synergistic bristle structure further amplifies the sensitivity of the *** cross-shaped configuration engineering of the synergistic microcrack-bristle structure further endows the tactile sensors with good capability to detect and distinguish the directions of the applied mechanical *** as-fabricated tactile sensors exhibit a high sensitivity(25.76 N^(−1)),low detection limit(5.4 mN),desirable stability(over 2,500 cycles),and good capability to resolve both mechanical intensity and directional *** promising application scenarios,surface texture recognition and biomimetic path explorations are successfully demonstrated with these tactile *** newly proposed tactile sensation strategy and technology have great potential applications in ingenious tactile sensation and construction of various robotic and bionic prostheses with high operational dexterity.

关键词： crack sensation directions

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Prediction of column failure modes based on artificial neural network

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Earthquake Engineering and Engineering Vibration 2023年第2期22卷 481-493页

作者： Wan Haitao Qi Yongle Zhao Tiejun ren wenjuan Fu Xiaoyan School of Civil Engineering and Architecture Henan UniversityKaifeng 475001China China Energy Engineering Group Guangdong Electric Power Design Institute Co. Ltd.Guangzhou 510663China

To implement the performance-based seismic design of engineered structures,the failure modes of members must be *** classification method of column failure modes is analyzed using data from the Pacific Earthquake Engineering Research Center(PEER).The main factors affecting failure modes of columns include the hoop ratios,longitudinal reinforcement ratios,ratios of transverse reinforcement spacing to section depth,aspect ratios,axial compression ratios,and flexure-shear *** study proposes a data-driven prediction model based on an artificial neural network(ANN)to identify the column failure *** this study,111 groups of data are used,out of which 89 are used as training data and 22 are used as test data,and the ANN prediction model of failure modes is *** results show that the proposed method based on ANN is superior to traditional methods in identifying the column failure modes.

关键词： performance-based seismic design failure mode column artificial neural network prediction model

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护理质量持续改进措施对子宫肌瘤患者生活质量的影响

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临床医学研究与实践 2024年第8期9卷 146-149页

作者：任文娟刘红邓晓红商洛市中心医院陕西商洛726000 西北妇女儿童医院陕西西安710061

目的探讨护理质量持续改进措施对子宫肌瘤患者生活质量的影响。方法选取2020年1月至12月收治的150例子宫肌瘤患者为研究对象,将其随机分为常规组和观察组,各75例。常规组给予常规护理干预,观察组给予护理质量持续改进措施干预。比较两... 详细信息

目的探讨护理质量持续改进措施对子宫肌瘤患者生活质量的影响。方法选取2020年1月至12月收治的150例子宫肌瘤患者为研究对象,将其随机分为常规组和观察组,各75例。常规组给予常规护理干预,观察组给予护理质量持续改进措施干预。比较两组的护理效果。结果护理后,观察组的子宫肌瘤疾病自护量表、健康调查简表(SF-36)评分高于常规组,心境状态量表(POMS)评分低于常规组,差异具有统计学意义(P<0.05)。观察组的导尿管拔除时间、胃肠功能恢复时间、术后下床时间、住院时间短于常规组,术后1 d疼痛评分低于常规组,差异具有统计学意义(P<0.05)。观察组的护理服务满意度高于常规组,差异具有统计学意义(P<0.05)。结论护理质量持续改进措施可提升子宫肌瘤患者的疾病了解程度,改善其心境状态,加快康复,提升生活质量及护理服务满意度,取得理想的护理效果。

关键词：子宫肌瘤护理质量持续改进措施自护能力生活质量

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不同表面形貌的接触线对浸金属碳滑板载流摩擦磨损性能的影响

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润滑与密封 2024年第2期49卷 59-66页

作者：何泉鑫曾子毅陈光雄任文娟赵鹏鹏董丙杰西南交通大学摩擦学研究所四川成都610031 四川建筑职业技术学院四川成都610031

在受电弓-接触网载流摩擦磨损过程中,接触线会产生不同的横截面形状,而接触线形貌的改变可能会影响弓网间的接触关系,进而影响弓网间的载流摩擦磨损性能。为研究不同表面形貌的接触线对浸金属碳滑板载流摩擦磨损性能的影响,利用环-块式... 详细信息

在受电弓-接触网载流摩擦磨损过程中,接触线会产生不同的横截面形状,而接触线形貌的改变可能会影响弓网间的接触关系,进而影响弓网间的载流摩擦磨损性能。为研究不同表面形貌的接触线对浸金属碳滑板载流摩擦磨损性能的影响,利用环-块式高速载流摩擦磨损试验机,研究载流条件下常规形貌、麻点形貌、斜切形貌的接触线与浸金属碳滑板的摩擦磨损性能,比较采用不同形貌接触线时的摩擦因数、电弧能量和浸金属碳滑板的磨损量、表面形貌。试验结果表明:在直流电情况下,常规接触线与浸金属碳滑板组成的摩擦副的摩擦因数最小,滑板磨损量最低;采用斜切形貌接触线时的摩擦因数最大,滑板磨损量最大。通过SEM电镜观测浸金属碳滑板表面的磨损形貌,发现接触线为常规形貌时,滑板以氧化磨损为主,有较多的氧化物产生;接触线为麻点形貌时,滑板以电弧烧蚀和磨粒磨损为主,产生了细小裂纹和烧蚀坑,有较多的磨屑和剥落层出现;接触线为斜切形貌时,滑板以电弧烧蚀为主,有大裂纹和犁沟产生,并且烧蚀区域出现了较多的白色小球。研究表明,当接触线的形貌发生改变时,会导致滑板磨耗增加并加剧接触副电弧放电,从而恶化接触副的状态。因此,当接触线磨损变形严重时,应及时进行更换。

关键词：浸金属碳滑板接触线表面形貌电弧能量摩擦磨损载流试验

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Transfer of disulfide bond formation modules via yeast artificial chromosomes promotes the expression of heterologous proteins in Kluyveromyces marxianus

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mLife 2024年第1期3卷 129-142页

作者： Pingping Wu wenjuan Mo Tian Tian Kunfeng Song Yilin Lyu Haiyan ren Jungang Zhou Yao Yu Hong Lu State Key Laboratory of Genetic Engineering School of Life SciencesFudan UniversityShanghaiChina Shanghai Engineering Research Center of Industrial Microorganisms ShanghaiChina

Kluyveromyces marxianus is a food-safe yeast with great potential for producing heterologous *** the yield in *** remains a challenge and incorporating large-scale functional modules poses a technical obstacle in *** address these issues,linear and circular yeast artificial chromosomes of ***(KmYACs)were constructed and loaded with disulfide bond formation modules from Pichia pastoris or *** modules contained up to seven genes with a maximum size of 15 *** carried telomeres either from *** or *** were transferred successfully into *** and stably propagated without affecting the normal growth of the host,regardless of the type of telomeres and configurations of *** increased the overall expression levels of disulfide bond formation genes and significantly enhanced the yield of various heterologous *** high-density fermentation,the use of KmYACs resulted in a glucoamylase yield of 16.8 g/l,the highest reported level to date in *** and metabolomic analysis of cells containing KmYACs suggested increased flavin adenine dinucleotide biosynthesis,enhanced flux entering the tricarboxylic acid cycle,and a preferred demand for lysine and arginine as features of cells overexpressing heterologous ***,supplementing lysine or arginine further improved the ***,KmYAC provides a powerful platform for manipulating large modules with enormous potential for industrial applications and fundamental *** the disulfide bond formation module via YACs proves to be an efficient strategy for improving the yield of heterologous proteins,and this strategy may be applied to optimize other microbial cell factories.

关键词： disulfide bond formation expression of heterologous proteins Kluyveromyces marxianus telomere yeast artificial chromosome

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Pyrimethamine upregulates BNIP3 to interfere SNARE-mediated autophagosome-lysosomal fusion in hepatocellular carcinoma

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Journal of Pharmaceutical Analysis 2024年第2期14卷 211-224页

作者： Jingjing Wang Qi Su Kun Chen Qing Wu Jiayan ren wenjuan Tang Yu Hu Zeren Zhu Cheng Cheng Kaihui Tu Huaizhen He Yanmin Zhang School of Pharmacy Health Science CenterXi'an Jiaotong UniversityXi'an710061China

Hepatocellular carcinoma (HCC) is one of the most common tumor types and remains a major clinical challenge. Increasing evidence has revealed that mitophagy inhibitors can enhance the effect of chemotherapy on HCC. However, few mitophagy inhibitors have been approved for clinical use in humans. Pyrimethamine (Pyr) is used to treat infections caused by protozoan parasites. Recent studies have reported that Pyr may be beneficial in the treatment of various tumors. However, its mechanism of action is still not clearly defined. Here, we found that blocking mitophagy sensitized cells to Pyr-induced apoptosis. Mechanistically, Pyr potently induced the accumulation of autophagosomes by inhibiting autophagosome-lysosome fusion in human HCC cells. In vitro and in vivo studies revealed that Pyr blocked autophagosome-lysosome fusion by upregulating BNIP3 to inhibit synaptosomal-associated protein 29 (SNAP29)-vesicle-associated membrane protein 8 (VAMP8) interaction. Moreover, Pyr acted synergistically with sorafenib (Sora) to induce apoptosis and inhibit HCC proliferation in vitro and in vivo. Pyr enhances the sensitivity of HCC cells to Sora, a common chemotherapeutic, by inhibiting mitophagy. Thus, these results provide new insights into the mechanism of action of Pyr and imply that Pyr could potentially be further developed as a novel mitophagy inhibitor. Notably, Pyr and Sora combination therapy could be a promising treatment for malignant HCC.

关键词： Pyrimethamine BNIP3 SNARE Autophagosome-lysosome fusion Hepatocellular carcinoma Sorafenib

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Effect of Empowering Education on Refined Nursing of Patients with Internal Double J Tubes after Surgery for Ureteral Stricture

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Open Journal of Nursing 2021年第5期11卷 291-301页

作者： Shasha Li Guili Cheng Huihong Huang wenjuan ren The Third Affiliated Hospital of Zhongshan University Guangzhou China

Objective: To investigate the effect of the theory of enabling education on the fine management of patients with internal double J tubes after ureteral stricture. Methods: Eighty patients with built-in double J tubes after ureteral stricture were selected from the urology department of a grade a hospital in Guangzhou. The patients were divided into control group and observation group by random number method, with 40 patients in each group. The control group received refined nursing after surgery, while the observation group received refined nursing including the theory of empowerment education after surgery on the basis of the control group. Results: After the intervention, the observation group had a higher standard rate of quality indicators, higher self-efficacy score than the control group (P ≤ 0.05), lower scores of ureteral stent-related symptoms, urinary system symptoms, pain symptoms, total health status, job performance, additional problems and total scores than the control group (P ≤ 0.05), and statistically significant differences were found in the total health status dimension and total scores (P ≤ 0.01). The nursing satisfaction survey, the scores of clinical nursing, health education, psychological counseling and nurse-patient communication were all higher than those in the control group (P ≤ 0.05), and the differences in health education and nurse-patient communication were statistically significant (P ≤ 0.01). Conclusion: The theory of enabling education can improve patients’ self-nursing level, promote the implementation of refined nursing quantitative indicators and nursing measures, relieve the poor symptoms of ureteral stricture patients, and improve patients’ satisfaction with nursing work.

关键词： Empowering Education Double J Tube Refined Care

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147例老年肺结核合并肺部感染患者病原菌分布及耐药性分析

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中国民康医学 2023年第12期35卷 4-6,10页

作者：任文娟河南宏力医院药学部河南长垣453400

目的:分析老年肺结核(PTB)合并肺部感染患者病原菌分布及耐药性。方法:选取2019年5月至2022年3月该院收治的147例老年肺结核合并肺部感染患者进行前瞻性研究,对患者痰液行细菌培养及药敏试验,并分析病原菌分布及耐药性。结果:147例老年... 详细信息

目的:分析老年肺结核(PTB)合并肺部感染患者病原菌分布及耐药性。方法:选取2019年5月至2022年3月该院收治的147例老年肺结核合并肺部感染患者进行前瞻性研究,对患者痰液行细菌培养及药敏试验,并分析病原菌分布及耐药性。结果:147例老年肺结核合并肺部感染患者痰液中共检出179株病原菌,其中革兰阴性菌122株(68.16%),以肺炎克雷伯菌、铜绿假单胞菌、鲍氏不动杆菌为主;革兰阳性菌46株(25.70%),以肺炎球菌、金黄色葡萄球菌、溶血葡萄球菌为主;真菌11株(6.15%),以白色念珠菌、热带假丝酵母菌为主;肺炎克雷伯菌对氨苄西林耐药率最高(100.00%),其次是头孢唑林(85.29%);铜绿假单胞菌对氨苄西林、复方新诺明、氨苄西林/舒巴坦耐药率最高(100.00%),其次是头孢唑林(89.66%);鲍氏不动杆菌对氨苄西林、头孢唑林耐药率最高(100.00%),其次为氯霉素(87.50%);肺炎球菌对阿米卡星耐药率最高(100.00%),其次为头孢曲松、青霉素,均为92.86%;金黄色葡萄球菌对阿米卡星、青霉素耐药率最高(100%),其次为头孢曲松(90.91%)。结论:老年肺结核合并肺部感染患者病原菌分布以革兰阴性菌为主,不同病原菌耐药性存在差异,且对常用抗菌药物耐药较严重。

关键词：肺结核肺部感染病原菌分布抗菌药物耐药性

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DFT Study on Mechanism of Pd(OAc)2-Catalyzed C-C Coupling reaction

DFT Study on Mechanism of Pd(OAc)2-Catalyzed C-C Coupling re...

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中国化学会第十二届全国量子化学会议

作者： wenjuan ren Ying ren Hai-shun Wu School of Chemistry and Materials Science Shanxi Normal University

The Pd(OAc)2-Catalyzed C-C Cross-Coupling reaction mechanism of 3-methoxyacetanilide with n-butyl acrylate in presence of HBF4 and additives has been investigated,using density functional theory(DFT)calculations at the B3LYP *** catalyst cycle proceeds through four main steps involving C-H activation,alkene insertion,β-hydride elimination,and recycling of *** is found that the C-H activation step is the rate-determining step over the whole reactions and in C-H activation step,the six-member pathway is the favorable *** alkene insertion andβ-hydride elimination steps,HBF4 decomposes slowly in aqueous solution(HBF4+H2O→BF3OH-+H++HF)and provide a source of HF to accelerate the *** addition,it is shown that water as solvent does not change the general trends for the reaction potential energy surface.

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双酚P对斑马鱼的生长和发育毒性

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生态毒理学报 2022年第5期17卷 383-392页

作者：杨倩任文娟刘济宁汪贞南京财经大学食品科学与工程学院南京210023 天津河海标测技术检测有限公司天津300450 生态环境部南京环境科学研究所南京210042

双酚A(bisphenol A,BPA)是一种典型的内分泌干扰物,目前许多国家出台了管控措施,因此一些BPA类似物,包括双酚P(bisphenol P,BPP)被开发用来替代BPA。目前很多研究发现BPA类似物具有与BPA相似的毒性效应,但是关于BPP毒性效应的研究还比... 详细信息

双酚A(bisphenol A,BPA)是一种典型的内分泌干扰物,目前许多国家出台了管控措施,因此一些BPA类似物,包括双酚P(bisphenol P,BPP)被开发用来替代BPA。目前很多研究发现BPA类似物具有与BPA相似的毒性效应,但是关于BPP毒性效应的研究还比较缺乏。本文以斑马鱼为研究模型,将胚胎暴露于0.1、0.2、0.3、0.4、0.6和0.8 mg·L^(-1)的BPP中至受精后60 dpf(days post fertilization,dpf),研究BPP对斑马鱼的发育毒性和内分泌干扰效应。结果表明,斑马鱼7 dpf-孵化率的降低和8 dpf-累积死亡率的升高均具有剂量-效应关系,半数效应浓度(50%effective concentration,EC 50)值分别为0.580 mg·L^(-1)和0.247 mg·L^(-1)。幼体生长阶段,30 dpf-畸形率的EC 50值为0.380 mg·L^(-1);对于体长和体质量抑制的30 d-EC 50≥0.6 mg·L^(-1)。斑马鱼的“假定”特定生长率(specific growth rate,SGR)和浓度存在显著的剂量-效应关系,随着BPP浓度增高,假定特定生长率均呈下降趋势,并且45~60 d的体质量和体长特定生长率的抑制效应浓度比30~45 d更低。激素水平测定结果表明,BPP暴露显著降低了斑马鱼体内的雄激素水平,提高了雌激素和卵黄蛋白原的水平。本研究结果表明,BPP对斑马鱼胚胎及幼鱼的生长发育具有一定的毒性效应。

关键词：双酚A类似物双酚P 斑马鱼发育毒性内分泌干扰效应

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