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The pivotal role of microglia in injury and the prognosis of subarachnoid hemorrhage

Neural Regeneration Research 2025年第7期20卷 1829-1848页

作者： wenjing.ning.shi lv Qian Wang Yuzhen Xu Department of Rehabilitation The Second Affiliated Hospital of Shandong First Medical UniversityTaianShandong ProvinceChina Department of Central Laboratory The Affiliated Taian City Central Hospital of Qingdao UniversityTaianShandong ProvinceChina

Subarachnoid hemorrhage leads to a series of pathological changes,including vascular spasm,cellular apoptosis,blood–brain barrier damage,cerebral edema,and white matter ***,which are the key immune cells in the central nervous system,maintain homeostasis in the neural environment,support neurons,mediate apoptosis,participate in immune regulation,and have neuroprotective *** evidence has shown that microglia play a pivotal role in the pathogenesis of subarachnoid hemorrhage and affect the process of injury and the prognosis of subarachnoid ***,microglia play certain neuroprotective roles in the recovery phase of subarachnoid *** approaches aimed at modulating microglia function are believed to attenuate subarachnoid hemorrhage *** provides new targets and ideas for the treatment of subarachnoid ***,an in-depth and comprehensive summary of the role of microglia after subarachnoid hemorrhage is still *** review describes the activation of microglia after subarachnoid hemorrhage and their roles in the pathological processes of vasospasm,neuroinflammation,neuronal apoptosis,blood–brain barrier disruption,cerebral edema,and cerebral white matter *** also discusses the neuroprotective roles of microglia during recovery from subarachnoid hemorrhage and therapeutic advances aimed at modulating microglial function after subarachnoid ***,microglia in subarachnoid hemorrhage are targeted with TLR inhibitors,nuclear factor-κB and STAT3 pathway inhibitors,glycine/tyrosine kinases,NLRP3 signaling pathway inhibitors,Gasdermin D inhibitors,vincristine receptorαreceptor agonists,ferroptosis inhibitors,genetic modification techniques,stem cell therapies,and traditional Chinese ***,most of these are still being evaluated at the laboratory *** clinical studies and data on subarachnoid hemorrhage are required to improve the treatment of subarachnoid hemor

关键词： apoptosis blood–brain barrier brain edema microglia neuroinflammation neuron neuroprotection subarachnoid hemorrhage vasoconstriction white matter injury

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Hierarchical hollow microspheres assembled from carbon nanosheets integrated with molybdenum carbide nanoparticles for boosting microwave absorption properties

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Nano Research 2025年第1期18卷 10-20页

作者： Zongsheng Chen Yahui Wang Yi Liu Zhigang Li Xiangyin lv Liping Liu Yajing Chang Jiaming shi Xiao Zhang State Key Laboratory of Pulsed Power Laser Technology School of Electronic EngineeringNational University of Defense TechnologyHefei 230037China Anhui Provincial Laboratory of Advanced Laser Technology School of Electronic EngineeringNational University of Defense TechnologyHefei 230037China Centre for Environmental and Energy Nanomaterials Anhui Key Laboratory of Nanomaterials and NanotechnologyCAS Centre for Excellence in NanoscienceInstitute of Solid State PhysicsHefei Institutes of Physical ScienceChinese Academy of SciencesHefei 230031China

Hierarchical hollow structure has demonstrated potential for enhancing electromagnetic(EM)attenuation and improving impedance matching,garnering significant attention for ***,we have successfully implemented compositional and structural engineering to fabricate hollow Mo2C/C microspheres with controllable composition by coupling interaction between dopamine hydrochloride and ammonium *** the synergistic effect of composition and hollow structure,the strongest reflection loss intensity and broadest effective absorption of the optimized sample reach-70.2 dB and 6.2 GHz,*** formation of hollow heterogeneous structures not only favors impedance matching feature,but also generates considerable contribution to EM attenuation ***,radar cross-section simulation data indicate that hollow Mo2C/C microspheres with compositional optimization and heterogeneous structures have broad prospects for practical applications.

关键词： electromagnetic absorption Mo2C/C microwave absorption hollow structure

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Self-supporting and dual-active 3D Co-S nanosheets constructed by ligand replacement reaction from MOF for rechargeable Al battery

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Journal of Energy Chemistry 2022年第6期31卷 35-43,I0002页

作者： Aijing lv Songle Lu Mingyong Wang Haotian shi wenjing Yan Shuqiang Jiao State Key Laboratory of Advanced Metallurgy University of Science and TechnologyBeijingBeijing 100083China Beijing Key Laboratory of Green Recovery and Extraction of Rare and Precious Metals University of Science and TechnologyBeijingBeijing 100083China National Center for Materials Service Safety University of Science and Technology BeijingBeijing 100083China

Metal sulfides with high theoretical capacities are expected as promising cathode materials of Al batteries(AIBs). However, powdery active materials are mainly synthesized and loaded on current collector by insulating binder without capacity. Meanwhile, S as inert element in metal sulfides can not usually provide capacity. So, powdery metal sulfides only exhibit limiting practical capacity and poor cycling stability due to weak conductivity and low mass utilization. Herein, the novel self-supporting and dual-active Co-S nanosheets on carbon cloth (i.e. Co-S/CC) with hierarchically porous structure are constructed as cathode of AIBs. Co-S nanosheets are derived from ZIF-67 nanosheets on CC by a facile ligand replacement reaction. As a result, the binder-free Co-S/CC cathode with good conductivity delivers excellent initial discharge capacity of 383.4 m Ah g^(-1)(0.211 m Ah cm^(-2)) at current density of 200 m A g^(-1)and maintain reversible capacity of 156.9 m Ah g^(-1)(0.086 m Ah cm^(-2)) with Coulombic efficiency of 95.8% after 500 cycles,which are much higher than those of the traditional slurry-coating cathodes. Both Co and S as active elements in Co-S/CC contribute to capacity, which leads to a high mass utilization. This work provides a significant strategy for the construction of self-supporting metallic cathode for advanced high-energy density Al battery.

关键词： Cobalt sulfide Ligand replacement reaction Self-supporting Aluminum battery

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Metabolic pathway modulation by olanzapine:Multitarget approach for treating violent aggression in patients with schizophrenia

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World Journal of Psychiatry 2025年第1期15卷 37-53页

作者： Yan-ning Song Shuang Xia Zhi Sun Yong-Chao Chen Lu Jiao Wen-Hua Wan Hong-Wei Zhang Xiao Guo Hua Guo Shou-Feng Jia Xiao-Xin Li shi-Xian Cao Li-Bin Fu Meng-Meng Liu Tian Zhou lv-Feng Zhang Qing-Quan Jia Department of Pharmacy The Affiliated Encephalopathy Hospital of Zhengzhou University(Zhumadian Second People's Hospital)Zhumadian 463000Henan ProvinceChina Department of Pharmacy The First Affiliated Hospital of Zhengzhou UniversityZhengzhou 450052Henan ProvinceChina Department of Pharmacy Zhumadian First People's HospitalZhumadian 463000Henan ProvinceChina Scientific Education Section The Affiliated Encephalopathy Hospital of Zhengzhou University(Zhumadian Second People's Hospital)Zhumadian 463000Henan ProvinceChina Department of Psychiatry The Affiliated Encephalopathy Hospital of Zhengzhou University(Zhumadian Second People's Hospital)Zhumadian 463000Henan ProvinceChina Clinical Laboratory The Affiliated Encephalopathy Hospital of Zhengzhou University(Zhumadian Second People's Hospital)Zhumadian 463000Henan ProvinceChina Publicity Division The Affiliated Encephalopathy Hospital of Zhengzhou University(Zhumadian Second People's Hospital)Zhumadian 463000Henan ProvinceChina

BACKGROUND The use of network pharmacology and blood metabolomics to study the patho-genesis of violent aggression in patients with schizophrenia and the related drug mechanisms of action provides new directions for reducing the risk of violent aggression and optimizing treatment *** To explore the metabolic regulatory mechanism of olanzapine in treating patients with schizophrenia with a moderate to high risk of violent *** Metabolomic technology was used to screen differentially abundant metabolites in patients with schizophrenia with a moderate to high risk of violent aggression before and after olanzapine treatment,and the related metabolic pathways were *** pharmacology was used to establish protein-protein interaction networks of the core targets of *** Ontology functional analysis and Kyoto Encyclopedia of Genes and Genomes pathway enrichment analysis were subsequently *** Compared with the healthy group,the patients with schizophrenia group presented significant changes in the levels of 24 metabolites related to the disruption of 9 metabolic pathways,among which the key pathways were the alanine,aspartate and glutamate metabolism and arginine biosynthesis *** treatment with olanzapine,the levels of 10 differentially abundant metabolites were significantly reversed in patients with *** effectively regulated six metabolic pathways,among which the key pathways were alanine,aspartate and glutamate metabolism and arginine biosynthesis *** core targets of olanzapine were involved in several key *** The metabolic pathways of alanine,aspartate,and glutamate metabolism and arginine biosynthesis are the key pathways involved in olanzapine treatment for aggressive schizophrenia.

关键词： Schizophrenia Violent aggression Olanzapine Metabolomics Network pharmacology

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300 MPa grade highly ductile biodegradable Zn-2Cu-(0.2-0.8)Li alloys with novel ternary phases

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Journal of Materials Science & Technology 2023年第26期157卷 234-245页

作者： Meng Cao Zhe Xue Zhao-Yong lv Jin-Ling Sun Zhang-Zhi shi Lu-ning Wang Beijing Advanced Innovation Center for Materials Genome Engineering State Key Laboratory for Advance Metals and MaterialsSchool of Materials Science and EngineeringUniversity of Science and Technology BeijingBeijing 100083China Orthopedics Department Peking University ShouGang HospitalBeijing 100144China Advanced Technology and Materials Co. Ltd.(AT&M)Beijing 100081China Liaocheng People’s Hospital Liaocheng Hospital Affiliated to Shandong First Medical UniversityLiaocheng 252000China

Although a few high-strength biodegradable Zn alloys with yield strengths(YSs)over 300 MPa in rolled state have been developed,their elongations(ELs)are generally less than 30%.This study developed rolled Zn-2Cu-x Li(x=0.2 wt.%,0.5 wt.%,0.8 wt.%)alloys with YSs of 316-335 MPa and ELs of 44%-61%.Three-dimensional atom probe(3DAP)and time of flight secondary ion mass spectrometry(TOF-SIMS)were employed to characterize Li *** kinds of Zn-Cu-Li ternary phases are identified,which are blockyε′-(Cu_(0.5),Li_(0.5))Zn 4,blockyβ′-(Li_(0.9),Cu_(0.1))Zn 4,and small roundγparticles with high Li content in the annealed *** identified phases are Zn,β-LiZn 4,andε-CuZn 4 *** the increase of Li content in the alloys,ε′phase with 6.50 at.%Cu transforms intoβ′phase with 2.12 at.%Cu,i.e.,the average level in the ***ε′phase,there exist nano-scale Li clusters andεphase,resulting inε′/ε*** Zn laths precipitate fromβ′phase,resulting inβ′/Zn lamellar *** lamel-lar structure is the matrix of Zn-2Cu-0.8Li and leads to near-isotropic *** tests show that degradation rates fall in the range of 153-196μm/year,which decrease with Li *** the alloys exert positive effects on the growth of MC3T3-E1 cells with 10%*** research reveals how microstructure evolves in Zn-2Cu-x Li alloys,which lays the foundation for their future applications.

关键词： Biodegradable Zn alloys Zn-Cu-Li ternary phase Microstructure

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ISP and PAP4 peptides promote motor functional recovery after peripheral nerve injury

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Neural Regeneration Research 2021年第8期16卷 1598-1605页

作者： shi-Qin lv Wutian Wu Guangdong-Hong Kong-Macao Institute of CNS Regeneration Ministry of Education CNS Regeneration Collaborative Joint LaboratoryJinan UniversityGuangzhouGuangdong ProvinceChina Re-Stem Biotechnology Co. Ltd.SuzhouJiangsu ProvinceChina

Both intracellular sigma peptide(ISP) and phosphatase and tensin homolog agonist protein(PAP4) promote nerve regeneration and motor functional recovery after spinal cord injury. However, the role of these two small peptides in peripheral nerve injury remains unclear. A rat model of brachial plexus injury was established by crush of the C6 ventral root. The rats were then treated with subcutaneous injection of PAP4(497 μg/d, twice per day) or ISP(11 μg/d, once per day) near the injury site for 21 successive days. After ISP and PAP treatment, the survival of motoneurons was increased, the number of regenerated axons and neuromuscular junctions was increased, muscle atrophy was reduced, the electrical response of the motor units was enhanced and the motor function of the injured upper limbs was greatly improved in rats with brachial plexus injury. These findings suggest that ISP and PAP4 promote the recovery of motor function after peripheral nerve injury in rats. The animal care and experimental procedures were approved by the Laboratory Animal Ethics Committee of Jinan University of China(approval No. 20111008001) in 2011.

关键词： axon brachial plexus injury crush injury intracellular sigma peptide motor function PAP4 peripheral nerve protection regeneration repair

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Recent advances on porous organic frameworks for the adsorptive removal of hazardous materials

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Journal of Environmental Sciences 2019年第6期31卷 169-185页

作者： shi-Wen lv Jing-Min Liu Zhi-Hao Wang Hui Ma Chun-Yang Li ning Zhao Shuo Wang Tianjin Key Laboratory of Food Science and Health School of Medicine Nankai University College of Environmental Science and Engineering Nankai University

Environmental pollution is one of the most serious problems facing mankind today,and has attracted widespread attention worldwide. The burgeoning class of crystalline porous organic framework materials, metal–organic frameworks and covalent organic frameworks present promising application potential in areas related to pollution control due to their interesting surface properties. In this review, the literature of the past five years on the adsorptive removal of various hazardous materials, mainly including heavy metal ions, harmful gases, organic dyes, pharmaceutical and personal care products, and radionuclides from the environment by using COFs and MOFs, is summarized. The adsorption mechanisms are also discussed to help understand their adsorption performance and selectivity. Additionally, some insightful suggestions are given to enhance the performance of MOFs and COFs in the adsorptive removal of various hazardous materials.

关键词： Metal-organic frameworks Covalent organic frameworks Adsorptive removal Hazardous materials

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Vehicle-to-grid service development logic and management formulation

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Journal of Modern Power Systems and Clean Energy 2019年第4期7卷 935-947页

作者： Lefeng shi Tong lv Yandi WANG School of Economics and Management Chongqing Normal UniversityChongqing 401331China School of Electrical Engineering Shandong UniversityJinan 250061China

Vehicle-to-grid(V2G)is regarded as the effective way to reconcile contradictions between an electric power system and electric vehicles(EVs).A lot of research has been carried out to affect this,often based on different technical and trade model *** value of theresearch is dependent on how reasonable the assumptions it makes *** paper presents a framework for analyzing V2G service development from a coevolutionary perspective in which the interactive relation between the diffusion of EVs and the upgrade of the distribution grid system is considered.A V2G service development logic and its management formulation are put ***,the motivations and contradictions of developing V2G services are *** a development phase division of the V2G services is proposed in view of the coevolution relation between the grid upgrade and the development of the ***,taking into account the characteristics of each phase,the physical trade structures and corresponding management hierarchies,management relations as well as management measures,are *** paper provides a new perspective of V2G service development,answers the core question on how to make the V2G vision come true in synergy with the development of EVs,and gives some advice on future V2G management paradigms.

关键词： Electric vehicle Vehicle-to-grid service Smart grid Aggregator

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Influence of confi ning pressure and impact loading on mechanical properties of amphibolite and sericite-quartz schist

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Earthquake Engineering and Engineering Vibration 2014年第2期13卷 215-222页

作者： Liu shi Xu Jinyu lv Xiaocong Department of Airfi eld and Building Engineering Air Force Engineering University College of Mechanics and Civil Architecture Northwest Polytechnic University

In order to investigate the dynamic mechanical properties of amphibolite and sericite-quartz schist under confi ning pressure, two rocks are subjected to impact loadings with different strain rates and confi ning pressures by using split Hopkinson pressure bar equipment with a confi ning pressure device. Based on the experimental results, the stress-strain curves are analyzed and the effects of confi ning pressure and strain rates on the dynamic compressive strength, peak strain and failure mode are summarized. The results show that:(1) The characteristics of two rocks in the ascent stage of the stressstrain curve are basically the same, but in the descent stage, the rocks gradually show plastic deformation characteristics as the confi ning pressure increases.(2) The dynamic compressive strength and peak strain of two rocks increase as the strain rate increases and the confi ning pressure effects are obvious.(3) Due to the effect of confi ning pressure, the normal stress on the damage surface of the rock increases correspondingly, the bearing capacity of the crack friction exceeds the material cohesion and the slippage of the fractured rock is controlled, which all lead to the compression and shear failure mode of rock. The theoretical analysis and experimental methods to study the dynamic failure mode and other related characteristics of rock are useful in developing standards for engineering practice.

关键词： rock mechanics SHPB with confi ning pressure device confi ning pressure strain rate impact loading

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Different conformational responses of the β2-adrenergic receptor-Gs complex upon binding of the partial agonist salbutamol or the full agonist isoprenaline

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National Science Review 2021年第9期8卷 111-120页

作者： Fan Yang Shenglong Ling Yingxin Zhou Yanan Zhang Pei lv Sanling Liu Wei Fang wenjing Sun Liaoyuan A.Hu Longhua Zhang Pan shi Changlin Tian Hefei National Laboratory of Physical Sciences at Microscale and School of Life Sciences University of Science and Technology of China Amgen Asia R&D Center Amgen Research Shanghai 201210 China3High Magnetic Field Laboratory Chinese Academy of Sciences

G protein-coupled receptors(GPCRs) are responsible for most cytoplasmic signaling in response to extracellular ligands with different efficacy profiles. Various spectroscopic techniques have identified that agonists exhibiting varying efficacies can selectively stabilize a specific conformation of the ***, the structural basis for activation of the GPCR-G protein complex by ligands with different efficacies is incompletely understood. To better understand the structural basis underlying the mechanisms by which ligands with varying efficacies differentially regulate the conformations of receptors and G proteins, we determined the structures of β2AR-Gαsβγ bound with partial agonist salbutamol or bound with full agonist isoprenaline using single-particle cryo-electron microscopy at resolutions of 3.26 ?A and3.80 ?A, respectively. Structural comparisons between the β2AR-Gs-salbutamol and β2AR-Gs-isoprenaline complexes demonstrated that the decreased binding affinity and efficacy of salbutamol compared with those of isoprenaline might be attributed to weakened hydrogen bonding interactions, attenuated hydrophobic interactions in the orthosteric binding pocket and different conformational changes in the rotamer toggle switch in TM6. Moreover, the observed stronger interactions between the intracellular loop 2 or 3(ICL2 or ICL3) of β2AR and Gαswith binding of salbutamol versus isoprenaline might decrease phosphorylation in the salbutamol-activated β2AR-Gs complex. From the observed structural differences between these complexes of β2AR, a mechanism of β2AR activation by partial and full agonists is proposed to provide structural insights into β2AR desensitization.

关键词： cryo-EM structure G protein-coupled receptor (GPCR) partial and full agonists conformational change desensitization

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