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Quantum-Inspired Distributed Memetic Algorithm

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Complex System Modeling and Simulation 2022年第4期2卷 334-353页

作者： Guanghui Zhang wenjing ma Keyi Xing Lining Xing Kesheng Wang the School of Information Science and Technology and the Hebei Key Laboratory of Agricultural Big Data Hebei Agricultural UniversityBaoding 071001China the School of Information Science and Technology Hebei Agricultural UniversityBaoding 071001China. the State Key Laboratory for manufacturing System Engineering and the Systems Engineering Institute Xi’an Jiaotong UniversityXi’an 710049China the School of Electronic Xidian UniversityXi’an 710071China the Department of Production and Quality Engineering Norwegian University of Science and TechnologyTrondheim 7491Norway

This paper proposed a novel distributed memetic evolutionary model,where four modules distributed exploration,intensified exploitation,knowledge transfer,and evolutionary restart are coevolved to maximize their strengths and achieve superior global *** exploration evolves three independent populations by heterogenous *** exploitation evolves an external elite archive in parallel with exploration to balance global and local *** transfer is based on a point-ring communication topology to share successful experiences among distinct search *** restart adopts an adaptive perturbation strategy to control search diversity *** computation is a newly emerging technique,which has powerful computing power and parallelized ***,this paper further fuses quantum mechanisms into the proposed evolutionary model to build a new evolutionary algorithm,referred to as quantum-inspired distributed memetic algorithm(QDma).In QDma,individuals are represented by the quantum characteristics and evolved by the quantum-inspired evolutionary optimizers in the quantum *** QDma integrates the superiorities of distributed,memetic,and quantum *** experiments are carried out to evaluate the superior performance of *** results demonstrate the effectiveness of special designs and show that QDma has greater superiority compared to the compared state-of-the-art algorithms based on Wilcoxon’s rank-sum *** superiority is attributed not only to good cooperative coevolution of distributed memetic evolutionary model,but also to superior designs of each special component.

关键词： distributed evolutionary algorithm memetic algorithm quantum-inspired evolutionary algorithm quantum distributed memetic algorithm

Apoptosis-enhanced ferroptosis therapy of pancreatic carcinoma through PAmaM dendrimer-iron(Ⅲ)complex-based plasmid delivery

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Science China Chemistry 2022年第4期65卷 778-788页

作者： wenjing ma Yue Gao Zhijun Ouyang Yu Fan Hongwei Yu Mengsi Zhan Han Wang Xiangyang Shi Mingwu Shen State Key Laboratory for Modification of Chemical Fibers and Polymer materials Shanghai Engineering Research Center of Nano-Biomaterials and Regenerative MedicineCollege of ChemistryChemical Engineering and BiotechnologyDonghua UniversityShanghai 201620China Department of Radiology Shanghai General HospitalShanghai Jiao Tong University School of MedicineShanghai 200080China

The development of promising strategies to improve the treatment efficacy of pancreatic carcinoma still remains to be a challenging *** report here the development of a new dendrimer-based nanomedicine formulation to tackle pancreatic carcinoma through apoptosis-enhanced ferroptosis *** this article,G5 dendrimers were partially modified with a Fe(Ⅲ)chelator hydroxyquinoline-2-carboxylic acid(8-HQC)on their periphery,entrapped with gold nanoparticles(Au NPs)within their internal cavities,and chelated with Fe(Ⅲ).The thus created dendrimer-entrapped Au NPs(Fe-Au DENP-HQC)with an Au core size of 1.9 nm and 20.0 Fe(Ⅲ)ions complexed per dendrimer are stable,have a pH-dependent Fe(Ⅲ)release profile,and can generate reactive oxygen species under the tumor microenvironment(TME)and effectively compact plasmid DNA encoding p53 protein to form polyplexes with a hydrodynamic size of 143.9 nm and a surface potential of 33.6 *** show that cancer cells treated with the created Fe-Au DENP-HQC/p53 polyplexes can be more significantly inhibited through vector-mediated chemodynamic therapy(CDT)effect via Fe(Ⅲ)-induced Fenton reaction and the p53 gene delivery-boosted cell apoptosis and oxidative stress in the TME than single-mode CDT and gene *** investigations using a xenografted tumor model validated the effectiveness of apoptosis-enhanced ferropotosis therapy through the downregulation of GPX-4 and SLC7A11proteins,upregulation of p53 and PTEN proteins,as well as histological ***,the dendrimer nanoplatform enabled tumor fluorescence imaging through gene delivery-mediated enhanced green fluorescent protein *** Fe(Ⅲ)-complexed dendrimer vector system may be developed as a promising theranostic nanoplatform for ferroptosis or ferroptosis-based combination therapy of other cancer types.

关键词： dendrimers ferroptosis gene delivery pancreatic carcinoma fluorescence imaging

Diverse structures and antihepatoma effect of sesquiterpenoid dimers from Artemisia eriopoda by AKT/STAT signaling pathway

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Signal Transduction and Targeted Therapy 2023年第3期8卷 898-900页

作者： Xiaofeng He wenjing ma Jing Hu Tianze Li Changan Geng Yunbao ma Mengfei Wang Kexin Yang Xuemei Zhang Ji-Jun Chen State Key Laboratory of Phytochemistry and Plant Resources in West China Kunming Institute of BotanyChinese Academy of SciencesKunming 650201PR China University of Chinese Academy of Sciences Beijing 100049PR China

Dear Editor,Liver cancer as a common malignant tumor has become a major source of morbidity and mortality worldwide.1 Currently,four synthetic drugs and three monoclonal antibody drugs have been approved for the treatment of hepatocellular carcinoma(HCC)since ***,the disadvantages of the above drugs such as low response rates,severe side effects,and drug resistance hamper their therapeutic *** and biologically diverse natural products are a major source in the search for novel antihepatoma agents.

关键词： drugs mortality Liver

UCHL5 inhibits U251 glioma cell proliferation and tumor growth via stabilizing and deubiquitinating PTEN

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BIOCELL 2023年第12期47卷 2617-2625页

作者： YUE XIAO wenjing ma XINYI CHEN WEIWEI HU QIANQIAN DI XIBAO ZHAO GUODONG HUANG WEILIN CHEN Guangdong Provincial Key Laboratory of Regional Immunity and Diseases Department of NeurosurgeryShenzhen Second People’s HospitalThe first Affiliated Hospital of Shenzhen UniversityShenzhen University Medical SchoolShenzhen UniversityShenzhen518055China Institute of Biological Therapy Department of ImmunologyShenzhen UniversityShenzhen518055China Department of Neurosurgery Second Affiliated HospitalZhejiang University School of MedicineHangzhou310058China

Glioma is the most common primary brain *** of new tumorigenesis mechanism of glioma is critical to determine more effective treatment targets as well as to develop effective prognosis methods that can enhance the treatment *** previously demonstrated that the deubiquitinase biquitin carboxyl-terminal hydrolase L5(UCHL5)was downregulated in human ***,the effect and mechanism of UCHL5 on the proliferation of glioma cells remains ***:Transfection of siRNA was used to knockdown the expression of UCHL5 in U251 *** 3-[4,5-dimethylthiazol-2-yl]-2,5 diphenyl tetrazolium bromide(MTT)assay,Edu assay,and colony formation assay were employed to identify the effect of UCHL5 on the proliferation of U251 glioma *** blotting and quantitative real-time PCR were carried out to detect the interaction of UCHL5 and *** effect of UCHL5 on the growth of glioma in vivo was evaluated in nude *** Immunohistochemistry(IHC)were performed to analysis the expression of UCHL5 and PTEN in human glioma ***:Here,we have reported that silencing of UCHL5 could promote the proliferation of U251 glioma cells through MTT assay,Edu assay,and colony formation ***,we revealed that UCHL5 stabilizes the phosphatase and tensin homolog(PTEN)expression by deubiquitination,thereby inhibiting cell proliferation in U251 *** xenograft experiments further demonstrated that silencing the UCHL5 expression could accelerate U251 cell growth in ***,in human glioma tissue microarray,the positive correlation between UCHL5 and PTEN expression was confirmed through IHC ***:UCHL5 restrains the proliferation of U251 glioma cells by stabilizing and deubiquitinating *** findings provide ideas for developing enhanced targeted PTEN therapy for patients with glioma.

关键词： Ubiquitination Glioblastoma Tumorigenesis UCH37

Deep-reinforcement-learning-based water diversion strategy

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Environmental Science and Ecotechnology 2024年第1期17卷 68-79页

作者： Qingsong Jiang Jincheng Li Yanxin Sun Jilin Huang Rui Zou wenjing ma Huaicheng Guo Zhiyun Wang Yong Liu State Environmental Protection Key Laboratory of All materials Flux in River Ecosystems College of Environmental Sciences and EngineeringPeking UniversityBeijing100871PR China Rays Computational Intelligence Lab Beijing Inteliway Environmental Ltd.Beijing100085PR China Yunnan Key Laboratory of Pollution Process and management of Plateau Lake-Watershed Yunnan Research Academy of Eco-environmental SciencesKunming650034PR Chin

Water diversion is a common strategy to enhance water quality in eutrophic lakes by increasing available water resources and accelerating nutrient *** effectiveness depends on changes in the source water and lake ***,the challenge of optimizing water diversion remains because it is difficult to simultaneously improve lake water quality and minimize the amount of diverted ***,we propose a new approach called dynamic water diversion optimization(DWDO),which combines a comprehensive water quality model with a deep reinforcement learning *** applied DWDO to a region of Lake Dianchi,the largest eutrophic freshwater lake in China and validated *** results demonstrate that DWDO significantly reduced total nitrogen and total phosphorus concentrations in the lake by 7%and 6%,respectively,compared to previous ***,annual water diversion decreased by an impressive 75%.Through interpretable machine learning,we identified the impact of meteorological indicators and the water quality of both the source water and the lake on optimal water *** found that a single input variable could either increase or decrease water diversion,depending on its specific value,while multiple factors collectively influenced real-time adjustment of water ***,using well-designed hyperparameters,DWDO proved robust under different uncertainties in model *** training time of the model is theoretically shorter than traditional simulation-optimization algorithms,highlighting its potential to support more effective decisionmaking in water quality management.

关键词： Dynamic water diversion optimization Deep reinforcement learning Process-based model Explainable decision-making Parameter uncertainty

Research Progress of Nickel Iron Bimetallic Series Electrocatalytic materials

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Expert Review of Chinese Chemical

Expert Review of Chinese Chemical 2024年第2期2卷 23-26页

作者： Yan Qiu wenjing ma College of Chemistry and Chemical Engineering Lanzhou Jiaotong University Qingdao university of science and technology

Hydrogen energy has become one of the recognized clean energy sources worldwide due to its advantages such as low cost,renewable energy,and green environmental *** water is currently one of the most promising solutions for providing hydrogen *** iron bimetallic electrocatalysts have abundant sources,low cost,clean and pollution-free properties,and strong catalytic performance,This article mainly reviews the development and research of bimetallic nickel iron oxides and nickel iron alloys in recent years,and explores their synthesis methods,properties,and stability in depth.

关键词： electrochemistry bimetallic nickel ferroelectric catalyst hydrogen evolution reaction oxygen evolution reaction

Integrative analysis of metabolome and transcriptome provides new insights into functional components of Lilii Bulbus

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Chinese Herbal Medicines 2024年第3期16卷 435-448页

作者： Wenjun Wei Tao Guo Wenguang Fan Mengshan Ji Yu Fu Conglong Lian Suiqing Chen wenjing ma Wenfang ma Shuying Feng School of Pharmacy Henan University of Chinese MedicineZhengzhou 450046China Henan Engineering Research Center of Medicinal and Edible Chinese Medicine Technology Zhengzhou 450046China School of Life Science and Engineering Lanzhou University of TechnologyLanzhou 730050China Lanzhou Shibai Agricultural Biotechnology Co. Ltd.Lanzhou 730050China Medical College Henan University of Chinese MedicineZhengzhou 450046China

Objective:Lilium brownii ***(LB)and ***(LL)are the main sources of medicinal lily(Lilii Bulbus,Baihe in Chinese)in ***,the functional components of these two species responsible for the treatment efficacy are yet not *** order to explore the therapeutic material basis of Lilii Bulbus,we selected *** ***(LD)only used for food as the control group to analyze the differences between LD and the other two(LB and LL).Methods:Metabolome and transcriptome were carried out to investigate the differences of active components in LD vs LB and LD vs *** of metabolome and transcriptome was analysed using various analysis methods,such as principal component analysis(PCA),hierarchical cluster analysis(HCA),and so *** expressed genes(DEGs)were enriched through KEGG and GO enrichment ***:The PCA and HCA of the metabolome indicated the metabolites were clearly separated and varied greatly in LL and LB contrasted with *** were 318 significantly differential metabolites(SDMs)in LD vs LB group and 298 SDMs in LD vs LL *** with LD group,the significant up-regulation of steroidal saponins and steroidal alkaloids were detected both in LB and LL groups,especially in LB *** HCA of transcriptome indicated that there was significant difference in LB vs LD group,while the difference between LL and LD varied ***,47540 DEGs in LD vs LB group and 18958 DEGs in LD vs LL group were ***,CYP450s involving in the biosynthesis of steroidal saponins and steroidal alkaloids were detected,and comparing with LD,CYP724,CYP710A,and CYP734A1 in LB and CYP90B in LL were all ***:This study suggested that steroidal saponins and steroidal alkaloids maybe the representative functional components of Lilii Bulbus,which can provide new insights for Lilii Bulbus used in the research and development of classic famous formula.

关键词： Lilium browniiF.E.Brown var.viridulum Baker Lilium davidii var.willmottiae(E.H.Wilson) Raffill Lilium lancifolium Thunb. metabolome transcriptome

Composition Analysis and Identification of Ancient Glass Products Based on L1 Regularization Logistic Regression

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Applied mathematics 2024年第1期15卷 51-64页

作者： Yuqiao Zhou Xinyang Xu wenjing ma School of Statistics and Applied mathematics Anhui University of Finance and Economics Bengbu China School of Accounting Anhui University of Finance and Economics Bengbu China School of management Science and Engineering Anhui University of Finance and Economics Bengbu China

In view of the composition analysis and identification of ancient glass products, L1 regularization, K-Means cluster analysis, elbow rule and other methods were comprehensively used to build logical regression, cluster analysis, hyper-parameter test and other models, and SPSS, Python and other tools were used to obtain the classification rules of glass products under different fluxes, sub classification under different chemical compositions, hyper-parameter K value test and rationality analysis. Research can provide theoretical support for the protection and restoration of ancient glass relics.

关键词： Glass Composition L1 Regularization Logistic Regression Model K-Means Clustering Analysis Elbow Rule Parameter Verification

Functional assembly of root-associated microbial consortia improves nutrient efficiency and yield in soybean

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Journal of Integrative Plant Biology 2021年第6期63卷 1021-1035页

作者： Cunhu Wang Yanjun Li Mingjia Li Kefei Zhang wenjing ma Lei Zheng Hanyu Xu Baofeng Cui Ran Liu Yongqing Yang Yongjia Zhong Hong Liao Root Biology Center College of Resources and EnvironmentFujian Agriculture and Forestry UniversityFuzhou 350002China

Root-associated microbes are critical for plant growth and nutrient acquisition. However, scant information exists on optimizing communities of beneficial root-associated microbes or the mechanisms underlying their interactions with host plants. In this report, we demonstrate that rootassociated microbes are critical influencers of host plant growth and nutrient acquisition. Three synthetic communities(SynComs) were constructed based on functional screening of 1,893 microbial strains isolated from root-associated compartments of soybean plants. Functional assemblage of SynComs promoted significant plant growth and nutrient acquisition under both N/P nutrient deficiency and sufficiency *** trials further revealed that application of SynComs stably and significantly promoted plant growth, facilitated N and P acquisition, and subsequently increased soybean yield. Among the tested communities, SynCom1 exhibited the greatest promotion effect, with yield increases of up to 36.1% observed in two field sites. Further RNA-seq implied that SynCom application systemically regulates N and P signaling networks at the transcriptional level, which leads to increased representation of important growth pathways, especially those related to auxin responses. Overall,this study details a promising strategy for constructing SynComs based on functional screening,which are capable of enhancing nutrient acquisition and crop yield through the activities of beneficial root-associated microbes.

关键词： growth promotion nitrogen phosphorus root-associated microbes SynCom soybean