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Identification and validation of novel prognostic fatty acid metabolic gene signatures in colon adenocarcinoma through systematic approaches

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Oncology Research 2024年第2期32卷 297-308页

作者： HENG ZHANG wenjing cheng HAIBO ZHAO WEIDONG CHEN QIUJIE ZHANG QING-QING YU Department of Laboratory Shandong Daizhuang HospitalJining272051China Jining No.1 People’s Hospital Shandong First Medical UniversityJining272000China

Colorectal cancer(CRC)belongs to the class of significantly malignant tumors found in humans.Recently,dysregulated fatty acid metabolism(FAM)has been a topic of attention due to its modulation in cancer,specifically CRC.However,the regulatory FAM pathways in CRC require comprehensive elucidation.Methods:The clinical and gene expression data of 175 fatty acid metabolic genes(FAMGs)linked with colon adenocarcinoma(COAD)and normal cornerstone genes were gathered through The Cancer Genome Atlas(TCGA)-COAD corroborating with the Molecular Signature Database v7.2(MSigDB).Initially,crucial prognostic genes were selected by uni-and multi-variate Cox proportional regression analyses;then,depending upon these identified signature genes and clinical variables,a nomogram was generated.Lastly,to assess tumor immune characteristics,concomitant evaluation of tumor immune evasion/risk scoring were elucidated.Results:A 8-gene signature,including ACBD4,ACOX1,CD36,CPT2,ELOVL3,ELOVL6,ENO3,and SUCLG2,was generated,and depending upon this,CRC patients were categorized within high-risk(H-R)and low-risk(L-R)cohorts.Furthermore,risk and age-based nomograms indicated moderate discrimination and good calibration.The data confirmed that the 8-gene model efficiently predicted CRC patients’prognosis.Moreover,according to the conjoint analysis of tumor immune evasion and the risk scorings,the H-R cohort had an immunosuppressive tumor microenvironment,which caused a substandard prognosis.Conclusion:This investigation established a FAMGs-based prognostic model with substantially high predictive value,providing the possibility for improved individualized treatment for CRC individuals.

关键词： Fatty acid metabolism Colorectal cancer Gene signatures Machine learning

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Mesoporous TiO_2/Carbon Beads: One-Pot Preparation and Their Application in Visible-Light-Induced Photodegradation

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Nano-Micro Letters 2015年第3期7卷 243-254页

作者： Xiaowei Li Yanqiu Jiang wenjing cheng Yudong Li Xianzhu Xu Kaifeng Lin Academy of Fundamental and Interdisciplinary Sciences Harbin Institute of Technology

Mesoporous Ti O2/Carbon beads have been prepared via a facile impregnation-carbonization approach, in which a porous anion-exchange resin and K2 Ti O(C2O4)2were used as hard carbon and titanium source, respectively.Characterization results reveal that the self-assembled composites have disordered mesostructure, uniform mesopores,large pore volumes, and high surface areas. The mesopore walls are composed of amorphous carbon, well-dispersed and confined anatase or rutile nanoparticles. Some anatase phase of Ti O2 was transformed to rutile phase via an increase of carbonization temperature or repeated impregnation of the resin with Ti O(C2O4)22-species. X-ray photoelectron spectroscopy, carbon, hydrogen, and nitrogen element analysis, and thermal gravity analysis results indicate the doping of carbon into the Ti O2 lattice and strong interaction between carbon and Ti O2 nanoparticles. A synergy effect by carbon and Ti O2 in the composites has been discussed herein on the degradation of methyl orange under visible light. The dye removal process involves adsorption of the dye from water by the mesopores in the composites, followed by photodegradation on the separated dye-loaded catalysts. Mesopores allow full access of the dye molecules to the surface of Ti O2 nanoparticles.Importantly, the bead format of such composite enables their straightforward separation from the reaction mixture in their application as a liquid-phase heterogeneous photodegradation catalyst.

关键词： Ti O2nanoparticles Mesoporous carbon Composite bead Visible light Easy separation

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Paraventricular Nucleus P2X7 Receptors Aggravate Acute Myocardial Infarction Injury via ROS-Induced Vasopressin-V1b Activation in Rats

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Neuroscience Bulletin 2021年第5期37卷 641-656页

作者： wenjing cheng Yinggang Sun Qin Wu Kokwin Ooi Yi Feng Chunmei Xia Danian Zhu Department of Physiology and Pathophysiology School of Basic Medical SciencesFudan UniversityShanghai 200032China Department of Cardiovascular Diseases Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghai 200092China Department of Medical Technology Jiangsu Vocational College of MedicineYancheng 224005China Department of Integrative Medicine and Neurobiology School of Basic Medical SciencesFudan UniversityShanghai 200032China

The present study was designed to investigate the mechanisms by which P2X7 receptors(P2X7Rs)mediate the activation of vasopressinergic neurons thereby increasing sympathetic hyperactivity in the paraventricular nucleus(PVN) of the hypothalamus of rats with acute myocardial ischemia(AMI). The left anterior descending branch of the coronary artery was ligated to induce AMI in rats. The rats were pretreated with BBG(brilliant blue G, a P2X7R antagonist), nelivaptan(a vasopressin V1b receptor antagonist), or diphenyleneiodonium(DPI) [an nicotinamide adenine dinucleotide phosphate(NADPH)oxidase inhibitor]. Hemodynamic parameters of the heart were monitored. Myocardial injury and cardiomyocyte apoptosis were assessed. In the PVN of AMI rats, P2X7R mediated microglial activation, while reactive oxygen species(ROS) and NADPH oxidase 2(NOX2) were higher than in the sham group. Intraperitoneal injection of BBG effectively reduced ROS production and vasopressin expression in the PVN of AMI rats. Moreover, both BBG and DPI pretreatment effectively reduced sympathetic hyperactivity and ameliorated AMI injury, as represented by reduced inflammation and apoptosis of cardiomyocytes.Furthermore, microinjection of nelivaptan into the PVN improved cardiac function and reduced the norepinephrine(AE) levels in AMI rats. Collectively, the results suggest that, within the PVN of AMI rats, P2X7R upregulation mediates microglial activation and the overproduction of ROS, which in turn activates vasopressinergic neuron V1b receptors and sympathetic hyperactivity, hence aggravating myocardial injury in the AMI setting.

关键词： PVN P2X7 receptor Vasopressin Reactive oxygen species c-fos Myocardial ischemia

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Valence state manipulation of Sm3＋ ions via a phase-shaped femtosecond laser field

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Photonics Research 2018年第2期6卷 144-148页

作者： YE ZHENG YUNHUA YAO LIANZHONG DENG wenjing cheng JIANPING LI TIANQING JIA JIANRONG QIU ZHENRONG SUN SHIAN ZHANG State Key Laboratory of Precision Spectroscopy East China Normal University Shanghai 200062 China School of Electronic & Electrical Engineering Shangqiu Normal University Shangqiu 476000 China State Key Laboratory of Silicon Materials Zhejiang University Hangzhou 310027 China Collaborative Innovation Center of Extreme Optics Shanxi University Taiyuan 030006 China

The ability to manipulate the valence state conversion of rare-earth ions is crucial for their applications in color displays, optoelectronic devices, laser sources, and optical memory. The conventional femtosecond laser pulse has been shown to be a well-established tool for realizing the valence state conversion of rare-earth ions, although the valence state conversion efficiency is relatively low. Here, we first propose a femtosecond laser pulse shaping technique for improving the valence state conversion efficiency of rare-earth ions. Our experimental results demonstrate that the photoreduction efficiency from Sm^(3+) to Sm^(2+) in Sm^(3+)-doped sodium aluminoborate glass using a π phase step modulation can be comparable to that using a transform-limited femtosecond laser field, while the peak laser intensity is decreased by about 63%, which is very beneficial for improving the valence state conversion efficiency under the laser-induced damage threshold of the glass sample. Furthermore, we also theoretically develop a(2 + 1)resonance-mediated three-photon absorption model to explain the modulation of the photoreduction efficiency from Sm^(3+)to Sm^(2+)under the π-shaped femtosecond laser field.

关键词：稀土离子通讯技术发展现状激光脉冲

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Agricultural Vulnerability to Drought in China's Agro-pastoral Ecotone:A Case Study of Yulin City,Shaanxi Province

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中国地理科学:英文版 2023年第5期33卷 934-945页

作者： LI Yuheng cheng wenjing ZUO Wenjie ZHANG Lingyue Institute of Geographic Sciences and Natural Resources Research Chinese Academy of SciencesBeijing 100101China College of Resources and Environment University of the Chinese Academy of SciencesBeijing 100049China College of Public Administration and Law Northeast Agricultural UniversityHarbin 150030China College of Economics and Management Northwest A&F UniversityYangling 712100China

Agro-pastoral ecotone of northern China is the prominent area for agricultural production,but it is also the most typical ecological fragile area with frequent drought disasters.Taking Yulin City at Shaanxi Province in China as the case area,the paper aims to investigate the spatio-temporal changes of agricultural vulnerability to drought in China’s agro-pastoral ecotone in the period 2000 to2020.The results show that:1)the agricultural vulnerability to drought in Yulin City has shifted from high vulnerability in the period2000–2010 to low vulnerability in the period 2011–2020.2)There exist obvious spatio-temporal differences of the agricultural vulnerability to drought in Yulin City during the research period.3)Four sensitive events and 14 resilient events were identified in the research and the crops of Yulin had become more resilient to drought.Finally,the paper put forward with policy implications to make adaptive strategies of agriculture to climate change in China’s agro-pastoral ecotone in the future,e.g.,carrying out agricultural zoning based on agricultural production conditions,intensifying the construction of disaster prevention and relief system,and integrating with modern agricultural technology to develop new type agriculture.

关键词： climate change agricultural vulnerability drought agro-pastoral ecotone Yulin City,China

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化妆品使用植物功效成分抑制痤疮的研究及相关专利分析

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中华中医药杂志 2024年第1期39卷 336-341页

作者：李璐瑶程文静狄飞倩张佳婵王昌涛安全石秀芹北京工商大学北京植物资源研究开发重点实验室北京100048 云南白药股份有限公司昆明650000

痤疮是一种慢性炎症性皮肤表现,其影响因素复杂多样。《已使用化妆品原料目录(2021年版)》规定了祛痘植物原料在化妆品领域的可使用范围。基于此,笔者从痤疮发生机制入手,详细阐述痤疮相关生物学变化;在调研文献资料的基础上,对未收录... 详细信息

痤疮是一种慢性炎症性皮肤表现,其影响因素复杂多样。《已使用化妆品原料目录(2021年版)》规定了祛痘植物原料在化妆品领域的可使用范围。基于此,笔者从痤疮发生机制入手,详细阐述痤疮相关生物学变化;在调研文献资料的基础上,对未收录其中的10种祛痘功效植物成分的作用机制进行了更新和综述;最后,对2002年至2022年已授权祛痘相关专利进行分析,探索祛痘产品的研究现状和发展趋势,为祛痘类产品的研发提供新思路。

关键词：痤疮痤疮发生机制植物活性成分化妆品 SOOPAT专利分析

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安罗替尼联合培美曲塞对晚期非鳞非小细胞肺癌JAK/STAT3信号传导通路的影响

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实用癌症杂志 2024年第6期39卷 981-983,987页

作者：郑庆凯程文静郑红陈苗赵晓光河南省焦作市人民医院 454000

目的研究安罗替尼联合培美曲塞对晚期非鳞非小细胞肺癌JAK/STAT3信号传导通路的影响。方法选取82例晚期非鳞非小细胞肺癌患者为此次试验对象,随机分成2组。对照组(41例)术后接受培美曲塞治疗,实验组(41例)在此基础上联合安罗替尼治疗。... 详细信息

目的研究安罗替尼联合培美曲塞对晚期非鳞非小细胞肺癌JAK/STAT3信号传导通路的影响。方法选取82例晚期非鳞非小细胞肺癌患者为此次试验对象,随机分成2组。对照组(41例)术后接受培美曲塞治疗,实验组(41例)在此基础上联合安罗替尼治疗。对比两组患者治疗前后Janus激酶(JAK)、转录激活因子3(STAT3)表达情况;对比两组患者临床疗效和化疗不良反应。结果治疗后两组患者JAK、STAT3表达均明显降低,且相比于对照组,实验组显著更低(P0.05)。结论对于晚期非鳞非小细胞肺癌患者,在培美曲塞基础上联合安罗替尼治疗,可有效抑制JAK/STAT3信号传导通路活性,临床疗效较高,并且不会增加不良反应的发生。

关键词：安罗替尼培美曲塞肺癌 JAK STAT3

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伊马替尼靶向治疗后胃肠间质瘤伴横纹肌肉瘤分化1例及文献复习

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临床与病理杂志 2024年第3期44卷 488-493页

作者：袁亦姝冯智超谭娟程文静刘杨中南大学湘雅三医院病理科长沙410013 中南大学湘雅三医院放射科长沙410013

胃肠间质瘤(gastrointestinal stromal tumor,GIST)是消化道最常见的间叶源性肿瘤。随着伊马替尼的应用,晚期GIST的疗效得到了显著改善。尽管多数患者接受伊马替尼治疗后获益,但仍有部分患者会发生继发性耐药。本例GIST患者接受伊马替... 详细信息

胃肠间质瘤(gastrointestinal stromal tumor,GIST)是消化道最常见的间叶源性肿瘤。随着伊马替尼的应用,晚期GIST的疗效得到了显著改善。尽管多数患者接受伊马替尼治疗后获益,但仍有部分患者会发生继发性耐药。本例GIST患者接受伊马替尼治疗15个月后出现了耐药及肿瘤进展,镜下示部分肿瘤细胞出现明显的多形性,免疫组织化学染色示伴横纹肌细胞分化。在进展的病灶中未发现c-Kit、PDGFRA基因的继发突变。由于GIST横纹肌肉瘤去分化罕见,本病例的报道将有助于伊马替尼治疗后GIST的诊断,避免误诊及漏诊。

关键词：胃肠间质瘤伊马替尼横纹肌肉瘤分化

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Advances in pharmacological effects of tanshinone ⅡA on pain

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中国药理学与毒理学杂志 2023年第7期37卷 524-525页

作者： cheng wenjing CHEN Xi ZHANG Danshen JING Yongshuai College of Chemistry and Pharmaceutical Engineering Hebei University of Science and Technology

Pain is one of the most serious problems plaguing human health today. Drug therapy is one of the main ways to treat pain in clinic. The analgesic drugs commonly used in clinical treatment of pain are often accompanied by many side effects, the analgesic effect is still not ideal. Salvia miltiorrhiza is a traditional medicinal material with the same origin as food and medicine. It has the functions of promoting blood circulation and removing blood stasis, relieving pain through menstrual circulation, and contains many effective ingredients such as tanshinone and salvianolic acid. Tanshinone is a kind of rosin diterpenoid compound, which mainly consists of o-quinone type and p-quinone type parent nucleus, and tanshinone Ⅱ A is the representative compound. The pharmacological mechanism of tanshinone Ⅱ A in labor pain mainly includes:(1) Regulate inflammatory factors.Inflammatory cytokines played an important role in the occurrence and progression of pain. It was found that the analgesic effect of tanshinone ⅡA was related to the antiinflammatory effect. Tanshinone Ⅱ A showed anti-injurious activity in various pain models, such as bone cancer pain and sciatic nerve ligation, and related studies found that tanshinone Ⅱ A could inhibit the expression of inflammatory factors TNF-α, IL-1β and IL-6 in the spinal cord of model rats. In the spinal nerve ligation model,tanshinone ⅡA also promoted the release of anti-inflammatory cytokine IL-10 in the spinal cord of rats.(2) Regulate signal pathways related to regulating spinal cord oxidation and apoptosis. Apoptosis and oxidation played an important role in the process of pain. When nerve injury was caused by stimulation, oxidative stress and apoptosis of nerve cells were involved in the mechanism of hyperalgesia. Tanshinone Ⅱ A sodium sulfonate could relieve pain by regulating apoptosis-related pathways. In neuralgia model, tanshinone ⅡA could reduce the apoptosis of spinal cord neurons by inhibiting oxidative stress response in rat spinal cord tissue. In addition,tanshinon

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Weighted Wavelet Estimate in Semiparametric Models with Heteroscedastic Errors

Weighted Wavelet Estimate in Semiparametric Models with Hete...

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2012年计算机应用与系统建模国际会议

作者： wenjing cheng School of Mathematics and Statistics Hubei Normal University

Using wavelet smoothing method, we consider the semiparametric regression model with independent heteroscedastic errors. We investigate the asymptotic normality and weak consistence rates of wavelet estimators.

关键词： Semiparametric regression model Wavelet estimate Asymptotic normality Weak consistence rates Heteroscedastic error

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