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Impact of adverse childhood experiences on the symptom severity of different mental disorders: a cross-diagnostic study

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General Psychiatry 2022年第2期35卷 127-136页

作者： wenjie gu Qing Zhao Chengmei Yuan Zhenghui Yi Min Zhao Zhen Wang Shanghai Mental Health Center Shanghai Jiao Tong University School of MedicineShanghai China

Background Adverse childhood experiences have a significant impact on different mental *** To compare differences in adverse childhood experiences among those with different mental disorders and their relationships in a cross-disorder *** The study included 1513 individuals aged≥18 years:339 patients with substance use disorders,125 patients with schizophrenia,342 patients with depression,136 patients with bipolar disorder,431 patients with obsessive-compulsive disorder(OCD),and 140 healthy *** Early Trauma Inventory Self Report-Short Form was used to investigate childhood traumatic experiences,and the Addiction Severity Index,Positive and Negative Syndrome Scale,Hamilton Depression Scale,Young Mania Rating Scale,and Yale-Brown Obsessive-Compulsive Scale were used to assess mental disorder *** and multivariate logistic regression were analysed between adverse childhood experiences and clinical *** Levels of adverse childhood experiences were significantly different among different mental ***,25.8%of patients with substance use disorders reported childhood trauma,which was significantly higher than found in the other four psychiatric disorder *** abuse scores were positively correlated with disease severity:the higher the total trauma score,the more severe the mental *** Adverse childhood experiences are a common phenomenon in those with mental disorders,and the level of trauma affects mental disorder *** abuse is closely related to many mental *** incidence or severity of mental disorders can be reduced in the future by reducing the incidence of adverse childhood experiences or by timely intervention in childhood trauma.

关键词： severity disorders childhood

Center Establishes Online Platform to Improve Domestic Services

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Women of China 2015年第7期 76-77页

作者： LI wenjie gu WENTONG

＂In recent years, domestic services have been combined with mobile apps and e-commerce -- more precisely, the online-to-offline （020） business model -- to show new potential,＂ says Li Jiaqing, Deputy Director of guangzhou （capital of South China＇s guangdoug Province） Service Center for Women and Children. He is also director of guangzhou Domestic Services Website. http：//www.38613861 .***.

关键词：服务中心国内平台电子商务移动应用业务模式中国南方网站服务

Combination of fruquintinib with venetoclax for the treatment of colorectal cancer

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Oncology Research 2025年第1期33卷 225-234页

作者： WEI ZHANG WEICHENG WANG RUI WANG XIAO HAN LIJUN ZHU wenjie guO YANHONG gu Department of Oncology The First Affiliated Hospital of Nanjing Medical UniversityNanjing210029China State Key Laboratory of Pharmaceutical Biotechnology School of Life SciencesNanjing UniversityNanjing210023China Department of Oncology The Affiliated Taizhou People’s Hospital of Nanjing Medical UniversityTaizhou225300China

Background:As a novel blocker of vascular endothelial growth factor receptor(VEGFR),fruquintinib has been approved for treating colorectal cancer(CRC).However,its dosage and therapeutic efficacy are limited by its widespread adverse ***,recognized as the initial inhibitor of B-cell lymphoma protein 2(BCL2),has shown potential in boosting the effectiveness of immunotherapy against *** study investigated the efficacy and mechanisms of fruquintinib combined with venetoclax in treating *** and Materials:We developed a colon cancer mouse model with the CT26 colon cell line to demonstrate fruquintinib and venetoclax’s efficacy against *** we employed various techniques to evaluate different aspects of the experimental *** was used to detect cell proliferation and angiogenesis in tumor *** blot analysis was utilized to examine the occurrence of cell apoptosis,and flow cytometry to quantitate immune cells within the tumor ***,immunofluorescence was employed to measure cytokine ***:The strongest inhibition on tumor growth was achieved by the combination of fruquintinib with venetoclax,as opposed to individual drug *** was found to amplify the impact of fruquintinib,leading to decreased cancer cell proliferation,increased cancer cell apoptosis,lowered angiogenesis,better vascular structure normalization,and improved immune cell ***:Our findings indicate that the addition of venetoclax enhances the impact of fruquintinib on vascular normalization and modulation of the tumor immune *** study presents the justification for utilizing the fruquintinib and venetoclax combination in treating *** holds promise in being assimilated into anticancer medications for CRC.

关键词： Colorectal cancer(CRC) B-cell lymphoma protein 2(BCL2) Venetoclax Vascular endothelial growth factor receptor(VEGFR) Fruquintinib Anti-angiogenesis Immunotherapy

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掘进机双向耦合建模截割参数优化研究

煤炭工程 2023年第8期55卷 170-175页

作者：顾文杰晋能控股煤业集团马道头煤业有限责任公司山西大同037003

针对掘进机的截割参数优化问题,利用离散元法-多体动力学(DEM-MBD)双向耦合技术,基于数值模拟、多目标优化方法,以某型号掘进机截割机构为工程对象,联合Pro/E、EDEM和RecurDyn建立掘进机截割过程的DEM-MBD双向耦合仿真模型,探究不同工... 详细信息

针对掘进机的截割参数优化问题,利用离散元法-多体动力学(DEM-MBD)双向耦合技术,基于数值模拟、多目标优化方法,以某型号掘进机截割机构为工程对象,联合Pro/E、EDEM和RecurDyn建立掘进机截割过程的DEM-MBD双向耦合仿真模型,探究不同工况对截割头受载情况及截割性能的影响,利用Design Expert中的Box-Bohnken试验法设计三因素三水平响应面回归试验,以截割比能耗、载荷均值、载荷波动系数为截割性能评价指标,通过主成分法将三维目标降维至截割综合评价度一维寻优模型,结果表明:当横摆速度为1.270 m/min、转速范围为44.158 r/min、垂直摆角为12.232°,此时截割综合评价度达0.903。

关键词：掘进机双向耦合数值模拟响应面法

Early Diagnosis of Bipolar Disorder Coming Soon:Application of an Oxidative Stress Injury Biomarker(BIOS)Model

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Neuroscience Bulletin 2022年第9期38卷 979-991页

作者： Zhiang Niu Xiaohui Wu Yuncheng Zhu Lu Yang Yifan Shi Yun Wang Hong Qiu wenjie gu Yina Wu Xiangyun Long Zheng Lu Shaohua Hu Zhijian Yao Haichen Yang Tiebang Liu Yong Xia Zhiyu Chen Jun Chen Yiru Fang Clinical Research Center and Division of Mood Disorders Shanghai Mental Health CenterShanghai Jiao Tong University School of MedicineShanghai200030China Division of Mood Disorders Shanghai Hongkou Mental Health CenterShanghai200083China Information and Statistics Department Shanghai Mental Health CenterShanghai200030China Department of Psychiatry Tongji HospitalTongji University School of MedicineShanghai200333China Department of Psychiatry First Affiliated HospitalZhejiang University School of MedicineHangzhou310003China Nanjing Brain Hospital The Affiliated Brain Hospital of Nanjing Medical UniversityNanjing210029China Shenzhen Mental Health Center Shenzhen518003China Affiliated Mental Health Center Zhejiang University School of MedicineHangzhou Seventh People’s HospitalHangzhou310013China CAS Center for Excellence in Brain Science and Intelligence Technology Shanghai200031China Shanghai Key Laboratory of Psychotic Disorders Shanghai201108China

Early distinction of bipolar disorder(BD)from major depressive disorder(MDD)is difficult since no tools are available to estimate the risk of *** this study,we aimed to develop and validate a model of oxidative stress injury for predicting *** were collected from 1252 BD and 1359 MDD patients,including 64 MDD patients identified as converting to BD from 2009 through 2018.30 variables from a randomly-selected subsample of 1827(70%)patients were used to develop the model,including age,sex,oxidative stress markers(uric acid,bilirubin,albumin,and prealbumin),sex hormones,cytokines,thyroid and liver function,and glycolipid *** analyses and the Least Absolute Shrinkage and Selection Operator were applied for data dimension reduction and variable *** logistic regression was used to construct a model for predicting bipolar disorder by oxidative stress biomarkers(BIOS)on a *** validation was assessed in the remaining 784 patients(30%),and independent external validation was done with data from 3797 matched patients from five other hospitals in China.10 predictors,mainly oxidative stress markers,were shown on the *** BIOS model showed good discrimination in the training sample,with an AUC of 75.1%(95%CI:72.9%–77.3%),sensitivity of 0.66,and specificity of *** discrimination was good both in internal validation(AUC 72.1%,68.6%–75.6%)and external validation(AUC 65.7%,63.9%–67.5%).In this study,we developed a nomogram centered on oxidative stress injury,which could help in the individualized prediction of *** better real-world practice,a set of measurements,especially on oxidative stress markers,should be emphasized using big data in psychiatry.

关键词： Early recognition Bipolar disorder Big data Oxidative stress BIOS model

Effects of Green Forage on Production Performance and Egg Quality of Suyou No.1 Laying Duck

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Animal Husbandry and Feed Science 2014年第6期6卷 328-330,341页

作者： Yuan Xuhong Zhang Shengfu Zhang Ling Liu Chenglin Zhou Yujun gu wenjie Jiangsu Agri-animal Husbandry Vocational College Jiangsu Gaoyou Duck Group

[ Objective ] The paper was to study the effects of green forage on production performance and egg quality of laying ducks. [ Method] According to one- factor randomized complete experimental design, 200 healthy Suyou No. 1 laying ducks aged 200 days were randomly divided into five groups, four repeats each group, and each repeat contained 10 laying ducks. Parts of formulated feed in groups I - IV were replaced with different types and quantities of green forage, and group V was set as control. The trim lasted for 42 d. [ Result] Replacing parts of formulated feed with green forage could improve the production performance of laying ducks （P 〉 0.05 ）, and the economic benefits also increased. For egg quality, Haugh unit was improved （ P 〉 0.05 ） ; yolk color increased significantly ; compared to control group, yolk color was significantly increased in groups with 100 g chicory and 70 g clover （P 〈0.05 ）, and was extremely increased in the group with 100 g clover （P 〈0.01 ）. [ Conclusion] The group with 100 g chicory had the best effect on production performance of laying ducks, and the group with 100 g clover had the best coloring effect on yolk.

关键词： Clover Chicory Suyou No. 1 laying duck Production performance Egg quality

强迫症患者的神经质人格和不成熟防御机制在童年创伤与强迫症状中的中介作用

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上海交通大学学报（医学版） 2022年第9期42卷 1315-1322页

作者：赵青顾文洁王振上海交通大学医学院附属精神卫生中心临床心理科上海200030

目的·探讨强迫症患者童年创伤、人格特质及心理防御机制特点,以及人格特质、防御方式在童年创伤与强迫症状之间的中介作用。方法·纳入113例符合美国《精神障碍诊断与统计手册》(第五版)(Diagnostic and Statistical Manual of Mental ... 详细信息

目的·探讨强迫症患者童年创伤、人格特质及心理防御机制特点,以及人格特质、防御方式在童年创伤与强迫症状之间的中介作用。方法·纳入113例符合美国《精神障碍诊断与统计手册》(第五版)(Diagnostic and Statistical Manual of Mental Disorders-5,DSM-5)诊断标准的强迫症患者(强迫症组),以及66例年龄、性别、受教育程度相匹配的健康志愿者(对照组)。使用Yale-Brown强迫症状量表(Yale-Brown Obsessive-Compulsive Scale,Y-BOCS)评估强迫症患者的症状严重程度;使用童年创伤问卷(Childhood Trauma Questionnaire,CTQ)评估患者16岁前的创伤经历;使用大五人格量表(NEO Five-Factor Inventory,NEO-FFI)测量其人格特质;使用防御方式问卷(Defense Style Questionnaire, DSQ)评估患者的防御方式类型,分析患者的童年创伤、强迫症状、人格与防御机制之间的相关性,及人格与防御机制在童年创伤与强迫症状间的中介作用。结果·强迫症组患者情感虐待[8(5,25)分vs 6(5,22)分]、不成熟防御机制[(4.65±1.01)分vs(3.60±0.99)分]评分高于对照组(均P<0.05)。强迫症患者Y-BOCS总分与CTQ中情感虐待分量表评分(r=0.211,P<0.05)、不成熟防御机制(r=0.274, P<0.05)呈正相关;NEO-FFI中神经质与不成熟防御机制呈正相关(r=0.468, P<0.05)。中介模型显示不成熟防御机制在情感虐待与强迫症状间起完全中介作用,中介作用大小为0.088 (95%CI 0.003~0.173,P<0.05);神经质在情感虐待和不成熟防御机制间起部分中介作用,中介作用大小为0.117 (95%CI 0.014~0.219,P<0.05)。结论·相比于健康人群,强迫症患者经历了更多童年期情感及躯体创伤,具有异常的神经质、外向性及尽责性的人格特质,倾向于使用不成熟防御机制。情感虐待通过神经质人格影响了不成熟防御机制,进而对强迫症状产生了影响。

关键词：强迫症童年创伤防御方式人格特征中介作用

Appropriate Metabolic Energy, Crude Protein, Calciumand Available Phosphorus Levels of Diet for BlackMuscovy Duck at 43-91 Days of Age

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Animal Husbandry and Feed Science 2018年第4期10卷 257-263页

作者： Zhang Ling gu wenjie Zhang Kai Duan Xiujun Qin Haorong Bian Youqing duan yongbo College of Animal Science Jiangsu Agri-animal Husbandry Vocational College Taizhou 225300 China Haimen Zhengyu Animal Husbandryand Veterinary Station Nantong 226100 China National Waterfowl Gene Bank Taizhou 225300 China 不详

[Objective] The paper was to study the effects of diet formulation with different nutrition levels on growth and slaughter performance ofblack muscovy duck at the age of 43-91 days. [Method] Totally 288 individuals of 43dayold black muscovy duck were randomly divided intonine treatments, four repeats each treatment and eight ducks each repeat. UsingL9 （34） orthogonal experiment design （four factors and three levels）,three metabolic energy levels （12.32, 12.72, 13.12 MJ/kg）, three crude protein levels （14%, 16%, 18%）, three calcium levels （0.6%, 0.8%, 1.0%）and three available phosphorus levels （0.30%, 0.45%, 0.6%） were designed, and a total of nine feeding groups （C1C9） were designed according todifferent nutritional levels. Through combination of feeding test （49 d） and metabolic test （pretest 4 d and formal test 3 d）, the growth performance,meat performance and apparent nutrient digestibility of ducks were determined. [Result] The ducks in experimental group C2 had the highest average daily gain, the lowest feed gain ratio, the largest body oblique length, chest width, chest depth and tibia length, which had significant or extremely significant differences with other groups （P〈0.05 or P〈0.01）. The slaughter rate, semieviscerated rate, eviscerated rate and meat quality ofducks in C2 group were higher （P〈0.05）. The apparent digestibility of crude protein and dietary metabolic energy in C2 group were 88.68% and63.07%, respectively, both were significantly or extremely significantly higher than the other groups（P〈0.05 or P〈0.01）, while the interaction effectof calcium and phosphorus level on apparent digestibility was not obvious. [Conclusion] Under the experimental conditions, the suitable metabolicenergy, crude protein, calcium, available phosphorus and total phosphorus levels of 43 -91 days old black muscovy ducks were 12.32 MJ/kg,16.10%, 0.92%, 0.45% and 0.68%, respectively.

关键词： Black muscovy duck Nutrition level Growth performance Meat performance Apparent digestibility

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一种非侵入式低功耗高精度的用电器识别算法

西安电子科技大学学报 2023年第1期50卷 149-157页

作者：吴拨云顾文杰何先灯西安电子科技大学通信工程学院陕西西安710071 西安电子科技大学电子工程学院陕西西安710071

非侵入式用电器识别是实现泛在电力物联网客户侧智能感知的关键技术。针对现有非侵入式用电器识别系统计算复杂度过高,不利于产业化的问题,提出了一种基于长短期记忆网络的低成本、低功耗、高精度且可应用于嵌入式微控制器的非侵入式用... 详细信息

非侵入式用电器识别是实现泛在电力物联网客户侧智能感知的关键技术。针对现有非侵入式用电器识别系统计算复杂度过高,不利于产业化的问题,提出了一种基于长短期记忆网络的低成本、低功耗、高精度且可应用于嵌入式微控制器的非侵入式用电器识别算法和系统。首先,对总线上的电流进行同步采集;其次,利用所提出的多参数的检测方法判断出用电器的投切事件;再次,利用长短期记忆网络,对投切时间点前后变化的数据进行识别,得到投切事件的用电器种类;最后,结合累积和判断出当前的用电器的种类和数量。仿真和实测结果表明,只需要针对单个用电器进行少量数据的训练,即可在嵌入式微控制器系统中对组合用电器实现高达99.6%的平均识别准确度,且系统功耗小于1.5 W。这种算法可进一步应用于统计各个用电器的投切时间点、使用时长和功耗总和等工作情况,为智能电网提供精细化的用户用电信息,并为电网能源管理和优化提供重要参考。

关键词：物联网长短期记忆网络识别电参数测量