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Pollination Biology of the Endangered Herbal Medicines Dendrobium chrysotoxum(Orchidaceae)

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Phyton-International Journal of Experimental Botany 2023年第7期92卷 1975-1986页

作者： Kai Luo yanbing Bai yan Jiang Guiling Li Min Jia Yongguo He Zhijun Yao Ziwei Xiao Xiaoqiong Liu wenjie Liu Shanshan Yin Zesheng Li Medicinal Plant Research Center Dehong Tropical Agriculture Research Institute of YunnanRuili678600China Human Resources Management Office The People’s Hospital of XiangyunXiangyun672100China

Pollination biology studies of the endangered herbal medicines Dendrobium chrysotoxum were conducted in natural pollination conditions using flower observation,pollinator observation and artificial pollination *** of *** with fragrance and nectar were pollinated by Ctenoplectra davidi Valhalla(Hymenoptera:Apidae)*** floral structure of *** adapted precisely to its *** had a low capsule setting(0.17%)under natural ***,compared to open pollination,artificial pollination experiments showed a significant increase in capsule setting,and *** was cross-compatible and self-compatible,but there was pollinator limitation *** study will provide important information for the preservation of this endangered species.

关键词： Breeding system Dendrobium chrysotoxum pollination pollination biology

ON POTENT ELEMENTS AND PSEUDO CLEAN RINGS

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数学杂志 2025年第1期45卷 39-47页

作者： DING yan GAO Han-peng LIU Xin-yi yan Zi-yi ZHANG Ting School of Mathematical Sciences Anhui UniversityHefei 230601China

In this paper,potent index of an element and pseudo clean rings are *** properties and examples of pseudo clean rings are *** also show that Zm is pseudo clean for every 2≤m∈Z and pseudo clean rings are ***,we prove... 详细信息

关键词： clean rings strongly J-clean rings pseudo clean rings potent elements

Short-term efficacy of early percutaneous cholecystostomy for pancreatitis and factors associated with recurrence and mortality

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World Journal of Gastroenterology 2025年第6期31卷 20-33页

作者： Xin yan Feng Xie Xiao-Dan Zhao Liang Li Jia-Xian Meng Department of Nuclear Medicine The People’s Hospital of Liaoning ProvinceShenyang 110016Liaoning ProvinceChina Department of Interventional Medicine Jin Qiu Hospital of Liaoning ProvinceShenyang 110016Liaoning ProvinceChina Department of General Surgery The People’s Hospital of Liaoning ProvinceShenyang 110016Liaoning ProvinceChina Department of Science and Education The People’s Hospital of Liaoning ProvinceShenyang 110016Liaoning ProvinceChina

BACKGROUND Percutaneous cholecystostomy(PC)can be used as a bridging therapy for moderately severe acute biliary pancreatitis(MSABP).Currently,there are only a limited number of reports of MSABP using *** To assess the short-term outcomes of early PC in MSABP and factors associated with recurrence and death in *** Patients who received conservative treatment or PC for acute biliary pancreatitis(ABP)in Liaoning Provincial People’s Hospital from January 2017 to July 2022 were collected.A total of 54 patients with MSABP who received early-stage PC and 29 patients who received conservative *** short-term efficacy of PC was *** on whether there is a recurrence,compare the characteristics of the pre-PC and explore the factors of ***-PC features were compared and predictors were discussed,depending on the *** After 3 days of PC treatment,patients experienced a reduction in inflammatory markers compared to the conservative *** PC,patients were divided into non-recurrence(n=37)and recurrence(n=10)groups,and the results showed that age was an independent correlation affecting ABP recurrence[odds ratio(OR)=0.937,95%confidence interval(CI):0.878-0.999;P=0.0470.7).When the Youden index maximum was 0.565,the cut-off value was 5.5,the sensitivity was 71.4%,and the specificity was 85.1%.CONCLUSION PC is an important method in the early years(<72 hours)of *** is a protective factor against recurrence of *** pre-PC CCI is significantly associated with mortality.

关键词： Acute biliary pancreatitis Percutaneous cholecystostomy The revised Atlanta classification Charleson Comorbidity Index Yoden index

Rising above:exploring the therapeutic potential of natural product-based compounds in human cancer treatment

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Traditional Medicine Research 2025年第3期10卷 56-74页

作者： Li-yan yang Shi-Zeng Lei Wen-Jing Xu Yu-Xin Lai Ying-Ying Zhang Ying Wang Zhong-Lei Wang School of Physics and Physical Engineering Qufu Normal UniversityQufu 273165China Beijing National Laboratory for Molecular Sciences Institute of ChemistryChinese Academy of SciencesBeijing 100190China Key Laboratory of Green Natural Products and Pharmaceutical Intermediates in Colleges and Universities of Shandong Province School of Chemistry and Chemical EngineeringQufu Normal UniversityQufu 273165China School of Pharmaceutical Sciences Key Laboratory of Bioorganic PhosphorusChemistry and Chemical Biology(Ministry of Education)Tsinghua UniversityBeijing 100084China

Tumors,due to their diversity and heterogeneity,pose a significant threat to human *** resistance is a prevalent and grave issue in clinical treatment,resulting in treatment failure and cancer *** resistance renders conventional drug therapies ineffective,presenting a substantial challenge to human health and medical *** natural products as potential sources for anti-cancer drugs could lead to the development of innovative and efficacious cancer *** article aims to investigate the health implications of natural products(such as paclitaxel,podophyllotoxin,homoharringtonine,camptothecin,and vinblastine)in the discovery of anti-cancer drugs while discussing the methods and progress made in researching novel anti-cancer drugs derived from natural *** paper discusses the diversity,intricate structures,and target affinity of natural products along with their structural modification techniques,combination therapies utilization possibilities with prodrugs or ***,considering the escalating multidrug resistance observed in tumors nowadays;certain natural products offer new insights and approaches for discovering effective anti-tumor drugs that are crucial for addressing global public health *** challenges faced by natural products during drug development including issues related to bioavailability toxicity concerns as well as limited resources are examined *** opportunities current issues along with future challenges are highlighted aiming at facilitating the clinical translation of original anti-cancer drugs using natural products.

关键词： tumors multidrug resistance natural products camptothecin future challenges

Prognostic value of inflammatory markers in predicting recurrencefree survival in gastrointestinal stromal tumor patients:A nomogram-based approach

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World Journal of Gastrointestinal Oncology 2025年第2期17卷 45-55页

作者： Jin-Long Zhao Mao-Ying Wang yan-Zhi Lv Ye-Jiang Zhou Department of General Surgery(Gastrointestinal Surgery) The Affiliated Hospital of Southwest Medical UniversityLuzhou 646000Sichuan ProvinceChina Department of Anesthesiology People’s Hospital of Qingbaijiang DistrictChengdu 610300Sichuan ProvinceChina

BACKGROUND There are currently no relevant studies at home or abroad that combine inflammatory indicators and nomograms to predict the prognosis of gastrointestinal stromal tumor(GIST)patients after *** purpose of this study was to investigate the predictive value of related inflammatory indicators[systemic immune-inflammation index(SII),neutrophil/lymphocyte ratio(NLR),platelet/lymphocyte ratio(PLR)and monocyte/Lymphocyte ratio(MLR)]in patients undergoing GIST surgery,incorporating relevant risk factors to establish a nomogram prediction model,with the aim of better predicting the prognosis of GIST *** To explore the relationships between the SII,NLR,PLR,and MLR and postoperative recurrence in patients with *** This study retrospectively included patients who underwent GIST surgery from January 2014 to January 2017 and analyzed the potential relationships between the preoperative SII,NLR,PLR,and MLR and clinicopathological *** independent risk factors influencing the prognosis of GIST patients were obtained via multivariate regression analysis,and a nomogram model based on the independent risk factors was *** Among the 124 GIST patients included in the present study,31(25%)experienced recurrence within 5 ***-Meier survival analysis revealed a correlation between the MLR and PLR and tumor size(P=0.016 and P=0.002,respectively).The preoperative SII,MLR,NLR,and PLR were significantly associated with recurrence-free survival(RFS)(P<0.05).The multivariate analysis results identified the PLR,MLR,and targeted therapy as independent prognostic factors for patient *** Preoperative MLR and PLR,which are independent risk factors for GIST recurrence,were correlated with *** based on the PLR,MLR and targeted therapy can be used for clinical treatment.

关键词： Gastrointestinal stromal tumor Inflammatory index Prognosis Nomogram Systemic immune-inflammation index

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向日葵抗列当机制和防控技术研究进展

中国油料作物学报 2025年第1期47卷 20-36页

作者：闫宁宁张键赵君内蒙古农业大学内蒙古呼和浩特010010

向日葵是重要的油料作物,在我国的种植面积和产量仅次于大豆、花生和油菜。列当的寄生导致向日葵植株矮小、籽粒灌浆不足,影响向日葵的产量和品质。列当于1866年在俄国的向日葵田被首次报导,随后因各国间的向日葵引种被广泛传播,给世界... 详细信息

向日葵是重要的油料作物,在我国的种植面积和产量仅次于大豆、花生和油菜。列当的寄生导致向日葵植株矮小、籽粒灌浆不足,影响向日葵的产量和品质。列当于1866年在俄国的向日葵田被首次报导,随后因各国间的向日葵引种被广泛传播,给世界向日葵生产带来巨大危害。在罗马尼亚的调查发现,列当已经从A小种进化到了I小种甚至更高级别。列当毒力不断进化的原因主要有二,一是列当庞大的种子库提供了丰富的突变材料,二是各种群间或种群与野生种间的基因流动使基因组不断重组,提高了种群的遗传多样性,两者都加速了列当的毒力进化过程。向日葵对列当的抗性多数属于垂直抗性,由单个显性基因控制,抗性基因和列当中的无毒基因一一对应,符合基因对基因学说,可以运用于抗性育种,缺点是抗性容易被毒力更强的列当小种克服,因此需要聚合多个显性基因或数量抗性基因。抗性基因的挖掘方面,从农家种、栽培种和野生种中目前已经定位的基因包括Or1~Or7、OrDEB2和OrSII等。随着DNA分子标记的发展和向日葵基因组的发布,抗性基因的定位也更加精细,如OrDEB2基因定位在4号染色体上半段一个0.9 cM区间内,对应于基因组一个1.38 Mb的区间,共获得了9个候选基因可以直接应用于向日葵对列当抗性反应的研究。向日葵的列当抗性可分为3个阶段:芽管附着前、吸器初始化和吸器建立后,每个阶段都进化出了相应的物理和化学屏障阻止列当的寄生,因此利用向日葵的抗性机制培育不同的抗性品种成为防控列当最经济有效的手段之一。其它防控措施还包括列当发生早期的预测预报、农艺措施、化学防治和生物防治等,综合利用这些措施可以达到最佳防效。本文综述了列当种子萌发机理、列当的寄生过程、生理小种的国内外分布、向日葵抗列当机制以及新的列当防控技术,认为对于列当防控技术的研究,需要植物病理学、农药学、育种学等多学科配合;在阐述清楚向日葵-列当互作机制的基础上,开发新的药剂和抗列当品种;将分子生物学和信息技术运用于向日葵抗列当材料筛选、抗性基因挖掘、向日葵生理生化改变等方面,缩短育种时间,加速防控技术的开发和完善。

关键词：向日葵列当向日葵抗列当机制防控技术

Single cell transcriptomic analysis identifies novel vascular smooth muscle subsets under high hydrostatic pressure

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Science China(Life Sciences) 2021年第10期64卷 1677-1690页

作者： Zhenzhen Chen Haizeng Zhang Yingnan Bai Changting Cui Shuangyue Li wenjie Wang Yue Deng Qiannan Gao Lu Wang Wei Qi Lijun Zhang yan yang Bin Geng Jun Cai Hypertension Center Department of Cardiac SurgeryFuwai HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeState Key Laboratory of Cardiovascular DiseaseNational Center for Cardiovascular DiseasesBeijing 100191China Novogene Bioinformatics Technology Co. Ltd.Beijing 100015China

Although some co-risk factors and hemodynamic alterations are involved in hypertension progression,their direct biomechanical effects are ***,we constructed a high-hydrostatic-pressure cell-culture system to imitate constant hypertension and identified novel molecular classifications of human aortic smooth muscle cells(HASMCs)by single-cell transcriptome *** 100-mmHg(analogous to healthy human blood pressure)or 200-mmHg(analogous to hypertension)hydrostatic pressure for 48 h,HASMCs showed six distinct vascular SMC(VSMC)clusters according to differential gene expression and gene ontology enrichment ***,two novel HASMC subsets were identified,named the inflammatory subset,with CXCL2,CXCL3 and CCL2 as markers,and the endothelial-function inhibitory subset,with AKR1C2,AKR1C3,SERPINF1 as *** inflammatory subset promoted CXCL2&3 and CCL2 chemokine expression and secretion,triggering monocyte migration;the endothelial-function inhibitory subset secreted SERPINF1 and accelerated prostaglandin F2αgeneration to inhibit *** expression of the two VSMC subsets was greatly increased in arterial media from patients with hypertension and experimental animal models of ***,we identified high hydrostatic pressure directly driving VSMCs into two new subsets,promoting or exacerbating endothelial dysfunction,thereby contributing to the pathogenesis of cardiovascular diseases.

关键词： single cell RNA-seq hypertension VSMCs hydrostatic pressure

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“赶考”精神融入高校思想政治教育研究

教育理论与实践 2025年第6期45卷 41-44页

作者：龙春霞荣燕中国人民警察大学马克思主义学院河北廊坊065000

“赶考”精神是中国共产党百年奋斗征程中形成的宝贵精神财富,从历史性、本体性和价值性三个方面准确立体把握“赶考”精神的精神实质,是其融入高校思想政治教育的前提和基础。进入新时代,大学生面临着理想信念之考、初心使命之考、政... 详细信息

“赶考”精神是中国共产党百年奋斗征程中形成的宝贵精神财富,从历史性、本体性和价值性三个方面准确立体把握“赶考”精神的精神实质,是其融入高校思想政治教育的前提和基础。进入新时代,大学生面临着理想信念之考、初心使命之考、政治认同之考、意志力、抗压抗挫折力和应变能力之考,“赶考”精神融入高校思想政治教育的实践进路是:提高思想政治教育主体对“赶考”精神的认知,在高校思想政治理论课教学中融入“赶考”精神,在高校思想政治教育的过程中贯彻“赶考”精神,丰富能够承载并传播“赶考”精神的教育载体,把“赶考”精神浸润在高校思想政治教育的环境中。

关键词：高校思想政治教育 “赶考”精神大学生理想信念政治认同初心使命

Prediction of posthepatectomy liver failure in patients withhepatocellular carcinoma through ultrasound elastography

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World Journal of Gastroenterology 2025年第4期31卷 160-163页

作者： yan-Qing Ma Xi-Ren Xu Jie Li Yi Lin Zheng Guan Department of Radiology Zhejiang Provincial People’s Hospital(Affiliated People’s HospitalHangzhou Medical College)Hangzhou 310014Zhejiang ProvinceChina

In this article,we comment on the article by Cheng et al published in *** liver failure(PHLF)remains a leading cause of hepatectomyrelated mortality and can be evaluated according to liver reserve *** stiffness(LS)measured by ultrasonic elastography and spleen area demonstrate a strong correlation with hepatic proliferation,fibrosis,and portal vein congestion,thus indirectly reflecting liver reserve *** article highlights a meticulous study aimed at investigating the potential of two-dimensional shear wave elastography in assessing LS,as well as its integration with spleen area,surgical factors,and laboratory indicators,for predicting the risk of PHLF in hepatocellular carcinoma *** this article,we discussed the non-invasive elastography modality by ultrasound and magnetic resonance imaging to assess *** on literature data,we subsequently suggested that several risk factors may contribute to PHLF,including excessive intrahepatic neutrophil accumulation,the formation of neutrophil extracellular traps,end-stage liver disease scores,and albumin-bilirubin ***,a more comprehensive study incor-porating detailed information requires further investigation.

关键词： Posthepatectomy liver failure Liver stiffness Hepatocellular carcinoma Elastography Ultrasound Magnetic resonance imaging