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Hypercoagulation after neoadjuvant immunochemotherapy as a new prognostic indicator in patients with locally advanced gastric cancer undergoing surgery

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World Journal of Gastrointestinal Oncology 2025年第3期17卷 91-103页

作者： Tian-Hao Li xiong Sun Cheng-Guo Li Yu-Ping Yin Kai-xiong Tao Department of Gastrointestinal Surgery Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022Hubei ProvinceChina

BACKGROUND Coagulation status is closely related to the progression of malignant *** the era of neoadjuvant immunochemotherapy(NICT),the prognostic utility of coagulation indicators in patients with locally advanced gastric cancer(LAGC)undergoing new treatments remains to be *** To determine whether hypercoagulation is an effective prognostic indicator in patients with LAGC who underwent radical resection after *** A retrospective analysis of clinical data from 104 patients with LAGC,who underwent radical resection after NICT between 2020 and 2023,was *** and fibrinogen concentrations were measured one week before NICT,and again one week before surgery,to analyze the association between these two indicators and their combined indices[non-hypercoagulation(D-dimer and fibrinogen concentrations within the upper limit of normal)vs hypercoagulation(D-dimer or fibrinogen concentrations above the upper limit of normal)]with *** radical resection,patients were followed-up *** median follow-up duration was 21 *** Data collected after NICT revealed that the three-year overall survival(OS)and disease-free survival(DFS)rates the non-hypercoagulation group were significantly better than those in the hypercoagulation group[94.4%vs 78.0%(P=0.019)and 87.0%vs 68.0%(P=0.027),respectively].Multivariate analysis indicated that hypercoagulation after NICT was an independent factor for poor postoperative OS[hazard ratio(HR)4.436,P=0.023]and DFS(HR 2.551,P=0.039).Pre-NICT data demonstrated no statistically significant difference in three-year OS between the non-hypercoagulation and hypercoagulation groups(88.3%vs 84.1%,respectively;P=0.443).CONCLUSION Hypercoagulation after NICT is an effective prognostic indicator in patients with LAGC undergoing radical gastrectomy.

关键词： Locally advanced gastric cancer Coagulation Neoadjuvant immunochemotherapy Prognosis Radical gastrectomy

利妥昔单抗联合二线方案治疗七例复发难治性霍奇金淋巴瘤患者疗效观察

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中华血液学杂志 2015年第7期36卷 578-582页

作者：刘慧敏李姮熊文婕易树华邹德慧邱录贵中国医学科学院、北京协和医学院血液学研究所、血液病医院实验血液学国家重点实验室天津300020

目的探讨利妥昔单抗联合二线方案治疗复发难治性霍奇金淋巴瘤（HL）患者的疗效及安全性.方法 7例复发难治性HL患者中2例接受R-GDP（E）[利妥昔单抗、吉西他滨、顺铂、地塞米松、（依托泊苷）]方案治疗,2例接受R-IGVP（利妥昔单抗、异... 详细信息

目的探讨利妥昔单抗联合二线方案治疗复发难治性霍奇金淋巴瘤（HL）患者的疗效及安全性.方法 7例复发难治性HL患者中2例接受R-GDP（E）[利妥昔单抗、吉西他滨、顺铂、地塞米松、（依托泊苷）]方案治疗,2例接受R-IGVP（利妥昔单抗、异环磷酰胺、吉西他滨、长春瑞滨、泼尼松）方案治疗,3例接受R-BEACOPP（利妥昔单抗、博来霉素、依托泊苷、多柔比星、环磷酰胺、长春新碱、甲基苄肼、泼尼松）方案治疗.观察患者治疗过程中及其后的不良反应和疗效.结果 7例患者中男3例,女4例,发病时中位年龄21（12～36）岁;结节性淋巴细胞为主型HL（NLPHL）1例,经典型HL 6例（包括4例结节硬化型,1例淋巴细胞为主型和1例混合细胞型）.中位疗程数为4（1～4）个,中位随访时间为29（24～58）个月.7例患者中4例达完全缓解,2例达疾病稳定,1例死亡.2年总生存率为85.7％.不良反应均可耐受,以骨髓抑制为主.5例患者化疗后行外周血自体造血干细胞移植治疗.结论利妥昔单抗联合二线方案治疗复发难治性HL患者安全、有效.

关键词：复发霍奇金病外周血干细胞移植利妥昔单抗

Atomic-scale insights into microscopic mechanisms of grain boundary segregation in Al−Cu alloys

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Transactions of Nonferrous Metals Society of China 2025年第1期35卷 1-12页

作者： xiong SHUAI Hong MAO Sai TANG Yi KONG Yong DU State Key Laboratory of Powder Metallurgy Central South UniversityChangsha 410083China College of Mechanical Engineering Hunan Institute of Science and TechnologyYueyang 414006China National Key Laboratory of Science and Technology on High-strength Structural Materials Central South UniversityChangsha 410083China

This study aims to clarify the mechanisms for the grain boundary(GB)segregation through investigating the absorption of excess solute atoms at GBs in Al−Cu alloys by using the hybrid molecular dynamics/Monte Carlo *** segregation mechanisms,substitutional and interstitial mechanisms,are *** intergranular defects,including dislocations,steps and vacancies,and the intervals in structural units are conductive to the prevalence of interstitial *** substitutional mechanism is favored by the highly ordered twin ***,the two mechanisms affect the GB structure *** is quantified that interstitial mechanism is less destructive to GB structure than substitutional one,and often leads to a segregation level being up to about 6 times higher than the *** findings contribute to atomic scale insights into the microscopic mechanisms about how solute atoms are absorbed by GB structures,and clarify the correlation among intergranular structures,segregation mechanisms and kinetics.

关键词： grain boundaries segregation Al−Cu alloy intergranular structure molecular dynamics simulation Monte Carlo simulation

Remediation mechanism of high concentrations of multiple heavy metals in contaminated soil by Sedum alfredii and native microorganisms

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Journal of Environmental Sciences 2025年第1期147卷 179-188页

作者： Zihe Wang Han Zhang Ying xiong Lieyu Zhang Jianglong Cui Guowen Li Caili Du Kaiyang Wen State Key Laboratory of Environmental Criteria and Risk Assessment Chinese Research Academy of Environmental SciencesBeijing 100012China Beijing Water Science and Technology Institute Beijing 100044China School of Architecture and Civil Engineering Chengdu UniversityChengdu 610106China

Pollution accident of nonferrous metallurgy industry often lead to serious heavy metal pollution of the surrounding *** of contaminated soil is an environmental and sustainable technology,and soil native microorganisms in the process of phytoremediation also participate in the remediation of heavy ***,the effects of high concentrations of multiple heavy metals(HCMHMs)on plants and native soil microorganisms remain ***,further clarification of themechanism of phytoremediation of HCMHMs soil by plants and native soil microorganisms is *** the plant Sedum alfredii(***)to restore HCMHM-contaminated soil,we further explored the mechanism of *** and native soil microorganisms in the remediation of HCMHM *** results showed that(i)*** can promote heavy metals from non-rhizosphere soil to rhizosphere soil,which is conducive to the effect of plants on heavy *** addition,it can also enrich the absorbed heavy metals in its roots and leaves;(ii)native soil bacteria can increase the abundance of signal molecule-synthesizing enzymes,such as trpE,trpG,bjaI,rpfF,ACSL,and yidC,and promote the expression of the pathway that converts serine to cysteine,then synthesize substances to chelate heavy *** addition,we speculated that genes such as K19703,K07891,K09711,K19703,K07891,and K09711 in native bacteria may be involved in the stabilization or absorption of heavy *** results provide scientific basis for *** to remediate heavy metals contaminated soils,and confirm the potential of phytoremediation of HCMHM contaminated soil.

关键词： Microbial remediation Phytoremediation Sedum alfredii

Influence of introducing Zr,Ti,Nb and Ce elements on externally solidified crystals and mechanical properties of high-pressure die-casting Al–Si alloy

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International Journal of Minerals,Metallurgy and Materials 2025年第1期32卷 147-153页

作者： Junjie Li Wenbo Yu Zhenyu Sun Weichen Zheng Liangwei Zhang Yanling Xue Wenning Liu Shoumei xiong Center of Materials Science and Engineering School of Mechanical and Electronic Control EngineeringBeijing Jiaotong UniversityBeijing 100044China Traffic&Transportation Engineering Central South UniversityChangsha 410075China Shanghai Synchrotron Radiation Facility Shanghai Advanced Research InstituteChinese Academy of SciencesShanghai 201204China School of Materials Science and Engineering Tsinghua UniversityBeijing 100084China

High pressure die casting(HPDC)AlSi10Mn Mg alloy castings are widely used in the automobile *** can optimize the mechanical properties of castings through heat treatment,while the release of thermal stress arouses the deformation of large integrated ***,the development of non-heat treatment Al alloys is becoming the hot *** addition,HPDC contains externally solidified crystals(ESCs),which are detrimental to the mechanical properties of *** achieve high strength and toughness of non-heat treatment die-casting Al-Si alloy,we used AlSi9Mn alloy as matrix with the introduction of Zr,Ti,Nb,and *** influences on ESCs and mechanical properties were systematically investigated through three-dimensional reconstruction and thermodynamic *** results reveal that the addition of Ti increased ESCs'size and porosity,while the introduction of Nb refined ESCs and decreased ***,large-sized Al_3(Zr,Ti)phases formed and degraded the mechanical *** introduction of Ce resulted in the poisoning effect and reduced mechanical properties.

关键词： aluminium alloy high-pressure die-casting externally solidified crystals non-heat treatment

Solar flare forecasting based on a Fusion Model

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Earth and Planetary Physics 2025年第1期9卷 171-181页

作者： YiYang Li ShiYong Huang SiBo Xu ZhiGang Yuan Kui Jiang QiYang xiong RenTong Lin School of Earth and Space Science Technology Hubei Luojia LaboratoryWuhan UniversityWuhan 430072China

Solar flare prediction is an important subject in the field of space *** learning technology has greatly promoted the development of this *** this study,we propose a novel solar flare forecasting model integrating Deep Residual Network(ResNet)and Support Vector Machine(SVM)for both≥C-class(C,M,and X classes)and≥M-class(M and X classes)*** collected samples of magnetograms from May 1,2010 to September 13,2018 from Space-weather Helioseismic and Magnetic Imager(HMI)Active Region Patches and then used a cross-validation method to obtain seven independent data *** then utilized five metrics to evaluate our fusion model,based on intermediate-output extracted by ResNet and SVM using the Gaussian kernel *** results show that the primary metric true skill statistics(TSS)achieves a value of 0.708±0.027 for≥C-class prediction,and of 0.758±0.042 for≥M-class prediction;these values indicate that our approach performs significantly better than those of previous *** metrics of our fusion model’s performance on the seven datasets indicate that the model is quite stable and robust,suggesting that fusion models that integrate an excellent baseline network with SVM can achieve improved performance in solar flare ***,we also discuss the performance impact of architectural innovation in our fusion model.

关键词： solar flare pace weather deep learning Fusion Model

CO_(2)-mediated bicarbonate conversion to concentrated formate in a CEM-based electrolyzer

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Journal of Energy Chemistry 2025年第1期100卷 605-611页

作者： Haocheng xiong Donghuan Wu Haonan Li Andrew Li Qikun Hu Siyao Song Bingjun Xu Qi Lu State Key Laboratory of Chemical Engineering Department of Chemical EngineeringTsinghua UniversityBeijing 100084China College of Chemistry and Molecular Engineering Peking UniversityBeijing 100871China Ordos Laboratory Inner Mongolia 017000China

Renewable energy-driven bicarbonate conversion to valuable chemicals presents an attractive strategy for mitigating CO_(2)emissions,as bicarbonate can be efficiently generated from the capture of atmospheric CO_(2)using alkaline solutions with reactive *** this work,we present a CO_(2)-mediated bicarbonate conversion to pure formate using a cation exchange membrane-based electrolyzer with a 25 cm^(2)electrode *** electrolysis achieved selectivities exceeding 75%for formate at a total current of 2.5 A,achieving formate concentrations up to 1.2 M and yields as high as 95%over extended *** techno-economic assessment confirmed the economic viability of the process,highlighting the potential for bicarbonate electrolysis as a sustainable method for producing valuable chemicals.

关键词： Electrocatalysis Techno-economic assessments Electrochemistry Flow electrolyzer

国外大学社会服务职能的源起、发展及对我国的启示

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襄阳职业技术学院学报 2021年第6期20卷 127-131页

作者：熊文杰夏明国武汉商学院武汉430056 武昌理工学院武汉430000

大学社会服务职能最早出现在美国,《莫里尔法案》的通过标志着社会服务职能的正式确立。但从19世纪后期开始欧美国家大学纷纷转向以教学科研为主,直到20世纪80年代在知识经济、全球化和金融及环境危机的刺激下,主流大学才重拾社会服务... 详细信息

大学社会服务职能最早出现在美国,《莫里尔法案》的通过标志着社会服务职能的正式确立。但从19世纪后期开始欧美国家大学纷纷转向以教学科研为主,直到20世纪80年代在知识经济、全球化和金融及环境危机的刺激下,主流大学才重拾社会服务职能。当前社会服务职能已经成为大学的第三职能,从单向知识输出发展成为了双向参与,这对我国大学社会服务职能也具有重要的借鉴意义。

关键词：大学社会服务职能双向参与

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数字孪生战场:概念、架构与技术

系统工程与电子技术 2025年第1期47卷 141-152页

作者：熊宇涵李雄中山大学系统科学与工程学院广东广州510275

当前作战仿真模型存在态势理解滞后、物理模型无法更新等问题,这些问题将影响后续态势推演与决策效果。为此,提出数字孪生战场的概念,并建立数字孪生战场的4层架构模型。基于这种模型,分析其在战场空间的部署方式及寿命周期运用,探讨其... 详细信息

当前作战仿真模型存在态势理解滞后、物理模型无法更新等问题,这些问题将影响后续态势推演与决策效果。为此,提出数字孪生战场的概念,并建立数字孪生战场的4层架构模型。基于这种模型,分析其在战场空间的部署方式及寿命周期运用,探讨其潜在运用价值。同时,从多源数据采集与处理、孪生战场建模、模型动态更新和态势推演与决策4个视角出发,讨论数字孪生战场建模所需的关键技术。随着作战仿真模型的运用,可以帮助指挥机构做出更高效的决策。

关键词：数字孪生战场指挥决策多源数据采集作战建模模型更新态势推演