检索结果-南通市图书馆

Nanocarrier-mediated siRNA delivery:a new approach for the treatment of traumatic brain injury-related Alzheimer's disease

引用

Neural Regeneration Research 2025年第9期20卷 2538-2555页

作者： Jie Jin Huajing Zhang Qianying Lu Linqiang Tian Sanqiao Yao Feng Lai Yangfan Liang Chuanchuan Liu Yujia Lu Sijia Tian Yanmei Zhao wenjie ren Institute of Disaster and Emergency Medicine Tianjin UniversityTianjinChina Key Laboratory for Disaster Medicine Technology TianjinChina Henan Medical Key Laboratory for Research of Trauma and Orthopedics The Third Affiliated Hospital of Xinxiang Medical UniversityXinxiangHenan ProvinceChina Clinical Medical Center of Tissue Engineering and Regeneration Xinxiang Medical UniversityXinxiangHenan ProvinceChina Institutes of Health Central Plain Xinxiang Medical UniversityXinxiangHenan ProvinceChina School of Public Health Xinxiang Medical UniversityXinxiangHenan ProvinceChina

Traumatic brain injury and Alzheimer's disease share pathological similarities,including neuronal loss,amyloid-βdeposition,tau hyperphosphorylation,blood-brain barrier dysfunction,neuroinflammation,and cognitive ***,traumatic brain injury can exacerbate Alzheimer's disease-like pathologies,potentially leading to the development of Alzheimer's *** offer a potential solution by facilitating the delive ry of small interfering RNAs across the blood-brain barrier for the targeted silencing of key pathological genes implicated in traumatic brain injury and Alzheimer's disease.U nlike traditional approaches to neuro regeneration,this is a molecula r-targeted strategy,thus avoiding non-specific drug *** review focuses on the use of nanocarrier systems for the efficient and precise delive ry of siRNAs,discussing the advantages,challenges,and future *** principle,siRNAs have the potential to target all genes and non-targetable protein s,holding significant promise for treating various *** the various therapeutic approaches currently available for neurological diseases,siRNA gene silencing can precisely"turn off"the expression of any gene at the genetic level,thus radically inhibiting disease progression;however,a significant challenge lies in delivering siRNAs across the blood-brain *** have received increasing attention as an innovative drug delive ry tool fo r the treatment of brain *** are considered a potential therapeutic strategy with the advantages of being able to cross the blood-brain barrier,targeted drug delivery,enhanced drug stability,and multifunctional *** use of nanoparticles to deliver specific modified siRNAs to the injured brain is gradually being recognized as a feasible and effective *** this strategy is still in the preclinical exploration stage,it is expected to achieve clinical translation in the future,creating a new field of molecular tar

关键词： blood-brain barrier cognitive dysfunction exosomes gene silencing immunotherapy inorganic nanomaterials liposome nanoparticles neuroinflammation polymer nanoparticles stem cells

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Spatial and temporal distribution of acetochlor in sediments and riparian soils of the Songhua River Basin in northeastern China

引用

Journal of Environmental Sciences 2011年第10期23卷 1684-1690页

作者： Xiaoyin Sun Qixing Zhou wenjie ren Xuhui Li Liping ren Key Laboratory of Terrestrial Ecological Process Institute of Applied Ecology Chinese Academy of Sciences Shenyang 110016 China Graduate School of the Chinese Academy of Sciences Beijing 100049 China College of Geography and Tourism Shandong Qufu Normal University Qufu 273165 China Key Laboratory of Pollution Processes and Environmental Criteria （Ministry of Education） College of Environmental Science and Engineering Nankai University Tianjin 300071 China

The Songhua River Basin is a burgeoning agricultural area in the modern times in China. Particularly in recent years, increasing chemical fertilizers and pesticides have been applied with the development of agricultural production. However, the situation of non- point source pollution （NSP） from agricultural production in this basin is still obscure. In order to solve the problem, the occurrence and distribution of acetochlor in sediments and riparian soils of the Songhua River Basin before rain season and after rain season were investigated. In addition, total organic carbon was analyzed. The result showed that the concentration of acetochlor ranged from 0.47 to 11.76 μg/kg in sediments and 0.03 to 709.37 μg/kg in riparian soils. During the high flow period in 2009, the mean concentration was 4.79 μg/kg in sediments and 0.75 μg]kg in riparian soils, respectively. Similarly, the mean concentration was 2.53 μg/kg in sediments and 61.36μg/kg in riparian soils, during the average flow period in 2010. There was a significant correlation between the concentration of acetochlor and total organic carbon in surface sediments. Moreover, the distribution of acetochlor in sediments of the Songhua River was significantly correlated to land use and topography of the watershed. The investigated data suggested that the concentration of acetochlor in the Songnen Plain and the Sanjiang Plain was higher than that in the other areas of the basin, and riparian buffering zones in these areas bad been destroyed by human activities. The optimal agricultural measures to alleviate the contamination of pesticides should be adopted, including controlling agricultural application of acetochlor and ecological restoration of riparian buffering strips.

关键词： acetochlor Songhua River Basin non-point source pollution optimal agricultural measure

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Integration of Chemical Methods and Biomarkers for Assessment of Chlorimuron-Ethyl Bioavailability in Soil

引用

Pedosphere 2016年第3期26卷 273-281页

作者： ren wenjie WANG Meie ZHOU Qixing TENG Ying Key Laboratory of Soil Environment and Pollution Remediation of Chinese Academy of Sciences Institute of Soil ScienceChinese Academy of Sciences Key Laboratory of Pollution Ecology and Environmental Engineering Institute of Applied EcologyChinese Academy of Sciences State Key Laboratory of Urban and Regional Ecology Research Centre for Eco-Environmental SciencesChinese Academy of Sciences Key Laboratory of Pollution Processes and Environmental Criteria(Ministry of Education) College of Environmental Science and EngineeringNankai University

Bioavailability is a critical factor for assessing the environmental risk of organic pollutants in soil. In this study, extractions with 3 different solvents, including 2 aqueous solutions, calcium chloride(CaCl_2) and a phosphate buffer solution(PBS), and a mixture of aqueous solution and organic solvent, a PBS-methanol(8:2,volume/volume) mixture(PBS-M), were performed to assess the bioavailability of chlorimuron-ethyl in soil in comparison to a battery of toxicity tests in wheat seedlings. The results indicated that the peroxidase(POD) activity in wheat leaves after 7 d of exposure was one of the sensitive biomarkers of chlorimuron-ethyl in *** extractability of chlorimuron-ethyl by all the 3 solvents decreased with exposure time, and the rate of decrease of the PBS-M extraction between 1 and 7 d of exposure was substantially higher than those of the aqueous solution extractions. Chlorimuron-ethyl gradually changed from a water-soluble form into a soil organic matter(SOM)-bound form in the soil. The PBS extraction correlated best with the POD activity in the leaves after 7 d of exposure.

关键词： chemical extraction environmental risk organic pollutants organic solvent peroxidase activity phosphate buffer solution toxicity test

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Theoretical kinetic quantitative calculation predicted the expedited polysulfides degradation

引用

Nano Research 2023年第10期16卷 12035-12042页

作者： Siyu Zhang Xianchao Rong Tao Li wenjie ren Hao ren Linjie Zhi Mingbo Wu Zhongtao Li State Key Laboratory of Heavy Oil Processing College of Chemical EngineeringChina University of Petroleum(East China)Qingdao 266580China National Engineering Center of Coal slurry and Coal Chemical Co. Ltd.LTDJinan 250014China

The performance of lithium-sulfur battery is restricted by the lower value of electrode conductance and the sluggish LiPSs degradation ***,the degradation rate of polysulfides was mostly attributed to the catalytic energy barrier in previous,which is unable to give accurate predictions on the performance of lithium-sulfur ***,a quantitative framework relating the battery performance to catalytic energy barrier and electrical conductivity of the cathode host is developed here to quantitate the *** the model compound,calculated-Ti_(4)O_(7)(c-Ti_(4)O_(7))has the highest comprehensive index with excellent electrical conductivity,although the catalytic energy barrier is not *** inputting the experimental properties such as impedance and charge/discharge data into the as-build model,the final conclusion is still in line with our prediction that Ti_(4)O_(7)host shows the most excellent electrochemical ***,the accurate model here would be attainable to design lithium-sulfur cathode materials with a bottom–up manner.

关键词： lithium-sulfur batteries shuttle effect polysulfide degradation first-principles calculation semi-empirical model

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

A highly effective polycyclic aromatic hydrocarbon-degrading bacterium,Paracoccus ***-2,shows opposite remediation potential in two soil types

引用

Pedosphere 2022年第5期32卷 673-685页

作者： Wei CHEN Ying TENG wenjie ren Yongming LUO Yao YU Key Laboratory of Soil Environment and Pollution Remediation Institute of Soil ScienceChinese Academy of SciencesNanjing 210018(China) Institute of Agricultural Resources and Environment Jiangsu Academy of Agricultural SciencesNanjing 210014(China) School of Resources and Environmental Engineering Hefei University of TechnologyHefei 230009(China)

Bioaugmentation is an efficient and eco-friendly strategy for the bioremediation of polycyclic aromatic hydrocarbons(PAHs).Since the degrading abilities of soils can greatly alter the abilities of PAH-degrading bacteria,illustrating the potential and mechanism of highly efficient degrading bacteria in different soil environments is of great importance for bioremediation.A PAH-degrading bacterium,Paracoccus aminovorans HPD-2,and two soil types,red and paddy soils,with distinct PAH-degrading abilities,were selected for this study.A soil microcosm experiment was performed by adding pyrene(PYR)and benzo[a]pyrene(B[a]P).Illumina sequencing was used to examine bacterial community *** results showed that inoculation with HPD-2 significantly elevated PYR and B[a]P degradation rates by 44.7%and 30.7%,respectively,in the red soil,while it only improved the degradation rates by 1.9%and 11%,respectively,in the paddy *** investigate the underlying mechanism,the fate of strain HPD-2 and the response of the indigenous bacterial communities were *** HPD-2 occupied certain niches in both soils,and the addition of the bacterium changed the native community structure more noticeably in the red soil than in the paddy *** addition of PAHs and strain HPD-2 significantly changed the abundances of 7 phyla among the 15 detected phyla in the red *** the paddy soil,5 of the 12 dominant phyla were significantly affected by PAHs and the inoculation of HPD-2,while 6new phyla were detected in the low-abundance phyla(rent mechanism of the highly effective PAH-degrading strain HPD-2 in two different soil type

关键词： bacterial inoculation benzo[a]pyrene bioremediation organic contaminant paddy soil Paracoccus aminovorans pyrene red soil

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Real-Time Generation of Reflections in the Optimized Image Space

引用

Chinese Journal of Electronics 2020年第5期29卷 812-818页

作者： ZHANG Yanci YU Hanyou XIE Ruilin MENG Xiaoyou ren wenjie XIE Kaili LIU Yanli College of Computer Science Sichuan University

This paper proposes a novel imagebased method to generate real-time *** algorithm aims to solve the problem of missing reflections in previous screen space based methods *** of computing reflections in the image space decided by the current eye position,our method conducts most of the reflection calculations in a new image space,which is determined by a carefully chosen camera position at *** major criteria used to choose this optimized camera position is to make its corresponding image space contain as much as possible scene information to generate *** experimental results indicate that most of the missing reflections problems can be fixed by moving the reflection computations to this new image *** also prove that the performance gains achieved by executing computations in the new image space can cancel out most of the overhead to generate it.

关键词： Reflections Ray marching Image space G-buffer

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Optimization of Ex-Situ Washing Removal of Polycyclic Aromatic Hydrocarbons from a Contaminated Soil Using Nano-Sulfonated Graphene

引用

Pedosphere 2017年第3期27卷 527-536页

作者： GAN Xinhong TENG Ying ren wenjie MA Jun Peter CHRISTIE LUO Yongming Key Laboratory of Soil Environment and Pollution Remediation Institute of Soil Science Chinese Academy of Sciences University of Chinese Academy of Sciences College of Materials and Chemistry Tongren University

Ex-situ soil washing technology offers advantages such as speed and efficiency of remediation and range of application and has been developed to conform with legal requirements and best management practices in USA and some European countries. In this study, nano-sulfonated graphene （SGE） was used as a washing agent to evaluate different processing （washing） parameters for the ectopic leaching removal of polycyclic aromatic hydrocarbons （PAHs） from a coking plant soil. X-ray photoelectron spectroscopy （XPS） and fourier transform infrared spectroscopy （FTIR） were used to analyze the characteristics of the SGE tested. The results showed that SGE had a strong adsorption capacity for PAHs through the role of π-π, H-π, and anion-π interactions. The washing parameters, an SGE concentration of 2000 mg L-1, a liquid/soil （L/S） ratio of 10：1, and 4 cycles of successive washing, were set to arrive to the optimum condition for achieving more than 80% of PAH removal. Under the optimum condition, the PAH removal rate decreased with increasing ring numbers. After one washing cycle at SGE concentration of 2000 mg L-1 and L/S ratio of 10：1, the PAH removal rate of the SCE tested was much higher than that of Tween 80 （TW80） or methyl-β-cyclodextrin （MCD）（P 〈 0.01）. Therefore, SGE is a promising material for the nanoremediation of PAH-contaminated soils.

关键词： adsorption capacity leaching mechanism nanoremediation optimum condition washing agent washing parameter

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Legacy of herbicides in water from Hailun City,Northeast China:Occurrence,source,and ecological risk assessment

引用

Journal of Environmental Sciences 2024年第11期145卷 50-63页

作者： Jun Ma wenjie ren Hongzhe Wang Jiayin Song Junfeng Jia Hong Chen Changyin Tan Ying Teng School of Geographic Sciences Hunan Normal UniversityChangsha 410081China Key Laboratory of Soil Environment and Pollution Remediation Institute of Soil ScienceChinese Academy of SciencesNanjing 210008China College of Materials and Chemistry Tongren UniversityTongren 554300China

Herbicides(HBCs)are extensively used in modern ***,their potential negative impacts on environmental media have emerged as a significant environmental *** this study,we employed positivematrix factorization(PMF)to identify the potential sources of ***,we utilized amulti-matrix ecological riskmodel to assess the risks associated with HBCs in both surface water and groundwater in the black soil region of Northeast *** findings revealed that the levels of15HBCs in surface water and groundwater ranged from585.84 to 6466.96 ng/L and 4.80 to 11,774.64 ng/L,*** PMF results indicated that surface runoff and erosion accounted for 50%of the total HBCs in water,serving as the primary *** tested HBCs exhibited acute risk values within acceptable *** risk index for the∑15HBCs was categorized as“moderate risk”in 31%of the surface waters and 13%of the ***,4%of the groundwater sampling sites reached the“high risk”*** chronic risk quotient of∑15HBCs in surface water and groundwater was 92%and 62%at the“high risk”level,***,noncarcinogenic HBCs contributed more significantly to the ecotoxicology of the aquatic system than carcinogenic *** study provides comprehensive information on the legacy of HBCs in water bodies and emphasizes the potential risks posed by HBCs to aquatic *** results obtained from this study could help relevant management authorities in developing and implementing effective regulations tomitigate the ecological and environmental risks associated with HBCs.

关键词： Herbicide Surface and groundwater Source apportionment Ecological risk assessment

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Degradation of pyrene by immobilized microorganisms in saline-alkaline soil

引用

Journal of Environmental Sciences 2012年第9期24卷 1662-1669页

作者： Shanxian Wang Xiaojun Li Wan Liu Peijun Li Lingxue Kong wenjie ren Haiyan Wu Ying Tu Institute of Applied Ecology Chinese Academy of Sciences Shenyang 110016 China Graduate University of Chinese Academy of Sciences Beijing 100049 China Centre for Material and Fiber Innovation Institute for Technology and Research Innovation Deakin University Geelong Vic 3217 Australia College of Resource and Environmental Engineering Liaoning Technical University Fuxin 123000 China

Biodegradation of polycyclic aromatic hydrocarbons （PAHs） is very difficult in saline-alkaline soil due to the inhibition of microbial growth under saline-alkaline stress. The microorganisms that can most effectively degrade PAHs were screened by introducing microorganisms immobilized on farm byproducts and assessing the validity of the immobilizing technique for PAHs degradation in pyrene-contaminated saline-alkaline soil. Among the microorganisms examined, it was found that Mycobacterium sp. B2 is the best, and can degrade 82.2% and 83.2% of pyrene for free and immobilized cells after 30 days of incubation. The immobilization technique could increase the degradation of pyrene significantly, especially for fungi. The degradation of pyrene by the immobilized microorganisms Mucor sp. F2, fungal consortium MF and co-cultures of MB＋MF was increased by 161.7% （P 〈 0.05）, 60.1% （P 〈 0.05） and 59.6% （P 〈 0.05） after 30 days, respectively, when compared with free F2, MF and MB＋ME Scanning electron micrographs of the immobilized microstructure proved the positive effects of the immobilized microbial technique on pyrene remediation in saline- alkaline soil, as the interspace of the carder material structure was relatively large, providing enough space for cell growth. Co-cultures of different bacterial and fungal species showed different abilities to degrade PAHs. The present study suggests that Mycobacterium sp. B2 can be employed for in situ bioremediation of PAHs in saline-alkaline soil, and immobilization of fungi on farm byproducts and nutrients as carriers will enhance fungus PAil-degradation ability in saline-alkaline soil.

关键词： saline-alkaline soil immobilization PAHs-degrading microorganisms biodegradation characteristics Mycobacterium

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Influence of kaolinite and montmorillonite on benzo[a]pyrene biodegradation by Paracoccus aminovorans HPD-2 and the underlying interface interaction mechanisms

引用

Pedosphere 2022年第2期32卷 246-255页

作者： Xinhong GAN Ying TENG Jian XU Ning ZHANG wenjie ren Ling ZHAO Peter CHRISTIE Yongming LUO Key Laboratory of Soil Environment and Pollution Remediation Institute of Soil ScienceChinese Academy of SciencesNanjing 210008China State Environmental Protection Key Laboratory of Soil Environmental Management and Pollution Control Nanjing Institute of Environmental ScienceMinistry of Ecology and Environment(MEE)of ChinaNanjing 210042China University of Chinese Academy of Sciences Beijing 100049China

Clay minerals play an important role in biogeochemical ***,kaolinite and montmorillonite,the two most abundant and widespread clay minerals with typical layered structures,were selected to investigate and compare their effects on the biodegradation of benzo[a]pyrene(BaP)by Paracoccus aminovorans HPD-2 and to investigate the underlying interface ***,the BaP degradation efficiency was significantly higher 7 d after montmorillonite addition,reaching 68.9%(Prential bacterial growth,BaP bio-accessibility,interface interaction,and the buffering effect may explain the differential effects of the different minerals on polycyclic aromatic hydrocarbon *** observations improve our understanding of the mechanisms by which clay minerals,organic pollutants,and degrading bacteria interact during the biodegradation process and provide a theoretical basis for increasing the biodegradation of soil pollutants by native microorganisms under field conditions.

关键词： bio-accessibility cell viability clay mineral degrading bacteria nano-scale secondary ion mass spectrometry polycyclic aromatic hydrocarbon

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：