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基于空间自相关的常规城市公交车辆危险驾驶热点路段识别

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华南理工大学学报（自然科学版） 2024年第4期52卷 138-150页

作者：张文会刘拓宋雅靖苏嘉祺东北林业大学土木与交通学院黑龙江哈尔滨150040 比亚迪汽车工业有限公司商用车研究院广东深圳518118

为了获得公交危险驾驶状态的空间分布特征,采用空间自相关性分析方法,识别危险驾驶状态的空间集聚性,确定危险驾驶状态热点路段,并对显著性影响因素进行分析。首先,采集4个季度各1周公交车辆卫星定位数据样本,修复重复数据、异常数据和... 详细信息

为了获得公交危险驾驶状态的空间分布特征,采用空间自相关性分析方法,识别危险驾驶状态的空间集聚性,确定危险驾驶状态热点路段,并对显著性影响因素进行分析。首先,采集4个季度各1周公交车辆卫星定位数据样本,修复重复数据、异常数据和缺失数据,并以公交站点为节点划分空间区段,对每个区段进行编号;接着,将速度过快、急加速、急减速和急转弯确定为危险驾驶状态,参照车辆运动学特性获得4种危险驾驶状态阈值,并计算4种危险驾驶状态的统计学指标和全局莫兰指数,结果表明,公交车辆危险驾驶状态具有空间集聚性(空间随机分布概率p2.58),速度过快状态(全局莫兰指数为0.731)的空间集聚性最为显著;然后,分别对4种危险驾驶状态进行局部空间自相关性分析,绘制了90%、95%和99%置信度下的莫兰散点图和Lisa集聚图,结合城市地图,获得危险驾驶状态的热点路段;最后,选取路段长度、车道数、平直度等9个指标,对比分析了OLS模型、SLE模型、SEM模型和SDM模型的拟合优度,采用SDM模型获得4种危险驾驶状态的显著性影响因素。文中研究结果可为公交车辆危险驾驶状态空间识别、精细化安全运行管理提供理论依据。

关键词：交通运输工程公交车辆运行安全热点路段空间自相关

Microbiome and metabolome dysbiosis analysis in impaired glucose tolerance for the prediction of progression to diabetes mellitus

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Journal of Genetics and Genomics 2024年第1期51卷 75-86页

作者： Boxun Zhang Xuan Zhang Zhen Luo Jixiang Ren Xiaotong Yu Haiyan Zhao Yitian Wang wenhui Zhang Weiwei Tian Xiuxiu Wei Qiyou Ding Haoyu Yang Zishan Jin Xiaolin Tong Jun Wang Linhua Zhao Institute of Metabolic Diseases Guang'anmen HospitalChina Academy of Chinese Medical SciencesBeijing 100053China Faculty of Biological Science and Technology Baotou Teacher's CollegeBaotouInner Mongolia 014030China CAS Key Laboratory of Pathogenic Microbiology and Immunology Institute of MicrobiologyChinese Academy of SciencesBeijing 100101China Infinitus(China)Company Ltd GuangzhouGuangdong 510405China Affiliated Hospital of Changchun University of Chinese Medicine ChangchunJilin 130021China Department of Endocrinology Guang'anmen HospitalChina Academy of Chinese Medical SciencesBeijing 100053China Xinjiekou Community Health Service Center in Xicheng District Beijing 100035China Department of Spleen and Stomach Shenzhen Traditional Chinese Medicine HospitalShenzhenGuangdong 518033China University of Chinese Academy of Sciences Beijing 100049China Beijing University of Chinese Medicine Beijing 100105China Northeast Asia Institute of Traditional Chinese Medicine Changchun University of Chinese MedicineChangchunJilin 130117China

Gut microbiota and circulating metabolite dysbiosis predate important pathological changes in glucose metabolic disorders;however,comprehensive studies on impaired glucose tolerance(IGT),a diabetes mellitus(DM)precursor,are lacking.Here,we perform metagenomic sequencing and metabolomics on 47 pairs of individuals with IGT and newly diagnosed DM and 46 controls with normal glucose tolerance(NGT);patients with IGT are followed up after 4 years for progression to DM.Analysis of baseline data reveals significant differences in gut microbiota and serum metabolites among the IGT,DM,and NGT groups.In addition,13 types of gut microbiota and 17 types of circulating metabolites showed significant differences at baseline before IGT progressed to DM,including higher levels of Eggerthella unclassified,Coprobacillus unclassified,Clostridium ramosum,L-valine,L-norleucine,and L-isoleucine,and lower levels of Eubacterium eligens,Bacteroides faecis,Lachnospiraceae bacterium 3_1_46FAA,Alistipes senegalensis,Megaspaera elsdenii,Clostridium perfringens,α-linolenic acid,10E,12Z-octadecadienoic acid,and dodecanoic acid.A random forest model based on differential intestinal microbiota and circulating metabolites can predict the progression from IGT to DM(AUC=0.87).These results suggest that microbiome and metabolome dysbiosis occur in individuals with IGT and have important predictive values and potential for intervention in preventing IGT from progressing to DM.

关键词： Impaired glucose tolerance Diabetes mellitus Gut microbiota Metabolomics

Double-blinded,randomized clinical trial of Gegen Qinlian decoction pinpoints Faecalibacterium as key gut bacteria in alleviating hyperglycemia

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Precision Clinical Medicine 2024年第1期7卷 21-33页

作者： Zezheng Gao wenhui Zhang Lisha He Han Wang Yufei Li Xiaotian Jiang Sha DI Xinmiao Wang Xuan Zhang Lin Han Yanwen liu Chengjuan Gu Mengyi Wu Xinhui He Lei Cheng Jun Wang Xiaolin Tong Linhua Zhao Institute of Metabolic Diseases Guang'anmen HospitalChina Academy of Chinese Medical SciencesBeijing 100053China Department of Endocrinology Guang anmen HospitalChina Academy of Chinese Medical SciencesBeijing 100053China CAS Key Laboratory of Pathogenic Microbiology and Immunology Institute of MicrobiologyChinese Academy of SciencesBeijing 100101China University of Chinese Academy of Sciences Beijing 100049China Chengdu University of Traditional Chinese Medicine Chengdu 611137China School of Chinese Materia Medica Beijing University of Chinese MedicineBeijing 100029China Centre for Evidence-Based Chinese Medicine Beijing University of Chinese MedicineBeijing 100029China Department of Endocrinology Affiliated Hospital of Changchun University of Chinese MedicineChangchun 13000oChina Biologicals Science and Technology Institute Baotou Teacher's CollegeBaotou 014030China Department of Endocrinology Zhengzhou T.C.M.HospitalZhengzhou 450007China Shenzhen Hospital Guangzhou University of Chinese Medicine(Futian)Shenzhen 518000China Department of Cardiology Guangdong Provincial Hospital of Chinese MedicineGuangzhou 510120China Department of Cardiology Yunnan Provincial Hospital of Traditional Chinese MedicineKunming 650000China Key Laboratory of Development and Application of Rural Renewable Energy Biogas Institute of Ministry of Agriculture and Rural AffairsChengdu 610041China

Background:Accumulating evidence suggests that metabolic disorders,including type 2 diabetes mellitus(T2DM),can be treated with traditional Chinese medicine formulas,such as the Gegen Qinlian decoction(GQD).This study elucidates the mechanisms by which gut microbes mediate the anti-diabetic effects of GQD.Methods:We conducted a double-blind randomized clinical trial involving 120 untreated participants with T2DM.During the 12-week intervention,anthropometric measurements and diabetic traits were recorded every 4 weeks.Fecal microbiota and serum metabolites were measured before and after the intervention using 16S rDNA sequencing,liquid chromatography-mass spectrometry,and Bio-Plex panels.Results:Anti-diabetic effects were observed in the GQD group in the human trial.Specifically,glycated hemoglobin,fasting plasma glucose,and two-hour postprandial blood glucose levels were significantly lower in the GQD group than in the placebo group.Additionally,Faecalibacterium was significantly enriched in the GQD group,and the short-chain fatty acid levels were higher and the serum inflammation-associated marker levels were lower in the GQD group compared to the placebo group.Moreover,Faecalibacterium abundance negatively correlated with the levels of serum hemoglobin,fasting plasma glucose,and pro-inflammatory cytokines.Finally,the diabetes-alleviating effect of Faecalibacterium was confirmed by oral administration of Faecalibacterium prausnitzi(DSMZ 17677)in T2DMmousemodel.Conclusions:GQD improved type 2 diabetes primarily by modulating the abundance of Faecalibacterium in the gut microbiota,alleviating metabolic disorders and the inflammatory state.

关键词： double-blinded randomized controlled trial type 2 diabetes mellitus Gegen Qinlian decoction Faecalibacterium metabolic disorders inflammation

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考虑竞争和风险的平台融资最优授信额度策略

系统工程理论与实践 2024年第4期44卷 1246-1257页

作者：刘露王文慧李勇建牛水叶山东科技大学经济管理学院青岛266590 南开大学商学院天津300071 山东大学国际创新转化学院青岛266237

平台融资是纾解中小企业融资难题的有效方式,授信额度优化是平台融资亟待解决的关键问题.本文建立了突发事件风险影响下,由两个相互竞争供应商和单个电商平台组成的平台型供应链决策模型,运用Stackelberg-Nash博弈方法给出两竞争供应商... 详细信息

平台融资是纾解中小企业融资难题的有效方式,授信额度优化是平台融资亟待解决的关键问题.本文建立了突发事件风险影响下,由两个相互竞争供应商和单个电商平台组成的平台型供应链决策模型,运用Stackelberg-Nash博弈方法给出两竞争供应商均衡供货策略和电商平台最优授信额度策略,通过灵敏度分析探究供应商风险承受能力等关键参数对最优授信额度策略的影响.研究结果表明:当风险承受能力较高时,电商平台最优策略是向供应商发放充足授信额度,且最优授信额度随供应商竞争水平递增;当风险承受能力适中时,电商平台最优策略是限制供应商授信额度,且最优授信额度随供应商竞争水平递减;当风险承受能力足够低时,电商平台最优策略是不向供应商发放任何授信额度.供应商异质情形下,电商平台应当将有限授信额度全部给予风险承受能力较高的供应商且对风险承受能力较低的供应商不予授信.本研究为平台型供应链合理制定最优授信额度策略提供了管理启示和政策建议.

关键词：平台金融授信额度资金约束平台竞争融资风险

Using geochemical tracing system to identify new types of gas sources in marine strata of the Hotan River Gas Field in the Tarim Basin

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Science China Earth Sciences 2010年第6期53卷 844-853页

作者： wenhui liu DianWei Zhang Bo Gao Ming Fan Exploration and Production Research Institute Sinopec Beijing 100083 China

There are natural gas sources of various modes of occurrence in superimposed basins. Besides the conventional kerogen and ancient oil reservoir, dispersed soluble organic matter (DSOM) is an important direct gas source. Because of its wide distribution, great potential to generate gas and proneness to crack under catalysis, DSOM is an important type of gas source in the highly evolved zones in marine strata. Through the geological and geochemical analysis that reflects the long-period evolvement and multiple gas accumulation processes in marine strata, and using the ternary geochemical tracing system, here we study the origin and accumulation of the natural gas in the Hotan River Gas Field in the Tarim Basin. The natural gas is produced from highly evolved and cracked DSOM in the Hotan River Gas Field, and it is accumulated after migrating for a long distance along faults. This conclusion is of great significance to the further expansion of the oil and gas exploration fields in the Tarim Basin.

关键词： dispersed soluble organic matter (DSOM) cracking gas Hotan River Gas Field carbon isotopic composition geological tracing system

负载天然色素的生物基智能包装指示器研究进展

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食品科学技术学报 2024年第1期42卷 20-31页

作者：雷桥张文惠上海海洋大学食品学院上海201306 上海水产品加工及贮藏工程技术研究中心上海201306

智能包装指示器能够基于其检测、感知和记录产品环境变化的能力为消费者提供被包装食品新鲜度、安全性或食品环境条件(温度、pH值、气体氛围)等的有效信息,是传统包装传播信息能力的延伸,并且有助于改善危害分析与关键控制点(HACCP)和... 详细信息

智能包装指示器能够基于其检测、感知和记录产品环境变化的能力为消费者提供被包装食品新鲜度、安全性或食品环境条件(温度、pH值、气体氛围)等的有效信息,是传统包装传播信息能力的延伸,并且有助于改善危害分析与关键控制点(HACCP)和质量分析与关键控制点(QACCP)系统,有助于现场检测不安全食品,识别潜在的健康危害,并制定策略以减少或消除食品安全问题发生。生物基智能包装系统因采用可降解、可再生材料向消费者直观显示包装食品在供应链中的品质相关信息,契合循环经济和可持续发展的需求而备受关注。介绍了以天然色素(花青素、叶绿素、姜黄素和甜菜素等)为敏感元件,以生物基聚合物(多糖、蛋白质、脂质和改性纤维素等)为载体的环境友好型智能包装指示器(pH值感应、时间-温度感应、气体感应等)的类型、功能适应性及其在监控食品品质、储运环境等方面的新趋势、新进展。

关键词：智能包装生物基聚合物天然色素指示器食品保鲜

Distributed Average Consensus in Multi-agent Networks with Limited Bandwidth and Time-delays

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IEEE/CAA Journal of Automatica Sinica 2014年第2期1卷 193-203页

作者： wenhui liu Feiqi Deng Jiarong Liang Haijun liu College of Automation Science and Engineering South China University of Technology School of Computer Electronics and InformationGuangxi University School of Mathematics and Statistics Zhengzhou University

This paper studies the distributed average consensus problem of multi-agent digital networks with time-delays. For the network, each agent can only exchange symbolic data with its neighbours. We provide a distributed average consensus protocol which uses the quantized and time-delay information. We consider two types of dynamic encoders/decoders in our protocol.One uses inverse proportion function as scaling function, while the other uses exponential function as scaling function. All agents can reach average consensus asymptotically with our protocol.Furthermore, we show that the average consensus protocol is robust to finite symmetric time-delays, but is sensitive to asymmetric time-delays that will destroy the average consensus of the networks. Finally, simulations are presented to illustrate validity of our theoretical results.

关键词： Protocols Quantization (signal) Decoding Bandwidth Algorithm design and analysis Communication channels

大学生公共安全教育的现状分析与优化路径——基于9省份大学生公共安全素养调查的分析

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福建师范大学学报（哲学社会科学版） 2024年第3期 154-167,172页

作者：刘济良赵文慧河南大学教育学部河南开封475004

大学生公共安全教育具有提升大学生公共安全风险预防和风险应对能力的双重目标。可以以大学生公共安全教育九个维度全面把握大学生公共安全教育的现状。目前,我国大学生公共安全素养有待提升,其中公共安全基本素养、社会安全、公共卫生... 详细信息

大学生公共安全教育具有提升大学生公共安全风险预防和风险应对能力的双重目标。可以以大学生公共安全教育九个维度全面把握大学生公共安全教育的现状。目前,我国大学生公共安全素养有待提升,其中公共安全基本素养、社会安全、公共卫生安全、公共意外伤害和自然灾害五个维度相对薄弱,大学生公共安全素养在性别、年级和学科背景方面存在显著性差异。今后,大学生公共安全教育需要从五个方面优化:建立健全高校公共安全教育体系,全面提质增效;开设系统性公共安全教育理论课程,筑牢理论基石;关注公共安全教育薄弱内容,强化实践性技能培训;建设专业化公共安全教育师资队伍,实现价值引领;基于差异化泛在学习需求,搭建智能化服务平台。

关键词：大学生公共安全安全素养安全教育

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论美好课堂生活及其创建之路

全球教育展望 2024年第1期53卷 30-39页

作者：赵文慧刘济良河南大学教育学部开封475004

美好课堂生活承载着对课堂生活优质化的价值期许,旨在达成师生双方互相生命滋养的理想课堂教学效果。美好课堂生活以物质生活为基础保障、以理性生活为主要内容、以关系生活为表现形式、以道德生活为核心环节,彰显着润泽生命、促进幸福... 详细信息

美好课堂生活承载着对课堂生活优质化的价值期许,旨在达成师生双方互相生命滋养的理想课堂教学效果。美好课堂生活以物质生活为基础保障、以理性生活为主要内容、以关系生活为表现形式、以道德生活为核心环节,彰显着润泽生命、促进幸福、完善德性和推进发展的重要意义。美好课堂生活之创建需要优化课堂教学空间,促进身心“在场”的具身学习;提升教学交往素养,在相互关怀中玉成师生幸福;重构课堂教学秩序,培育学生参与公共生活的能力;关注教学育人过程,突显学生评价话语的德性关照。

关键词：美好生活课堂生活教学交往学习共同体