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Engineering 2024年第2期33卷 77-89页

作者： Xiangkun He wenhui huang Chen Lv School of Mechanical and Aerospace Engineering Nanyang Technological UniversitySingapore 639798Singapore

While autonomous vehicles are vital components of intelligent transportation systems,ensuring the trustworthiness of decision-making remains a substantial challenge in realizing autonomous driving.Therefore,we present a novel robust reinforcement learning approach with safety guarantees to attain trustworthy decision-making for autonomous vehicles.The proposed technique ensures decision trustworthiness in terms of policy robustness and collision safety.Specifically,an adversary model is learned online to simulate the worst-case uncertainty by approximating the optimal adversarial perturbations on the observed states and environmental dynamics.In addition,an adversarial robust actor-critic algorithm is developed to enable the agent to learn robust policies against perturbations in observations and dynamics.Moreover,we devise a safety mask to guarantee the collision safety of the autonomous driving agent during both the training and testing processes using an interpretable knowledge model known as the Responsibility-Sensitive Safety Model.Finally,the proposed approach is evaluated through both simulations and experiments.These results indicate that the autonomous driving agent can make trustworthy decisions and drastically reduce the number of collisions through robust safety policies.

关键词： Autonomous vehicle Decision-making Reinforcement learning Adversarial attack Safety guarantee

Fractal Characteristics and Main Controlling Factors of High-Quality Tight Sandstone Reservoirs in the Southeastern Ordos Basin

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Journal of Earth Science 2024年第2期35卷 631-641页

作者： Ruilin Hao wenhui huang Jiu Bo Li Yuan Key Laboratory for Marine Reservoir Evolution and Hydrocarbon Abundance Mechanism School of Energy ResourcesChina University of GeosciencesMinistry of EducationBeijing100083China

Due to the complex conditions and strong heterogeneity of tight sandstone reservoirs,the reservoirs should be classified and the controlling factors of physical properties should be studied.Cast thin section observations,cathodoluminescence,scanning electron microscopy(SEM),X-ray diffraction(XRD),and high-pressure mercury injection(HPMI)were used to classify and optimize the reservoir.The Brooks-Corey model and stepwise regression were used to study the fractal dimension and main controlling factors of the physical properties of the high-quality reservoir.The results show that the reservoirs in the study area can be divided into four types,and the high-quality reservoir has the best physical properties and pore-throat characteristics.In the high-quality reservoir,the homogeneity of transitional pores was the best,followed by that of micropores,and the worst was mesopores.The porosity was controlled by depth and kaolinite.The model with standardized coefficients is y=12.454−0.778×(Depth)+0.395×(Kaolinite).The permeability was controlled by depth,illite/montmorillonite,and siliceous cement,and the model with standardized coefficients is y=1.689−0.683×(Depth)−0.395×(Illite/Montmorillonite)−0.337×(Siliceous Cement).The pore-throat evolutionary model shows that the early-middle diagenetic period was when the reservoir physical properties were at their best,and the kaolinite intercrystalline pores and residual intergranular pores were the most important.

关键词： fractal dimension main controlling factors stepwise regression high-quality tight sandstone reservoir Ordos Basin petroleum geolgoy

Microglial NLRP3 inflammasome-mediated neuroinflammation and therapeutic strategies in depression

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Neural Regeneration Research 2024年第9期19卷 1890-1898页

作者： Qiuqin Han wenhui Li Peiqing Chen Lijuan Wang Xiwen Bao Renyan huang Guobin Liu Xiaorong Chen Department of Scientific Research Shanghai University of Medicine&Health Sciences Affiliated Zhoupu HospitalShanghaiChina Department of Traditional Chinese Vascular Surgery Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese MedicineShanghaiChina Department of Physiology Laboratory of Neurodegenerative DiseasesChangzhi Medical CollegeChangzhiShanxi ProvinceChina

Previous studies have demonstrated a bidirectional relationship between inflammation and depression.Activation of the nucleotide-binding oligomerization domain,leucine-rich repeat,and NLR family pyrin domain-containing 3(NLRP3)inflammasomes is closely related to the pathogenesis of various neurological diseases.In patients with major depressive disorder,NLRP3 inflammasome levels are significantly elevated.Understanding the role that NLRP3 inflammasome-mediated neuroinflammation plays in the pathogenesis of depression may be beneficial for future therapeutic strategies.In this review,we aimed to elucidate the mechanisms that lead to the activation of the NLRP3 inflammasome in depression as well as to provide insight into therapeutic strategies that target the NLRP3 inflammasome.Moreover,we outlined various therapeutic strategies that target the NLRP3 inflammasome,including NLRP3 inflammatory pathway inhibitors,natural compounds,and other therapeutic compounds that have been shown to be effective in treating depression.Additionally,we summarized the application of NLRP3 inflammasome inhibitors in clinical trials related to depression.Currently,there is a scarcity of clinical trials dedicated to investigating the applications of NLRP3 inflammasome inhibitors in depression treatment.The modulation of NLRP3 inflammasomes in microglia holds promise for the management of depression.Further investigations are necessary to ascertain the efficacy and safety of these therapeutic approaches as potential novel antidepressant treatments.

关键词： depression microglia neuroinflammation NLRP3 inflammasome

Lignocellulosic fraction-induced niche differentiation within dissimilatory iron reducing bacterial groups in a paddy soil

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Soil Ecology Letters 2024年第1期6卷 77-88页

作者： Yunbin Jiang Wenting Hu Kailou Liu Shangshu huang Fengwu Zhou Cheng Han Huan Deng wenhui Zhong Jiangsu Provincial Key Laboratory of Materials Cycling and Pollution Control School of GeographyNanjing Normal UniversityNanjing 210023China Jiangsu Centerfor Collaborative Innovation in Geographical Information Resource Development and Application Nanjing 210023China National Engineering and Technology Research Center for Red Soil Improvement Jiangxi Institute of Red Soil and Germplasm ResourcesNanchang 331717China Schoolof Environment Nanjing Normal UniversityNanjing 210023China

Responses of soil DIRB to lignocellulosic fractions during a 6-week microcosm incubation were investigated.Anaeromyxobacter,Bacillus,and Clostridium maintained their domi-nance throughout the incubation.Distinct DIRB groups proliferated under specific lignocellulosic fraction amendments.Limits of insufficient ferric iron on the proliferation varied by DIRB group.Dissimilatory iron reducing bacteria(DIRB)are phylogenetically and physi-ologically diverse in paddy soils,where iron reduction closely couples with the oxidation of rice straw-derived carbon in the straw returning scenarios.However,few studies have addressed the niche differentiation within DIRB groups during the degradation of lignocellulosic fractions of rice straw.This study conducted a 6-week microcosm incubation experiment to reveal the distinct responses of DIRB groups under specific lignocellulosic fraction amendments with and without ferrihydrite(Fh)addition in a flooded paddy Ultisol.Results showed that the total absolute abundance of the 19 detected DIRB groups did not vary significantly during the incubation.Anaeromyxobacter,Bacillus,and Clostridium were the dominant DIRB groups for all lignocellulosic treatments whereas Thermincola was dominant but only under xylan amendment with Fh addition.DIRB-nodes in the co-occurrence networks of bacterial community mainly belonged to Anaeromyxobacter and Bacillus.Clostridium and Thermincola,Alkaliphilus and Anaeromyxobacter,and Alicyclobacillus,Desulfobulbus,and Desulfosporosinus were specifically proliferated under xylan,cellulose,and lignin amendments,respectively.Whether the proliferation was limited by insufficient ferric iron varied by bacterial group.These findings suggested the lignocellulosic fraction-induced niche differentiation within DIRB groups,which advanced our understanding of the ecology of DIRB in paddy soils under straw returning.

关键词： cellulose hemicellulose lignin bacterial community diversity co-occurrence networks

Progenies of NG2 glia: what do we learn from transgenic mouse models ?

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Neural Regeneration Research 2021年第1期16卷 43-48页

作者： Qilin Guo Anja Scheller wenhui huang Molecular Physiology Center for Integrative Physiology and Molecular Medicine(CIPMM)University of SaarlandHomburgGermany

In the mammalian central nervous system,nerve-glia antigen 2(NG2)glia are considered the fourth glial population in addition to astrocytes,oligodendrocytes and microglia.The fate of NG2 glia in vivo has been carefully studied in several transgenic mouse models using the Cre/loxP strategy.There is a clear agreement that NG2 glia mainly serve as progenitors for oligodendrocytes and a subpopulation of astrocytes mainly in the ventral forebrain,whereas the existence of a neurogenic potential of NG2 glia is lack of adequate evidence.This mini review summarizes the findings from recent studies regarding the fate of NG2 glia during development.We will highlight the age-and-region-dependent heterogeneity of the NG2 glia differentiation potential.We will also discuss putative reasons for inconsistent findings in various transgenic mouse lines of previous studies.

关键词： astrogliogenesis cell fate Cre/loxP system development differentiation embryonic brain neurogenesis NG2 glia oligodendrocyte lineage oligodendrocyte precursor cells

维持性血液透析患者合并导管相关性血流感染预后的危险因素分析

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中华危重病急救医学 2024年第2期36卷 183-188页

作者：陈彩合马淑燕黄文辉甘肃中医药大学第一临床医学院兰州730000 甘肃省人民医院肾病科兰州730000

目的分析维持性血液透析(MHD)患者非住院期间发生导管相关性血流感染(CRBSI)的病原菌分布特征及影响预后的危险因素。方法采用回顾性对照研究,选择2020年1月至2023年5月在甘肃省人民医院肾病科因非住院期间发生CRBSI收治的34例以半永久... 详细信息

目的分析维持性血液透析(MHD)患者非住院期间发生导管相关性血流感染(CRBSI)的病原菌分布特征及影响预后的危险因素。方法采用回顾性对照研究,选择2020年1月至2023年5月在甘肃省人民医院肾病科因非住院期间发生CRBSI收治的34例以半永久导管为通路进行MHD的病例为研究对象。分析MHD患者非住院期间发生CRBSI的病原菌分布特点;所有患者入院后积极给予抗感染治疗,通过电子病历系统收集患者的一般资料、实验室检查指标及住院期间预后情况。根据住院期间的治疗结果将患者分为预后不良组(14例)和预后良好组(20例),采用单因素和多因素Logistic回归分析影响患者预后的危险因素,并绘制受试者工作特征曲线(ROC曲线)评估其对预后的预测价值。结果34例患者中共分离出28株病原菌,其中革兰阳性菌25株,葡萄球菌属为最多见病原菌,占总数的82.15%,金黄色葡萄球菌16株(57.15%),包括耐甲氧西林金黄色葡萄球菌(MRSA)6株(21.43%),表皮葡萄球菌7株(25.00%),包括耐甲氧西林表皮葡萄球菌(MRSE)3株(10.71%);革兰阴性菌3株,铜绿假单胞菌、大肠埃希菌、鲍曼不动杆菌各1株。单因素分析显示,MHD合并CRBSI患者预后不良组发热时间比预后良好组明显延长〔d:8.50(3.75,45.00)比2.50(1.00,4.75),P<0.01〕,血清红细胞沉降率(ESR)、C-反应蛋白(CRP)、随机血糖(GLU)均明显高于预后良好组〔ESR(mm/1 h):82.36±24.98比56.95±35.65,CRP(mg/L):123.45±74.10比67.35±55.22,GLU(mmol/L):8.74±3.66比6.42±1.95,均P<0.05〕。多因素Logistic回归分析显示,血清CRP为MHD合并CRBSI患者预后不良的独立危险因素〔优势比(OR)=1.020,95%可信区间(95%CI)为1.002~1.038,P=0.025〕。ROC曲线分析显示,血清CRP预测MHD合并CRBSI患者预后不良的曲线下面积(AUC)为0.711;最佳截断值为104.65 mg/L时,敏感度64.3%,特异度为85.0%,说明其具有较好的预测价值。结论MHD患者非住院期间发生CRBSI时,主要以革兰阳性菌感染为主;且其预后不良主要与较高的血清CRP水平有关;血清CRP水平能有效筛选MHD合并CRBSI患者预后不良的高危人群。

关键词：维持性血液透析导管相关性血流感染预后危险因素

Belimumab shows promise in neuropsychiatric lupus:Another challenge to find the offender

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Rheumatology & Autoimmunity 2023年第2期3卷 115-119页

作者： Shuilian Yu Zhongjun Hou Zhiping Liu Zeying Lin Ling Zhong Qilin Yang wenhui huang Department of Rheumatology Second Affiliated HospitalGuangzhou Medical UniversityGuangzhouGuangdongChina Department of Radiology Second Affiliated HospitalGuangzhou Medical UniversityGuangzhouGuangdongChina Ophthalmic Center Second Affiliated HospitalGuangzhou Medical UniversityGuangzhouGuangdongChina Department of Pathology Second Affiliated HospitalGuangzhou Medical UniversityGuangzhouGuangdongChina Department of Critical Care Second Affiliated HospitalGuangzhou Medical UniversityGuangzhouGuangdongChina

Introduction:Agents that can be used for the treatment of neuropsychiatric lupus(NPSLE)are lacking in the therapeutic armamentarium.Belimumab is a monoclonal antibody targeting the B-cell activating factor(BAFF)and is approved by the US Food and Drug Administration as an additional treatment for systemic lupus erythematosus patients with persistent disease activity and lupus nephritis(LN);however,severe active central nervous system manifestations were excluded.Case Report:We report on a treatment-naïve LN patient with refractory NPSLE complicated with progressive posterior reversible encephalopathy syndrome(PRES)who was successfully treated via the combination of mycophenolate and belimumab,resulting in reversal of persistent headache and neuroradiologic manifestations.Conclusion:Research on this topic could be relevant for identifying a possible correlation between BAFF and psychiatric NPSLE manifestations.

关键词： belimumab lupus nephritis neuropsychiatric lupus posterior reversible encephalopathy syndrome

Principle and numerical demonstration of high power all-fiber coherent beam combination based on self-imaging effect in a square core fiber

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Photonics Research 2022年第2期10卷 444-455页

作者： Yuefang Yan Yu Liu Haoyu Zhang Yue Li Yuwei Li Xi Feng Donglin Yan Jianjun Wang Honghuan Lin Feng Jing wenhui huang Rumao Tao Laser Fusion Research Center China Academy of Engineering PhysicsMianyang 621900China Key Laboratory of Particle&Radiation Imaging(Tsinghua University) Ministry of EducationBeijing 100084China

The self-imaging effect in a square core fiber has been investigated, and an integrated all-fiber combiner has been proposed based on a large mode area double clad fiber, which can be employed to construct high power coherent beam combining sources in the all-fiber format. The influence of various parameters on beam quality(M^(2)) and efficiency of the all-fiber coherent beam combiner has been studied numerically, which reveals that the near diffraction-limited laser beam can be achieved. A principle demonstration of the self-imaging effect has been carried out experimentally in a square core fiber, which proves the feasibility of beam combining with the square fiber, and that it is a promising way to develop high power coherent beam combination sources.

关键词： fiber power beam

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光注入提升晶体硅异质结太阳电池性能的研究

太阳能学报 2024年第4期45卷 519-523页

作者：沈旭宇黄信二吕文辉湖州师范学院理学院湖州313000 湖州师范学院工学院湖州313000 湖州爱康光电科技有限公司湖州313117

该文制备工业尺寸的晶体硅异质结太阳电池,研究光注入对电池光电性能的影响。实验结果表明:光注入有效提升了晶体硅异质结太阳电池的光电转换效率,经过光注入后电池光电转换绝对效率提升了0.33%,均值达到24.47个百分点。对比光注入前后... 详细信息

该文制备工业尺寸的晶体硅异质结太阳电池,研究光注入对电池光电性能的影响。实验结果表明:光注入有效提升了晶体硅异质结太阳电池的光电转换效率,经过光注入后电池光电转换绝对效率提升了0.33%,均值达到24.47个百分点。对比光注入前后的光电性能参数,其效率提升的主要因素是光注入使得电池的填充因子被有效提升。结合光注入前后电池的Suns-Voc测试,证实了光注入能使电池的串联电阻大比例降低。因此,光注入改善电池性能的主要物理原因可归结为:串联电阻的降低提升了电池的填充因子。

关键词：硅太阳电池异质结光注入光电转换效率串联电阻

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Design of a L-band cavity optimized for Robinson instability in the TTX-II storage ring

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Radiation Detection Technology and Methods 2019年第1期3卷 1-7页

作者： Tenghui Rui wenhui huang Accelerator Laboratory Department of Engineering PhysicsTsinghua UniversityBeijing 100084China

Background Tsinghua Thomson Scattering X-ray Source Phase II is a Thomson scattering-based X-ray source currently under development at Accelerator Laboratory in Tsinghua University.Purpose The purpose of this paper is to design a L-band cavity for the storage ring and to study the coupled bunch instability induced by the HOMs of the cavity.Methods The growth rates and tune shifts of the coupled bunch instability are calculated with approximation formulas and simulated with particle tracking code.The frequency of HOMs is optimized that the Landau damping can suppress the coupled bunch instability.A prototype cavity is manufactured and cold-tested.Results The HOM frequencies can be tuned away from beam spectrum,and the CBI instability can be easily suppressed with Landau damping.Conclusion Without HOM dampers or feedback system,the HOMs can be tuned during design phase such that the CBI instability can be suppressed.

关键词： Robinsoninstability HOM Landaudamping TTX