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Targeting TLR4 and regulating the Keap1/Nrf2.pathway with andrographolide to suppress inflammation and ferroptosis in LPS-induced acute lung injury

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Chinese Journal of Natural Medicines 2024年第10期22卷 914-928页

作者： LI Yichen HUANG Liting LI Jilang LI Siyuan LV Jianzhen ZHONG Guoyue GAO Ming YANG Shilin HAN Shan HAO wenhui Life Sciences Institute Guangxi Medical University College of Pharmacy Guangxi University of Chinese Medicine National Pharmaceutical Engineering Center for Solid Preparation in Chinese Herbal.Medicine Jiangxi University of Traditional Chinese Medicine Xinjiang Key Laboratory of Molecular Biology for Endemic Diseases Department of Biochemistry and Molecular BiologySchool of Basic Medical Sciences Xinjiang Medical University

Acute lung injury（ALI） is a severe inflammatory condition with a high mortality rate, often precipitated by sepsis. The pathophysiology of ALI involves complex mechanisms, including inflammation, oxidative stress, and ferroptosis, a novel form of regulated cell death. This study explores the therapeutic potential of andrographolide（AG）, a bioactive compound derived from Andrographis, in mitigating Lipopolysaccharide（LPS）-induced inflammation and ferroptosis. Our research employed in vitro experiments with RAW2.4.7 macrophage cells and in vivo studies using a murine model of LPS-induced ALI. The results indicate that AG significantly suppresses the production of pro-inflammatory cytokines and inhibits ferroptosis in LPS-stimulated RAW2.4.7 cells. In vivo, AG treatment markedly reduces lung edema, decreases inflammatory cell infiltration, and mitigates ferroptosis in lung tissues of LPS-induced ALI mice. These protective effects are mediated via the modulation of the Toll-like receptor 4（TLR4）/Kelch-like ECH-associated protein 1（Keap1）/Nuclear factor erythroid 2.related factor 2.Nrf2. signaling pathway. Molecular docking simulations identified the binding sites of AG on the TLR4 protein(Kd value:-33.5 kcal·mol-1), and these interactions were further corroborated by Cellular Thermal Shift Assay（CETSA） and SPR assays. Collectively, our findings demonstrate that AG exerts potent anti-inflammatory and anti-ferroptosis effects in LPS-induced ALI by targeting TLR4 and modulating the Keap1/Nrf2.pathway. This study underscores AG's potential as a therapeutic agent for ALI and provides new insights into its underlying mechanisms of action.

关键词： Acute lung injury Andrographolide Ferroptosis Kelch-like ECH-associated protein 1/Nuclear factor erythroid 2.related factor 2 Toll-like receptor 4

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胃癌化疗患者营养治疗的研究进展

肿瘤研究与临床 2024年第2期36卷 149-153页

作者：丁雅倩薛文慧杨文慧山西医科大学第三医院(山西白求恩医院、山西医学科学院、同济山西医院)肿瘤中心太原030032 山西省肿瘤医院中国医学科学院肿瘤医院山西医院山西医科大学附属肿瘤医院消化内科太原030013

胃癌是世界第五大最常见的癌症,化疗是主要治疗方法之一,由于化疗药物导致的不良反应,约87%的患者合并营养不良。虽然营养治疗理念不断推进,仍然缺乏足够的重视,导致胃癌患者营养不良的治愈率较低。营养不良作为胃癌患者独立的死亡风险... 详细信息

胃癌是世界第五大最常见的癌症,化疗是主要治疗方法之一,由于化疗药物导致的不良反应,约87%的患者合并营养不良。虽然营养治疗理念不断推进,仍然缺乏足够的重视,导致胃癌患者营养不良的治愈率较低。营养不良作为胃癌患者独立的死亡风险因素,不仅导致不良临床结局,还会造成巨大的社会经济负担。文章总结了近年来胃癌化疗患者的营养支持治疗,包括对营养评估工具的选择、营养治疗的方法及效果,并对未来普遍应用于临床进行展望。

关键词：胃肿瘤胃肠外营养辅助治疗肠内营养

Tomato detection method using domain adaptive learning for dense planting environments

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农业工程学报 2024年第13期40卷 134-145页

作者： LI Yang HOU wenhui YANG Huihuang RAO Yuan WANG Tan JIN Xiu ZHU Jun College of Information and Artificial Intelligence Anhui Agricultural UniversityHefei 230036China Key Laboratory of Agricultural Sensors Ministry of Agriculture and Rural AffairsHefei 230036China College of Engineering Anhui Agricultural UniversityHefei 230036China

This study aimed to address the challenge of accurately and reliably detecting tomatoes in dense planting environments,a critical prerequisite for the automation implementation of robotic ***,the heavy reliance on extensive manually annotated datasets for training deep learning models still poses significant limitations to their application in real-world agricultural production *** overcome these limitations,we employed domain adaptive learning approach combined with the YOLOv5 model to develop a novel tomato detection model called as TDA-YOLO(tomato detection domain adaptation).We designated the normal illumination scenes in dense planting environments as the source domain and utilized various other illumination scenes as the target *** construct bridge mechanism between source and target domains,neural preset for color style transfer is introduced to generate a pseudo-dataset,which served to deal with domain ***,this study combines the semi-supervised learning method to enable the model to extract domain-invariant features more fully,and uses knowledge distillation to improve the model's ability to adapt to the target ***,for purpose of promoting inference speed and low computational demand,the lightweight FasterNet network was integrated into the YOLOv5's C3 module,creating a modified C3_Faster *** experimental results demonstrated that the proposed TDA-YOLO model significantly outperformed original YOLOv5s model,achieving a mAP(mean average precision)of 96.80%for tomato detection across diverse scenarios in dense planting environments,increasing by 7.19 percentage points;Compared with the latest YOLOv8 and YOLOv9,it is also 2.17 and 1.19 percentage points higher,*** model's average detection time per image was an impressive 15 milliseconds,with a FLOPs(floating point operations per second)count of 13.8 *** acceleration processing,the detection accuracy of the TDA-YOLO mo

关键词： plants models domain adaptive tomato detection illumination variation semi-supervised learning dense planting environments

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促进就业视角的英国城市更新实践及其启示

现代城市研究 2024年第8期39卷 82-89页

作者：郑文晖南昌大学建筑工程学院江西省土木建筑学会城市更新专业委员会

文章从促进就业的视角审视英国城市更新实践。通过历程回顾、成效评析、政策梳理和典型实践剖析,总结出英国城市更新中促进就业的实践经历了政府主导、房地产驱动、多元协同驱动、“城市—街区”平行推动等历程。从以综合性更新为路径... 详细信息

文章从促进就业的视角审视英国城市更新实践。通过历程回顾、成效评析、政策梳理和典型实践剖析,总结出英国城市更新中促进就业的实践经历了政府主导、房地产驱动、多元协同驱动、“城市—街区”平行推动等历程。从以综合性更新为路径、以顺应产业发展为基础、以促进职住平衡等方面为关键概括英国促进就业的城市更新导向。剖析完善规划框架、倡导精明增长、加强配套服务、提高响应能力、使用分区工具、鼓励自主更新等促进就业的规划策略。解析多元协同促进就业的城市更新模式。最后,结合英国的启示,提出我国在实施城市更新行动中促进就业的建议。

关键词：城市更新就业英国政策启示

高温高压应用环境下陶瓷外壳设计加工及可靠性评估

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微电子学 2024年第2期54卷 304-310页

作者：刘文辉西安电子科技大学西安710068 芯业时代科技有限公司西安710000

为满足碳化硅二极管在高温(大于2.0℃)、高压(大于2. kV)环境下的应用需求,采用注浆成型的陶瓷加工工艺制作了一款三腔室外壳。与传统塑料封装相比,陶瓷外壳提高了器件的工作温度和绝缘耐压特性,发挥了碳化硅材料的高温应用优势。针对... 详细信息

为满足碳化硅二极管在高温(大于2.0℃)、高压(大于2. kV)环境下的应用需求,采用注浆成型的陶瓷加工工艺制作了一款三腔室外壳。与传统塑料封装相比,陶瓷外壳提高了器件的工作温度和绝缘耐压特性,发挥了碳化硅材料的高温应用优势。针对高低温循环试验后因材料形变导致陶瓷外壳开裂的问题,使用Ansys软件仿真了温度变化导致的结构应力,并优化了外壳隔墙结构,优化后的外壳结构通过了环境应力试验。参照此结构可以采用单腔室、双腔室、多腔室的结构开发出不同电压等级外壳。同样,参照此结构可以采用不同大小的腔室开发出不同正向整流能力的外壳。

关键词：碳化硅陶瓷整流器硅堆超高压可靠性

知识生产、文本流变与阐释的陷阱--以《望夫云》传说为中心的考察

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原生态民族文化学刊 2024年第1期16卷 118-130,156页

作者：杨文辉云南大学图书馆昆明650091

有关《望夫云》的知识生产经历了一个较长时间的历史过程,是洱海区域的地方性知识与中原传统知识资源有机交融的结果。基于文献记录的梳理表明,《望夫云》不是产生于南诏时期,而是在明代见于载录的多种知识资源基础上,由知识精英于清初... 详细信息

有关《望夫云》的知识生产经历了一个较长时间的历史过程,是洱海区域的地方性知识与中原传统知识资源有机交融的结果。基于文献记录的梳理表明,《望夫云》不是产生于南诏时期,而是在明代见于载录的多种知识资源基础上,由知识精英于清初重新书写而正式产生。文本所反映的,是明末清初洱海区域的社会情境;当下对《望夫云》的主流认知,则肇始于徐嘉瑞先生对《望夫云》的重新建构与阐释。

关键词：知识生产文本流变民间传说望夫云

Unveiling the nexus:Decoding interactions between regulated cell death and systemic lupus erythematosus pathogenesis for innovative therapeutic avenues

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Rheumatology & Autoimmunity 2024年第1期4卷 1-10页

作者： Qing Tan wenhui Huang Yu Zheng Mingyan Li Yi Tao Shuilian Yu Department of Rheumatology The Second Affiliated Hospital of Guangzhou Medical UniversityGuangzhou Medical UniversityGuangdongGuangzhouChina Department of Urology The Second Affiliated Hospital of Guangzhou Medical UniversityGuangzhou Medical UniversityGuangdongGuangzhouChina Department of Cardiology The Second Affiliated Hospital of Guangzhou Medical UniversityGuangzhou Medical UniversityGuangdongGuangzhouChina

Systemic lupus erythematosus(SLE)is characterized by disruptions in cell death pathways and impaired clearance of apoptotic cells,resulting in immune dysregulation and tissue *** review explores the complex interplay of regulated cell death(RCD)mechanisms,including apoptosis,necroptosis,pyroptosis,NETosis,autophagy,and ferroptosis,in the pathogenesis of *** pathways release autoantigens and danger signals,triggering autoimmune reactions and *** various RCDs have mutual associates to support immune dysregulation and are associated with *** intrinsically induces immune tolerance by packaging dying cells into immunologically inert *** in apoptotic clearance will result in impaired ***,pyroptosis,NETosis,and ferroptosis lead to cell membrane destruction,production of intracellular immunostimulatory components,and triggering a strong inflammatory immune *** autophagic activity affects the development,differentiation,function,and metabolism of many immune cell *** the interconnections between cell death pathways and SLE sheds light on the disease's underlying mechanisms and provides opportunities for novel therapeutic *** convergence of precision medicine and innovative strategies targeting these intricate pathways holds promise for expanding the landscape of SLE treatment.

关键词： autoimmunity immune dysregulation innovative therapies regulated cell death systemic lupus erythematosus therapeutic targets

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科技创新视角下中国农业“走出去”战略研究

价格理论与实践 2024年第4期 11-15,82页

作者：陈文晖北京服装学院时尚研究院

2.06年农业“走出去”战略正式提出以来,中国农业“走出去”取得显著成效。但是,在贸易保护主义和投资保护主义的影响下,农业对外贸易和农业对外投资领域的传统战略逐渐面临新环境的挑战,科技创新逐渐成为推进中国农业“走出去”战略的... 详细信息

2.06年农业“走出去”战略正式提出以来,中国农业“走出去”取得显著成效。但是,在贸易保护主义和投资保护主义的影响下,农业对外贸易和农业对外投资领域的传统战略逐渐面临新环境的挑战,科技创新逐渐成为推进中国农业“走出去”战略的强劲动力。本文以科技创新的视角,全面分析了推进中国农业“走出去”战略的机理、现状与面临的挑战。从提升农产品科技竞争力、深化目标市场研究和开拓以及加强保障机制建设方面提出推进农业“走出去”的创新路径。

关键词：科技创新中国农业 “走出去”

IRS辅助的毫米波MIMO系统多目标波束赋形算法

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北京邮电大学学报 2024年第3期47卷 124-129页

作者：王晓辉许鹏常文慧沈阳航空航天大学电子信息工程学院沈阳110136

针对分布式智能反射面(IRS)辅助的毫米波多输入多输出(MIMO)系统中无法兼顾能量效率和频谱效率的问题,提出一种基于能量效率和频谱效率权衡的多目标优化的主、被动波束赋形算法。首先,利用线性加权法建立能量效率和频谱效率的多目标优... 详细信息

针对分布式智能反射面(IRS)辅助的毫米波多输入多输出(MIMO)系统中无法兼顾能量效率和频谱效率的问题,提出一种基于能量效率和频谱效率权衡的多目标优化的主、被动波束赋形算法。首先,利用线性加权法建立能量效率和频谱效率的多目标优化框架;其次,利用交替优化算法联合优化主动波束赋形和被动波束赋形;最后,利用半正定松弛算法解决非凸的单位模约束问题。仿真实验结果表明,所提算法可以根据实际通信业务灵活调节权衡系数,以实现能量效率与频谱效率之间的均衡。

关键词：毫米波多输入多输出智能反射面波束赋形能量效率频谱效率