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海洋中药治疗骨质疏松的用药规律及作用机制

中国组织工程研究 2025年第17期29卷 3713-3723页

作者：赖越林轩徐淼刘欢沈剑粦黄文华广东医科大学第一临床医学院广东省湛江市524023 莆田学院环境与生物工程学院福建省莆田市351100 福建医科大学基础医学院福建省福州市350100 西南医科大学附属中医医院骨科四川省泸州市646000 莆田学院附属医院中心实验室福建省莆田市351100 南方医科大学基础医学院人体解剖学国家重点学科广东省数字医学与生物力学重点实验室广东省医学3D打印应用转化工程技术研究中心广东省广州市510515

背景:海洋中药为治疗骨质疏松提供了一种潜在有效且不易产生不良反应的方法。目的:应用数据挖掘和网络药理学方法分析并探讨中医临床治疗骨质疏松的用药规律及作用机制。方法:采用数据挖掘和网络药理学方法,对国家知识产权局批准的治疗... 详细信息

背景:海洋中药为治疗骨质疏松提供了一种潜在有效且不易产生不良反应的方法。目的:应用数据挖掘和网络药理学方法分析并探讨中医临床治疗骨质疏松的用药规律及作用机制。方法:采用数据挖掘和网络药理学方法,对国家知识产权局批准的治疗骨质疏松的海洋中药专利处方进行用药模式和作用机制研究,并特别关注这些处方中的核心中药成分,利用超高效液相色谱串联质谱对牡蛎-续断-淫羊藿组成的复方药组核心成分进行全面的鉴定分析。结果与结论:①从国家知识产权局(SIPO)网站建立到2024-04-01,检索发现381项骨质疏松治疗的授权专利,共鉴定出48首含有海洋中药的中成药处方,这些处方包含183味中药,其中13种海洋中药用药频次共574次,单首专利组方中用药味数2-41种不等;②牡蛎是最常用的海洋中药,续断、淫羊藿、地黄、杜仲是最常用的非海洋中药;关联规则分析确定了牡蛎、续断和淫羊藿为核心药物群;网络药理学分析显示该核心药组治疗骨质疏松的核心靶点包括ALB、AKT1、TP53、PPARG和SRC;核心药组发挥疗效的核心成分为谷甾醇、甘草素、臭山羊碱、木犀草素、山奈酚;③GO与KEGG富集分析显示,Rap1/丝裂原活化蛋白激酶信号通路在核心药物组的骨质疏松作用机制中起着重要作用;④分子对接结果显示核心成分与核心靶点之间存在良好的相互作用;⑤超高效液相色谱串联质谱检测复方药组核心成分为木犀草素、谷甾醇、山奈酚等,与网络药理学鉴定的药物成分相符合;对复方药组成分进行定量分析得出,黄酮类化合物、萜类化合物以及生物碱这3类物质在药物成分占比中较大。

关键词：骨质疏松海洋中药数据挖掘网络药理学分子对接

Coke precursor as an intermediate during the alkylation of isobutane/butene over a solid superacid

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Science China Chemistry 2004年第2期47卷 173-178页

作者： XIE wenhua FU Qiang Research Institute of Petroleum Processing Sinopec Beijing 100083 China Research Institute of Petroleum Processing Sinopec Beijing 100083 China

Alkylation of isobutane/butene was conducted on a Br?nsted-Lewis conjugated solid superacid. It is found that some hydrocarbons accumulated on the catalyst surface. These hydrocarbons, as called coke precursor, played an intermediate role at the initial stage of the alkylation before they lead the catalyst to lose its activity. The presence of the intermediate is beneficial to the alkylation between isobutane and butene, while increase the TMP content and TMP/DMH ratio in the products

关键词： alkylation, isobutane/butene, solid superacid, intermediate.

Optimal Design of Multiple Stresses Accelerated Life Test Plan Based on Transforming the Multiple Stresses to Single Stress

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Chinese Journal of Mechanical Engineering 2014年第6期27卷 1125-1132页

作者： GAO Liang CHEN wenhua QIAN Ping PAN Jun HE Qingchuan College of Mechanical and Electrical Engineering Sichuan Agricultural University Zhejiang Province's Key Laboratory for Reliability Technology of Mechanical & Electrical Products Zhejiang Sci-Tech University

For planning optimum multiple stresses accelerated life test plans, a commonly followed guiding principle is that all parameters of the life-stress relationship should be estimated, and the number of the stress level combinations must be no less than the number of parameters of the life-stress relationship. However, the general objective of an accelerated life test（ALT） is to assess thep-th quantile of the product life distribution under normal stress. For this objective,estimating all model parameters is not necessary, and this will increase the cost of test. Based on the theoretical conclusion that the stress level combinations of the optimum multiple stresses ALT plan locate on a straight line through the origin of coordinate, it is proposed that a design idea of planning the optimum multiple stresses ALT plan through transforming the problem of designing an optimum multiple stresses ALT plan to designing an optimum single stress ALT plan. Moreover, a method of planning the optimum multiple stresses ALT plan which can avoid estimating all model parameters is established. An example shows that, the proposed plan which only has two stress level combinations could achieve an accuracy no less than the traditional plan, and save the test time and cost on one stress level combination at least; when the actual product life is less than the design value, even the deviation of the model initial parameters value is up to 20%, the variance of the estimation of thep-th quantile of the proposed plan is still smaller than the traditional plans approximately 25%. A design method is provided for planning the optimum multiple stresses ALT which uses the statistical optimum degenerate test plan as the optimum multiple stresses accelerated life test plan.

关键词： multiple stresses accelerated testing optimum design test planning

DRA Audio Coding Standard

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Chinese Journal of Electronics 2014年第3期23卷 521-526页

作者： MA wenhua XU Jing MA Yuanzhe YOU Yuli Department of Computers Cisco School of InformaticsGuangdong University of Foreign Studies Department of Science and Technology Guangdong Rising Assets Management Co. Department of Biomedical Science and Technology South China University of Technology Guangdong Provincial Key Laboratary for Digital Audio Technology

DRA(Dynamic resolution adaptation)audio coding standard was shown to deploy transientlocalized MDCT to effectively suppress pre-echo artifacts and statistic allocation of codebooks to improve the compression efficiency of Huffman coding. Its quantizers and Huffman codebooks are designed in such a way that a signal path of 24 bits is provided throughout the codec so that high audio quality can be delivered if bit rate *** simple, it delivers state-of-the-arts compression efficiency as shown by five rounds of ITU-R BS.11116 compliant subjective listening tests.

关键词： Audio coding Standard Listening test Modified discrete cosine transform(MDCT) Huffman coding

gt-C3N4 coordinated single atom as an efficient electrocatalyst for nitrogen reduction reaction

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Nano Research 2019年第5期12卷 1181-1186页

作者： Lifu Zhang Wanghui Zhao wenhua Zhang Jing Chen Zhenpeng Hu School of Physics Nankai UniversityTianjin 300071China Hefei National Laboratory for Physical Sciences at the Microscale CAS Key Laboratory of Materials for Energy Conversion and Synergetic Innovation Centre of Quantum Information & Quantum PhysicsUniversity of Science and Technology of ChinaHefei 230026China Collaborative Innovation Center of Extreme Optics Shanxi UniversityTaiyuan 030006China

The electrochemical reduction of nitrogen to ammonia is a promising way to produce ammonia at mild *** design and preparation of an efficient catalyst with high ammonia selectivity is critical for the real *** this work,a series of transition metal (TM =Sc,Ti,V,Cr,Mn,Fe,Co,Ni,Cu,Zn,Y,Zr,Nb,Mo,Tc,Ru,Rh,Pd,Ag,and Cd) atoms supported by gt-C3N4 (TM/gt-C3N4) are investigated as electrocatalysts for the nitrogen reduction reaction (NRR) based on density functional *** is found that Mo/gt-C3N4 with a limiting potential of-0.82 V is the best catalyst for standing-on adsorbed N2 *** for lying-on adsorbed N2 cases,V/gt-C3N4 with a limiting potential of-0.79 V is berer than other *** is believed that this work provides several promising candidates for the non-noble metal electrocatalysts for NRR at mild condition.

关键词： nitrogen reduction reaction single-atom catalyst first-principles calculation Gibbs free energy

Continuity of the robustness of contextuality of empirical models

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Science China(Physics,Mechanics & Astronomy) 2016年第10期59卷 11-18页

作者： HuiXian Meng HuaiXin Cao wenhua Wang Liang Chen Yajing Fan School of Mathematics and Information Science Shaanxi Normal University School of Ethnic Nationalities Education Shaanxi Normal University

Recently, the robustness of contextuality(RoC) of an empirical model was discussed in [Sci. China-Phys. Mech. Astron. 59,640303(2016)], many important properties of the RoC have been proved except for its boundedness and continuity. The aim of this paper is to find an upper bound for the RoC over all of empirical models and prove that the RoC is a continuous function on the set of all empirical models. Lastly, a relationship between the RoC and the extent of violating the noncontextual inequalities is established for an n-cycle contextual box. This relationship implies that the RoC can be used to quantify the contextuality of n-cycle boxes.

关键词： empirical model robustness of contextuality boundedness continuity

Species-specific Response of Photosynthesis to Burning and Nitrogen Fertilization

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Journal of Integrative Plant Biology 2008年第5期50卷 565-574页

作者： Yanfang Zhang Shuli Niu wenhua Xu Yi Han State Key Laboratory of Vegetation and Environmental Change Institute of Botany Chinese Academy of Sciences Beijing 100093 China Graduate University of Chinese Academy of Sciences Beijing 100049 China

The present study was conducted to examine photosynthetic characteristics of three dominant grass species （Agropyron cristatum, Leymus chinensis, and Cleistogenes squarrosa） and their responses to burning and nitrogen fertilization in a semiarid grassland in northern China. Photosynthetic rate （Pn）, stomatal conductance （gs）, and water use efficiency （WUE） showed strong temporal variability over the growing season. C. squarrosa showed a significantly higher Pn and WUE than A. cristatum and L. chinensis. Burning stimulated Pn of A. cristatum and L. chinensis by 24-59% （P 〈 0.05） in the early growing season, but not during other time periods. Light-saturated photosynthetic rate （Pmax） in A. cristatum and the maximum apparent quantum yield （Фmax） in A. cristatum and L. chinensis were significantly enhanced by burning （16-67%） in both the fertilized and unfertilized plots. The main effect of burning on Pn, Pmax and Фmax was not significant in C. squarrosa. The burning-induced changes in soil moisture could explain 51% （P= 0.01） of the burning-induced changes in Pn of the three species. All three species showed positive responses to N fertilization in terms of Pn, Pmax, and Фmax. The stimulation of Pn under N fertilization was mainly observed in the early growing season when the soil extractable N content was significantly higher in the fertilized plots. The N fertilization-induced changes in soil extractable N content could explain 66% （P = 0.001） of the changes in Pn under N fertilization. The photosynthetic responses of the three species indicate that burning and N fertilization will potentially change the community structure and ecosystem productivity in the semiarid grasslands of northern China.

关键词： Agropyron cristatum burning Cleistogenes squarrosa Leymus chinensis nitrogen fertilization photosynthesis

Entransy analysis of open thermodynamic systems

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Chinese Science Bulletin 2012年第22期57卷 2934-2940页

作者： CHENG XueTao WANG wenhua LIANG XinGang Key Laboratory for Thermal Science and Power Engineering of Ministry of Education Department of Engineering MechanicsTsinghuaUniversityBeijing 100084China

The concept of entransy developed in recent years can describe the heat transport *** paper extends this concept to the open thermodynamic system and defines the concept of enthalpy *** entransy balance equation of steady open thermodynamic systems,as well as the concept of entransy loss,is *** entransy balance equation is applied to analyzing and discussing the air standard *** is found that the entransy loss rate can describe the change in net power output from the cycle but the entropy generation rate cannot when the heat absorbed by the working medium is from the combustion reaction of the gas *** the working medium is heated by a high temperature stream,both the maximum entransy loss rate and the minimum entropy generation rate correspond to the maximum net power output from the ***,the concept of entransy loss is an appropriate figure of merit that describes the cycle performance.

关键词：热力学系统循环性能平衡方程功率输出工作介质生成速率损失率传输能力

Evaluation of the k-nearest neighbor method for forecasting the influent characteristics of wastewater treatment plant

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Frontiers of Environmental Science & Engineering 2016年第2期10卷 299-310页

作者： Minsoo KIM Yejin KIM Hyosoo KIM wenhua PIAO Changwon KIM Department of Civil and Environmental Engineering Pusan National University Busan 609-735 Republic of Korea Department of Civil and Environmental Engineering Catholic University of Pusan Busan 609-757 Republic of Korea EnvironSoft Co. Ltd. #511 Industry-University Co.Bld. Pusan Nationai University Busan 609-735 Republic of Korea

The k-nearest neighbor （k-NN） method was evaluated to predict the influent flow rate and four water qualities, namely chemical oxygen demand （COD）, suspended solid （SS）, total nitrogen （T-N） and total phosphorus （T-P） at a wastewater treatment plant （WWTP）. The search range and approach for determining the number of nearest neighbors （NNs） under dry and wet weather conditions were initially optimized based on the root mean square error （RMSE）. The optimum search range for considering data size was one year. The square root-based （SR） approach was superior to the distance factor-based （DF） approach in determining the appropriate number of NNs. However, the results for both approaches varied slightly depending on the water quality and the weather conditions. The influent flow rate was accurately predicted within one standard deviation of measured values. Influent water qualities were well predicted with the mean absolute percentage error （MAPE） under both wet and dry weather conditions. For the seven-day prediction, the difference in predictive accuracy was less than 5% in dry weather conditions and slightly worse in wet weather conditions. Overall, the k-NN method was verified to be useful for predicting WWTP influent characteristics.

关键词： influent wastewater prediction data-drivenmodel k-nearest neighbor method (k-NN)