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The anti-inflammatory feature of glucagon-like peptide-1 and its based diabetes drugs-Therapeutic potential exploration in lung injury

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Acta Pharmaceutica Sinica B 2022年第11期12卷 4040-4055页

作者： Juan Pang Jia Nuo Feng wenhua ling Tianru Jin Department of Nutrition School of Public HealthSun Yat-sen UniversitynstituteGuangzhou 510080China Division of Advanced Diagnostics Toronto General Hospital Research IUniversity Health NetworkToronto M5G 1L7Canada Department of Physiology Faculty of MedicineUniversity of TorontoToronto M5S 1AICanada Banting and Best Diabetes Centre Faculty of MedicineUniversity of ToromtoToronto M5G 2C4Canada

Since 2005,GLP-1 receptor(GLP-IR)agonists(GLP-IRAs)have been developed as therapeutic agents for type 2 diabetes(T2D).GLP-IR is not only expressed in pancreatic islets but also other organs,especially the ***,controversy on extra pancreatic GLP-IR expression still needs to be further resolved,utilizing different tools including the use of more reliable GLP-IR antibodies in immune-staining and ***-pancreatic expression of GLP-IR has triggered extensive investigations on extra-pancreatic functions of GLP-1RAs,aiming to repurpose them into therapeutic agents for other *** studies have demonstrated promising anti-infammatory features of *** those features are directly mediated by GLP-IR expressed in immune cells also remains *** a brief review on GLP-1 as an incretin hormone and the development of GLP-IRAs as therapeutic agents for T2D,we have summarized our current understanding of the antiinflammatory features of GLP-IRAS and commented on the controversy on extra-pancreatic GLP-IR *** main part of this review is a literature discussion on GLP-IRA utilization in animal models with chronic airway diseases and acute lung injuries,including studies on the combined use of mesenchymal stem cell(MSC)based *** is followed by a brief summary.

关键词： Anti inflammation Exenatide GLP-1R GLP-1RAs Liraglutide Lung injury MSC-based therapy TxNIP

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Commentary:Can FXR serve as a potential target for COVID-19 prevention?

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Acta Pharmaceutica Sinica B 2023年第4期13卷 1786-1788页

作者： Juan Pang Jia Nuo Feng wenhua ling Tianru Jin Division of Nutrition School of Public HealthSun Yat-sen UniversityGuangzhou 510080China Banting and Best Diabetes Centre Faculty of MedicineUniversity of TorontoTorontoON M5G 2C4Canada Dept.of Physiology University of TorontoTorontoON M5G 1X8Canada Division of Advanced Diagnostics Toronto General Hospital Research InstituteUniversity Health NetworkTorontoON M5G 2C4Canada

A research article has been accepted by Nature very recently entitled:FXR inhibition may protect from SARS-CoV-2 infection by reducing *** is a multiple-author study by 80 scientists from 40 different research units in UK,Germany,Greece,USA,Austria,Sweden,and Norway,with Teresa Brevini as the 1st author and one of the senior authors^(1).The pre-print of this study was posted online back to June 7,2021(bioRxiv).

关键词： COVID-19 ACE2 FXR Bile acid

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Inhibition of S-adenosylhomocysteine Hydrolase induces cellular senescence in rat aorta vascular smooth muscle cells via NF-κB-SASP pathway

Inhibition of S-adenosylhomocysteine Hydrolase induces cellu...

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中国营养学会第十五届全国营养科学大会

作者： Jiaxin Mi wenhua ling Sun Yat-sen University

Recently, an increasing trend has been observed in the incidence and mortality rate of atherosclerotic cardiovascular disease(ASCVD) in China. Atherosclerosis(AS) occurs primarily in large and medium-sized arteries, including endothelial cells and vascular smooth muscle cells(VSMCs), the latter promotes plaque formation. Accordingly, aging VSMCs are considered as crucial cellular components of the atherosclerotic plaques. Further research found that senescent smooth muscle cells will become secretory cells at a later stage, that is senescence-associated secretory phenotypes(SASP). SASP contributes to the senescence of pre-senescent cells, thereby promoting senescence. NF-κB plays an important role in the induction of SASP. When cells are senescent or DNA damage is induced, NF-κB translocated to the nucleus where it binds to the promoters of several SASP genes to regulate their transcription. Many factors, such as pathogen exposure, inflammatory cytokines, radiation, and other stress signals can activate the NF-κB pathway. As SAH is a potent inhibitor of DNMTs, however, it is worth noting that the expression of inflammatory factors and NF-κB can be regulated by DNMTs. SAH is an endogenous inhibitor of cell methyltransferases, and it is hydrolyzed and converted into homocysteine(Hcy) by S-adenosylhomocysteine Hydrolase(SAHH), which is a reversible process. A large number of studies have suggested that SAH may play a key role in the development of AS. However, the role and the mechanism underlying the action of SAH in cellular senescence and AS progression remain unclear, although it is known that elevated intracellular SAH levels are associated with vascular aging. Furthermore, our study confirmed that elevated intracellular SAH levels can result in the hypomethylation of the NF-κB promoter region. Based on our results, we concluded that the SAHH-SAH–NF-κB–SASP pathway can act as a novel potential biological target for ameliorating vascular senescence and for the trea

关键词： S-adenosylhomocysteine inhibition rat aorta vascular smooth muscle cells NF-κB senescence-associated secretory phenotype CpG islands DNA methylation vascular aging AS

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Anthocyanin attenuates disturbance of intestinal barrier in high-fat/high-cholesterol diet-challenged mice through regulating the response of T-helper 17 cells

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Food Science and Human Wellness 2023年

作者： Qiannan Liu Juan Pang Yi Tang Yiran You Jiaxin Mi Jinghe Xiao Yu Chen wenhua ling Department of Nutrition， School of Public Health， Sun Yat-sen University Laboratory of Clinical Pharmacy and Adverse Drug Reaction， West China Hospital， Sichuan University Department of nutrition， The First People's Hospital of Zhaoqing Guangdong Provincial Key Laboratory of Food， Nutrition and Health

Anthocyanin， as a typical food bioactive molecule， is capable of reversing inflammatory， oxidative and allergic condition thus contributes to intestinal health. We were wondering whether anthocyanin has influence on the infiltration of inflammatory cells into the intestinal mucosa and thus help enhancing intestinal barrier which could be damaged in some metabolic diseases. In this study， the influence of anthocyanin (administered orally) on the alterations (including structure and permeability) of the intestinal mucosa in mice in response to a high-fat and high-cholesterol (HFHC) diet was investigated. Primary T helper 17 (Th17) cells were isolated from mouse intestine tissues to observe the modulatory role of anthocyanin through the transcription 3 phosphorylation (p-stat3). The results indicated that anthocyanin significantly alleviated HFHC-induced impairment in the intestinal structures and permeability in a dose-dependent manner; moreover， anthocyanin appeared to inhibit HFHC induced the expression of p-stat3， thereby disturbing Th17 cell differentiation. In high-fat diet (HFD， cholesterol level non-modified)-challenged mice selective p-stat3 inhibitor significantly reversed the effects of anthocyanin， which were decreased amount of IL-17A (produced and released from Th17 cells) and the protected intestinal structure/function. In summary， the results of this study suggests that anthocyanin may attenuate the damage of intestinal barrier in HFHC mice through regulating intestinal STAT3-Th17-IL17A signal transduction pathway.

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Phytochemicals and Health

Phytochemicals and Health

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首届中国西部营养与健康、亚健康学术会议

作者： ling wenhua Sun Yat-sen University

Phytochemicals and Health Classification of food Animal food Plant food{Nutrients Phytochemicals Phytochemicals——bioactive nonnutrient plant compoundsClassification of dietary hytochemicals Classification of dietary... 详细信息

关键词：中国西部亚健康 Phytochemicals and Health 学术论文汇编

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膳食模式与慢性病防治

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中华预防医学杂志 2018年第3期52卷 217-220页

作者：凌文华中山大学公共卫生学院营养学系广东省营养膳食与健康重点实验室广州510080

随着社会和经济的快速发展，我国慢性病发病率和死亡率均呈现出快速上升趋势。2012年我国居民死亡原因前三位分别为恶性肿瘤、心脏病和脑血管疾病，这三者造成的死亡率占全因死亡率的68％。慢性病发病的危险因素很多，其中不合理的营养... 详细信息

随着社会和经济的快速发展，我国慢性病发病率和死亡率均呈现出快速上升趋势。2012年我国居民死亡原因前三位分别为恶性肿瘤、心脏病和脑血管疾病，这三者造成的死亡率占全因死亡率的68％。慢性病发病的危险因素很多，其中不合理的营养膳食，特别是营养过剩或营养不均衡，是其重要的危险因素。

关键词：慢性病膳食膳食模式

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Gut microbiota,inflammation,and molecular signatures of host response to infection

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Journal of Genetics and Genomics 2021年第9期48卷 792-802页

作者： Wanglong Gou Yuanqing Fu Liang Yue Geng-Dong Chen Xue Cai Menglei Shuai Fengzhe Xu Xiao Yi Hao Chen Yi Zhu Mian-Li Xiao Zengliang Jiang Zelei Miao Congmei Xiao Bo Shen Xiaomai Wu Haihong Zhao wenhua ling Jun Wang Yu-Ming Chen Tiannan Guo Ju-Sheng Zheng College of Life Sciences Zhejiang UniversityHangzhou 310058China Key Laboratory of Growth Regulation and Translational Research of Zhejiang Province School of Life SciencesWestlake UniversityHangzhou 310024China Center for Infectious Disease Research Westlake Laboratory of Life Sciences and BiomedicineHangzhou 310024China Institute of Basic Medical Sciences Westlake Institute for Advanced StudyHangzhou 310024China Key Laboratory of Structural Biology of Zhejiang Province School of Life SciencesWestlake UniversityHangzhou 310024China Guangdong Provincial Key Laboratory of Food Nutrition and HealthDepartment of EpidemiologySchool of Public HealthSun Yat-sen UniversityGuangzhou 510275China Taizhou Hospital Wenzhou Medical UniversityLinhai 325035China CAS Key Laboratory for Pathogenic Microbiology and Immunology Institute of MicrobiologyChinese Academy of SciencesBeijing 100101China

Gut microbial dysbiosis has been linked to many noncommunicable ***,little is known about specific gut microbiota composition and its correlated metabolites associated with molecular signatures underlying host response to ***,we describe the construction of a proteomic risk score based on 20 blood proteomic biomarkers,which have recently been identified as molecular signatures predicting the progression of the *** demonstrate that in our cohort of 990 healthy individuals without infection,this proteomic risk score is positively associated with proinflammatory cytokines mainly among older,but not younger,*** further discover that a core set of gut microbiota can accurately predict the above proteomic biomarkers among 301 individuals using a machine learning model and that these gut microbiota features are highly correlated with proinflammatory cytokines in another independent set of 366 *** metabolomics analysis suggests potential amino acid-related pathways linking gut microbiota to host metabolism and ***,our multi-omics analyses suggest that gut microbiota composition and function are closely related to inflammation and molecular signatures of host response to infection among healthy *** results may provide novel insights into the cross-talk between gut microbiota and host immune system.

关键词： Gut microbiota Proinflammatory cytokines Proteomic biomarkers COVID-19 Host infection response

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广州市健康体检人群非酒精性脂肪肝患病情况及相关危险因素分析

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中华医学杂志 2016年第46期96卷 3706-3709页

作者：葛辉陈君孙毅明凌文华中山大学附属第一医院保健科广州510080 南方医科大学珠江医院中山大学公共卫生学院

目的探讨广州市非精性脂肪肝（NAFLD）的患病情况及相关危险因素。方法采用横断面研究方法，选取2014年1月至2015年1月在中山大学附属第一医院进行健康体检者为研究对象，收集体格检查（身高、体重、血压等）、实验室检测（血脂、血糖... 详细信息

目的探讨广州市非精性脂肪肝（NAFLD）的患病情况及相关危险因素。方法采用横断面研究方法，选取2014年1月至2015年1月在中山大学附属第一医院进行健康体检者为研究对象，收集体格检查（身高、体重、血压等）、实验室检测（血脂、血糖、肝功能等）及肝胆超声诊断等数据，采用描述性方法分析疾病的分布特征，以及单因素和多因素logistic回归分析方法分析疾病的危险因素。结果NAFLD人群患病率为16．9％，男性患病率高于女性（P〈0．001）。男性患病高峰年龄为41～50岁，女性患者为50～60岁。Logistic回归分析，结果显示体质指数（BMI）、舒张压、丙氨酸转氨酶（ALT）、γ-谷氨酰转移酶（GGT）、空腹血糖、三酰甘油（TG）、高密度脂蛋白（HDL）以及低密度脂蛋白（LDL）为影响NAFLD独立危险因素（P〈0．05）。HDL越高NAFLD发病风险越低，而且其他指标均为越高发病风险越高。结论广州市NAFLD患病率较高，与代谢综合征相关的指标是发病的毹盼因素。

关键词：非酒精性脂肪肝患病危险因素

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我国常见蔬菜和水果中花色素含量

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营养学报 2010年第6期32卷 592-597页

作者：李桂兰凌文华郎静陈裕明广东省营养膳食与健康重点实验室中山大学公共卫生学院广州510080 医学统计与流行病学系中山大学公共卫生学院广州510080

目的测定我国常见蔬菜和水果中花色素的含量。方法收集我国广州、天津、重庆和武汉四个地区的常见蔬菜和水果样本,采用高效液相色谱的方法分析和定量了飞燕草素、矢车菊素和芍药素三种花色素。结果蔬菜样本中紫包菜和紫苏中三种花色素... 详细信息

目的测定我国常见蔬菜和水果中花色素的含量。方法收集我国广州、天津、重庆和武汉四个地区的常见蔬菜和水果样本,采用高效液相色谱的方法分析和定量了飞燕草素、矢车菊素和芍药素三种花色素。结果蔬菜样本中紫包菜和紫苏中三种花色素含量最高;水果样本中桑椹和杨梅花色素含量最高。结论不同产地和品种的蔬菜和水果中花色素含量有很大差别,蔬菜中花色素以矢车菊素和飞燕草素为主,水果中花色素以矢车菊素为主。

关键词：花色素 HPLC 定量蔬菜日摄入量

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氧化修饰LDL与动脉粥样硬化

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岭南心血管病杂志 1999年第2期5卷 141-143页

作者：马静凌文华中山医科大学营养系广州市510089

动脉粥样硬化(Atherosclerosis, AS)的发病机理十分复杂,至今没有完全阐明,因而对AS的防治缺乏有效的措施.近20年来,大量的研究认为氧化修饰的LDL(Ox-LDL)在AS发生和发展中起着十分重要的作用.随着对Ox-LDL引起AS作用的深入了解,国外学... 详细信息

动脉粥样硬化(Atherosclerosis, AS)的发病机理十分复杂,至今没有完全阐明,因而对AS的防治缺乏有效的措施.近20年来,大量的研究认为氧化修饰的LDL(Ox-LDL)在AS发生和发展中起着十分重要的作用.随着对Ox-LDL引起AS作用的深入了解,国外学者已经开始将抗氧化剂用于抗AS发展的研究.本文将综述Ox-LDL在AS发展中的作用和抗氧化剂防治AS的进展.

关键词：巨噬细胞动脉粥样硬氧化修饰清道夫受体内皮细胞抗氧化剂泡沫细胞形成溶血卵磷脂单核细胞溶酶体

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