检索结果-南通市图书馆

FAM89A and IFI44L for distinguishing between viral and bacterial infections in children with febrile illness

Pediatric Investigation 2021年第3期5卷 195-202页

作者： Shufeng Tian Jikui Deng wenhua huang Linlin Liu Yunsheng Chen Yongqiang Jiang Gang Liu Key Laboratory of Major Diseases in Children Ministry of EducationResearch Unit of Critical Infection in ChildrenChinese Academy of Medical Sciences2019RU016Department of Infectious DiseasesBeijing Children’s HospitalCapital Medical UniversityNational Center for Children’s HealthBeijingChina Department of Infectious Diseases Shenzhen Children’s HospitalShenzhenGuangdongChina State Key Laboratory of Pathogens and Biosecurity Institute of Microbiology and EpidemiologyBeijingChina Department of Clinical Laboratory Shenzhen Children’s HospitalShenzhenGuangdongChina

Importance: The current lack of reliable rapid tests for distinguishing between bacterial and viral infections has contributed to antibiotic ***: This study aimed to develop a novel biomarker assay that integratesFAM89A andIFI44L measurements to assist in differentiating between bacterial and viral ***: This prospective study recruited children with febrile illness from two hospitals between July 1, 2018, and June 30, 2019. A panel of three experienced pediatricians performed reference standard diagnoses of all patients (i.e., bacterial or viral infection) using available clinical and laboratory data, including a 28-day follow-up assessment. Assay operators were blinded to the reference standard diagnoses. The expression levels ofFAM89A andIFI44L were determined by quantitative real-time polymerase chain reaction ***: Of 133 potentially eligible patients with suspected bacterial or viral infection, 35 were excluded after the application of exclusion criteria. The resulting cohort included 98 patients: 59 with viral diagnoses and 39 with bacterial diagnoses. The areas under the curve (AUCs) of diagnoses usingFAM89A andIFI44L were 0.694 [95% confidence interval (CI): 0.583-0.804] and 0.751 (95%CI: 0.651-0.851), respectively. The disease risk score (DRS) [log2(FAM89A expression) - log2(IFI44L expression)] signature achieved an improved area under the receiver operating characteristic curve (AUC, 0.825;95%CI: 0.735-0.915), compared with the AUC generated from individual host RNA. A combination of the DRS and the C-reactive protein (CRP) level achieved an AUC of 0.896 (95%CI: 0.825-0.966). Optimal cutoffs for the DRS and CRP level were -3.18 and 19.80 mg/L, ***: The DRS was significantly more accurate than the CRP level in distinguishing between bacterial and viral infections;the combination of these two parameters exhibited greater sensitivity and specificity. This study provides information that could b

关键词： FAM89A IFI44L Febrile children Bacterial infection Viral infection

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Crystal-phase-controlled PtSn intermetallic nanowires for efficient methanol oxidation

引用

Science China Chemistry 2024年

作者： Siyu Cao Mengfan Li Zihan Guo Li Gong Yangfan Lu wenhua Zhang Yu Ni Lei Gao Chao Ma Hongwen huang College of Materials Science and Engineering Changsha University of Science and Technology College of Materials Science and Engineering Hunan University Zhejiang Provincial Engineering Research Center of Oxide Semiconductors for Environmental and Optoelectronic Applications Institute of Wenzhou Zhejiang University State Key Laboratory of Silicon Materials School of Materials Science and Engineering Zhejiang University Department of Chemical Physics University of Science and Technology of China China Power Engineering Consulting Group Co. LTD Shenzhen Research Institute of Hunan University

Developing highly efficient Pt-based methanol oxidation reaction（MOR） catalysts is pivotal for direct methanol fuel cells. Phase engineering of nanomaterials offers a promising strategy to improve their catalytic performance, yet achieving phase modulation in one-dimensional nanowires（NWs） remains a great challenge. Herein, we report a facile and one-pot synthesis approach for the crystal-phase-controlled Pt-Sn intermetallic nanowires（NWs）, realizing the crystal-phases regulation of face-centered cubic Pt3Sn intermetallic NWs（FCC-Pt3Sn INTNWs） and hexagonal close-packed PtSn intermetallic NWs（HCP-PtSn INTNWs） by adjusting the amounts of Sn precursors. Notably, the FCC-Pt3Sn INTNWs exhibit high mass and specific activities of6.4 A mg-1Pt and 11.8 m A cm–2, respectively, surpassing its counterparts, the HCP-PtSn INTNWs and commercial Pt/C *** a 10,000 s durability test, the FCC-Pt3Sn INTNWs still maintain a mass activity of 5.6 A mg-1Pt, which is 24.3 times higher than that of commercial Pt/C catalyst. This dramatic enhancement of MOR performance is primarily attributed to the phasecontrolled structure and accelerated removal of CO intermediates（CO*）. Theoretical calculations and CO stripping experiments demonstrate that the FCC-Pt3Sn INTNWs lower the energy barrier for converting CO* into COOH* by reducing CO* binding and enhancing OH adsorption, thus significantly improving the MOR activity, CO tolerance, and stability.

关键词：

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

FMEA在卷包工序产品品质风险管理中的应用

引用

烟草科技 2014年第4期47卷 26-30,34页

作者：黄雯华厦门烟草工业有限责任公司

为更好地控制生产过程中卷烟产品品质,根据卷包工序的生产特点和卷烟产品品质要求,将FMEA(Failure Mode and Effects Analysis)风险评估技术应用于卷包工序产品品质风险管理。通过对各风险因素进行风险排序,确定需要重点关注的风险因素... 详细信息

为更好地控制生产过程中卷烟产品品质,根据卷包工序的生产特点和卷烟产品品质要求,将FMEA(Failure Mode and Effects Analysis)风险评估技术应用于卷包工序产品品质风险管理。通过对各风险因素进行风险排序,确定需要重点关注的风险因素,得出卷烟产品品质风险管理的FMEA风险评价方法,并构建了卷包工序产品品质风险管理FMEA模式。结果表明:在卷包工序实施FMEA产品品质风险管理,能够全流程识别产品品质风险点并进行控制,有效降低了产品品质风险,减少了生产成本,卷烟纸消耗由3220 m/箱降低为3217 m/箱,滤棒消耗由8395支/箱降低为8382支/箱,商标纸消耗由2512张/箱降低为2507张/箱,提升了企业生产管理水平。

关键词：卷包工序产品品质风险识别风险评估风险控制

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

一种基于最大似然估计的宽带单脉冲测角改进方法

引用

系统工程与电子技术 2023年第12期45卷 3845-3851页

作者：汪海波黄文华巴涛邵浩姜悦西北核技术研究所高功率微波技术重点实验室陕西西安710024

电大尺寸目标的宽带散射回波可看成多个强散射中心的共同作用结果,回波表现为高分辨距离像(high-resolution range profiles,HRRP)的特点。如何利用多个散射中心的回波能量,以提升单脉冲测角的性能是值得深入研究的问题。本文给出的宽... 详细信息

电大尺寸目标的宽带散射回波可看成多个强散射中心的共同作用结果,回波表现为高分辨距离像(high-resolution range profiles,HRRP)的特点。如何利用多个散射中心的回波能量,以提升单脉冲测角的性能是值得深入研究的问题。本文给出的宽带雷达单脉冲测角的最大似然估计(maximum likelihood estimate,MLE)算法,该方法能够积累扩散到多个距离单元的回波能量,从HRRP中获得信噪比(signal to noise ratio,SNR)增益。提出了一种基于回波本身来确定目标距离支集的方法,并在距离支集上实施MLE算法。仿真研究表明:本文所提方法相比于加权平均法和最强点法,能够有效利用距离方向多个散射点的回波能量。MLE算法的均方根误差(root mean square error,RMSE)性能逼近克拉美罗下界(Carmer Rao low bound,CRLB)。

关键词：宽带雷达单脉冲最大似然估计距离支集

来源：

维普期刊数据库

同方期刊数据库博看期刊评论

在线全文

学校读者我要写书评

暂无评论

广西医疗机构精神卫生资源服务利用及配置公平性

引用

中国心理卫生杂志 2023年第1期37卷 19-23页

作者：黄文华朱平华广西壮族自治区脑科医院广西柳州545000 广西医科大学人文学院南宁530021

目的:为优化广西医疗卫生机构精神卫生资源服务利用状况及配置公平性提供资料参考。方法:根据《全国精神卫生资源调查工作方案》,采用国家精神卫生项目办设计的《全国精神卫生医疗机构调查表》面向广西216家开设有精神科(心理科)的医疗... 详细信息

目的:为优化广西医疗卫生机构精神卫生资源服务利用状况及配置公平性提供资料参考。方法:根据《全国精神卫生资源调查工作方案》,采用国家精神卫生项目办设计的《全国精神卫生医疗机构调查表》面向广西216家开设有精神科(心理科)的医疗卫生机构收集精神卫生服务资源相关数据,对机构、床位、人员数量等进行描述性分析,按人口和地理面积分布绘制洛伦兹曲线,用基尼系数表达公平性。结果:2020年广西精神科执业(助理)医师、护士、心理治疗师/咨询师、床位资源的密度分别为每10万人口2.99人、11.57人、1.10人、76张,按人口分布的医师、护士和床位资源相对公平,按地理分布的精神科床位配置处于警戒状态。结论:广西精神卫生资源分布不合理,按地理面积分布的医师、护士、床位配置公平性有待提高。

关键词：精神卫生服务利用配置公平性广西

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Study on the promotion of lymphocytes in patients with COVID-19 by broad-spectrum chemokine receptor inhibitor vMIP-Ⅱ and its Mechanism of signal transmission in vitro

引用

Signal Transduction and Targeted Therapy 2021年第4期6卷 1101-1103页

作者： Shiyu Li Shuting Liu Zhenyou Jiang Lixia Feng Yong Gao Youyu Chen Anding Xu wenhua huang Nuofu Zhang Hanxiao Sun Institute of Genomic Medicine College of PharmacyJinan UniversityGuangzhouChina Department of Anatomy School of Basic Medical SciencesSouthern Medical UniversityGuangzhouChina Departments of Microbiology and Immunology Medical CollegeJinan UniversityGuangzhouChina Nanyang People's Hospital HenanChina Union Hospital Tongji Medical CollegeHuazhong University of Science and TechnologyWuhanChina Guangzhou Overseas Chinese Hospital GuangzhouChina Institute of Respiratory Diseases GuangzhouChina

Dear Editor,COVID-19 cases showed a significant decrease in the number of peripheral CD4^(+) and CD8^(+)T cells accompanied by overactivation of cells.1 HHV8-derived viral macrophage inflammatory protein vMIP-Ⅱ is the only broad-spectrum chemokine receptor inhibitor that binds to three subtribes of chemokine receptors,which can significantly increase the specific cell immune response in infected organisms and have an effect of reducing plasma viral load on the viremia period.24 Here we report the effect of vMIP-Ⅱ in COVID-19.

关键词： chemokine lymphocytes patients

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Amygdalin ameliorates apoptosis and imbalance of osteogenic/lipogenic homeostasis caused by NOX4/ROS/p38MAPK signaling activation to treat glucocorticoid-associated necrosis of the femoral head

引用

Food Science and Human Wellness 2024年

作者： Huihui Xu Kai'ao Zou Haipeng huang Qinghe Zeng Xu Wang Ping'er Wang wenhua Yuan Luwei Xiao Jiali Chen Peijian Tong Hongting Jin he First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Chinese Medicine) The First College of Clinical Medicine， Zhejiang Chinese Medical University Institute of Orthopaedics and Traumatology of Zhejiang Province

The study aimed to explore the efficacy and potential mechanisms of a naturally aromatic cyanogenic compound-amygdalin (AMY) in treating glucocorticoid (GC)-associated necrosis of the femoral head (GANFH). We demonstrated that GC exacerbates the oxidative stress (OS) microenvironment via promoting nicotinamide adenine dinucleotide phosphate oxidase 4 (NOX4) expression in human， rat， and mesenchymal stem cells (MSCs) samples， thus generating excessive ROS， leading to increased apoptosis and unbalanced osteolipogenic differentiation. Furthermore， computational docking results revealed that AMY could bind specifically to the predicted binding sites of NOX4. Additionally， AMY ameliorated the OS microenvironment of MSCs via decreasing NOX4 expression and inhibiting NOX4/ROS/p38MAPK signaling， thereby reversing the GC-induced apoptosis and imbalanced osteolipogenic differentiation， and ultimately alleviating GANFH. In summary， we demonstrated for the first time that AMY attenuated apoptosis and maintained osteolipogenic differentiation balance in MSCs via specifically targeting NOX4， inhibiting NOX4/ROS/p38MAPK signaling， thereby treating GANFH.

关键词：

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

基于5G和VR技术的武器使用训练体系研究

引用

湖南警察学院学报 2023年第1期35卷 100-105页

作者：黄文华广西警察学院实战射击教研室广西南宁530028

5G通信技术的高传输能力和超低延时推动VR技术向无线化、轻量化发展,使VR能够适应更多场景的训练。运用VR技术开展武器使用训练,既低耗高效、经济安全,又能提升民警武器使用训练的频率和效率、帮助民警完成心理脱敏、提高民警适应各种... 详细信息

5G通信技术的高传输能力和超低延时推动VR技术向无线化、轻量化发展,使VR能够适应更多场景的训练。运用VR技术开展武器使用训练,既低耗高效、经济安全,又能提升民警武器使用训练的频率和效率、帮助民警完成心理脱敏、提高民警适应各种环境的武器使用能力和协同作战能力。基于5G和VR技术的武器使用训练体系以VR为载体,以公安实战为先导,创新武器使用训练模式,将武器使用训练与现代科学技术相融合,提升公安机关武器使用训练水平。

关键词： 5G 虚拟现实技术武器使用训练体系

来源：

维普期刊数据库博看期刊

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

3D打印技术在康复支具制作的应用研究

引用

中国医学物理学杂志 2022年第10期39卷 1310-1312页

作者：詹佳楠杨洋黄文华广东医科大学基础医学院/人体解剖与组织胚胎学教研室广东东莞523808 南方医科大学基础医学院人体解剖学国家重点学科/广东省数字医学与生物力学重点实验室/广东省医学3D打印应用转化工程技术研究中心广东广州510515

康复支具作为保护受损部位,限制与矫正肢体异常活动的体外装置在康复治疗学领域一直发挥着不可替代的作用,3D打印技术为患者提供更为精准的个性化康复治疗服务。本文从概述康复支具制备的规范与必要流程出发,详细介绍了国内外3D打印技... 详细信息

康复支具作为保护受损部位,限制与矫正肢体异常活动的体外装置在康复治疗学领域一直发挥着不可替代的作用,3D打印技术为患者提供更为精准的个性化康复治疗服务。本文从概述康复支具制备的规范与必要流程出发,详细介绍了国内外3D打印技术在康复支具制作中的应用案例,简要分析了该技术在康复支具制备与应用中的优势与不足,最终对其在康复支具制作中的发展前景做出展望。

关键词： 3D打印技术康复支具矫形器综述

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

The Technology of Line-spectrum Enhancement Based on Image Processing

The Technology of Line-spectrum Enhancement Based on Image P...

引用

The 2011 International Symposium on Manufacturing Systems Engineering (ISMSE 2011)

作者： Daizhu Zhu wenhua huang Shanghai Marine Electric Equipment Institute

Time-frequency spectrogram analysis is a basic method in passive radar and sonar. It′s necessary to enhance the line-spectrum to improve the performance in low SNR（Signal to Noise Ratio） and strong interference presented that wider detecting range and long reacting time can be obtained. The traditional line-spectrum enhancing technology based on signal′s coherence can′t work well in very low SNR, and the performance will drop sharply when the line-spectrums are close in frequencies or the number of line-spectrums increases. A new method which combines image processing with signal processing is brought out to overcome these defects. It can work well when the SNR in frequency domain is close to 0d B,which is much lower than ALE and other traditional technology. The results derived from simulation and trial data analysis show that it′s stable and can be applied in the field with line-spectrums.

关键词： Time-frequency spectrogram line-spectrum enhancement line-spectrum extraction image processing detection and discrimination

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：