检索结果-南通市图书馆

泛素-蛋白酶体系统与神经系统疾病的研究进展

在线全文

学校读者我要写书评

暂无评论

中风与神经疾病杂志 2024年第6期41卷 567-571页

作者：唐瑞天刘文虎梁金刘宗宝(综述) 陈合成(审校) 甘肃省人民医院脑血管病中心甘肃省脑血管病重点实验室甘肃兰州730000 甘肃省人民医院神经外科二病区甘肃兰州730000

泛素-蛋白酶体系统(UPS)是一种内部蛋白质分解机制,是细胞一系列生命过程的重要调节器,可处理大部分细胞的蛋白质周转,可去除老化、损坏和错误折叠的蛋白质,与各种疾病的发生发展密切相关。近年来各个领域对该系统的研究已渐渐成为热点... 详细信息

泛素-蛋白酶体系统(UPS)是一种内部蛋白质分解机制,是细胞一系列生命过程的重要调节器,可处理大部分细胞的蛋白质周转,可去除老化、损坏和错误折叠的蛋白质,与各种疾病的发生发展密切相关。近年来各个领域对该系统的研究已渐渐成为热点,多项研究表明UPS的异常变化与炎症、糖尿病、肝肾疾病、肿瘤等疾病的发生有关,与神经系统疾病也有着密不可分的联系。本文就泛素-蛋白酶体系统的组成及其在神经系统疾病中的作用和治疗进展进行综述。

关键词：泛素-蛋白酶体系统降解神经系统泛素

维普期刊数据库博看期刊

在线全文

学校读者我要写书评

暂无评论

添加剂型高模量沥青混合料性能试验对比研究

交通节能与环保 2024年第1期20卷 147-150,155页

作者：张文虎季正军张志远杨永富山东省路桥集团有限公司山东济南250014 山东省交通科学研究院山东济南250031

针对干线沥青路面在重载交通条件下的早期损坏问题,本文选用3种不同类型的高模量剂,分别在其最佳掺量下配制高模量改性沥青,对3种沥青胶结料及SBS改性沥青的技术指标进行试验对比分析,并在此基础上进行沥青混合料的配合比设计,最终实现... 详细信息

针对干线沥青路面在重载交通条件下的早期损坏问题,本文选用3种不同类型的高模量剂,分别在其最佳掺量下配制高模量改性沥青,对3种沥青胶结料及SBS改性沥青的技术指标进行试验对比分析,并在此基础上进行沥青混合料的配合比设计,最终实现对高模量沥青混合料的高温稳定性、低温抗裂性、水稳定性、动态模量等路用性能评价。

关键词：道路工程高模量沥青混合料高模量剂路用性能动态模量

Maneuver control of the hypersonic gliding vehicle with a scissored pair of control moment gyros

在线全文

学校读者我要写书评

暂无评论

Science China(Technological Sciences) 2018年第8期61卷 1150-1160页

作者： ZHAO Kun CAO DengQing HUANG wenhu School of Astronautics Harbin Institute of Technology

A maneuver control approach using a scissored pair of control moment gyros is proposed to improve the penetration ability of a hypersonic gliding vehicle(HGV) with a relatively high lift-drag ratio. Then, a multivariable strong coupling nonlinear bank-toturn dynamical model is established for the case of lateral maneuvering of an HGV equipped with a scissored pair of control moment gyros. According to the requirement of coordinated turning of the HGV in a lateral maneuver, a decoupling controller based on feedback linearization and a linear quadratic optimal algorithm is designed. Finally, the large airspace maneuvering trajectories of the HGV including S-shaped, cycloid and spiral maneuvering modes are designed by applying overload control technology. Simulations demonstrate that the designed maneuvering trajectory significantly increases the airspace range and flexibility of the vehicle. The coordinated turn control system achieves an accurate and rapid tracking of the maneuvering trajectories in large airspace.

关键词：控制途径超音速车辆罗盘旋转滑行动态模型控制技术

在线全文

学校读者我要写书评

暂无评论

装配式防撞护栏方案与车辆碰撞仿真性能分析

武汉理工大学学报（交通科学与工程版） 2024年第3期48卷 515-520页

作者：陈镇付军李贯超黄豪杰柯文汇闵亦斌武汉市市政工程机械化施工有限公司武汉430023 武汉理工大学船海与能源动力工程学院武汉430063

本文以武汉市某大道高架桥SA级装配式混凝土防撞护栏为工程背景,提出了一种新型C40混凝土装配式防撞护栏竖向连接设计方案,即预埋H型钢焊接与浆锚连接相结合,护栏节段之间通过钢筋连接.基于LS-DYNA分别建立了1.5 t小型客车、14 t大型客... 详细信息

本文以武汉市某大道高架桥SA级装配式混凝土防撞护栏为工程背景,提出了一种新型C40混凝土装配式防撞护栏竖向连接设计方案,即预埋H型钢焊接与浆锚连接相结合,护栏节段之间通过钢筋连接.基于LS-DYNA分别建立了1.5 t小型客车、14 t大型客车和25 t大型货车20°斜向撞击装配式护栏的有限元模型.通过阻挡性能、缓冲性能和导向性能等评价指标,评价装配式防撞护栏的安全性能.结果表明:在车辆碰撞作用下,护栏的竖向连接与纵向连接均未失效,护栏具备良好的阻挡性能.碰撞过程中,纵向加速度分量峰值和横加速度分量峰值均低于200 m/s 2,满足标准中加速度评价指标,护栏具备良好的缓冲性能.碰撞结束后,小客车驶出角度为7.8°,大型客车与大型货车驶离护栏轨迹几乎平行与护栏,满足规范要求,护栏具备良好的导向性能.

关键词：装配式混凝土护栏竖向连接有限元分析车辆碰撞安全评估

维普期刊数据库博看期刊

银离子敷料联合复方多粘菌素B软膏治疗深Ⅱ度烧伤感染性创面的疗效观察

在线全文

学校读者我要写书评

暂无评论

中国美容医学 2024年第4期33卷 25-29页

作者：马雅宁赵鹏孟素玉徐文虎胡荔男王康邢台市第五医院烧伤整形科河北邢台054000

目的:探讨银离子敷料联合复方多粘菌素B软膏治疗深Ⅱ度烧伤感染性创面的疗效。方法:选取149例深Ⅱ度烧伤感染性创面患者,依照乱数表法分为观察组(n=75例)和对照组(n=74例),对照组给予复方多粘菌素B软膏治疗,观察组在对照组基础上加用银... 详细信息

目的:探讨银离子敷料联合复方多粘菌素B软膏治疗深Ⅱ度烧伤感染性创面的疗效。方法:选取149例深Ⅱ度烧伤感染性创面患者,依照乱数表法分为观察组(n=75例)和对照组(n=74例),对照组给予复方多粘菌素B软膏治疗,观察组在对照组基础上加用银离子敷料治疗。统计比较两组创面恢复相关指标、创面疼痛程度、血清炎性因子和疼痛介质水平、临床疗效及瘢痕情况。结果:治疗后,观察组感染控制时间、住院时间、创面愈合时间均短于对照组(P<0.05),治疗21 d后的创面愈合率高于对照组(P<0.05)。观察组治疗后各时间点疼痛评分均低于对照组(P<0.05);治疗21 d后,观察组血清C反应蛋白、白介素-6、神经肽Y、前列腺素E2水平均低于对照组(P<0.05),创面愈合总有效率高于对照组(P<0.05);创面愈合后6个月,观察组温哥华瘢痕量表各评分及总分均低于对照组(P<0.05)。结论:银离子敷料联合复方多粘菌素B软膏治疗深Ⅱ度烧伤感染性创面能促进创面愈合,减轻创面疼痛程度,并能有效抑制血清炎性因子、疼痛介质水平,减轻创面瘢痕程度,提升创面美学效果。

关键词：银离子敷料复方多粘菌素B软膏深Ⅱ度烧伤感染性创面炎性因子瘢痕

维普期刊数据库博看期刊

Construction of Circular Economy Industrial System

在线全文

学校读者我要写书评

暂无评论

Chinese Journal of Population,Resources and Environment 2007年第4期5卷 26-30页

作者： Cao Man Ye wenhu Research Center for China Sustainable Development Peking University Beijing 100871 China

It is difficult to realize the transformation from tradi- tional economy industrial system to circular economy industrial system. Regarding primary raw materials as the indicators, the industrial system has been specified according to the divergence among the indicators and the circular utilization modes. In com- parison with the association among industrial systems, the rela- tionship among industrial sub-systems is named as industrial cross-linking in this paper. The industrial system which could completely utilize and recycle the indicators should be increased and strengthened, and the circular economy industrial system with complete industrial association and industrial cross-linking should also be constructed. Taking the development of circular agricul- tural system basing on the traditional agricultural system as an example, the traditional agricultural products are regarded as the indicators which have been divided into foodstuff and crop straws which are used to produce food and articles for use, like fertilizer, energy and papers etc. The way to construct the circular agricul- tural industrial system is to increase the industrial systems that could utilize the products generated from crop straws, feces and other castoffs and transform the wastewater and other trucks into environmental friendly products. It has also been pointed out that the construction of circular economy industrial system is condu- cive to the foundation of circular industrial economics and the establishment of the construction layout of circular economy and the application schemes. Suggestions to the theoretical and prac- tical work of the next step have also been brought forward in this paper.

关键词：循环经济工业系统工业结构环境保护

A wall-thickness compensation strategy for wax pattern of hollow turbine blade

在线全文

学校读者我要写书评

暂无评论

Chinese Journal of Aeronautics 2019年第8期32卷 1982-1993页

作者： Kang CUI wenhu WANG Ruisong JIANG Dezhong ZHAO Key Laboratory of Contemporary Design and Integrated Manufacturing Technology Ministry of EducationNorthwestern Polytechnical University

As an important index affecting the aerodynamic performance and the structural strength of hollow turbine blades, the wall-thickness precision of the blade is mainly inherited from the positional relationship between the corresponding wax pattern and the internal ceramic core.However, due to locating errors, the actual position of ceramic core is always deviated from the ideal position, which makes it difficult to guarantee the wall-thickness precision of the wax pattern.To solve this problem, a wall-thickness compensation strategy is proposed in this paper. Firstly,based on the industrial computed tomography(ICT) technique and curve matching algorithms, a model reconstruction method is developed, with which the 3D model of a trial wax pattern can be easily constructed. After that, focusing on eliminating the wall-thickness errors of the trial wax pattern, an optimization method for the pose of the ceramic core in the wax pattern is proposed. Then, by mapping the optimal pose of the ceramic core to length adjustments of the locating rods, the wall-thickness errors of the wax pattern can be greatly reduced. A case study is also given to illustrate the effectiveness of the proposed compensation strategy.

关键词： Hollow turbine blade Locating compensation Model reconstruction Pose optimization Wax pattern Wall-thickness error

H2/CO/air premixed and partially premixed flame structure at different pressures based on reaction limit analysis

在线全文

学校读者我要写书评

暂无评论

Science Bulletin 2018年第19期63卷 1260-1266页

作者： Zaigang Liu Wenjun Kong Jean-Louis Consalvi wenhu Han Key Laboratory of Light-Duty Gas-Turbine Institute of Engineering Thermophysics Chinese Academy of Sciences Beijing 100190 China School of Engineering Sciences. University of Chinese Academy of Sciences Beijing 100049 China IUSTI UMR 7343 Aix-Marseille Universite CNRS Marseille 13453 France

Premixed and partially premixed flames (PPFs) of H2/CO/air syngas are studied numerically to investigate the effect of pressure on syngas PPF structure. Chemical characteristics of the syngas flame at different pressures are investigated based on reaction limit analysis using a one-dimensional configuration. The results show that CO affects the syngas reaction limits through both physical effects that consist mainly in dilution and chemical effects that are related to both R23 (CO+OH=CO2+H) and HCO pathway. In particular, the HCO pathway weakens the flame at low pressures due to the chain-terminating effect of R25 (HCO+O2=CO+HO2) and R26 (HCO+H=CO+H2), and enhances the flame at high pressures because of the contribution of R25 to the HO2chain-branching process. These CO chemical characteristics are also observed in the premixed zone of 50%H2+50%CO syngas PPFs whereas only R23 is important in the non-premixed zone.

关键词：火焰结构低压力反应化学特征化学效果 PPF HCO HO2

Wave localization in randomly disordered periodic layered piezoelectric structures

在线全文

学校读者我要写书评

暂无评论

Acta Mechanica Sinica 2006年第6期22卷 559-567页

作者： Fengming Li Yuesheng Wang Chao Hu wenhu Huang Department of Aerospace Science and Mechanics Harbin Institute of Technology Harbin 150001 China Institute of Engineering Mechanics Beijing Jiaotong University Beijing 100044 China School of Aerospace Engineering and Mechanics TongJi University Shanghai 200092 China Department of Aerospace Engineering and Mechanics Harbin Institute of Technology Harbin 150001 China

Considering the mechnoelectrical coupling, the localization of SH-waves in disordered periodic layered piezoelectric structures is studied. The waves propagating in directions normal and tangential to the layers are considered. The transfer matrices between two consecutive unit cells are obtained according to the continuity conditions. The expressions of localization factor and localization length in the disordered periodic structures are presented. For the disordered periodic piezoelectric structures, the numerical results of localization factor and localization length are presented and discussed. It can be seen from the results that the frequency passbands and stopbands appear for the ordered periodic structures and the wave localization phenomenon occurs in the disordered periodic ones, and the larger the coefficient of variation is, the greater the degree of wave localization is. The widths of stopbands in the ordered periodic structures are very narrow when the properties of the consecutive piezoelectric materials are similar and the intervals of stopbands become broader when a certain material parameter has large changes. For the wave propagating in the direction normal to the layers the localization length has less dependence on the frequency, but for the wave propagating in the direction tangential to the layers the localization length is strongly dependent on the frequency.

关键词： Disordered periodic layered piezoelectric structures Transfer matrix Lyapunov exponent Localization factor Localization length