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Asian Journal of Pharmaceutical Sciences 2024年第1期19卷 86-102页

作者： Xiaoling Fu Yutong Song Xianquan Feng Zhihong Liu wenhao gao Hongtao Song Qian Zhang School of Pharmacy Fujian Medical UniversityFuzhou 350108China Fuzong Clinical Medical College of Fujian Medical University Fuzhou 350025China First school of clinical medicine Nanjing Medical UniversityNanjing 211166China

Amultifunctional liposomal polydopamine nanoparticle(MPM@Lipo)was designed in this study,to combine chemotherapy,photothermal therapy(PTT)and oxygen enrichment to clear hyperproliferating inflammatory cells and improve the hypoxic microenvironment for rheumatoid arthritis(RA)treatment.MPM@Lipo significantly scavenged intracellular reactive oxygen species and relieved joint hypoxia,thus contributing to the repolarization of M1 macrophages into M2 phenotype.Furthermore,MPM@Lipo could accumulate at inflammatory joints,inhibit the production of inflammatory factors,and protect cartilage in vivo,effectively alleviating RA progression in a rat adjuvant-induced arthritis model.Moreover,upon laser irradiation,MPM@Lipo can elevate the temperature to not only significantly obliterate excessively proliferating inflammatory cells but also accelerate the production of methotrexate and oxygen,resulting in excellent RA treatment effects.Overall,the use of synergistic chemotherapy/PTT/oxygen enrichment therapy to treat RA is a powerful potential strategy.

关键词： Polydopamine Thermosensitive liposomes Photothermal therapy Oxygen generation Rheumatoid arthritis

Genomic insights into the genetic basis of cotton breeding in China

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Molecular Plant 2023年第4期16卷 662-677页

作者： Yiqian Li Zhanfeng Si Guoping Wang Zhuolin Shi Jinwen Chen Guoan Qi Shangkun Jin Zegang Han wenhao gao Yue Tian Yun Mao Lei Fang Yan Hu Hong Chen Xiefei Zhu Tianzhen Zhang zhejiang Provincial Key Laboratory of Crop Genetic Resources the Advanced Seed InstitutePlant Precision Breeding AcademyCollege of Agriculture and BiotechnologyZhejiang UniversityHangzhouChina Xinjang Production and Construction Corps Seventh Division Agricultural Research Institute KuintunChina state Key Laboratory of Crop Genetics and Germplasm Enhancement Nanjing Agricutural UniversityNanjingChina College of Biotechnology Jiangsu University of Science and TechnologyZhenjiangChina Key Laboratory of China Northwestern Inland Region Ministry of AgricultureCotton Research InstituteXinjiang Academy of Agricultural and Reclamation ScienceShiheziChina

The excellent Upland cotton(Gossypium hirsutum)cultivars developed since 1949 have made a huge contribution to cotton production in China,the world's largest producer and consumer of cotton.However,the genetic and genomic basis for the improvements of these cotton cultivars remains largely unclear.In this study,we selected 16 Upland cotton cultivars with important historical status in Chinese cotton breeding and constructed a multiparent,advanced generation,intercross(MAGiC)population comprising 920 recombinant inbred lines.A genome-wide association study using the MAGIC population identified 54 genomic loci associated with lint yield and fiber quality.Of them,25(46.30%)pleiotropic genomic loci cause simultaneous changes of lint yield and/or fiber quality traits,revealing complex trade-offs and linkage drags in Upland cotton agronomic traits.Deep sequencing data of 11 introduced ancestor cultivars and publicly available resequencing datasets of 839 cultivars developed in China during the past 70 years were integrated to explore the historical distribution and origin of the elite or selected alleles.Interestingly,85%oftheseelitealleles were selectedandfixed fromdifferent Americanancestors,consistentwithcotton breeding practices in China.However,seven elite alleles of native origin that are responsible for Fusarium wilt resistance,early maturing,good-quality fiber,and other characteristics were not found in American an-cestors but have greatly contributed to Chinese cotton breeding and wide cultivation.Taken together,these results provide a genetic basis for further improving cotton cultivars and reveal that the genetic composition of Chinese cotton cultivars is narrow and mainly derived from early introduced American varieties.

关键词： cotton MAGiC population GWAS whole-genome sequencing pleiotropic loci breeding history

Synergistic enhancement effect of polydopamine-polyethyleneimine hybrid films for a visible-light photoelectrochemical biosensing interface

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ChemPhysMater 2023年第1期2卷 69-76页

作者： Jingkai Shan wenhao gao Xinyue Liu Jinhui Feng Li Dai Huan Wang Dawei Fan Hongmin Ma Qin Wei Collaborative Innovation Center for Green Chemical Manufacturing and Accurate Detection Key Laboratory of Interfacial Reaction&Sensing Analysis in Universities of ShandongSchool of Chemistry and Chemical EngineeringUniversity of JinanJinan 250022China

Photoelectrochemical(PEC)active interfaces exhibiting visible-light responses and good electron-transfer ca-pabilities are key to the development of PEC biosensors.In this study,bioinspired polydopamine(PDA)-polyethyleneimine(PEI)hybrid films were designed to engineer inorganic semiconductors and construct PEC biosensing interfaces.The charge-transfer capability and visible-light-response property of PDA were combined with the electron-attracting ability of PEI to produce a synergistic PEC-enhancement effect.The achieved PEC-enhancement effect was versatile for photoanode and photocathode semiconductors.Further,the role of PEI doping was revealed via electrochemical investigations.Compared with the PDA sensing platform,the hybrid sensing interface offered by the PDA-PEI film exhibited enhanced analytical performances toward ascorbic acid(AA),achieving a larger detection range and a lower limit of detection.

关键词： Polydopamine Polyethyleneimine Biomimetic interface Photoelectrochemical biosensor

不同壁材对ARA微胶囊理化性质和稳定性的影响

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农业工程学报 2024年第12期40卷 295-303页

作者：李萌张芹郑舒磊闵俊宁高文浩任皓威刘宁东北农业大学乳品科学教育部重点实验室哈尔滨150030 东北农业大学食品学院哈尔滨150030

为了筛选更优的壁材包埋花生四烯酸(arachidonic acid, ARA),该研究以ARA为芯材,乳清蛋白(whey protein, W)、乳清蛋白-葡萄糖浆(whey protein-glucose syrup, WG)和乳清蛋白-葡萄糖浆-乳糖(whey protein-glucose syrup-lactose, WGL)为壁材制备微胶囊,并对ARA微胶囊的包埋率、含水率、溶解度、堆积密度、休止角、粒径分布、微观形貌和氧化稳定性及热稳定性进行比较分析。结果表明,WGL的包埋率为98.64%,含水率为2.85%,溶解度为89.83%,堆积密度为0.54 g/mL,休止角为35.87°,粒径分布较均匀,其理化性质优于W和WG;表面结构呈完整球形、结构致密,有利于微胶囊的贮藏;采用碘滴定法测定过氧化值,在25和50℃贮藏条件下WGL的过氧化值分别为19.92和32.75 mmol/kg,均显著低于W和WG(P<0.05),表明WGL具有较高的氧化稳定性;由差示扫描量热法和热重法可知WGL的熔解温度和质量保留率最高分别为107℃和27.55%,表明WGL具有良好的热稳定性。综上,WGL的综合性质优于W和WG,表明WGL对ARA有较好的包埋和保护作用,该研究结果对选择合适的壁材包埋ARA微胶囊具有一定的参考意义。

关键词：温度理化性质稳定性 ARA 微胶囊壁材

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大数据时代城市智慧物流建设演化博弈分析

河南工业大学学报（社会科学版） 2024年第1期40卷 50-58页

作者：顾翠伶高文豪河南工业大学管理学院河南郑州450001

城市智慧物流的建设需要各利益主体共同参与。通过演化博弈的方法,基于城市智慧物流建设中多主体采用不同策略组合的收益函数,构建了地方政府、物流企业和居民的多主体演化博弈模型。通过计算该模型的均衡点,并利用MATLAB软件对模型均... 详细信息

城市智慧物流的建设需要各利益主体共同参与。通过演化博弈的方法,基于城市智慧物流建设中多主体采用不同策略组合的收益函数,构建了地方政府、物流企业和居民的多主体演化博弈模型。通过计算该模型的均衡点,并利用MATLAB软件对模型均衡点的稳定性进行讨论和参数敏感性分析,得出以下研究结论:初始参与意愿对地方政府、物流企业和居民的系统演化结果有不同的影响;地方政府成本的降低能够极大地提升其引导的积极性;政府应加强对城市智慧物流的宣传,制定企业智慧物流的判断标准和评价体系,以抑制企业投机行为。为促进城市智慧物流的高质量发展,应该合理引导各利益主体在城市智慧物流建设中的行为选择。

关键词：智慧物流演化博弈均衡分析

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针刺促卵泡发育和排卵的机制研究

中华生殖与避孕杂志 2024年第4期44卷 380-384页

作者：李佳嘉高红艳王钰王怡聪肖艳童小雨高文浩胡薇冯异复旦大学上海医学院基础医学院中西医结合学系、复旦大学医学神经生物学国家重点实验室和脑科学协同创新中心、复旦大学中西医结合研究院上海200032 上海中医药大学科技人文研究院上海201203

女性患者卵泡发育与排卵障碍是不孕症的主要原因,而针刺在促卵泡发育和排卵中具有显著疗效和独特优势,本文通过总结相关文献发现针刺促卵泡发育与排卵的机制主要涉及以下五个方面:改善下丘脑-垂体-卵巢轴功能;调节卵巢局部稳态;调节糖... 详细信息

女性患者卵泡发育与排卵障碍是不孕症的主要原因,而针刺在促卵泡发育和排卵中具有显著疗效和独特优势,本文通过总结相关文献发现针刺促卵泡发育与排卵的机制主要涉及以下五个方面:改善下丘脑-垂体-卵巢轴功能;调节卵巢局部稳态;调节糖脂代谢,纠正内分泌紊乱;调整系统和局部交感神经;调节情绪障碍。本文总结上述机制以期为卵泡发育及排卵障碍相关疾病的基础研究及临床治疗提供理论参考,同时也对针刺促卵泡发育与排卵的研究提出了一些思考。

关键词：针刺多囊卵巢综合征不孕症卵泡发育排卵障碍

黄龙五彩池源水区渗漏特征分析和人工降渗保育综合研究

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中国岩溶 2024年第1期43卷 33-47页

作者：刘馨泽张清明唐淑田长宝高文皓周亚萍陈洪伟韩梅东孙东四川省地质环境调查研究中心四川成都610081 黄龙国家级风景名胜区管理局四川松潘623300 成都理工大学材料与化学化工学院四川成都610059

黄龙世界自然遗产地核心景观之五彩池,其源水区上游转花池泉群地表溢流后,在灌丛林区中形成较为强烈的渗漏,导致五彩池涵养水量下降,出现一定程度退化。通过野外调查、长期监测、取样测试等手段,查明源水区水体径流渗漏特征及原因,分析... 详细信息

黄龙世界自然遗产地核心景观之五彩池,其源水区上游转花池泉群地表溢流后,在灌丛林区中形成较为强烈的渗漏,导致五彩池涵养水量下降,出现一定程度退化。通过野外调查、长期监测、取样测试等手段,查明源水区水体径流渗漏特征及原因,分析人工降渗手段对五彩池钙华景观演化影响。结果表明:(1)五彩池源水区河道发生了极为强烈的入渗,造成五彩池涵养水量下降,平均径流渗漏占比达51%,月动态变化较小,造成渗漏增强的原因主要为高山柳灌丛根劈、冻融等增加钙华有效孔隙度形成强渗透层;(2)源水区强渗漏造成五彩池下游边缘出现失水黑化,后沟地表水替换了彩池群内原有景观水体(水体置换)引发“灰化”现象;(3)通过人工保育降低源水区强渗漏,五彩池内涵养水量出现明显增加,北边缘彩池群黑化消失,东侧灰化现象减弱,五彩池钙华水域景观范围扩大16.3%,径流渗漏量比前期减少34%,主要景观涵养期内,进入五彩池的涵养水量占比由保育前的49%增加至83%,月平均涵养水量由4892 m^(3)·d^(-1)增加至8674 m^(3)·d^(-1),涵养水量增加77%;(4)降低源水区渗漏,增加下游彩池群涵养水量,对钙华水域景观范围扩大、恢复起到了明显的促进作用,为黄龙世界自然遗产地核心价值的保护提供了重要的依据。

关键词：转花池渗漏灌丛人工保育五彩池

基于网络药理学与代谢组学和分子对接的整合药理学策略研究温胆汤治疗慢性阻塞性肺疾病的作用机制

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中国药学杂志 2024年第11期59卷 998-1010页

作者：牛旭东何溢琨何梓龙陈爱灵高文浩任腾飞朱珍珍汪芳任睿楠林松王天阳齐齐哈尔医学院基础医学院黑龙江齐齐哈尔161006 齐齐哈尔医学院药学院黑龙江齐齐哈尔161006 齐齐哈尔医学院基础医学院基础医学科研中心黑龙江齐齐哈尔161006 黑龙江省药食同源资源与代谢性疾病防治重点实验室黑龙江齐齐哈尔161006

目的探讨温胆汤治疗慢性阻塞性肺疾病(chronic obstructive pulmonary disease,COPD)的作用机制。方法首先,基于网络药理学方法,利用中药系统药理学数据库与分析平台(TCMSP)、Swiss Target Prediction和Metascape等数据库,揭示温胆汤治... 详细信息

目的探讨温胆汤治疗慢性阻塞性肺疾病(chronic obstructive pulmonary disease,COPD)的作用机制。方法首先,基于网络药理学方法,利用中药系统药理学数据库与分析平台(TCMSP)、Swiss Target Prediction和Metascape等数据库,揭示温胆汤治疗COPD的潜在机制;其次,采用代谢组学方法,研究温胆汤对COPD诱发内源性代谢物紊乱的干预作用;最后,借助MetScape算法,整合网络药理学与代谢组学研究结果,并采用分子模拟对接和分子生物学方法,深入研究温胆汤治疗COPD的作用机制。结果网络药理学结果揭示温胆汤的102个潜在活性成分及其治疗COPD的98个潜在靶点。进一步分析显示温胆汤的11个潜在药效物质,包括3-叔丁基己二酸、6-甲基姜辣二醇双乙酸酯和甘草异黄烷酮等可能通过调节脂质与动脉粥样硬化、环磷腺苷(cyclic adenosine monophosphate,cAMP)信号通路、磷脂酰肌醇3激酶-蛋白激酶B(phosphoinositide 3-kinase-protein kinase B,PI3K-Akt)信号通路和白介素17(interleukin-17,IL-17)信号通路等发挥疗效。另一方面代谢组学研究显示,丙二醇、N-乙酰神经氨酸、苏氨酸、原胆酸、2-氧异戊酸酯、乙酰磷酸、柠檬酸盐和异丁酸等9种内源性物质,可能是温胆汤治疗COPD的关键代谢物。最后整合分析显示,脂质代谢与氨基酸代谢可能是温胆汤治疗COPD的关键过程,黄嘌呤脱氢酶(xanthine dehydrogenase,XDH)、激酶插入区受体(kinase insert domain receptor,KDR)、磷酸二酯酶5A(phosphodiesterase 5A,PDE5A)、细胞色素P450家族2亚家族C成员9(cytochrome P450 family 2 subfamily C member 9,CYP2C9)和成员19(cytochrome P450 family 2 subfamily C member 19,CYP2C19)等同氧化和炎症相关的基因可能是温胆汤发挥治疗作用的关键靶点;并且结果显示温胆汤可有效改善COPD大鼠肺部充血、水肿和炎性细胞浸润等多种病理状态,显著降低COPD大鼠肺组织中白细胞介素-6(interleukin-6,IL-6)、肿瘤坏死因子α(tumor necrosis factor-α,TNF-α)含量和丙二醛(malonaldehyde,MDA)活性,提高超氧化物歧化酶(superoxide dismutase,SOD)活性;而且分子对接结果也揭示了潜在药效物质与核心靶点基因之间的关联性。结论基于代谢组学、网络药理学和分子对接的整合药理学研究表明温胆汤可能通过调控炎症反应、氧化应激、脂质代谢和氨基酸代谢等途径实现治疗COPD的作用。

关键词：温胆汤慢性阻塞性肺疾病网络药理学代谢组学分子对接炎症因子

Plotinus:A Satellite Internet Digital Twin System

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Journal of Communications and Information Networks 2024年第1期9卷 24-33页

作者： Yue gao Kun Qiu Zhe Chen Wenjun Zhu Qi Zhang Handong Luo Quanwei Lin Ziheng Yang wenhao Liu The Intelligent Networking and Computing Research Center and School of Computer Science Fudan UniversityShanghai 200433China

The development of space-air-ground integrated networks (SAGIN) requires sophisticated satellite Internet emulation tools that can handle complex, dynamic topologies and offer in-depth analysis. Existing emulation platforms struggle with challenges like the need for detailed implementation across all network layers, real-time response, and scalability. This paper proposes a digital twin system based on microservices for satellite Internet emulation,namely Plotinus,which aims to solve these problems. Plotinus features a modular design, allowing for easy replacement of the physical layer to emulate different aerial vehicles and analyze channel interference. It also enables replacing of path computation methods to simplify testing and deploying algorithms. In particular, Plotinus allows for real-time emulation with live network traffic,enhancing practical network models. The evaluation result shows Plotinus’s effective emulation of dynamic satellite networks with real-world devices. Its adaptability for various communication models and algorithm testing highlights Plotinus’s role as a vital tool for developing and analyzing SAGIN systems, offering a cross-layer,real-time,and scalable digital twin system.

关键词： network emulation framework dynamic topology adjustment microservice architecture

Design of pH-responsive antimicrobial peptide melittin analog-camptothecin conjugates for tumor therapy

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Asian Journal of Pharmaceutical Sciences 2024年第1期19卷 135-146页

作者： Sujie Huang Yuxuan gao Ling Ma Bo Jia wenhao Zhao Yufan Yao Wenyuan Li Tongyi Lin Rui Wang Jingjing Song Wei Zhang Institute of Pharmacology School of Basic Medical SciencesLanzhou UniversityLanzhou 730000China Key Laboratory of Preclinical Study for New Drugs of Gansu Province School of Basic Medical Sciences&Research Unit of Peptide ScienceChinese Academy of Medical SciencesLanzhou UniversityLanzhou 730000China State Key Laboratory of Veterinary Etiological Biology College of Veterinary MedicineLanzhou UniversityLanzhou 730000China Lanzhou University Second Hospital Lanzhou UniversityLanzhou 730000China

Melittin,a classical antimicrobial peptide,is a highly potent antitumor agent.However,its significant toxicity seriously hampers its application in tumor therapy.In this study,we developed novel melittin analogs with pH-responsive,cell-penetrating and membranelytic activities by replacing arginine and lysine with histidine.After conjugation with camptothecin(CPT),CPT-AAM-1 and CPT-AAM-2 were capable of killing tumor cells by releasing CPT at low concentrations and disrupting cell membranes at high concentrations under acidic conditions.Notably,we found that the C-terminus of the melittin analogs was more suitable for drug conjugation than the N-terminus.CPT-AAM-1 significantly suppressed melanoma growth in vivo with relatively low toxicity.Collectively,the present study demonstrates that the development of antitumor drugs based on pH-responsive antimicrobial peptide-drug conjugates is a promising strategy.

关键词： Antimicrobial peptide Peptide-drug conjugate Cell-penetrating activity Membrane disruption Antitumor activity