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Petroleum 2021年第4期7卷 477-484页

作者： An Zhang Mingjing Jiang wenhao du School of Civil Engineering Suzhou University of Science and TechnologySuzhouJiangsu215009China Shandong Provincial Key Laboratory of Marine Environment and Geological Engineering Ocean University of ChinaQingdao266000China State Key Laboratory for Disaster Reduction in Civil Engineering Tongji University Shanghai200092China Department of Geotechnical Engineering College of Civil EngineeringTongji UniversityShanghai200092China Department of Civil Engineering Tianjin UniversityTianjin300072China Tongji Architectural Design(Group)Co. Ltd.No.1230 Siping RoadShanghai200092China

In this study,the Discrete Element Method(DEM)was employed to investigate numerically the effects of hydrate cementation and intermediate principal stress on the stress-dilatancy relation of graincementing type methane hydrate-bearing sediment(MHBS)by conducting a series of conventional and true triaxial tests.A novel 3D thermo-hydro-mechanical-chemical(THMC)contact model for MHBS was *** numerical results show that with increasing hydrate saturation and back pressure,or decreasing confining pressure,temperature and salinity,the stress-dilation relation of grain-cementing type MHBS evolves from dilation-dominant to *** the clean sand samples,the relationship between the normalized stress ratio h/Mcr and the dilatancy rate d is close under different intermediate principal stress ***,for the MHBS samples,this relationship is still affected by the intermediate principal stress coefficient b,due to the effect of hydrate cementation.

关键词： Stress-dilatancy Cementation Methane hydrate bearing sediment Discrete element method Intermediate principal stress

Effect of oxide film on nanoscale mechanical removal of pure iron

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Friction 2018年第3期6卷 307-315页

作者： Jinwei LIU Liang JIANG Changbang DENG wenhao du Linmao QIAN Tribology Research Institute State Key Laboratory of Traction Power Southwest Jiaotong University Institute of Machinery Manufacturing Technology China Academy of Engineering Physics

In this paper, the properties of an oxide film formed on a pure iron surface after being polished with an H2O-based acidic slurry were investigated using an atomic force microscope （AFM）, Auger electron spectroscopy （AES）, and angle-resolved X-ray photoelectron spectroscopy （AR-XPS） to partly reveal the material removal mechanism of pure iron during chemical mechanical polishing （CMP）. The AFM results show that, when rubbed against a cone-shaped diamond tip in vacuum, the material removal depth of the polished pure iron first slowly increases to 0.45 nm with a relatively small slope of 0.11 nm/μN as the applied load increases from 0 to 4 μN, and then rapidly increases with a large slope of 1.98 nm/μN when the applied load further increases to 10 μN. In combination with the AES and AR-XPS results, a layered oxide film with approximately 2 nm thickness （roughly estimated from the sputtering rate） is formed on the pure iron surface. Moreover, the film can be simply divided into two layers, namely. an outer layer and an inner layer. The outer layer primarily consists of FeOOH （most likely α-FeOOH） and possibly Fe2O3 with a film thickness ranging from 0.36 to 0.48 nm （close to the 0.45 nm material removal depth at the 4 μN turning point）, while the inner layer primarily consists of Fe304. The mechanical strength of the outer layer is much higher than that of the inner layer. Moreover, the mechanical strength of the inner layer is quite close to that of the pure iron substrate. However, when a real CMP process is applied to pure iron, pure mechanical wear by silica particles generates almost no material removal due to the extremely high mechanical strength of the oxide film. This indicates that other mechanisms, such as in-situ chemical corrosion-enhanced mechanical wear, dominate the CMP process.

关键词： oxide film nanoscale mechanical removal pure iron chemical mechanical polishing

Development of a potent benzonitrile-based inhibitor of glutaminyl-peptide cyclotransferase-like protein(QPCTL)with antitumor efficacy

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Signal Transduction and Targeted Therapy 2024年第1期9卷 44-46页

作者： Lei Yu Pengcheng Zhao Yaoliang Sun Zening Zheng wenhao du Lishan Zhang Yaxu Li Longyan Xie Shilin Xu Ping Wang Tongji University Cancer Center Shanghai Tenth People’s HospitalSchool of MedicineTongji UniversityShanghaiChina Department of Medicinal Chemistry Shanghai Institute of Materia MedicaChinese Academy of SciencesShanghaiChina

Dear Editor,Immune checkpoint therapies manipulating the immune system to eliminate tumor cells have shown remarkable clinical efficacy in treating various ***47,an emerging efficient immune checkpoint,is crucial for cancer cells to evade macrophagemediated phagocytosis by interaction with signal-regulatory proteinα(SIRPα).Antibodies blocking the CD47/SIRPαinteraction have been effective to promote macrophage-mediated phagocytosis in various types of cancer in mice and ***47 is not only highly expressed in tumor cells,but also normal cells,such as red blood cells(RBCs).Thus,during clinical trials involving cancer patients,anti-CD47 antibodies may promote the macrophagesmediated phagocytosis of RBCs,ultimately inducing undesirable anemia side *** contrast,small molecule inhibitors interrupting CD47/SIRPαaxis have shown potential to overcome the anemia,possibly due to their lower immunogenicity and shorter half-life compared to antibodies.1 Hence,developing the novel strategies,especially those without the anemia side effect,to intervene in CD47/SIRPαinteraction will benefit cancer immunotherapy.

关键词： anemia overcome eliminate

Effects of Angelica sinensis extracts on lipid oxidation in fish feeds and growth performance of juvenile Jian carp(Cyprinus carpio var. Jian)

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Animal Nutrition 2019年第1期5卷 109-114页

作者： Huatao Li Dandan Yang Zhihao Li Mingquan He Fengyi Li Jun Jiang Siyi Tang Peiyuan Peng wenhao du Yuting Ma Ying Liu Key Laboratory of Sichuan Province for Conservation and Utilization of Fishes Resources in the Upper Reaches of the Yangtze River Neijiang Normal University College of Life Sciences Neijiang Normal University College of Animal Science and Technology Sichuan Agricultural University

The study was to explore the effect of the extracts of Angelica sinensis(EAs) on lipid oxidation in fish feeds compared with ethoxyquin(EQ) and the effect of dietary EAs on growth performance of carp(Cyprinus carpio var. Jian). Firstly, fish feeds were respectively added with EQ, and ethyl ether extract ethyl acetate extract(EAE), acetone extract, ethanol extract(EE) and aqueous extract(AQE) of Angelica sinensis, except for the control. The results showed that EAs and EQ inhibited lipid oxidation in fish feed(P < 0.05). Of all of the examined EAs, EAE showed the strongest protective effects against lipid oxidation(P < 0.05). Moreover, EAE at high concentrations showed a stronger effect on lipid oxidation compared with EQ(P < 0.05). Then, 7 experimental diets respectively supplemented with 0.0, 1.0, 2.0, 3.0, 4.0, 5.0 and 6.0 g/kg of EAE were fed to the respective treatment groups for 30 d. Four replicates were performed for each treatment group; 20 carp(mean weight: 12.10 ± 0.13 g) were in each replicate. The result indicated that dietary EAE improved the growth performance in carp(P < 0.05). The appropriate con centration of EAE for carp growth was estimated to be 3.643 g/kg diet. Thus, EAE could be used as a natural antioxidant in feeds for Jian carp.

关键词： Angelica sinensis Extracts Ethoxyquin Lipid oxidation Growth performance

Nucleolus localization of SpyCas9 affects its stability and interferes with host protein translation in mammalian cells

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Genes & Diseases 2022年第3期9卷 731-740页

作者： Renke Tan wenhao du Yiyang Liu Xiaoji Cong Meirong Bai Chenxiao Jiang Zengxia Li Minjia Tan Dengke K.Ma Qiang Huang Wei Jiang Yongjun Dang Key Laboratory of Metabolism and Molecular Medicine the Ministry of EducationDepartment of Biochemistry and Molecular BiologySchool of Basic Medical SciencesShanghai Medical CollegeFudan UniversityShanghai 200032PR China State Key Laboratory of Genetic Engineering School of Life SciencesFudan UniversityShanghai 200043PR China Drug Discovery and Design Center State Key Laboratory of Drug ResearchShanghai Institute of Materia MedicaChinese Academy of SciencesShanghai 201203PR China Cardiovascular Research Institute University of CaliforniaSan FranciscoCA 94158USA

The CRISPR/Cas9 system,originally derived from the prokaryotic adaptive immune system,has been developed as efficient genome editing *** enables precise gene manipulation on chromosomal DNA through the specific binding of programmable sgRNA to target DNA,and the Cas9 protein,which has endonuclease activity,will cut a double strand break at specific ***,Cas9 is a foreign protein in mammalian cells,and the potential risks associated with its introduction into mammalian cells are not fully *** this study,we performed pull-down and mass spectrometry(MS)analysis of Streptococcus pyogenes Cas9(SpyCas9)interacting proteins in HEK293T cells and showed that the majority of Cas9-associated proteins identified by MS were localized in the ***,we further discovered that the Cas9 protein contains a sequence encoding a nucleolus detention signal(NoDS).Compared with wild-type(WT)Cas9,NoDS-mutated variants of Cas9(mCas9)are less stable,although their gene editing activity is minimally *** of WT Cas9,but not mCas9,causes general effects on transcription and protein translation in the host ***,identification of NoDS in Cas9 will improve the understanding of Cas9's biological function in vivo,and the removal of NoDS in Cas9 may enhance its safety for future clinical use.

关键词： CRISPR/Cas9 Gene editing Global transcription Nucleolus detention signal Translation

Robust Path Loss Map Construction based on LDFF-Net

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Robust Path Loss Map Construction based on LDFF-Net

氯化镁/氯化1-丁基-3-甲基咪唑改性淀粉/聚丁二酸丁二醇酯共混材料的结构与性能

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作者： wenhao du Jian Jin Wei Gong Li Li Zhenzhen Jiao The Department of Control Science and Engineering Tongji University China Academy of Information and Communications Technology Shanghai Research Institute for Intelligent Autonomous Systems Tongji University

When transmitter characteristics are unknown,path loss inference model depend on electromagnetic signal samples to deduce signal propagation *** to spatial discontinuities in sampling data,these models require advanced inferential techniques to address missing data and enhance accuracy,highlighting existing methods' need for improved precision in electromagnetic *** response to the aforementioned requirement,this paper proposes a deep learning framework named LDFF-Net to generate continuous path loss values in geographic space,thereby creating path loss *** framework is characterized by a lightweight feature fusion strategy,a multi-level autoencoder structure,and a progressively enhanced dilated convolution *** learns the propagation characteristics of electromagnetic signals through measured electromagnetic data and the distribution of urban *** conducted on open-source datasets have demonstrated that this model achieves an accuracy that is 10% higher than the most advanced methods in various scenarios and experimental setups,while also exhibiting superior robustness.

关键词： Path Loss Map Lightweight Feature Fusion Strategy Multi-Level Autoencoder

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高等学校化学学报 2018年第7期39卷 1611-1616页

作者：杨召杰雷蓓杜文浩张熙高分子材料工程国家重点实验室四川大学高分子研究所成都610065

用氯化镁/氯化1-丁基-3-甲基咪唑([BMIM]Cl)复合增塑剂改性淀粉/聚丁二酸丁二醇酯(PBS)共混材料,采用红外光谱(FTIR)、扫描电子显微镜(SEM)、差示扫描量热分析(DSC)、X射线衍射分析(XRD)及力学性能测试等方法研究了氯化镁/[BMIM]Cl改性... 详细信息

用氯化镁/氯化1-丁基-3-甲基咪唑([BMIM]Cl)复合增塑剂改性淀粉/聚丁二酸丁二醇酯(PBS)共混材料,采用红外光谱(FTIR)、扫描电子显微镜(SEM)、差示扫描量热分析(DSC)、X射线衍射分析(XRD)及力学性能测试等方法研究了氯化镁/[BMIM]Cl改性淀粉/PBS共混材料的结构和性能.结果表明,氯化镁能与淀粉及PBS形成较强的相互作用,从而破坏淀粉及PBS原有的氢键,导致淀粉/PBS共混体系结构和性能的改变.与[BMIM]Cl改性体系相比,氯化镁/[BMIM]Cl改性体系能进一步增强淀粉与PBS的界面结合力,提高共混体系的相容性;使淀粉/PBS的熔融焓、结晶度及结晶温度降低,冷结晶温度升高;提高共混体系的力学强度和断裂伸长率,抑制[BMIM]Cl因高效增塑产生的强度降低作用.采用氯化镁/[BMIM]Cl改性淀粉/PBS可制备出具有良好力学性能的淀粉/PBS共混材料.

关键词：聚丁二酸丁二醇酯改性淀粉离子液体氯化镁

慢刀伺服车削刀具半径定向补偿的分段逼近求解

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中国机械工程 2020年第17期31卷 2017-2023页

作者：李佳伟杜文浩韩长庆中国工程物理研究院机械制造工艺研究所绵阳621900

复杂曲面的慢刀伺服车削加工过程中,采用刀具法向补偿算法会在各个直线轴产生补偿量,加工法向矢量突变的曲面时,这种算法并非最优,将补偿量只应用于负载较低的直线轴却是更优的选择。提出一种基于线段逼近的刀具半径定向补偿数值求解算... 详细信息

复杂曲面的慢刀伺服车削加工过程中,采用刀具法向补偿算法会在各个直线轴产生补偿量,加工法向矢量突变的曲面时,这种算法并非最优,将补偿量只应用于负载较低的直线轴却是更优的选择。提出一种基于线段逼近的刀具半径定向补偿数值求解算法来求解定向刀位点,通过半径细分的策略使法向误差收敛。算法实例验证及与相关算法的对比结果显示,该算法适用于点云构成的曲面或分段曲面的刀具半径补偿。

关键词：慢刀伺服半径补偿复杂曲面细分策略

HPMC/P(AM-co-AA)-Zr^(4+)/NaCl导电水凝胶的制备与性能

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高分子材料科学与工程 2022年第8期38卷 1-8,17页

作者：张甲樋杜文浩陈彦霏张熙高分子材料工程国家重点实验室四川大学高分子研究所四川成都610065

为制备具有良好力学性能和导电性能的水凝胶,在羟丙基甲基纤维素(HPMC)存在的条件下,以丙烯酰胺(AM)和丙烯酸(AA)为共聚单体、Zr^(4+)为交联剂,通过原位自由基聚合制备了HPMC/P(AM-co-AA)-Zr^(4+)/NaCl双网络水凝胶,并对其力学性能、导... 详细信息

为制备具有良好力学性能和导电性能的水凝胶,在羟丙基甲基纤维素(HPMC)存在的条件下,以丙烯酰胺(AM)和丙烯酸(AA)为共聚单体、Zr^(4+)为交联剂,通过原位自由基聚合制备了HPMC/P(AM-co-AA)-Zr^(4+)/NaCl双网络水凝胶,并对其力学性能、导电性能及相关传感性能进行了研究。结果表明,所制备的HPMC/P(AM-co-AA)-Zr^(4+)/NaCl水凝胶断裂应变达1820%、断裂强度为0.77 MPa、断裂能为4210 kJ/m^(3),电导率为8.44 S/m,可实现力学性能与导电性能的平衡。该水凝胶具有良好的回复能力和较高应变灵敏度,表现出宽的应变窗口(0%~800%),可望用于应变传感器。

关键词：羟丙基甲基纤维素丙烯酰胺-丙烯酸共聚物导电水凝胶力学性能导电性能应变传感器

射频等离子体球化制备钨粉的选区激光熔化成形研究

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稀有金属材料与工程 2021年第12期50卷 4457-4464页

作者：杜文豪施麒吴安如刘辛周凡湖南工程学院湖南湘潭411100 广东省科学院材料与加工研究所广东广州510650 国家钛及稀有金属粉末冶金工程技术研究中心广东广州510650 广东省金属强韧化技术与应用重点实验室广东广州510650

以不规则的钨粉为原材料,采用射频等离子体球化技术制备了球形钨粉,重点研究了选区激光熔化制造纯钨零件,系统研究了工艺参数(激光功率、扫描速度)对制备的纯钨样品致密化、显微组织、显微硬度和压缩性能的影响,从而反馈指导钨粉球化工... 详细信息

以不规则的钨粉为原材料,采用射频等离子体球化技术制备了球形钨粉,重点研究了选区激光熔化制造纯钨零件,系统研究了工艺参数(激光功率、扫描速度)对制备的纯钨样品致密化、显微组织、显微硬度和压缩性能的影响,从而反馈指导钨粉球化工艺参数的优化。结果表明:球化后钨粉形状规则且球化率高于98%,钨粉的振实密度和松装密度增大,流动性增强。同时球化后的钨粉具有良好的选区激光熔化适用性,打印样品件的致密度在84.15%~95.65%之间。研究发现,随激光功率的增大,打印件的致密度、显微硬度和抗压强度呈先上升后下降的趋势,裂纹和孔洞呈先减少后增多的趋势。随着扫描速度的增大,打印件的致密度和硬度降低,裂纹增多。因此,探究合适的打印参数对钨粉的选区激光熔化成形有着重要意义。

关键词：钨粉射频等离子体球化选区激光熔化显微硬度