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Signal Transduction and Targeted Therapy 2024年第1期9卷 44-46页

作者： Lei Yu Pengcheng Zhao Yaoliang Sun Zening Zheng wenhao du Lishan Zhang Yaxu Li Longyan Xie Shilin Xu Ping Wang Tongji University Cancer Center Shanghai Tenth People’s HospitalSchool of MedicineTongji UniversityShanghaiChina Department of Medicinal Chemistry Shanghai Institute of Materia MedicaChinese Academy of SciencesShanghaiChina

Dear Editor,Immune checkpoint therapies manipulating the immune system to eliminate tumor cells have shown remarkable clinical efficacy in treating various ***47,an emerging efficient immune checkpoint,is crucial for cancer cells to evade macrophagemediated phagocytosis by interaction with signal-regulatory proteinα(SIRPα).Antibodies blocking the CD47/SIRPαinteraction have been effective to promote macrophage-mediated phagocytosis in various types of cancer in mice and ***47 is not only highly expressed in tumor cells,but also normal cells,such as red blood cells(RBCs).Thus,during clinical trials involving cancer patients,anti-CD47 antibodies may promote the macrophagesmediated phagocytosis of RBCs,ultimately inducing undesirable anemia side *** contrast,small molecule inhibitors interrupting CD47/SIRPαaxis have shown potential to overcome the anemia,possibly due to their lower immunogenicity and shorter half-life compared to antibodies.1 Hence,developing the novel strategies,especially those without the anemia side effect,to intervene in CD47/SIRPαinteraction will benefit cancer immunotherapy.

关键词： anemia overcome eliminate

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人工智能与企业新质生产力——机制与效应

工业技术经济 2024年第10期43卷 22-31页

作者：吴俊珺杜文豪首都经济贸易大学国际经济管理学院北京100071 浙江工商大学统计与数学学院杭州310018

人工智能是企业新质生产力发展的重要引擎。本文基于2011~2023年中国A股上市公司数据,构建了企业层面的人工智能和新质生产力的测度指标,实证检验了人工智能对企业新质生产力发展的影响效应与作用机制。结果表明:人工智能显著促进了企... 详细信息

人工智能是企业新质生产力发展的重要引擎。本文基于2011~2023年中国A股上市公司数据,构建了企业层面的人工智能和新质生产力的测度指标,实证检验了人工智能对企业新质生产力发展的影响效应与作用机制。结果表明:人工智能显著促进了企业新质生产力发展,经过内生性处理与稳健性检验后,该结论依然成立。此外,人工智能具有显著的规模效应,其在高分位点处对企业新质生产力的促进效应优于低分位点。异质性分析表明,对于东部地区、高新技术和高市场竞争企业,人工智能对企业新质生产力的促进效应更加明显。机制分析证实,人工智能对企业新质生产力的促进效应主要通过赋能科技创新、劳动力技能结构优化和效率提升3条路径实现。

关键词：人工智能企业新质生产力驱动效应科技创新劳动力技能结构企业全要素生产率规模效应异质性

Three-dimensional DEM investigation of the stress-dilatancy relation of grain-cementing type methane hydrate-bearing sediment

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Petroleum 2021年第4期7卷 477-484页

作者： An Zhang Mingjing Jiang wenhao du School of Civil Engineering Suzhou University of Science and TechnologySuzhouJiangsu215009China Shandong Provincial Key Laboratory of Marine Environment and Geological Engineering Ocean University of ChinaQingdao266000China State Key Laboratory for Disaster Reduction in Civil Engineering Tongji University Shanghai200092China Department of Geotechnical Engineering College of Civil EngineeringTongji UniversityShanghai200092China Department of Civil Engineering Tianjin UniversityTianjin300072China Tongji Architectural Design(Group)Co. Ltd.No.1230 Siping RoadShanghai200092China

In this study,the Discrete Element Method(DEM)was employed to investigate numerically the effects of hydrate cementation and intermediate principal stress on the stress-dilatancy relation of graincementing type methane hydrate-bearing sediment(MHBS)by conducting a series of conventional and true triaxial tests.A novel 3D thermo-hydro-mechanical-chemical(THMC)contact model for MHBS was *** numerical results show that with increasing hydrate saturation and back pressure,or decreasing confining pressure,temperature and salinity,the stress-dilation relation of grain-cementing type MHBS evolves from dilation-dominant to *** the clean sand samples,the relationship between the normalized stress ratio h/Mcr and the dilatancy rate d is close under different intermediate principal stress ***,for the MHBS samples,this relationship is still affected by the intermediate principal stress coefficient b,due to the effect of hydrate cementation.

关键词： Stress-dilatancy Cementation Methane hydrate bearing sediment Discrete element method Intermediate principal stress

国内儿童友好型城市绿地公共开放空间研究综述

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低温建筑技术 2024年第8期46卷 8-12页

作者：杜文浩张喆韦猛西南林业大学园林园艺学院昆明650224

城市绿地中的公共开放空间是儿童健康成长、充分接触自然的重要场所。随着当下儿童友好型城市建设的大力开展,系统全面地构建儿童友好的绿地空间体系,为儿童打造便捷舒适、安全有趣、生态自然、文明友好的城市绿地环境,提升儿童群体在... 详细信息

城市绿地中的公共开放空间是儿童健康成长、充分接触自然的重要场所。随着当下儿童友好型城市建设的大力开展,系统全面地构建儿童友好的绿地空间体系,为儿童打造便捷舒适、安全有趣、生态自然、文明友好的城市绿地环境,提升儿童群体在城市中的幸福感、安全感与获得感。文中通过线上收集整理近15年儿童友好型研究等相关领域的文献,依托科学计量分析软件CiteSpace进行可视化分析,对当今国内的研究现状进行探索,分析发现研究热点主要涵盖设计策略、案例研究、评价研究三方面内容。通过对上述内容的分析、归纳与梳理,充分总结当今国内的儿童友好型城市绿地公共开放空间建设倾向,为儿童友好型城市绿地建设与研究提供新的思路。

关键词：儿童友好型城市绿地公共开放空间可视化分析

刀具偏心跳动下侧铣硬脆材料的瞬时铣削力模型

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航空学报 2024年第4期45卷 270-279页

作者：马廉洁杜文豪赵镇邱喆东北大学机械工程与自动化学院沈阳110819 东北大学秦皇岛分校控制工程学院秦皇岛066004

以侧铣可加工微晶陶瓷为对象,建立了瞬时整体铣削力模型,研究了刀具偏心跳动状态下立铣刀侧刃铣削瞬时铣削力。通过铣削刀具与工件的次摆线运动,获得了其瞬时切削厚度、瞬时切削面积。通过线性搜索法确定了刀具偏心量和偏心角的最优解,... 详细信息

以侧铣可加工微晶陶瓷为对象,建立了瞬时整体铣削力模型,研究了刀具偏心跳动状态下立铣刀侧刃铣削瞬时铣削力。通过铣削刀具与工件的次摆线运动,获得了其瞬时切削厚度、瞬时切削面积。通过线性搜索法确定了刀具偏心量和偏心角的最优解,利用一维搜索算法进行了瞬时铣削力作用点的精确求解,并以刀具偏心跳动状态下的瞬时转角予以表达。以Martellotti模型为基础,建立了新的瞬时铣削力模型。以最小二乘法进行了瞬时铣削力模型系数辨识。并从铣削力作用点(瞬时转角)视角,研究了瞬时铣削力的变化特性。铣削实验验证结果表明,铣削力模型预测值与实验值吻合程度较高,平均相对误差不超过8%,该瞬时铣削力模型具有较高的预测精度。

关键词：刀具偏心跳动瞬时铣削力模型瞬时切削面积铣削力作用点硬脆材料

Effect of oxide film on nanoscale mechanical removal of pure iron

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Friction 2018年第3期6卷 307-315页

作者： Jinwei LIU Liang JIANG Changbang DENG wenhao du Linmao QIAN Tribology Research Institute State Key Laboratory of Traction Power Southwest Jiaotong University Institute of Machinery Manufacturing Technology China Academy of Engineering Physics

In this paper, the properties of an oxide film formed on a pure iron surface after being polished with an H2O-based acidic slurry were investigated using an atomic force microscope （AFM）, Auger electron spectroscopy （AES）, and angle-resolved X-ray photoelectron spectroscopy （AR-XPS） to partly reveal the material removal mechanism of pure iron during chemical mechanical polishing （CMP）. The AFM results show that, when rubbed against a cone-shaped diamond tip in vacuum, the material removal depth of the polished pure iron first slowly increases to 0.45 nm with a relatively small slope of 0.11 nm/μN as the applied load increases from 0 to 4 μN, and then rapidly increases with a large slope of 1.98 nm/μN when the applied load further increases to 10 μN. In combination with the AES and AR-XPS results, a layered oxide film with approximately 2 nm thickness （roughly estimated from the sputtering rate） is formed on the pure iron surface. Moreover, the film can be simply divided into two layers, namely. an outer layer and an inner layer. The outer layer primarily consists of FeOOH （most likely α-FeOOH） and possibly Fe2O3 with a film thickness ranging from 0.36 to 0.48 nm （close to the 0.45 nm material removal depth at the 4 μN turning point）, while the inner layer primarily consists of Fe304. The mechanical strength of the outer layer is much higher than that of the inner layer. Moreover, the mechanical strength of the inner layer is quite close to that of the pure iron substrate. However, when a real CMP process is applied to pure iron, pure mechanical wear by silica particles generates almost no material removal due to the extremely high mechanical strength of the oxide film. This indicates that other mechanisms, such as in-situ chemical corrosion-enhanced mechanical wear, dominate the CMP process.

关键词： oxide film nanoscale mechanical removal pure iron chemical mechanical polishing

基于潜在类别分析的老年人健康分类与健康信息服务优化研究

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医学信息学杂志 2024年第7期45卷 42-48页

作者：刘喜文杜文豪王诗淇张军亮雒保军新乡医学院卫生健康管理学院新乡453003 新乡医学院卫生信息资源研究中心新乡453003

目的/意义依据异质性健康状态对老年人分类,探讨老年人健康状态的潜在类别及其影响因素,促进老年健康信息服务精准化。方法/过程利用中国健康与养老追踪调查2018年数据,应用潜在类别分析方法依据老年人健康状态分类,运用回归分析找出主... 详细信息

目的/意义依据异质性健康状态对老年人分类,探讨老年人健康状态的潜在类别及其影响因素,促进老年健康信息服务精准化。方法/过程利用中国健康与养老追踪调查2018年数据,应用潜在类别分析方法依据老年人健康状态分类,运用回归分析找出主要影响因素。结果/结论根据健康状况可将老年人分为4类;年龄、性别、教育水平、有无退休金是影响老年人健康分组的显著因素。应依据老年人异质性健康特征提供服务优化策略,促进老年人身心健康。

关键词：老年人健康信息服务优化策略潜在类别分析

Effects of Angelica sinensis extracts on lipid oxidation in fish feeds and growth performance of juvenile Jian carp(Cyprinus carpio var. Jian)

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Animal Nutrition 2019年第1期5卷 109-114页

作者： Huatao Li Dandan Yang Zhihao Li Mingquan He Fengyi Li Jun Jiang Siyi Tang Peiyuan Peng wenhao du Yuting Ma Ying Liu Key Laboratory of Sichuan Province for Conservation and Utilization of Fishes Resources in the Upper Reaches of the Yangtze River Neijiang Normal University College of Life Sciences Neijiang Normal University College of Animal Science and Technology Sichuan Agricultural University

The study was to explore the effect of the extracts of Angelica sinensis(EAs) on lipid oxidation in fish feeds compared with ethoxyquin(EQ) and the effect of dietary EAs on growth performance of carp(Cyprinus carpio var. Jian). Firstly, fish feeds were respectively added with EQ, and ethyl ether extract ethyl acetate extract(EAE), acetone extract, ethanol extract(EE) and aqueous extract(AQE) of Angelica sinensis, except for the control. The results showed that EAs and EQ inhibited lipid oxidation in fish feed(P < 0.05). Of all of the examined EAs, EAE showed the strongest protective effects against lipid oxidation(P < 0.05). Moreover, EAE at high concentrations showed a stronger effect on lipid oxidation compared with EQ(P < 0.05). Then, 7 experimental diets respectively supplemented with 0.0, 1.0, 2.0, 3.0, 4.0, 5.0 and 6.0 g/kg of EAE were fed to the respective treatment groups for 30 d. Four replicates were performed for each treatment group; 20 carp(mean weight: 12.10 ± 0.13 g) were in each replicate. The result indicated that dietary EAE improved the growth performance in carp(P < 0.05). The appropriate con centration of EAE for carp growth was estimated to be 3.643 g/kg diet. Thus, EAE could be used as a natural antioxidant in feeds for Jian carp.

关键词： Angelica sinensis Extracts Ethoxyquin Lipid oxidation Growth performance

Simulation of gas-solids heat transfer in cyclone pyrolyzer using CFD-DEM model

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Particuology 2024年第2期85卷 155-166页

作者： Nan Zhang Xueer Pan Jingxuan Yang Qian Liu wenhao Lian Xiao du Zhonglin Zhang Xiaogang Hao Guoqing Guan College of Chemical Engineering and Technology Taiyuan University of TechnologyTaiyuan030024China School of Chemistry and Chemical Engineering North University of ChinaTaiyuan030051China Shanxi Jinke Technology Service Company Limited Taiyuan030000China Labraory of Eey onveron Engineerng Institute f Rgional Innvation(RI)Hosaki Univerty3-BunkychoHiroak036-8561Japan

Fast heat transfer in the pyrolyzer can increase the yield of pyrolysis gas and tar,and improve the quality of *** with the downer pyrolyzer,the cyclone pyrolyzer can simultaneously achieve high solids holdup and violent turbulence,and correspondingly faster heat *** this work,the heat transfer behavior in the cyclone pyrolyzer is specifically studied using the computational fluid dynamics-discrete element *** simulation results reveal that the gas-solids heat convection contributes mainly to the heat transfer process,and the heat radiation and conduction are relatively small and almost negligible,*** with the downer pyrolyzer under the same operating conditions,the heating rate is significantly increased in the cyclone *** analyzing the flow characteristics in the cyclone pyrolyzer,it is found that the region of high convective heat transfer rate coincides with that of natural cyclone ***,the final coal temperature increases with the increase of gas velocity and exists a maximum *** results can offer some qualitative understanding of the heat transfer behavior in the cyclone pyrolyzer.

关键词： Cyclone pyrolyzer Rapidly heating Heat convection Natural cyclone length CFD-DEM

A brand new green coating technology for realizing the regulation of spherical propellant energy release process

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Defence Technology（防务技术） 2024年第6期36卷 78-94页

作者： wenhao Fan Yajun Ding Zhongliang Xiao School of Chemistry and Chemical Engineering Nanjing University of Science and TechnologyNanjing210094China Key Laboratory of Special Energy Materials Nanjing University of Science and TechnologyMinistry of EducationNanjing 210094China

To achieve the controllable release of energy of nitrocellulose-based propellants,this paper combines the cellulose-based nanocomposites aqueous coating(Surelease®-NC)with fluidized bed coating equipment to successfully prepare the coated spherical propellant for the first *** effects of fluidized bed coating temperature,air velocity,flow speed and atomization pressure on the adhesion rate,coating integrity and coating uniformity of the coated spherical propellant were investigated,and the preparation of coated spherical propellant with homogeneous size and structural integrity was achieved for the first *** microscopic morphology,chemical structure,water vapor adsorption behavior,combustion performance,and ageing resistance property of the coated spherical propellant were systematically investigated by,Fourier transforms infrared spectroscopy(FTIR),Micro confocal raman spectrometer,field scanning electron microscopy(SEM),dynamic vapor adsorption techniques,and closed bomb test,confirming the surface core-shell structure and the tightly bonded interfacial structure of coated spherical ***,the coated spherical propellant has good hygroscopic,excellent progressive burning and long storage stability.

关键词： Nanocomposites aqueous coating Fluidized bed coating equipment Coated spherical propellant Controllable release of energy Long storage stability