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Microstructure Evolution and Mechanical Properties of Friction Stir Welded Al-Cu-Li Alloy

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Acta Metallurgica Sinica(English Letters) 2024年第5期37卷 855-871页

作者： Peng chen wenhao chen Jiaxin chen Zhiyu chen Yang Tang Ge Liu Bensheng Huang Zhiqing Zhang School of New Energy and Materials Southwest Petroleum UniversityChengdu 610500China Sichuan Provincial Engineering Research Center of Advanced Materials Manufacturing Technology for Shale Gas High-Efficient Exploitation Southwest Petroleum UniversityChengdu 610500China College of Materials Science and Engineering Chongqing UniversityChongqing 400045China School of Mechatronic Engineering Southwest Petroleum UniversityChengdu 610500China School of Robot Engineering Yangtze Normal UniversityChongqing 408100China

The investigation concentrates on friction stir welded(FSW)Al-Cu-Li alloy concerning its local microstructural evolution and mechanical *** grain features were characterized by electron back scattered diffraction(EBSD)technology,while precipitate characterization was conducted by using transmission electron microscopy(TEM)aligned along[011]Al and[001]Al zone *** mechanical properties are evaluated through micro-hardness and tensile *** can be found that nugget zones exhibit finely equiaxed grains evolved through complete dynamic recrystallization(DRX),primarily occurring in continuous dynamic recrystallization(CDRX)and discontinuous dynamic recrystallization(DDRX).In the thermal-mechanically affected zone(TMAZ),numerous sub-structured grains,exhibiting an elongated morphology,were created due to partial DRX,signifying the dominance of CDRX,DDRX,and geometric dynamic recrystallization(GDRX)in this region.T_(1)completely dissolves in the nugget zone(NZ)leading to the formation of Guinier-Preston zones and increase ofδ′,β′and S′.Conversely,T_(1)partially solubilizes in TMAZ,the lowest hardness zone(LHZ)and heat affected zone(HAZ),and the residual T_(1)undergoes marked coarsening,revealing various T_(1)*** solubilization and coarsening of T_(1)are primary contributors to the degradation of hardness and strength.θ′primarily dissolves and coarsens in NZ and TMAZ,whilst this precipitate largely coarsens in HAZ and LHZ.σ,TB,grain boundary phases(GBPs)and precipitate-free zone(PFZ)are newly generated during FSW.σexists in the TMAZ,LHZ and HAZ,whereas TB nucleates in *** and PFZ mostly develop in LHZ and HAZ,which can cause strain localization during tensile deformation,potentially leading to LHZ joint fracture.

关键词： Al-Cu-Li alloy Friction stir welding Microstructure evolution Mechanical properties

Enhancing the Tribological Performance of Conductive Grease Through the Modification of Polypyrrole with Ionic Liquids

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China Petroleum Processing & Petrochemical Technology 2024年第3期26卷 158-172页

作者： Xia Yanqiu chen wenhao Jiang Zhirong Yang Kuo School of Energy Power and Mechanical Engineering North China Electric Power UniversityBeijing 102206China

This study prepared four types of ionic liquid-modified polypyrrole(IL-modified PPy)as conductive additives and investigated their tribological performance and conductivity in polytetrafluoroethylene lubricating *** results indicated that IL-modified PPy effectively enhanced the anti-wear performance and conductivity of the base *** the additives,1-octyl-3-methylimidazolium tetrafluoroborate([OMIm][BF4])modified PPy showed superior performance compared to the other three additives,with the best effect observed at a mass fraction of 0.5%.X-ray photoelectron spectroscopy analysis revealed that IL-modified PPy forms a stable friction chemical film during the friction process,effectively enhancing the lubrication performance and conductivity of the base *** indicates broad potential applications in the field of conductive lubrication.

关键词： conductive lubricating grease ILs modified PPy anti-friction and anti-wear additive

Unique and independent role of the GABAB1 subunit in embryo implantation and uterine decidualization in mice

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Genes & Diseases 2021年第1期8卷 79-86页

作者： wenhao chen Qian Zhang Haibin Wang Dongmei Tan Yi Tan Laboratory Animal Center Chongqing Medical UniversityChongqing400016PR China Reproductive Medical Center The First Affiliated Hospital of Xiamen UniversityXiamen361003FujianPR China Fujian Provincial Key Laboratory of Reproductive Health Research Medical College of Xiamen UniversityXiamen361102FujianPR China

Embryo implantation and decidualization are crucial for successful pregnancy,which include multiple genes and signaling pathways,while the precise mechanism regarding embryo implantation and decidualization has yet to be *** GABA which activates GABA_(A)or GABA_(B)receptors has been found playing an important role in early *** we seek to investigate whether GABA_(B)receptors participate in embryo implantation in *** study first characterized the spatiotemporal expression pattern of GABA_(B)receptors in the uterus during the peri-implantation period and found that GABA_(B1)expression was drastically upregulated in stromal cells on days 4e6,a period of embryo implantation and early stages of *** delayed implantation and oil-induced decidualization models were further used to confirm that the GABA_(B1)was associated with embryo implantation and *** also found estrogen or progesterone had no directly effect on expression of GABA_(B1)in ovariectomized *** we were unable to detect significant GABA_(B2)which couples with GABA_(B1)to form whole GABA_(B)receptors,and the agonist and antagonist of whole GABA_(B)receptors had weak effect on the proliferation and differentiation of stromal cells as well,we excluded the possibility whole GABA_(B)receptors function,and concluded it should be non-classical signals of GABA_(B1)involving in embryo implantation and *** studies should focus on investigating the roles and mechanisms of GABA_(B1)during embryo implantation and decidualization.

关键词： Decidualization Embryo implantation Endometrial stromal cells GABAB1 Ovarian hormones Proliferation

Cytokine regulation of immune tolerance

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Burns & Trauma 2014年第1期2卷 11-17页

作者： Jie Wu Aini Xie wenhao chen Department of Surgery Center for Immunobiology and Transplantation ResearchHouston Methodist Research InstituteHouston Methodist HospitalHoustonTexasUnited States

The immune system provides defenses against invading pathogens while maintaining immune tolerance to *** immune homeostasis is harmonized by the direct interactions between immune cells and the cytokine environment in which immune cells develop and ***,we discuss three non-redundant paradigms by which cytokines maintain or break immune *** firstly describe how anti-inflammatory cytokines exert direct inhibitory effects on immune cells to enforce immune tolerance,followed by discussing other cytokines that maintain immune tolerance through inducing CD_(4)^(+) Foxp_(3)^(+) regulatory T cells(Tregs),which negatively control immune ***(IL)-2 is the most potent cytokine in promoting the development and survival of Tregs,thereby mediating immune ***-35 is mainly produced by Tregs,but its biology function remains to be defi ***,we discuss the actions of proinflammatory cytokines that breach immune tolerance and induce autoimmunity,which include IL-7,IL-12,IL-21,and *** genetic studies have revealed the role of these cytokines(or their cognate receptors)in susceptibility to autoimmune *** together,we highlight in this review the cytokine regulation of immune tolerance,which will help in further understanding of human diseases that are caused by dysregulated immune system.

关键词： Cytokine immune tolerance T cell differentiation regulatory T cell

De Novo and Inherited SETD1A Variants in Early-onset Epilepsy

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Neuroscience Bulletin 2019年第6期35卷 1045-1057页

作者： Xiuya Yu Lin Yang Jin Li Wanxing Li Dongzhi Li Ran Wang Kai Wu wenhao chen Yi Zhang Zilong Qiu wenhao Zhou Division of Neonatology Children's Hospital of Fudan UniversityShanghai 201102China Clinical Genetic Center Children's Hospital of Fudan UniversityShanghai 201102China Key Laboratory of Birth Defects Children's Hospital of Fudan UniversityShanghai 201102China Institute of Biomedicine Sciences Fudan UniversityShanghai 200032China Department of Prenatal Diagnosis The Women and Children's Medical CenterGuangzhou 510623China Euler Genomics Beijing 102206China School of Life Sciences Peking UniversityBeijing 100191China Institute of Neuroscience CAS Center for Excellence in Brain Science and Intelligence TechnologyShanghai Institutes for Biological SciencesChinese Academy of SciencesShanghai 200031China Laboratory of Neonatal Diseases Ministry of HealthChildren's Hospital of Fudan UniversityShanghai 201102China

Early-onset epilepsy is a neurological abnormality in childhood, and it is especially common in the first2 years after birth. Seizures in early life mostly result from structural or metabolic disorders in the brain, and the genetic causes of idiopathic seizures have been extensively investigated. In this study, we identified four missense mutations in the SETD1 A gene(SET domain-containing 1 A, histone lysine methyltransferase): three de novo mutations in three individuals and one inherited mutation in a four-generation family. Whole-exome sequencing indicated that all four of these mutations were responsible for the seizures. Mutations of SETD1 A have been implicated in schizophrenia and developmental disorders, so we examined the role of the four mutations(R913 C, Q269 R, G1369 R, and R1392 H) in neural development. We found that their expression in mouse primary cortical neurons affected excitatory synapse development. Moreover, expression of the R913 C mutation also affected the migration of cortical neurons in the mouse *** further identified two common genes(Neurl4 and Usp39) affected by mutations of SETD1 A. These results suggested that the mutations of SETD1 A play a fundamental role in abnormal synaptic function and the development of neurons, so they may be pathogenic factors for neurodevelopmental disorders.

关键词： Early-onset epilepsy Whole-exome sequencing SETD1A Neural development

Quantitative study on the tension-compression yield asymmetry of a Mg-3Al-1Zn alloy with bimodal texture components

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Journal of Magnesium and Alloys 2022年第6期10卷 1680-1693页

作者： Lingyu Zhao wenhao chen Beian Zhou Cong He Changjian Yan Zhaoyang Jin Huihui Yu Yunchang Xin School of Mechanical Engineering Yangzhou UniversityYangzhou 225127China Key Laboratory for Light-weight Materials Nanjing Tech University 10009China National Institute for Materials Science 1-2-1 SengenTsukub1305-0047Japan Institute of Corrosion Science and Technology Guangdong 510070China Institute of Applied Physics Jiangxi Academy of SciencesNanchang 330029China

This study demonstrates the yield asymmetry in Mg-3Al-1Zn alloy containing both ND-texture(c-axis//ND(Normal direction))and TD-texture(c-axis//TD(Transverse direction))in a quantitative *** results showed that the yield asymmetry is strongly dependent on the distribution of bimodal texture components,on the basis of the successful establishment of the quantified relationship between pre-deformation parameters and texture components ***’s meaningful for providing key reference to texture *** behavior of bimodal textured Mg alloy under tension and compression was ***/TYS(compressive yield stress/tensile yield stress)equal to 1 is obtained,implying that the yield asymmetry is eliminated when two textures distribute at specific *** corresponding mechanism for the texture-dependence of tension-compression yield asymmetry is revealed by the analysis of slip/twinning activities and a compound use of the activation stress difference of slip/twinning(ΔStress)and geometrical compatibility factor(m′)between neighboring *** activity of{10■2}twinning and a quite similar boundary obstacle effect against slip/twinning transfer under tension and compression accounts for such good symmetry performance.

关键词： Mg alloy Texture Mechanical anisotropy Twinning Slip

Bacteria inactivation by sulfate radical:progress and non-negligible disinfection by-products

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Frontiers of Environmental Science & Engineering 2023年第3期17卷 23-36页

作者： Xin Zhou Xiaoya Ren Yu chen Haopeng Feng Jiangfang Yu Kang Peng Yuying Zhang wenhao chen Jing Tang Jiajia Wang Lin Tang College of Environmental Science and Engineering Hunan UniversityChangsha 410082China Key Laboratory of Environmental Biology and Pollution Control(Hunan University) Ministry of EducationChangsha 410082China

Sulfate radicals have been increasingly used for the pathogen inactivation due to their strong redox ability and high selectivity for electron-rich species in the last *** application of sulfate radicals in water disinfection has become a very promising ***,there is currently a lack of reviews of sulfate radicals inactivated pathogenic *** the same time,less attention has been paid to disinfection by-products produced by the use of sulfate radicals to inactivate *** paper begins with a brief overview of sulfate radicals’***,the progress in water disinfection by sulfate radicals is *** mechanism and inactivation kinetics of inactivating microorganisms are briefly *** that,the disinfection by-products produced by reactions of sulfate radicals with chlorine,bromine,iodide ions and organic halogens in water are also *** response to these possible challenges,this article concludes with some specific solutions and future research directions.

关键词： Sulfate radicals Disinfection by-products Inactivation mechanisms Bacterial inactivation Water disinfection

Delineating COVID-19 immunological features using single-cell RNA sequencing

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The Innovation 2022年第5期3卷 66-79页

作者： Wendao Liu Johnathan Jia Yulin Dai wenhao chen Guangsheng Pei Qiheng Yan Zhongming Zhao The University of Texas MD Anderson Cancer Center UTHealth Graduate School of Biomedical Sciences HoustonTX 77030USA Center for Precision Health School of Biomedical Informaticsthe University of Texas Health Science Center at HoustonHoustonTX 77030USA Immunobiology and Transplant Science Center Department of SurgeryHouston Methodist Research Institute and Institute forAcademic MedicineHouston Methodist HospitalHoustonTX 77030USA Department of Surgery Weill Cornell MedicineCornell UniversityNew YorkNY 10065USA Human Genetics Center School of Public Healththe University of Texas Health Science Center at HoustonHoustonTX 77030USA Department of Biomedical Informatics Vanderbilt University Medical CenterNashvilleTN 37203USA

Understanding the molecular mechanisms of coronavirus disease 2019(COVID-19)pathogenesis and immune response is vital for developing ***-cell RNA sequencing has been applied to delineate the cellular heterogeneity of the host response toward COVID-19 in multiple tissues and ***,we review the applications and findings from over 80 original COVID-19 single-cell RNA sequencing studies as well as many secondary analysis *** describe that single-cell RNA sequencing reveals multiple features of COVID-19 patients with different severity,including cell populations with proportional alteration,COVID-19-induced genes and pathways,severe acute respiratory syndrome coronavirus-2(SARS-CoV-2)infection in single cells,and adaptation of immune *** also collect published single-cell RNA sequencing datasets from original ***,we discuss the limitations in current studies and perspectives for future advance.

关键词： organs acute respiratory

Continuous Expression of Interferon Regulatory Factor 4 Sustains CD8^(+)T Cell Immunity against Tumor

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Research 2024年第3期2023卷 433-444页

作者： Anze Yu Jinfei Fu Zheng Yin Hui Yan Xiang Xiao Dawei Zou Xiaolong Zhang Xiongbing Zu Xian C.Li wenhao chen Immunobiology and Transplant Science Center Department of SurgeryHouston Methodist Research Institute and Institute for Academic MedicineHouston Methodist HospitalHoustonTXUSA Department of Urology First Affiliated HospitalSun Yat-sen UniversityGuangzhouGuangdongChina Systems Medicine and Bioengineering Department Houston Methodist Neal Cancer CenterHoustonTXUSA Department of Radiology Houston Methodist HospitalWeill Cornell MedicineHoustonTXUSA Department of Urology Xiangya HospitalCentral South UniversityChangshaHunanChina Department of Surgery Weill Cornell MedicineCornell UniversityNew YorkNYUSA.

T-cell-based immunotherapy is gaining momentum in cancer treatment;however,our comprehension of the transcriptional regulation governing T cell antitumor activity remains *** objective of this study was to explore the function of interferon regulatory factor 4(IRF4)in antitumor CD8^(+)T cells using the TRAMP-C1 prostate cancer and B16F10 melanoma *** achieve this,we generated an Irf4^(GFP-DTR) mouse strain and discovered that CD8^(+)tumor-infiltrating lymphocytes(TILs)expressing high levels of *** exhibited a more differentiated PD-1high cell *** administering diphtheria toxin to tumor-bearing Irf4^(GFP-DTR) mice,we partially depleted ***^(+)TILs and observed an accelerated tumor *** specifically explore the function of IRF4 in antitumor CD8^(+)T cells,we conducted 3 adoptive cell therapy(ACT)***,depleting ***^(+)CD8^(+)TILs derived from ACT significantly accelerated tumor growth,emphasizing their crucial role in controlling tumor ***,deleting the Irf4 gene in antitumor CD8^(+)T cells used for ACT led to a reduction in the frequency and effector differentiation of CD8^(+)TILs,completely abolishing the antitumor effects of ***,we performed a temporal deletion of the Irf4 gene in antitumor CD8^(+)T cells during ACT,starting from 20 days after tumor implantation,which significantly compromised tumor ***,sustained expression of IRF4 is essential for maintaining CD8^(+)T cell immunity in the melanoma model,and these findings carry noteworthy implications for the advancement of more potent immunotherapies for solid tumors.

关键词： sustained immunity implantation