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Stenting for intracranial stenosis:potential future for the prevention of disabling or fatal stroke

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Stroke & Vascular Neurology 2018年第3期3卷 140-146页

作者： wengui yu Wei-Jian Jiang Department of Neurology University of CaliforniaIrvineCaliforniaUSA New Era Stroke Care and Research Institute The Rocket Force General HospitalBeijingChina

Intracranial stenosis is a common cause of ischaemic strokes,in particular,in the Asian,African and Hispanic *** randomised multicentre study Stenting and Aggressive Medical Management for the Prevention of Recurrent stroke in Intracranial Stenosis(SAMMPRIS)showed 14.7% risk of stroke or death in the stenting group versus 5.8% in the medical group at 30 days,and 23% in the stenting group versus 15% in the medical group at a median follow-up of 32.4 *** results demonstrated superiority of medical management over stenting and have almost put the intracranial stenting to rest in recent *** note,16 patients(7.1%)in the stenting group had disabling or fatal stroke within 30 days mostly due to periprocedural complications as compared with 4 patients(1.8%)in the medical *** contrast,5 patients(2.2%)in the stenting group and 14 patients(6.2%)in the medical group had a disabling or fatal stroke beyond 30 days,indicating significant benefit of stenting if periprocedural complications can be ***,the results of the Chinese Angioplasty and Stenting for Symptomatic Intracranial Severe Stenosis trial and the Wingspan Stent System Post Market Surveillance Study(WEAVE trial)showed 2%-2.7% periprocedural *** is time to evaluate the role of intracranial stenting for the prevention of disabling or fatal stroke.

关键词： prevention intracranial Stent

Current management of spontaneous intracerebral haemorrhage

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Stroke & Vascular Neurology 2017年第1期2卷 21-29页

作者： Cyrus K Dastur wengui yu Department of Neurology University of California IrvineIrvineCaliforniaUSA

Intracerebral haemorrhage(ICH)is the most devastating and disabling type of *** hypertension(HTN)is the most common cause of spontaneous *** advances in neuroimaging,organised stroke care,dedicated Neuro-ICUs,medical and surgical management have improved the management of *** airway protection,control of malignant HTN,urgent reversal of coagulopathy and surgical intervention may increase the chance of survival for patients with severe *** lowering of systolic blood pressure to30 cbic centmetre)or symptomatic perihaematoma oedema,it may be beneficial to keep serum sodium level at 140–150 mEq/L for 7–10 days to minimise oedema expansion and mass *** and HTS can be used emergently for worsening cerebral oedema,elevated intracranial pressure(ICP)or pending *** should be administered via central line as continuous infusion(3%)or bolus(23.4%).Ventriculostomy is indicated for patients with severe intraventricular haemorrhage,hydrocephalus or elevated *** with large cerebellar or temporal ICH may benefit from emergent haematoma *** is important to start intermittent pneumatic compression devices at the time of admission and subcutaneous unfractionated heparin in stable patients within 48 hours of admission for prophylaxis of venous *** is no benefit for seizure prophylaxis or aggressive management of fever or *** aggressive comprehensive care may improve survival and functional recovery.

关键词： elevated routine mannitol

Coagulopathy reversal in intracerebral haemorrhage

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Stroke & Vascular Neurology 2020年第1期5卷 29-33页

作者： Alexander Jacob Sweidan Navneet Kaur Singh Joseph Luke Conovaloff Matthew Bower Leonid I Groysman Mohammad Shafie wengui yu Neurology University of California Irvine Medical CenterOrangeCaliforniaUSA Medicine University of California Irvine Medical CenterOrangeCaliforniaUSA

As intracerebral hemorrahge becomes more frequent as a result of an aging population with greater comorbidities,rapid identification and reversal of precipitators becomes increasingly *** aformentioned population will ever more likely be on some form of anticoagulant *** the mechanisms of these agents and means by which to reverse them early on is critical in managing the acute intracerebral hemorrhage.

关键词： likely mentioned reversal

Balloon Angioplasty for Symptomatic Intracranial Artery Stenosis (BASIS): protocol of a prospective, multicentre, randomised, controlled trial

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Stroke & Vascular Neurology 2024年第1期9卷 66-74页

作者： Xuan Sun Ming Yang Dapeng Sun Guangge Peng Yiming Deng Xingquan Zhao Liping Liu Ning Ma Feng Gao Dapeng Mo wengui yu Yongjun Wang Yilong Wang Zhongrong Miao Department of Interventional Neuroradiology Beijing Tiantan HospitalCapital Medical UniversityBeijingChina Department of Neurology Beijing Tiantan HospitalCapital Medical UniversityBeijingChina Department of Neurology Beijing Luhe HospitalCapital Medical UniversityBeijingChina Department of Neurology Comprehensive Stroke&Cerebrovascular CenterUniversity of California IrvineIrvineCaliforniaUSA Chinese Institute for Brain Research BeijingChina National Center for Neurological Diseases BeijingChina Advanced Innovation Center for Human Brain Protection Capital Medical UniversityBeijingChina China National Clinical Research Center for Neurological Diseases BeijingChina Beijing Laboratory of Oral Health Capital Medical UniversityBeijingChina

Background The superiority of balloon angioplasty plus aggressive medical management(AMM)to AMM alone for symptomatic intracranial artery stenosis(sICAS)on efficacy and safety profiles still lacks evidence from randomised controlled trials(RCTs).Aim To demonstrate the design of an RCT on balloon angioplasty plus AMM for *** Balloon Angioplasty for Symptomatic Intracranial Artery Stenosis(BASIS)trial is a multicentre,prospective,randomised,open-label,blinded end-point trial to investigate whether balloon angioplasty plus AMM could improve clinical outcome compared with AMM alone in patients with *** eligible in BASIS were 35–80 years old,with a recent transient ischaemic attack within the past 90 days or ischaemic stroke between 14 days and 90 days prior to enrolment due to severe atherosclerotic stenosis(70%–99%)of a major intracranial *** eligible patients were randomly assigned to receive balloon angioplasty plus AMM or AMM alone at a 1:1 *** groups will receive identical AMM,including standard dual antiplatelet therapy for 90 days followed by long-term single antiplatelet therapy,intensive risk factor management and life-style *** participants will be followed up for *** outcomes Stroke or death in the next 30 days after enrolment or after balloon angioplasty procedure of the qualifying lesion during follow-up,or any ischaemic stroke or revascularisation from the qualifying artery after 30 days but before 12 months of enrolment,is the primary *** BASIS trail is the first RCT to compare the efficacy and safety of balloon angioplasty plus AMM to AMM alone in sICAS patients,which may provide an alternative perspective for treating *** registration number NCT03703635;https://***.

关键词： balloon prospective centre

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急性缺血性脑卒中治疗基准数据的改进研究

脑与神经疾病杂志 2021年第11期29卷 666-671页

作者：刘诗蒙 yu wengui 首都医科大学附属北京天坛医院神经病学中心北京100070 美国加州大学欧文分校神经内科

目的尽管组织纤溶酶原激动剂(tPA)静脉溶栓治疗和血管内取栓治疗(EVT)是急性缺血性脑卒中(AIS)的有效治疗手段;但在临床实践中,启动上述治疗时间往往有延误。作者检验了美国单个高级卒中中心的质控数据,以期报道其在急性卒中处理的持续... 详细信息

目的尽管组织纤溶酶原激动剂(tPA)静脉溶栓治疗和血管内取栓治疗(EVT)是急性缺血性脑卒中(AIS)的有效治疗手段;但在临床实践中,启动上述治疗时间往往有延误。作者检验了美国单个高级卒中中心的质控数据,以期报道其在急性卒中处理的持续性质控基准数据改进情况。方法本研究纳入2013年1月-2018年12月美国单个高级卒中中心连续性的缺血性脑卒中患者。根据美国心脏协会(AHA)的卒中代码和2015年实施的简明改进协议对脑卒中患者进行管理。人口统计学和临床数据来自遵照指南(GWTG)-卒中登记处和电子病历。按照入院和实施质控改进举措的日期将患者分为3组。使用线性回归模型和Jonckheere-Terpstra检验分析质控指标,质控指标包括静脉tPA溶栓治疗和EVT率、入院-溶栓开始(DTN)时间和入院-动脉穿刺(DTP)时间。结果本研究共纳入1369例发病24h内的卒中患者,2013-2014年、2015-2016年和2017-2018年的静脉tPA溶栓率分别为20%、30%和22%;EVT率分别为9%、14%和15%。根据Jonckheere-Terpstra检验,DTN时间的中位数(57、45、39 min;P<0.001)和DTP时间中位数(172、130、114 min;P=0.009)在以上3个时间段内得到连续性的改善;2017年1月-2018年12月,80%的患者DTN时间≤60 min,63%的患者DTN时间≤45 min。结论遵循AHA指南和简明改进协议后,AIS的静脉溶栓/EVT率和治疗启动时间得到了不断改进。

关键词：急性缺血性卒中基准数据血管内取栓术静脉溶栓临床结局质控改进

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乙酰丹酚酸A对血小板花生四烯酸代谢的影响

药学学报 1998年第1期33卷 62-63页

作者：吁文贵徐理纳中国医学科学院中国协和医科大学药物研究所

乙酰丹酚酸Ａ对血小板花生四烯酸代谢的影响吁文贵徐理纳（中国医学科学院、中国协和医科大学药物研究所，北京１０００５０）乙酰丹酚酸Ａ（ａｃｅｔｙｌｓａｌｖｉａｎｏｌｉｃａｃｉｄＡ，ＡＳＡＡ）在体内外能明显抑制花生四烯酸（... 详细信息

乙酰丹酚酸Ａ对血小板花生四烯酸代谢的影响吁文贵徐理纳（中国医学科学院、中国协和医科大学药物研究所，北京１０００５０）乙酰丹酚酸Ａ（ａｃｅｔｙｌｓａｌｖｉａｎｏｌｉｃａｃｉｄＡ，ＡＳＡＡ）在体内外能明显抑制花生四烯酸（ａｒａｃｈｉｄｏｎｉｃａｃｉｄ，Ａ...

关键词：乙酰丹酚酸A 血小板花生四烯酸代谢

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Chinese Neurosurgical Journal 2020年第1期6卷 28-34页

作者： Liu Ao-Fei Li Chen yu wengui Lin Li-Mei Qiu Han-Cheng Zhang Yi-Qun Lv Xian-Li Wang Kai Liu Ce Jiang Wei-Jian Department of Vascular Neurosurgery New Era Stroke Care and Research InstituteThe PLA Rocket Force Characteristic Medical CenterNo.16 Xinjiekouwai StreetXicheng DistrictBeijing 100088China Department of Neurology University of CaliforniaIrvineIrvineCAUSA Department of Neurosurgery University of CaliforniaIrvineIrvineCAUSA Department of Neurosurgery Tsinghua Changgung Hospital of Tsinghua UniversityBeijingChina

Background:The development of carotid-cavernous fistulas(CCFs)during surgical recanalization of chronic internal carotid artery occlusion(ICAO)may be secondary to severe ICA dissection rather than a focal tear of the cavernous ICA seen in typical traumatic *** purpose of this study is to investigate the causal relationship between the CCFs and severe ICA dissections and to characterize technical outcomes after treatment with ***:Five patients underwent treatment with self-expanding stents due to intraprocedural CCF and ICA dissection following surgical removal of ICAO *** stents were telescopically placed via true channel of the *** of the procedure was evaluated with 30-day stroke and death *** success was determined by the efficacy of CCF obliteration and ICAO recanalization with ***:All CCFs were associated with spiral and long segmental dissection from the cervical to cavernous *** stenting,successful dissection reconstruction with TICI 3 was achieved in all patients,with complete(n=4)or partial CCF(n=1)*** patient had CCF syndrome,stroke,or death during follow-up of 6 to 37 months;but one patient had pulsatile tinnitus,which resolved 1 year *** at 6 to 24 months demonstrated CCF obliteration in all 5 patients and durable ICA patency in 4 ***:Intraprocedural CCFs with spiral and cervical-to-cavernous ICA dissection during ICAO surgery are dissection-related because of successful obliteration after stenting for dissection ***-expanding stenting through true channel of the dissection,serving as implanting stent-autograft,may be an optimal therapy for the atypical CCF complication from ICAO surgery.

关键词： Arterial dissection Carotid-cavernous fistula Hybrid surgery Internal carotid artery occlusion Stenting

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金属复合型摩擦阻尼器力学性能试验研究

噪声与振动控制 2023年第5期43卷 280-285页

作者：石文龙虞文桂张浩波王利民上海大学力学与工程科学学院土木工程系上海200444 上海史狄尔建筑减震科技有限公司上海200092 中国建筑科学研究院有限公司北京100013

提出了一种金属复合型摩擦阻尼器,通过预紧力试验和力学性能试验,研究了螺栓预紧力对阻尼器摩擦系数及摩擦荷载的影响,并以剪切型摩擦阻尼器作对照,对使用刹车片磨材的金属复合型摩擦阻尼器的力学性能进行分析。试验结果表明:摩擦阻尼... 详细信息

提出了一种金属复合型摩擦阻尼器,通过预紧力试验和力学性能试验,研究了螺栓预紧力对阻尼器摩擦系数及摩擦荷载的影响,并以剪切型摩擦阻尼器作对照,对使用刹车片磨材的金属复合型摩擦阻尼器的力学性能进行分析。试验结果表明:摩擦阻尼器的摩擦系数会随着预紧力的增加而小幅减小,因此摩擦荷载衰减比例低于预紧力衰减比例;刹车片磨材具有良好且稳定的性能;金属复合型摩擦阻尼器滞回曲线表现为三线型,实现阻尼器的分阶段屈服,双阶段耗能效果;金属复合型摩擦阻尼器的预紧力损失和阻尼力衰减较剪切型的要更小。

关键词：振动与波金属复合型预紧力摩擦材料力学性能双阶段耗能

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保护地番茄新品种苏粉8号的选育

中国蔬菜 2005年第10期 37-38页

作者：赵统敏余文贵徐鹤林江苏省农业科学院蔬菜研究所南京210014

苏粉8号系以GB9736为母本,TM9761为父本配制而成的适合保护地栽培的中熟番茄一代杂种.属无限生长型.果实高圆形,粉红色,果面光滑,果皮厚,耐贮运,品质佳,可溶性固形物含量5.0%,酸甜适中,单果质量200～250 g,产量6 000kg·(667 m2)-1以上... 详细信息

苏粉8号系以GB9736为母本,TM9761为父本配制而成的适合保护地栽培的中熟番茄一代杂种.属无限生长型.果实高圆形,粉红色,果面光滑,果皮厚,耐贮运,品质佳,可溶性固形物含量5.0%,酸甜适中,单果质量200～250 g,产量6 000kg·(667 m2)-1以上.高抗ToMV-0,1株系、叶霉病,抗枯萎病,中抗CMV.已在江苏、山东、四川、浙江等地示范推广逾266.7 hm2.

关键词：番茄苏粉8号一代杂种保护地番茄新品种可溶性固形物含量选育保护地栽培无限生长型单果质量