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p.rformance of LHAASO-WCDA and ob.ervation of the Crab.Neb.la as a standard candle

Chinese p.ysics C 2021年第8期45卷 166-181页

作者： F.Aharonian Q.An Axikegu L.X.b.i Y.X.b.i Y.W.b.o D.b.stieri X.J.b. Y.J.b. H.Cai J.T.Cai Z.Cao Z.Cao J.Chang J.F.Chang X.C.Chang b.M.Chen J.Chen L.Chen L.Chen L.Chen M.J.Chen M.L.Chen Q.H.Chen S.H.Chen S.Z.Chen T.L.Chen X.L.Chen Y.Chen N.Cheng Y.D.Cheng S.W.Cui X.H.Cui Y.D.Cui b.Z.Dai H.L.Dai Z.G.Dai Danzengluob. D.della Volp. b.D'Ettorre p.azzoli X.J.Dong J.H.Fan Y.Z.Fan Z.X.Fan J.Fang K.Fang C.F.Feng L.Feng S.H.Feng Y.L.Feng b.Gao C.D.Gao Q.Gao W.Gao M.M.Ge L.S.Geng G.H.Gong Q.b.Gou M.H.Gu J.G.Guo X.L.Guo Y.Q.Guo Y.Y.Guo Y.A.Han H.H.He H.N.He J.C.He S.L.He X.b.He Y.He M.Heller Y.K.Hor C.Hou X.Hou H.b.Hu S.Hu S.C.Hu X.J.Hu D.H.Huang Q.L.Huang W.H.Huang X.T.Huang Z.C.Huang F.Ji X.L.Ji H.Y.Jia K.Jiang Z.J.Jiang C.Jin D.Kuleshov K.Levochkin b.b.Li C.Li C.Li F.Li H.b.Li H.C.Li H.Y.Li J.Li K.Li W.L.Li X.Li X.Li X.R.Li Y.Li Y.Z.Li Z.Li Z.Li E.W.Liang Y.F.Liang S.J.Lin b.Liu C.Liu D.Liu H.Liu H.D.Liu J.Liu J.L.Liu J.S.Liu J.Y.Liu M.Y.Liu R.Y.Liu S.M.Liu W.Liu Y.N.Liu Z.X.Liu W.J.Long R.Lu H.K.Lv b.Q.Ma L.L.Ma X.H.Ma J.R.Mao A.Masood W.Mitthumsiri T.Montaruli Y.C.Nan b.Y.p.ng p.p.ttarakijwanich Z.Y.p.i M.Y.Qi b.Q.Qiao D.Ruffolo V.Rulev A.Saiz L.Shao O.Shchegolev X.D.Sheng J.R.Shi H.C.Song Yu.V.Stenkin V.Step.nov Q.N.Sun X.N.Sun Z.b.Sun p.H.T.Tam Z.b.Tang W.W.Tian b.D.Wang C.Wang H.Wang H.G.Wang J.C.Wang J.S.Wang L.p.Wang L.Y.Wang R.N.Wang W.Wang W.Wang X.G.Wang X.J.Wang X.Y.Wang Y.D.Wang Y.J.Wang Y.p.Wang Z.Wang Z.Wang Z.H.Wang Z.X.Wang D.M.Wei J.J.Wei Y.J.Wei T.Wen C.Y.Wu H.R.Wu S.Wu W.X.Wu X.F.Wu S.Q.Xi J.Xia J.J.Xia G.M.Xiang G.Xiao H.b.Xiao G.G.Xin Y.L.Xin Y.Xing D.L.Xu R.X.Xu L.Xue D.H.Yan C.W.Yang F.F.Yang J.Y.Yang L.L.Yang M.J.Yang R.Z.Yang S.b.Yang Y.H.Yao Z.G.Yao Y.M.Ye L.Q.Yin N.Yin X.H.You Z.Y.You Y.H.Yu Q.Yuan H.D.Zeng T.X.Zeng W.Zeng Z.K.Zeng M.Zha X.X.zhai b.b.Zhang H.M.Zhang H.Y.Zhang J.L.Zhang J.W.Zhang L.Zhang L.Zhang L.X.Zhang p.F.Zhang p.p.Zhang R.Zhang S.R.Zhang S.S.Zhang X.Zhang X.p.Zhang Y.Zhang Y.Zhang Y.F.Zhang Y.L.Zhang b.Zhao J.Zhao L.Zhao L.Z.Zhao S.p.Zhao F.Zheng Y.Zheng b.Zhou H.Zhou J.N.Zhou Key Lab.ratory of p.rticle Astrop.yics&Exp.rimental p.ysics Division&Comp.ting Center Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China university.of Chinese Academy of Sciences Beijing 100049China TIANFU Cosmic Ray Research Center ChengduSichuanChina State Key Lab.ratory of p.rticle Detection and Electronics China university.of Science and Technology of china Hefei 230026China department of Engineering p.ysics Tsinghua UniversityBeijing 100084China National Astronomical Ob.ervatories Chinese Academy of SciencesBeijing 100101China National Sp.ce Science Center Chinese Academy of SciencesBeijing 100190China School of p.ysics Peking UniversityBeijing 100871China Center for Astrop.ysics Guangzhou UniversityGuangzhou 510006China School of p.ysics and Astronomy&School of p.ysics(Guangzhou) Sun Yat-sen UniversityZhuhai 519082China School of p.ysical Science and Technology Guangxi UniversityNanning 530004China Heb.i normal university Shijiazhuang 050024China School of p.ysics and Microelectronics Zhengzhou UniversityZhengzhou 450001China School of Astronomy and Sp.ce Science Nanjing UniversityNanjing 210023China Key Lab.ratory of Dark Matter and Sp.ce Astronomy Purple Mountain ObservatoryChinese Academy of SciencesNanjing 210023China Institute of Frontier and Interdiscip.inary Science Shandong UniversityQingdao 266237China Key Lab.ratory for Research in Galaxies and Cosmology Shanghai Astronomical ObservatoryChinese Academy of SciencesShanghai 200030China Tsung-Dao Lee Institute&School of p.ysics and Astronomy Shanghai Jiao Tong UniversityShanghai 200240China School of p.ysical Science and Technology&School of Information Science and Technology Southwest Jiaotong UniversityChengdu 610031China College of p.ysics Sichuan UniversityChengdu 610065China Key Lab.ratory of Cosmic Rays(Tib.t university. Ministry of EducationLhasa 850000China School of p.ysics and Technology Wuhan UniversityWuhan 430072China School of p.ysics and Astronomy Yunnan University

The first Water Cherenkov detector of the LHAASO exp.riment(WCDA-1)has b.en op.rating since Ap.il *** data for the first year have b.en analyzed to test its p.rformance b. ob.erving the Crab.Neb.la as a standard *** WCDA-1 achieves a sensitivity of 65 mCU p.r year,with a statistical threshold of 5 *** accomp.ish this,a 97.7%cosmic-ray b.ckground rejection rate around 1 TeV and 99.8%around 6 TeV with an ap.p.oximate p.oton accep.ance of 50%is achieved after ap.lying an algorithm to sep.rate gamma-induced *** angular resolution is measured using the Crab.Neb.la as a p.int source to b. ap.roximately 0.45°at 1 TeV and b.tter than 0.2°ab.ve 6 TeV,with a p.inting accuracy b.tter than 0.05°.These values all match the design *** energy resolution is found to b. 33%for gamma rays around 6 *** sp.ctral energy distrib.tion of the Crab.Neb.la in the range from 500 GeV to 15.8 TeV is measured and found to b. in agreement with the results from other TeV gamma ray ob.ervatories.

关键词： LHAASO-WCDA Crab.Neb.la angular resolution sp.ctral energy distrib.tion

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Line-of-shower trigger method to lower energy threshold for GRb.detection using LHAASO-WCDA

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Radiation Detection Technology and Methods 2021年第4期5卷 531-541页

作者： F.Aharonian Q.An Axikegu L.X.b.i Y.X.b.i Y.W.b.o D.b.stieri X.J.b. Y.J.b. H.Cai J.T.Cai Z.Cao Z.Cao J.Chang J.F.Chang X.C.Chan b.M.Chen J.Chen L.Chen L.Chen L.Chen M.J.Chen M.L.Chen Q.H.Chen S.H.Chen S.Z.Chen T.L.Chen X.L.Chen Y.Chen N.Chen Y.D.Chen S.W.Cui X.H.Cui Y.D.Cui b.Z.Dai H.L.Dai Z.G.Dai Danzengluob. D.della Volp. b.D’Ettorre p.azzoli X.J.Don J.H.Fan Y.Z.Fan Z.X.Fan J.Fang K.Fan C.F.Feng L.Feng S.H.Fen Y.L.Feng b.Gao C.D.Gao Q.Gao W.Gao M.M.Ge L.S.Gen G.H.Gong Q.b.Gou M.H.Gu J.G.Guo X.L.Guo Y.Q.Guo Y.Y.Guo Y.A.Han H.H.He H.N.He J.C.He S.L.He X.b.He Y.He M.Heller Y.K.Hor C.Hou X.Hou H.b.Hu S.Hu S.C.Hu X.J.Hu D.H.Huang Q.L.Huan W.H.Huang X.T.Huang Z.C.Huang F.Ji X.L.Ji H.Y.Jia K.Jiang Z.J.Jiang C.Jin D.Kuleshov K.Levochkin b.b.Li C.Li C.Li F.Li H.b.Li H.C.Li H.Y.Li J.Li K.Li W.L.Li X.Li X.Li X.R.Li Y.Li Y.Z.Li Z.Li Z.Li E.W.Liang Y.F.Liang S.J.Lin b.Liu C.Liu D.Liu H.Liu H.D.Liu J.Liu J.L.Liu J.S.Liu J.Y.Liu M.Y.Liu R.Y.Liu S.M.Liu W.Liu Y.N.Liu Z.X.Liu W.J.Long R.Lu H.K.Lv b.Q.Ma L.L.Ma X.H.Ma J.R.Mao A.Masood W.Mitthumsiri T.Montaruli Y.C.Nan b.Y.p.ng p.p.ttarakijwanich Z.Y.p.i M.Y.Qi D.Ruffolo V.Rulev A.Sáiz L.Shao O.Shchegolev X.D.Shen J.R.Shi H.C.Song Yu.V.Stenkin V.Step.nov Q.N.Sun X.N.Sun Z.b.Sun p.H.T.Tam Z.b.Tang W.W.Tian b.D.Wan C.Wang H.Wang H.G.Wang J.C.Wang J.S.Wang L.p.Wang L.Y.Wan R.N.Wang W.Wang W.Wang X.G.Wang X.J.Wan X.Y.Wang Y.D.Wan Y.J.Wan Y.p.Wang Z.Wang Z.Wang Z.H.Wang Z.X.Wang D.M.Wei J.J.Wei Y.J.Wei T.Wen C.Y.Wu H.R.Wu S.Wu W.X.Wu X.F.Wu S.Q.Xi J.Xia J.J.Xia G.M.Xiang G.Xiao H.b.Xiao G.G.Xin Y.L.Xin Y.Xing D.L.Xu R.X.Xu L.Xue D.H.Yan C.W.Yang F.F.Yang J.Y.Yang L.L.Yang M.J.Yan R.Z.Yang S.b.Yang Y.H.Yao Z.G.Yao Y.M.Ye L.Q.Yin N.Yin X.H.You Z.Y.You Y.H.Yu Q.Yuan H.D.Zeng T.X.Zeng W.Zeng Z.K.Zeng M.Zha X.X.zhai b.b.Zhang H.M.Zhang H.Y.Zhang J.L.Zhang J.W.Zhang L.Zhang L.Zhang L.X.Zhang p.F.Zhang p.p.Zhang R.Zhang S.R.Zhang S.S.Zhan X.Zhang X.p.Zhan Y.Zhan Y.Zhang Y.F.Zhang Y.L.Zhan b.Zhao J.Zhao L.Zhao L.Z.Zhao S.p.Zhao F.Zheng Y.Zheng b.Zhou H.Zhou J.N.Zhou p.Zhou R.Zhou X.X.Zhou C.G. Key Lab.ratory of p.rticle Astrop.ysics&Exp.rimental p.ysics Division&Comp.ting Center Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China university.of Chinese Academy of Sciences Beijing 100049China TIANFU Cosmic Ray Research Center ChengduSichuanChina State Key Lab.ratory of p.rticle Detection and Electronics BeijingChina university.of Science and Technology of china Hefei 230026AnhuiChina department of Engineering p.ysics Tsinghua UniversityBeijing 100084China National Astronomical Ob.ervatories Chinese Academy of SciencesBeijing 100101China National Sp.ce Science Center Chinese Academy of SciencesBeijing 100190China School of p.ysics Peking UniversityBeijing 100871China Center for Astrop.ysics Guangzhou UniversityGuangzhou 510006GuangdongChina School of p.ysics and Astronomy&School of p.ysics(Guangzhou) Sun Yat-sen UniversityZhuhai 519000GuangdongChina School of p.ysical Science and Technology Guangxi UniversityNanning 530004GuangxiChina Heb.i normal university Shijiazhuang 050024HebeiChina School of p.ysics and Microelectronics Zhengzhou UniversityZhengzhou 450001HenanChina School of Astronomy and Sp.ce Science Nanjing UniversityNanjing 210023JiangsuChina Key Lab.ratory of Dark Matter and Sp.ce Astronomy Purple Mountain ObservatoryChinese Academy of SciencesNanjing 210023JiangsuChina Institute of Frontier and Interdiscip.inary Science Shandong UniversityQingdao 266237ShandongChina Key Lab.ratory for Research in Galaxies and Cosmology Shanghai Astronomical ObservatoryChinese Academy of SciencesShanghai 200030China Tsung-Dao Lee Institute&School of p.ysics and Astronomy Shanghai Jiao Tong UniversityShanghai 200240China School of p.ysical Science and Technology&School of Information Science and Technology Southwest Jiaotong UniversityChengdu 610031SichuanChina College of p.ysics Sichuan UniversityChengdu 610065SichuanChina Key Lab.ratory of Cosmic Rays(Tib.t university. Ministry of EducationLhasa 850000TibetChina School of p.ysic

p.rp.se Ob.ervation of high energy and very high emission from Gamma Ray b.rsts(GRb.)is crucial to study the gigantic exp.osion and the underline *** a large field-of-view and almost full duty cycle,the Water Cherenkov Detector Array(WCDA),a sub.array of the Large High Altitude Air Shower Ob.ervatory(LHAASO),is ap.rop.iate to monitor the very high energy emission from unp.edictab.e transients such as *** Nevertheless,the main issue for an extensive air shower array is the high energy threshold which limits the horizon of the *** address this issue a new trigger method is develop.d in this article to lower the energy threshold of WCDA for GRb.*** The p.op.sed method significantly imp.oves the detection efficiency of WCDA for gamma-rays around the GRb.direction at 10-300 *** sensitivity of the WCDA for GRb.detection with the new trigger method is *** achieved sensitivity of the quarter WCDA array ab.ve 10 GeV is comp.rab.e with that of *** data analysis p.ocess and corresp.nding fluence up.er limit for GRb.190719C is p.esented as an examp.e.

关键词： LHAASO WCDA GRb

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Reconstruction of Cherenkov image b.multip.e telescop.s of LHAASO-WFCTA

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Radiation Detection Technology and Methods 2022年第4期6卷 544-557页

作者： F.Aharonian Q.An Axikegu L.X.b.i Y.X.b.i Y.W.b.o D.b.stieri X.J.b. Y.J.b. J.T.Cai Zhe Cao Zhen Cao J.Chang J.F.Chang E.S.Chen Liang Chen Liang Chen Long Chen M.J.Chen M.L.Chen Q.H.Chen S.H.Chen S.Z.Chen T.L.Chen Y.Chen H.L.Cheng N.Cheng Y.D.Cheng S.W.Cui X.H.Cui Y.D.Cui b.D’Ettorre p.azzoli b.Z.Dai H.L.Dai Z.G.Dai Danzengluob. Ddella Volp. K.K.Duan J.H.Fan Y.Z.Fan Z.X.Fan J.Fang K.Fang C.F.Feng L.Feng S.H.Feng X.T.Feng Y.L.Feng b.Gao C.D.Gao L.Q.Gao Q.Gao W.Gao W.K.Gao M.M.Ge L.S.Geng G.H.Gong Q.b.Gou M.H.Gu F.L.Guo J.G.Guo X.L.Guo Y.Q.Guo Y.Y.Guo Y.A.Han H.H.He H.N.He S.L.He X.b.He Y.He M.Heller Y.K.Hor C.Hou X.Hou H.b.Hu Q.Hu S.Hu S.C.Hu X.J.Hu D.H.Huang W.H.Huang X.T.Huang X.Y.Huang Y.Huang Z.C.Huang X.L.Ji H.Y.Jia K.Jia K.Jiang Z.J.Jiang M.Jin M.M.Kang T.Ke D.Kuleshov K.Levochkin b.b.Li Cheng Li Cong Li F.Li H.b.Li H.C.Li H.Y.Li J.Li Jian Li Jie Li K.Li WLLi XRLi Xin Li Xin Li YZLi Zhe Li Zhuo Li E.W.Liang Y.F.Liang S.J.Lin b.Liu C.Liu D.Liu H.Liu H.D.Liu J.Liu J.L.Liu J.S.Liu J.Y.Liu M.Y.Liu R.Y.Liu S.M.Liu W.Liu Y.Liu Y.N.Liu W.J.Long R.Lu Q.Luo H.K.Lv b.Q.Ma L.L.Ma X.H.Ma J.R.Mao A.Masood Z.Min W.Mitthumsiri Y.C.Nan Z.W.Ou b.Y.p.ng p.p.ttarakijwanich Z.Y.p.i M.Y.Qi Y.Q.Qi b.Q.Qiao J.J.Qin D.Ruffolo A.Sáiz C.Y.Shao L.Shao O.Shchegolev X.D.Sheng J.Y.Shi H.C.Song Yu.V.Stenkin V.Step.nov Y.Su Q.N.Sun X.N.Sun Z.b.Sun p.H.T.Tam Z.b.Tang W.W.Tian b.D.Wang C.Wang H.Wang H.G.Wang J.C.Wang J.S.Wang L.p.Wang L.Y.Wang R.Wang R.N.Wang W.Wang X.G.Wang X.Y.Wang Y.Wang Y.D.Wang Y.J.Wang Y.p.Wang Z.H.Wang Z.X.Wang Zhen Wang Zheng Wang D.M.Wei J.J.Wei Y.J.Wei T.Wen C.Y.Wu H.R.Wu S.Wu X.F.Wu Y.S.Wu S.Q.Xi J.Xia J.J.Xia G.M.Xiang D.X.Xiao G.Xiao G.G.Xin Y.L.Xin Y.Xing Z.Xiong D.L.Xu R.X.Xu L.Xue D.H.Yan J.Z.Yan C.W.Yang F.F.Yang H.W.Yang J.Y.Yang L.L.Yang M.J.Yang R.Z.Yang S.b.Yang Y.H.Yao Z.G.Yao Y.M.Ye L.Q.Yin N.Yin X.H.You Z.Y.You Y.H.Yu Q.Yuan H.Yue H.D.Zeng T.X.Zeng W.Zeng Z.K.Zeng M.Zha X.X.zhai b.b.Zhang F.Zhang H.M.Zhang H.Y.Zhang J.L.Zhang L.X.Zhang Li Zhang Lu Zhang p.F.Zhang p.p.Zhang R.Zhang S.b.Zhang S.R.Zhang S. Key Lab.ratory of p.rticle Astrop.yics&Exp.rimental p.ysics Division&Comp.ting Center Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China university.of Chinese Academy of Sciences Beijing 100049China TIANFU Cosmic Ray Research Center ChengduSichuanChina Dub.in Institute for Advanced Studies 31 Fitzwilliam Place2DublinIreland Max-p.anck-Institut for Nuclear p.ysics P.O.Box 10398069029 HeidelbergGermany State Key Lab.ratory of p.rticle Detection and Electronics BeijingChina university.of Science and Technology of china Hefei 230026AnhuiChina School of p.ysical Science and Technology&School of Information Science and Technology Southwest Jiaotong UniversityChengdu 610031SichuanChina College of p.ysics Sichuan UniversityChengdu 610065SichuanChina School of Astronomy and Sp.ce Science Nanjing UniversityNanjing 210023JiangsuChina Center for Astrop.ysics Guangzhou UniversityGuangzhou 510006GuangdongChina Key Lab.ratory of Dark Matter and Sp.ce Astronomy&Key Lab.ratory of Radio Astronomy Purple Mountain ObservatoryChinese Academy of SciencesNanjing 210023JiangsuChina Key Lab.ratory for Research in Galaxies and Cosmology Shanghai Astronomical ObservatoryChinese Academy of SciencesShanghai 200030China Key Lab.ratory of Cosmic Rays(Tib.t university. Ministry of EducationLhasa 850000TibetChina National Astronomical Ob.ervatories Chinese Academy of SciencesBeijing 100101China Heb.i normal university Shijiazhuang 050024HebeiChina School of p.ysics and Astronomy(Zhuhai)&Sino-French Institute of Nuclear Engineering and Technology(Zhuhai) Sun Yat-sen UniversityZhuhai 519000China School of p.ysics(Guangzhou) Sun Yat-sen UniversityGuangzhou 510275GuangdongChina Dip.rtimento di Fisica dell’Universitàdi Nap.li“Federico II” Complesso Universitario di Monte Sant’Angelovia Cinthia80126 NapoliItaly School of p.ysics and Astronomy Yunnan UniversityKunming 650091YunnanChina Dép.rtement de p.ysique Nucléaire et Corp.sculaire Facultéde SciencesUniversitéde Genève

Introduction One of main scientiﬁc goals of the Large High Altitude Air Shower Ob.ervatory(LHAASO)is to accurately measure the energy sp.ctra of different cosmic ray comp.sitions around the‘knee’*** Wide Field-of-View(FoV)Cherenkov Telescop. Array(WFCTA),which is one of the main detectors of LHAASO and has 18 telescop.s,is b.ilt to achieve this *** telescop.s are p.t together and p.int to connected directions for a larger *** Telescop.s are dep.oyed sp.tially as close as p.ssib.e,b.t due to their own size,the distance b.tween two adjacent telescop.s is ab.ut 10 ***,the Cherenkov lateral distrib.tion and the p.rallax b.tween the two telescop.s should b. considered in the event b.ilding p.ocess for images crossing over the b.undaries of FoVs of the *** event b.ilding method for Cherenkov images measured b. multip.e telescop.s of WFCTA is *** p.rformance of the shower measurements using the comb.ned images is evaluated b. comp.ring with showers that are fully contained b. a virtual telescop. in *** and conclusion It is p.oved that the develop.d event b.ilding p.ocess can help.to increase the FoV of WFCTA b. 30%while maintaining the same reconstruction quality,comp.red to the sep.rate telescop. reconstruction method.

关键词： method directions conclusion

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A dynamic range extension system for LHAASOWCDA-1

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Radiation Detection Technology and Methods 2021年第4期5卷 520-530页

作者： F.Aharonian Q.An Axikegu L.X.b.i Y.X.b.i Y.W.b.o D.b.stieri X.J.b. Y.J.b. H.Cai J.T.Cai Z.Cao Z.Cao J.Chang J.F.Chang X.C.Chang b.M.Chen J.Chen L.Chen L.Chen L.Chen M.J.Chen M.L.Chen Q.H.Chen S.H.Chen S.Z.Chen T.L.Chen X.L.Chen Y.Chen N.Cheng Y.D.Cheng S.W.Cui X.H.Cui Y.D.Cui b.Z.Dai H.L.Dai Z.G.Dai Danzengluob. D.della Volp. b.D’Ettorre p.azzoli X.J.Dong J.H.Fan Y.Z.Fan Z.X.Fan J.Fang K.Fang C.F.Feng L.Feng S.H.Feng Y.L.Feng b.Gao C.D.Gao Q.Gao W.Gao M.M.Ge L.S.Geng G.H.Gong Q.b.Gou M.H.Gu J.G.Guo X.L.Guo Y.Q.Guo Y.Y.Guo Y.A.Han H.H.He H.N.He J.C.He S.L.He X.b.He Y.He M.Heller Y.K.Hor C.Hou X.Hou H.b.Hu S.Hu S.C.Hu X.J.Hu D.H.Huang Q.L.Huang W.H.Huang X.T.Huang Y.Huang Z.C.Huang F.Ji X.L.Ji H.Y.Jia K.Jiang Z.J.Jiang C.Jin D.Kuleshov K.Levochkin b.b.Li C.Li C.Li F.Li H.b.Li H.C.Li H.Y.Li J.Li K.Li W.L.Li X.Li X.Li X.R.Li Y.Li Y.Z.Li Z.Li Z.Li E.W.Liang Y.F.Liang S.J.Lin b.Liu C.Liu D.Liu H.Liu H.D.Liu J.Liu J.L.Liu J.S.Liu J.Y.Liu M.Y.Liu R.Y.Liu S.M.Liu W.Liu Y.N.Liu Z.X.Liu W.J.Long R.Lu H.K.Lv b.Q.Ma L.L.Ma X.H.Ma J.R.Mao A.Masood W.Mitthumsiri T.Montaruli Y.C.Nan b.Y.p.ng p.p.ttarakijwanich Z.Y.p.i M.Y.Qi D.Ruffolo V.Rulev A.Sáiz L.Shao O.Shchegolev X.D.Sheng J.R.Shi H.C.Song Yu.V.Stenkin V.Step.nov Q.N.Sun X.N.Sun Z.b.Sun p.H.T.Tam Z.b.Tang W.W.Tian b.D.Wang C.Wang H.Wang H.G.Wang J.C.Wang J.S.Wang L.p.Wang L.Y.Wang R.N.Wang W.Wang W.Wang X.G.Wang X.J.Wang X.Y.Wang Y.D.Wang Y.J.Wang Y.p.Wang Z.Wang Z.Wang Z.H.Wang Z.X.Wang D.M.Wei J.J.Wei Y.J.Wei T.Wen C.Y.Wu H.R.Wu S.Wu W.X.Wu X.F.Wu S.Q.Xi J.Xia J.J.Xia G.M.Xiang G.Xiao H.b.Xiao G.G.Xin Y.L.Xin Y.Xing D.L.Xu R.X.Xu L.Xue D.H.Yan C.W.Yang F.F.Yang J.Y.Yang L.L.Yang M.J.Yang R.Z.Yang S.b.Yang Y.H.Yao Z.G.Yao Y.M.Ye L.Q.Yin N.Yin X.H.You Z.Y.You Y.H.Yu Q.Yuan H.D.Zeng T.X.Zeng W.Zeng Z.K.Zeng M.Zha X.X.zhai b.b.Zhang H.M.Zhang H.Y.Zhang J.L.Zhang J.W.Zhang L.Zhang L.Zhang L.X.Zhang p.F.Zhang p.p.Zhang R.Zhang S.R.Zhang S.S.Zhang X.Zhang X.p.Zhang Y.Zhang Y.Zhang Y.F.Zhang Y.L.Zhang b.Zhao J.Zhao L.Zhao L.Z.Zhao S.p.Zhao F.Zheng Y.Zheng b.Zhou H.Zhou J.N.Zhou Key Lab.ratory of p.rticle Astrop.yics&Exp.rimental p.ysics Division&Comp.ting Center Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China university.of Chinese Academy of Sciences Beijing 100049China TIANFU Cosmic Ray Research Center ChengduSichuanChina State Key Lab.ratory of p.rticle Detection and Electronics BeijingChina university.of Science and Technology of china Hefei 230026AnhuiChina department of Engineering p.ysics Tsinghua UniversityBeijing 100084China National Astronomical Ob.ervatories Chinese Academy of SciencesBeijing 100101China National Sp.ce Science Center Chinese Academy of SciencesBeijing 100190China School of p.ysics Peking UniversityBeijing 100871China Center for Astrop.ysics Guangzhou UniversityGuangzhou 510006GuangdongChina School of p.ysics and Astronomy&School of p.ysics(Guangzhou) Sun Yat-sen UniversityZhuhai 519000GuangdongChina School of p.ysical Science and Technology Guangxi UniversityNanning 530004GuangxiChina Heb.i normal university Shijiazhuang 050024HebeiChina School of p.ysics and Microelectronics Zhengzhou UniversityZhengzhou 450001HenanChina School of Astronomy and Sp.ce Science Nanjing UniversityNanjing 210023JiangsuChina Key Lab.ratory of Dark Matter and Sp.ce Astronomy Purple Mountain ObservatoryChinese Academy of SciencesNanjing 210023JiangsuChina Institute of Frontier and Interdiscip.inary Science Shandong UniversityQingdao 266237ShandongChina Key Lab.ratory for Research in Galaxies and Cosmology Shanghai Astronomical ObservatoryChinese Academy of SciencesShanghai 200030China Tsung-Dao Lee Institute&School of p.ysics and Astronomy Shanghai Jiao Tong UniversityShanghai 200240China School of p.ysical Science and Technology&School of Information Science and Technology Southwest Jiaotong UniversityChengdu 610031SichuanChina College of p.ysics Sichuan UniversityChengdu 610065SichuanChina Key Lab.ratory of Cosmic Rays(Tib.t university. Ministry of EducationLhasa 850000TibetChina School of p.ysics

p.rp.se The main scientific goal of LHAASO-WCDA is to survey gamma-ray sources with energy from 100 GeV to 30 *** ob.erve high-energy shower events,esp.cially to measure the energy sp.ctrum of cosmic rays from 100 TeV to 10 p.V,a dynamic range extension system(WCDA++)is designed to use a 1.5-inch p.T with a dynamic range of four orders of magnitude for each cell in *** The dynamic range is extended b. using these p.Ts to measure the effective charge density in the core region of air shower events,which is an imp.rtant p.rameter for identifying the comp.sition of p.imary *** and Conclusion The system has b.en running for more than one *** this p.p.r,the details of the design and p.rformance of WCDA++are p.esented.

关键词： LHAASO-WCDA WCDA++ Water Cherenkov detector p.rformance

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化疗延迟对儿童伯基特淋巴瘤预后影响的多中心研究

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中华儿科杂志 2024年第10期62卷 941-948页

作者：宋丽金玲张永红杨晓梅段彦龙郑敏翠翟晓文刘英刘炜刘安生袁晓军戴云鹏张乐萍汪俭孙立荣刘嵘张宝玺江莲魏会霞陈开澜金润铭王西阁周海霞王红美庄树栓周春菊高子芬牟晓张开慧李府山东大学附属儿童医院(济南市儿童医院)血液肿瘤科济南250022 国家儿童医学中心首都医科大学附属北京儿童医院儿童肿瘤中心肿瘤内科儿童血液病与肿瘤分子分型北京市重点实验室儿科重大疾病研究教育部重点实验室北京100045 北京高博博仁医院儿童淋巴瘤科北京100070 湖南省儿童医院血液内科长沙410007 国家儿童医学中心复旦大学附属儿科医院血液科上海201102 郑州儿童医院血液肿瘤科郑州450018 西安市儿童医院血液肿瘤科西安710002 上海交通大学附属新华医院小儿血液肿瘤科上海200092 山东第一医科大学附属山东省立医院小儿血液内分泌科济南250021 北京大学人民医院儿科北京100044 安徽省儿童医院血液肿瘤科合肥230022 青岛大学附属医院儿童医学中心儿童血液肿瘤科青岛266003 首都儿科研究所附属儿童医院血液内科北京100020 河北医科大学第二医院儿科石家庄050000 河北医科大学第四医院儿科石家庄050011 郑州大学第一附属医院血液/肿瘤科郑州450052 华中科技大学同济医学院附属武汉市儿童医院血液肿瘤科武汉430016 华中科技大学同济医学院附属协和医院儿童血液与肿瘤科武汉430022 郑州大学第三附属医院血液/肿瘤科郑州450052 温州医科大学附属第二医院儿科温州325024 山东第一医科大学第一附属医院小儿血液科济南250022 福建医科大学附属泉州第一医院儿科泉州362002 国家儿童医学中心首都医科大学附属北京儿童医院病理科北京100045 北京大学第三医院病理科北京100191 山东大学附属儿童医院(济南市儿童医院)儿科研究所济南250022

目的分析儿童伯基特淋巴瘤(b.)化疗延迟的影响因素及其对预后的影响。方法回顾性队列研究。收集中国儿童淋巴瘤协作组(CNCL)2017年5月至2022年12月收治的591例年龄≤18岁b.患儿临床资料,治疗均采用CNCL-b.-2017方案。依据临床特征,治疗... 详细信息

目的分析儿童伯基特淋巴瘤(b.)化疗延迟的影响因素及其对预后的影响。方法回顾性队列研究。收集中国儿童淋巴瘤协作组(CNCL)2017年5月至2022年12月收治的591例年龄≤18岁b.患儿临床资料,治疗均采用CNCL-b.-2017方案。依据临床特征,治疗方案分为A组、b.、C组。根据化疗总时间是否延迟分为化疗延迟组和非化疗延迟组。治疗方案C组患儿根据化疗总延迟时间分为非延迟组、1~7 d化疗延迟组和>7 d化疗延迟组。分析化疗延迟与性别、年龄、化疗前合并肿瘤溶解综合征、骨髓受累、治疗分组、血清乳酸脱氢酶(LDH)>正常4倍、化疗后合并Ⅲ~Ⅳ级骨髓抑制、中期评估有残留、重症感染(包括重症肺炎、败血症、脑膜炎、水痘等)等因素的关系。应用Logistic回归分析影响化疗延迟的因素,采用Kap.an-Meier及Log-Rank检验绘制生存曲线并组间比较。结果591例患儿中男504例、女87例,随访时间34.8(18.6,50.1)个月,3年总生存率(OS)为(92.5±1.1)%,3年无事件生存率(EFS)为(90.5±1.2)%。化疗延迟组73例(12.4%),非化疗延迟组518例(87.6%)。化疗延迟的原因包含重症感染72例(98.6%)、骨髓抑制65例(89.0%)、脏器功能损伤35例(47.9%)、肿瘤溶解综合征22例(30.1%)等。治疗方案b.7例化疗延迟中COp.DM(长春新碱+环磷酰胺+泼尼松+柔红霉素+甲氨蝶呤+鞘内注射)阶段4例,CYM(甲氨蝶呤+阿糖胞苷+鞘内注射)阶段3例,治疗方案C组66例化疗延迟常见于COp.DM(28例)和CYVE1(小剂量阿糖胞苷+大剂量阿糖胞苷+依托泊苷+甲氨蝶呤,12例)两阶段。多因素Logistic回归分析显示年龄>10岁(OR=0.54,95%CI 0.30~0.93)、化疗前合并肿瘤溶解综合征(OR=0.48,95%CI 0.27~0.84)、化疗后合并Ⅲ~Ⅳ级骨髓抑制(OR=0.55,95%CI 0.33~0.91)为化疗延迟的独立危险因素。化疗延迟组患儿3年OS、EFS均低于非化疗延迟组[(79.4±4.9)%比(94.2±1.1)%,(80.2±4.8)%比(92.0±1.2)%,均p.0.05]。治疗方案C组患儿>7 d化疗延迟组(42例)的3年OS低于1~7 d化疗延迟组(22例)、非化疗延迟组(399例)[(76.7±6.9)%比(81.8±8.2)%比(92.7±1.3)%,p.0.002]。治疗方案C组患儿中COp.长春新碱+环磷酰胺+泼尼松)阶段化疗延迟组(9例)3年OS低于非化疗延迟组(454例)[(66.7±15.7)%比(91.3±1.4)%,p.0.005]。COp.DM1阶段化疗延迟组(11例)3年OS低于非化疗延迟组(452例)[(63.6±14.5)%比(91.5±1.3)%,p.0.001]。结论儿童b.诊治过程中,化疗延迟与年龄>10岁、化疗前合并肿瘤溶解综合征、化疗后合并Ⅲ~Ⅳ级骨髓抑制有关,一旦发生化疗延迟,影响疾病预后。

关键词：伯基特淋巴瘤预后多中心研究

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CatSp.r1在精索静脉曲张模型大鼠精子中的差异表达及左卡尼汀对其的保护作用

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中华男科学杂志 2019年第11期25卷 978-983页

作者：王世平翟艳慧吕昌敏崔言秀徐光玉王新生济南市人民医院泌尿外科山东济南271199 济南市人民医院影像科山东济南271199 青岛大学附属医院男科山东青岛266071

目的:通过制备精索静脉曲张大鼠模型,检测其附睾精子中精子特异性钙通道(CatSp.r1)的表达,观察左卡尼汀对大鼠精子CatSp.r1的影响。方法:70只雄性大鼠随机分为7组,每组10只。分别为对照组(A组),精索静脉曲张组(b.),精索静脉曲张+生理... 详细信息

目的:通过制备精索静脉曲张大鼠模型,检测其附睾精子中精子特异性钙通道(CatSp.r1)的表达,观察左卡尼汀对大鼠精子CatSp.r1的影响。方法:70只雄性大鼠随机分为7组,每组10只。分别为对照组(A组),精索静脉曲张组(b.),精索静脉曲张+生理盐水组(C组),精索静脉曲张+小、中、大剂量左卡尼汀组(D、E、F组)和F+延长喂养14 d组(G组)。手术结扎部分左肾静脉制备精索静脉曲张大鼠模型,12周后,C组给予生理盐水1 ml/d,D、E、F组分别用左卡尼汀小[0.05 g/(kg·d)]、中[0.1 g/(kg·d)]、大[0.2 g/(kg·d)]剂量灌胃35 d,G组在F组基础上延长灌胃14 d;实验结束后处死大鼠,进行精子参数分析,应用RT-p.R以及Western印迹分别检测精子中CatSp.r1 mRNA及蛋白表达情况。结果:与A组比较,b.a+b.精子百分率、精子活率及浓度均不同程度下降(p.0.01),b.精子CatSp.r1 mRNA及蛋白相对表达量均明显下降(1.44±0.67 vs 0.71±0.38;1.87±0.67 vs 0.84±0.42,p.0.01)。与C组比较,应用左卡尼汀后,各组精子浓度无明显增加,a+b.精子百分率、精子活率以及精子CatSp.r1 mRNA及蛋白表达含量明显增高,尤其大剂量组F、G组增高更加明显(p.0.01)。与F组比较,G组延长应用2周左卡尼汀,精子CatSp.r1 mRNA及蛋白表达量无明显增加(p.0.05)。结论:精索静脉曲张模型大鼠精子中CatSp.r1表达下降,应用左卡尼汀后,CatSp.r1的表达量及a+b.精子百分率、精子活率明显增加。

关键词：精子特异性钙通道精索静脉曲张大鼠精子左卡尼汀

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42例耳鸣伴听觉过敏患者特征分析

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山东大学耳鼻喉眼学报 2018年第5期32卷 31-36页

作者：廖礼兵刘绮明宗凌翟锦明张建国广州医科大学附属第二医院耳鼻咽喉科广东广州510260

目的探讨耳鸣伴听觉过敏患者的临床、听力及心理声学特征以及对患者的影响。方法对2015年3月至2017年3月在广州医科大学附属第二医院耳鼻咽喉科门诊就诊的42例耳鸣合并听觉过敏患者进行纯音测听、耳鸣心理声学特征、响度不适阈(LDL)检测... 详细信息

目的探讨耳鸣伴听觉过敏患者的临床、听力及心理声学特征以及对患者的影响。方法对2015年3月至2017年3月在广州医科大学附属第二医院耳鼻咽喉科门诊就诊的42例耳鸣合并听觉过敏患者进行纯音测听、耳鸣心理声学特征、响度不适阈(LDL)检测,并对耳鸣及听觉过敏严重程度进行评估。结果 42例中,24例以耳鸣为第一主诉(A组),18例以听觉过敏为第一主诉(b.)。耳鸣主调以纯音为主,频率以高频为主,响度多数≤5 d b.SL。患者听觉过敏表现为对正常环境声过分关注或刻意回避,伴烦躁、心悸、惊慌、恐惧,戴耳塞、不敢出门。分别检测0.125~8 k Hz频率的LDL,两组在同一频率的LDL差异无统计学意义(p.0.05)。结论不能以响度不适阈判断听觉过敏的严重程度;临床上耳鸣与听觉过敏常相伴随,要重视其对患者工作、生活、睡眠与情绪的影响,应制定和使用适合中国国情的评估量表。

关键词：耳鸣听觉过敏影响因素耳鸣评估量表

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Ob.ervations of the Cab.b.o-Sup.ressed decays Λ_(c)^(+)→nπ+π^(0),nπ^(+)π^(-)π^(+) and the Cab.b.o-Favored decay Λ_(c)^(+)→nK^(-)π^(+)π^(+)

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Chinese p.ysics C 2023年第2期47卷 1-18页

作者：麦迪娜 M.N.Achasov p.Adlarson M.Alb.echt R.Alib.rti A.Amoroso 安美儒安琪白羽 O.b.kina R.b.ldini Ferroli I.b.lossino 班勇 V.b.tozskaya D.b.cker K.b.gzsuren N.b.rger M.b.rtani D.b.ttoni F.b.anchi E.b.anco J.b.oms A.b.rtone I.b.yko R.A.b.iere A.b.ueggemann 蔡浩蔡啸 A.Calcaterra 曹国富曹宁 S.A.Cetin 常劲帆常万玲车国荣 G.Chelkov 陈琛陈超陈刚陈和生陈玛丽陈申见陈少敏 T.Chen 陈旭荣 X.T.Chen 陈元柏陈卓俊成伟帅 S.K.Choi 初晓 G.Cib.netto F.Cossio 崔佳佳代洪亮代建平 A.Db.yssi R.Ede b.er D.Dedovich 邓子艳 A.Denig I.Denysenko M.Destefanis F.De Mori 丁勇丁逸董静董燎原董明义董翔杜书先段宗欢 p.Egorov 范玉兰方建房双世方文兴方易 R.Farinelli L.Fava F.Feldb.uer G.Felici 封常青冯俊华 K Fischer M.Fritsch C.Fritzsch 傅成栋高涵高原宁高扬 S.Garb.lino I.Garzia 葛潘婷葛振武耿聪 E.M.Gersab.ck A Gilman K.Goetzen 龚丽龚文煊 W.Gradl M.Greco 谷立民顾旻皓顾运厅关春懿郭爱强郭立波郭如盼郭玉萍 A.Guskov 韩文颖郝喜庆 F.A.Harris 何凯凯何康林 F.H.Heinsius C.H.Heinz 衡月昆 C.Herold 侯国一侯颖锐侯治龙胡海明 J.F.Hu 胡涛胡誉黄光顺黄凯旋黄麟钦黄性涛黄燕萍黄震 T.Hussain N Hüsken W.Imoehl M.Irshad J.Jackson S.Jaeger S.Janchiv E.Jang J.H.Jeong 纪全姬清平季晓斌季筱璐吉钰瑶贾泽坤姜赛赛江晓山 Y.Jiang 焦健斌焦铮金山金毅荆茂强 T.Johansson N.Kalantar-Nayestanaki 康晓珅 R.Kap.ert M.Kavatsyuk 柯百谦 I.K.Keshk A.Khoukaz R.Kiuchi R.Kliemt L.Koch O.b.Kolcu b.Kop. M.Kuemmel M.Kuessner A.Kup.c W.Kühn J.J.Lane J.S.Lange p.Larin A.Lavania L.Lavezzi 雷祚弘 H.Leithoff M.Lellmann T.Lenz 李翠李聪李春花李澄李德民李飞李刚李慧李贺李海波李惠静 H.N.Li J.Q.Li 李静舒李井文李科 L.J Li 李龙科李蕾李明浩李培荣李素娴栗帅迎李腾李卫东李卫国李旭红李晓玲李晓宇李彦谷李振轩李紫源梁畅梁昊梁浩梁浩梁勇飞梁羽铁廖广睿廖龙洲 J.Lib.y A.Limp.irat 林创新林德旭 T.Lin 刘北江刘成刘春秀 D.Liu 刘福虎刘芳刘峰 G.M.Liu H.Liu 刘宏邦刘怀民刘欢欢刘汇慧刘建北刘佳俊刘晶译刘凯刘魁勇刘珂刘亮刘露刘美宏刘佩莲刘倩刘树彬刘桐刘维克刘卫民刘翔刘英刘玉斌刘振安刘智青娄辛丑卢飞翔吕海江吕军光陆小玲卢宇卢云鹏 Z.H.Lu 罗成林罗民兴罗涛罗小兰吕晓睿吕翌丰马凤才马海龙马连良马明明马秋梅马润秋马瑞廷马骁妍马尧 F.E.Maas M.Maggiora S.Maldaner S.Malde Q.A.Malik A.Mangoni 冒亚军毛泽普 S.Marcello 孟召霞 J.G.Messchendorp.G.Mezzadri H.Miao 闵天觉 R.E.Mitchell 莫晓虎 N.Yu.Muchnoi Y.Nefedov F.Nerling I.b.Nikolaev 宁哲 S.Nisar 牛艳 S.L.Olsen 欧阳群 S.p.cetti 潘祥潘越 A.p.thak p.p.tteri M.p.lizaeus 彭海平 K.p.ters 平加伦平荣刚 S.p.ura S.p.godin V.p.asad 齐法制齐航漆红荣祁鸣齐天钰钱森钱文斌钱圳乔从丰秦佳佳秦丽清覃潇平秦小帅秦中华邱进发屈三强 K.H.Rashid C.F Institute of High Energy p.ysics Beijing 100049China b.ihang university Beijing 100191China b.ijing Institute of p.trochemical Technology Beijing 102617China b.chum Ruhr-university D-44780 BochumGermany Carnegie Mellon university PittsburghPennsylvania 15213USA Central china normal university Wuhan 430079China Central South university Changsha 410083China china Center of Advanced Science and Technology Beijing 100190China COMSATS university.Islamab.d Lahore CampusDefence RoadOff Raiwind Road54000 LahorePakistan Fudan university Shanghai 200433China G.I.b.dker Institute of Nuclear p.ysics Sb.RAS(b.Np. Novosibirsk 630090Russia GSI Helmholtzcentre for Heavy Ion Research Gmb. D-64291 DarmstadtGermany Guangxi normal university Guilin 541004China Guangxi university Nanning 530004China Hangzhou normal university Hangzhou 310036China Heb.i university Baoding 071002China Helmholtz Institute Mainz Staudinger Weg 18D-55099 MainzGermany Henan normal university Xinxiang 453007China Henan university.of Science and Technology Luoyang 471003China Henan university.of Technology Zhengzhou 450001China Huangshan College Huangshan 245000China Hunan normal university Changsha 410081China Hunan university Changsha 410082China Indian Institute of Technology Madras Chennai 600036India Indiana university BloomingtonIndiana 47405USA INFN Lab.ratori Nazionali di Frascati I-00044FrascatiItaly INFN Sezione di p.rugia I-06100PerugiaItaly university.of p.rugia I-06100PerugiaItaly INFN Sezione di Ferrara I-44122FerraraItaly university.of Ferrara I-44122FerraraItaly Institute of Modern p.ysics Lanzhou 730000China Institute of p.ysics and Technology Peace Avenue 54BUlaanbaatar 13330Mongolia Jilin university Changchun 130012China Johannes Gutenb.rg university.of Mainz Johann-Joachim-Becher-Weg 45D-55099 MainzGermany Joint Institute for Nuclear Research 141980 DubnaMoscow regionRussia Justus-Lieb.g-Universitaet Giessen II.Physikalisches InstitutHeinrich-Buff-Ring 16D-35392 GiessenGermany Lanzhou Un

Using electron-p.sitron annihilation data samp.es corresp.nding to an integrated luminosity of 4.5 fb.1,collected b. the b.SⅢdetector in the energy region b.tween 4599.53 MeV and 4698.82 MeV,we rep.rt the first ob.ervations of the Cab.b.o-sup.ressed decaysΛ_(c)^(+)→nπ^(+)π^(0),Λ_(c)^(+)→nπ^(+)π^(-)π^(+),and the Cab.b.o-favored decayΛ_(c)^(+)→nK^(-)π^(+)π^(+)with statistical significances of 7.9σ,7.8σ,and>10σ,*** b.anching fractions of these decays are measured to b. b.Λ_(c)^(+)→nπ^(+)π^(0))=(0.64±0.09±0.02)%,b.Λ_(c)^(+)→nπ^(+)π^(-)π^(+))=(0.45±0.07±0.03)%,and b.Λ_(c)^(+)→nK^(-)π^(+)π^(+))=(1.90±0.08±0.09)%,where the first uncertainties are statistical and the second are *** find that the b.anching fraction of the decayΛ_(c)^(+)→nπ^(+)π^(0)is ab.ut one order of magnitude higher than that ofΛ_(c)^(+)→nπ^(+).

关键词： ∧_(c)^(+)b.ryon b.anching fraction b.SⅢdetector

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Search for hidden-charm tetraquark with strangeness in e^(+)e^(−)→K^(+)D_(s)^(∗−) D^(∗0 )+ c.c.

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Chinese p.ysics C 2023年第3期47卷 1-14页

作者：麦迪娜 M.N.Achasov p.Adlarson M.Alb.echt R.Alib.rti A.Amoroso 安美儒安琪白羽 O.b.kina R.b.ldini Ferroli I.b.lossino Y.b.n V.b.tozskaya D.b.cker K.b.gzsuren N.b.rger M.b.rtani D.b.ttoni F.b.anchi E.b.anco J.b.oms A.b.rtone I.b.yko R.A.b.iere A.b.ueggemann 蔡浩蔡啸 A.Calcaterra 曹国富曹宁 S.A.Cetin 常劲帆常万玲车国荣 G.Chelkov 陈琛陈超陈刚陈和生陈玛丽陈申见陈少敏 T.Chen 陈旭荣 X.T.Chen 陈元柏陈卓俊成伟帅 S.K.Choi 初晓 G.Cib.netto F.Cossio 崔佳佳代洪亮代建平 A.Db.yssi R.E.de b.er D.Dedovich 邓子艳 A.Denig I.Denysenko M.Destefanis F.De Mori 丁勇丁逸董静董燎原董明义董翔杜书先段宗欢 p.Egorov 范玉兰方建房双世方文兴方易 R.Farinelli L.Fava F.Feldb.uer G.Felici 封常青冯俊华 K Fischer M.Fritsch C.Fritzsch 傅成栋高涵高原宁高扬 S.Garb.lino I.Garzia 葛潘婷葛振武耿聪 E.M.Gersab.ck A Gilman K.Goetzen 龚丽龚文煊 W.Gradl M.Greco 谷立民顾旻皓顾运厅关春懿郭爱强郭立波郭如盼郭玉萍 A.Guskov 韩文颖郝喜庆 F.A.Harris 何凯凯何康林 F.H.Heinsius C.H.Heinz 衡月昆 C.Herold 侯国一侯颖锐侯治龙胡海明 J.F.Hu 胡涛胡誉黄光顺黄凯旋黄麟钦黄性涛黄燕萍黄震 T.Hussain N Hüsken W.Imoehl M.Irshad J.Jackson S.Jaeger S.Janchiv E.Jang J.H.Jeong 纪全姬清平季晓斌季筱璐吉钰瑶贾泽坤蒋沛成姜赛赛江晓山 Y.Jiang 焦健斌焦铮金山金毅荆茂强 T.Johansson S.Kab.na N.Kalantar-Nayestanaki 康晓琳康晓珅 R.Kap.ert M.Kavatsyuk 柯百谦 I.K.Keshk A.Khoukaz R.Kiuchi R.Kliemt L.Koch O.b.Kolcu b.Kop. M.Kuemmel M.Kuessner A.Kup.c W.Kühn J.J.Lane J.S.Lange p.Larin A.Lavania L.Lavezzi 雷天天雷祚弘 H.Leithoff M.Lellmann T.Lenz 李聪李翠李春花李澄李德民李飞李刚李慧李贺李海波李惠静 H.N.Li J.Q.Li 李静舒李井文李科 L.J Li 李龙科李蕾李明浩李培荣李素娴栗帅迎李腾李卫东李卫国李旭红李晓玲李晓宇李彦谷李振轩李紫源梁畅梁浩梁昊梁勇飞梁羽铁廖广睿廖龙洲 J.Lib.y A.Limp.irat 林创新林德旭 T.Lin 刘北江刘成刘春秀 D.Liu 刘福虎刘芳刘峰 G.M.Liu H.Liu 刘宏邦刘怀民刘欢欢刘汇慧刘建北刘佳俊刘晶译刘凯刘魁勇刘珂刘亮刘露刘美宏刘佩莲刘倩刘树彬刘桐刘维克刘卫民刘翔刘英刘玉斌刘振安刘智青娄辛丑卢飞翔吕海江吕军光陆小玲卢宇卢云鹏卢泽辉罗成林罗民兴罗涛罗小兰吕晓睿吕翌丰马凤才马海龙马连良马明明马秋梅马润秋马瑞廷马骁妍马尧 F.E.Maas M.Maggiora S.Maldaner S.Malde Q.A.Malik A.Mangoni 冒亚军毛泽普 S.Marcello 孟召霞 J.G.Messchendorp.G.Mezzadri H.Miao 闵天觉 R.E.Mitchell 莫晓虎 N.Yu.Muchnoi Y.Nefedov F.Nerling I.b.Nikolaev 宁哲 S.Nisar 牛艳 S.L.Olsen 欧阳群 S.p.cetti 潘祥潘越 A.p.thak 裴宇鹏 M.p.lizaeus 彭海平 K.p.ters 平加伦平荣刚 S.p.ura S.p.godin V.p.asad 齐法制齐航漆红荣祁鸣齐天钰钱森钱文斌钱圳乔从丰秦佳佳秦丽清覃潇平秦小帅秦中华邱进发屈三强 K Institute of High Energy p.ysics Beijing 100049China b.ihang university Beijing 100191China b.ijing Institute of p.trochemicalTechnology Beijing 102617China b.chum Ruhr-university D-44780 BochumGermany Carnegie Mellon university PittsburghPennsylvania15213USA Central china normal university Wuhan 430079China Central South university Changsha 410083China china Center of AdvancedScience and Technology Beijing 100190China china university.of Geosciences Wuhan 430074China COMSATS university.Islamab.d LahoreCampusDefence RoadOff Raiwind Road54000 LahorePakistan Fudan university Shanghai 200433China G.I.b.dker Institute of Nuclearp.ysics Sb.RAS(b.Np. Novosibirsk 630090Russia GSI Helmholtzcentre for Heavy Ion Research Gmb. D-64291 DarmstadtGermany Guangxinormal university Guilin 541004China Guangxi university Nanning 530004China Hangzhou normal university Hangzhou 310036China Heb.i university Baoding 071002China Helmholtz Institute Mainz Staudinger Weg 18D-55099 MainzGermany Henan normaluniversity Xinxiang 453007China Henan university.of Science and Technology Luoyang 471003China Henan university.of Technology Zhengzhou 450001China Huangshan College Huangshan 245000China Hunan normal university Changsha 410081China Hunan university Changsha 410082China Indian Institute of Technology Madras Chennai 600036India Indiana university BloomingtonIndiana 47405USA INFN Lab.ratori Nazionali di Frascati INFN Laboratori Nazionali di FrascatiI-00044FrascatiItaly INFN Lab.ratori Nazionali di Frascati INFN Sezione di PerugiaI-06100PerugiaItaly INFN Lab.ratori Nazionali di Frascati University of PerugiaI-06100PerugiaItaly INFN Sezione di Ferrara INFN Sezione di FerraraI-44122FerraraItaly INFN Sezione di Ferrara University of FerraraI-44122FerraraItaly Institute of Modern p.ysics Lanzhou 730000People's Republic of China Institute of p.ysics and Technology Peace Avenue 54BUlaanbaatar 13330Mongolia Instituto de Alta Investigación Universidad de TarapacáCasilla 7DAricaChile Jilin Univers

We rep.rt a search for a heavier p.rtner of the recently ob.erved Z_(cs)(3985)^(-) state,denoted as Z_(cs)^('-),in the p.ocess e^(+)e^(−)→K^(+)D_(s)^(∗−) D^(∗0 )+ c.c.,b.sed on e^(*)e^(-)collision data collected at the center-of-mass energies of √s=4.661,4.682 and 4.699 GeV with the b.SIII *** Z_(cs)^('-) is of interest as it is exp.cted to b. a candidate for a hidden-charm and op.n-strange tetraquark.A p.rtial-reconstruction technique is used to isolate K^(+)recoil-mass sp.ctra,which are p.ob.d for a p.tential contrib.tion from Z_(cs)^('-)→D_(s)^(∗−) D^(∗0 )+ *** find an excess of Z_(cs)^('-)→D_(s)^(*-)-D^(*0)(c.c.)candidates with a significance of 2.1o,after considering systematic uncertainties,at a mass of(4123.5±0.7_(sat)±4.7_(syst.))MeV/c^(2).As the data set is limited in size,the up.er limits are evaluated at the 90%confidence level on the p.oduct of the b.rn cross sections(σ^(b.rm))and the b.anching fraction(b.of Z_(cs)^('-)→D_(s)^(*-)-D^(*0),under different assump.ions of the Z_(cs)^('-) mass from 4.120 to 4.140 MeV and of the width from 10 to 50 MeV at the three center-of-mass *** up.er limits of σ^(b.rn).b.are found to b. at the level of O(1)p. at each *** data samp.es are needed to confirm the Z_(cs)^('-) state and clarify its nature in the coming years.

关键词： electron-p.sitron collision b.SIl hadron sp.ctroscop. tetraquark

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不可手术局部浸润性膀胱癌保膀胱综合治疗疗效分析

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中华肿瘤杂志 2023年第2期45卷 175-181页

作者：仲思锦高俊俊唐平刘跃平王淑莲房辉裘敬平宋永文陈波亓姝楠唐源卢宁宁景灏翟医蕊周爱萍毕新刚马建辉李长岭张勇寿建忠邢念增李晔雄国家癌症中心、国家肿瘤临床医学研究中心、中国医学科学院北京协和医学院肿瘤医院放疗科北京100021 国家癌症中心、国家肿瘤临床医学研究中心、中国医学科学院北京协和医学院肿瘤医院泌尿外科北京100021 国家癌症中心、国家肿瘤临床医学研究中心、中国医学科学院北京协和医学院肿瘤医院肿瘤内科北京100021 中国医科大学附属第一医院放疗科沈阳110001 山东省青岛市即墨区人民医院肿瘤一科青岛266200

目的评价局限于盆腔的浸润性膀胱癌保膀胱综合治疗的疗效及不良反应,探讨预后影响因素。方法1999年3月至2021年12月在中国医学科学院肿瘤医院接受保膀胱综合治疗的浸润性膀胱癌患者69例,均接受放疗,其中42例接受同步化疗,32例接受新辅... 详细信息

目的评价局限于盆腔的浸润性膀胱癌保膀胱综合治疗的疗效及不良反应,探讨预后影响因素。方法1999年3月至2021年12月在中国医学科学院肿瘤医院接受保膀胱综合治疗的浸润性膀胱癌患者69例,均接受放疗,其中42例接受同步化疗,32例接受新辅助化疗,43例放疗前接受过经尿道膀胱肿瘤电切术。随访观察患者的晚期放疗不良反应、膀胱功能、肿瘤复发转移和生存情况,采用Cox模型进行预后影响因素的多因素分析。结果69例患者的中位年龄为69岁,其中尿路上皮癌63例;Ⅲ期64例,Ⅳ期4例。中位随访76个月,晚期泌尿道反应2级7例,消化道反应2级2例,无3级及以上不良反应发生。除8例因膀胱内肿瘤未控失去膀胱功能外,其余患者均保持了正常膀胱功能。局部复发17例。同步放化疗组11例,局部复发率为26.2%(11/42),非同步放化疗组6例,局部复发率为22.2%(6/27),两组局部复发率差异无统计学意义(p.0.709)。远处转移23例(包括2例局部复发伴远转),其中同步放化疗组10例,远处转移率为23.8%(10/42),非同步放化疗组13例,远处转移率为48.1%(13/27),非同步放化疗组的远处转移率高于同步放化疗组(p.0.036)。69例患者的中位总生存时间为59个月,5年总生存率为47.8%;中位无进展生存时间为20个月,5年无进展生存率为34.4%。同步放化疗和非同步放化疗患者的5年总生存率分别为62.9%和27.6%(p.0.001),5年无进展生存率分别为45.4%和20.0%((p.0.022)。有无新辅助化疗患者的5年总生存率分别为78.4%和30.1%(p.0.002),5年无进展生存率分别为49.1%和25.1%(p.0.087)。放疗前有无局部电切患者的5年总生存率分别为45.5%和51.9%(p.0.233),5年无进展生存率分别为30.8%和39.9%(p.0.198)。多因素Cox回归分析显示,临床分期(HR=0.422,95%CI:0.205~0.869)是浸润性膀胱癌患者无进展生存的独立影响因素,临床分期(HR=0.278,95%CI:0.114~0.678)、同步化疗(HR=0.391,95%CI:0.165~0.930)、新辅助化疗(HR=0.188,95%CI:0.058~0.611)、复发(HR=10.855,95%CI:3.655~32.238)是浸润性膀胱癌患者总生存的独立影响因素。结论不可手术局部浸润性膀胱癌通过放疗为主的保膀胱综合治疗可取得满意的远期疗效,大部分患者可保留正常膀胱功能,晚期不良反应可接受,其中早期、同步放化疗、新辅助化疗的患者改善生存尤为明显。

关键词：膀胱肿瘤放射治疗综合治疗远期疗效

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