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Two stages power generation test of the hot dry rock exploration and production demonstration project in the Gonghe Basin,northeastern Qinghai-Tibet plateau,China

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China Geology 2024年第3期7卷 409-421页

作者： Er-yong Zhang Dong-guang Wen Gui-ling wang Xian-peng Jin Lin-you Zhang Hai-dong Wu Wen-shi wang Cheng-ming Ye Wei weng Kuan Li Jin-sheng Wu Xian-chun Tang Chong-yuan Zhang Qing-da Feng Sheng Lian Li-sha Hu Gui-lin Zhu Xing-long Xie Bin Wu Dan wang Xue Niu Zhao-xuan Niu Dong-lin Liu Hui Zhang Wen-hao Xu Shu-qing Yao Li Yang Center for Hydrogeology and Environmental Geology Survey China Geological SurveyMinistry of Natural ResourcesTianjin 300304China Institute of Hydrogeology and Environmental Geology Chinese Academy of Geological SciencesChina Geological SurveyShijiazhuang 050061China Institute of Exploration Techniques Chinese Academy of Geological SciencesChina Geological SurveyLangfang 065000China Institute of Exploration Engineering China Geological SurveyMinistry of Natural ResourcesBeijing 100083China Institute of Exploration Technology Chinese Academy of Geological SciencesChengdu 611734China Chinese Academy of Geological Sciences China Geological SurveyBeijing 100037China Institute of Geomechanics Chinese Academy of Geological SciencesChina Geological SurveyBeijing 100081China Geoscience Documentation Center China Geological SurveyMinistry of Natural ResourcesBeijing 100083China

The Hot Dry Rock(HDR)is considered as a clean and renewable energy,poised to significantly contribute to the global energy decarbonization *** HDR projects worldwide have accumulated valuable experience in efficient drilling and completion,reservoir construction,and fracture *** 2019,China Geological Survey(CGS)initiated a demonstration project of HDR exploration and production in the Gonghe Basin,aiming to overcome the setbacks faced by HDR *** the ensuing four years,the Gonghe HDR project achieved the first power generation in 2021,followed by the second power generation test in *** establishing the primary well group in the initial phase,two directional wells and one branch well were *** progress was made in successfully constructing the targeted reservoir,realizing inter-well connectivity,power generation and grid connection,implementing of the real-time micro-seismic monitoring.A closed-loop technical validation of the HDR exploration and production was ***,many technical challenges remain in the process of HDR industrialization,such as reservoir fracture network characterization,efficient drilling and completion,multiple fracturing treatment,continuous injection and production,as well as mitigation of induced seismicity and numerical simulation technology.

关键词： Power generation Hot dry rock(HDR) Enhanced geothermal system(EGS) Genesis mechanism Gonghe Basin Directional drilling Reservoir construction Circulation test Induced seismicity Clean energy exploration engineering

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Bio-Inspired Gelatin-Based Adhesive Modified with Waterborne Polyurethane on Click Chemistry

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Journal of Renewable Materials 2022年第11期10卷 2747-2763页

作者： xuechuan wang Wenying Zhao Xugang Dang Yiqing wang Huijie Zhang College of Bioresources Chemical and Materials Engineering Shaanxi University of Science and TechnologyXi’an710021China National Demonstration Center for Experimental Light Chemistry Engineering Education Shaanxi University of Science and TechnologyXi’an710021China

As a non-toxic,highly reactive biomass material,gelatin is wildly used as the component of biomass-based ***,like most aqueous adhesives,gelatin-based adhesives suffer from long solidifying time or high solidifying temperature due to the low volatility of water,which highly limits the application potential of gelatinbased *** by the fast adhesion of marine organisms through the formation of chemical crosslinks,herein,a kind of low temperature curable eco-friendly gelatin-based adhesive with good adhesive properties and fast curing at low temperature is developed by introducing clicking chemical Diels-Alder(DA)reaction between blocked waterborne polyurethane(MWPU)and *** furfuryl glycidyl ether(FGE)and 4-Maleimidophenol(4-HPM)for the DA reaction are grafted on gelatin,and the end-capping of MWPU,*** the addition of MWPU and FGE,the cross-linking degree of gelatin increased,and the adhesion properties of the adhesive were *** shear strength and T-peel strength of the modified adhesive reached 0.95 MPa and 1.42 N/mm,respectively,after the curing time of 8 min at 40℃,which can meet the application requirements as adhesive for bio-medical use.

关键词： Gelatin blocked waterborne polyurethane eco-friendly adhesive skin solid wastes

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H_(2)O_(2)改性活性炭高效催化转化NO_(2)制NO

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高校化学工程学报 2024年第3期38卷 493-499页

作者：穆仕芳王洪亮王艳辜俊超翁育靖孙琦张玉龙河南理工大学安全科学与工程学院河南焦作454003 河南省煤炭绿色转化重点实验室河南焦作454003 河南理工大学化工学院河南焦作454003

为了探究含氧官能团对活性炭转化NO_(2)制NO能力的影响,采用过氧化氢(H_2O_(2))对活性炭进行改性。对改性前后的催化剂进行N_2物理吸附-脱附、Boehm滴定、X射线光电子能谱、拉曼光谱等表征并对其转化NO_(2)能力进行评价,结果表明:过氧... 详细信息

为了探究含氧官能团对活性炭转化NO_(2)制NO能力的影响,采用过氧化氢(H_2O_(2))对活性炭进行改性。对改性前后的催化剂进行N_2物理吸附-脱附、Boehm滴定、X射线光电子能谱、拉曼光谱等表征并对其转化NO_(2)能力进行评价,结果表明:过氧化氢表面改性增加了活性炭微孔面积和表面含氧官能团的含量,尤其是增加了表面酚羟基的含量,进而促进了NO_(2)在活性炭表面的吸附和催化转化,经质量分数为20%的H_2O_(2)处理后的活性炭的反应性能最佳,在150℃下NO_(2)转化率99.8%。

关键词：活性炭改性二氧化氮转化含氧官能团孔结构

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Electrochemical biomaterials for self-powered implantable“tissue batteries”:A tutorial review

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Nano Research 2023年第4期16卷 5447-5463页

作者： Manhui Zheng xuechuan wang Ouyang Yue Zhongxue Bai Boqiang Cui Xinhua Liu College of Bioresources Chemical and Materials Engineering Shaanxi University of Science&TechnologyXi'an 710021China Institute of Biomass&Functional Materials Shaanxi University of Science&TechnologyXi'an 710021China

Currently,due to improvements in living standards,people are paying more attention to all-around disease prevention and health ***-powered implantable“tissue batteries”integrated with electrochemical materials are essential for disease prevention,diagnosis,treatment,postoperative therapy,and healthcare *** propose and define new concepts of“tissue batteries”-self-powered tissue batteries(SPTBs)-are flexible self-powered implantable systems or platforms based on electroactive biomaterials,acting at the interface of biological *** on the electrical phenomenon of living organisms in life activities,there has been an increased attention to SPTBs for tissue repair *** take advantages of both the preeminent biocompatibility of biomaterials and the promotion of time-honored electrical stimulation therapy for tissue recovery,which are very promising for human illness ***,studies on clinical applications of SPTBs are impeded by a lack of comprehensive cognitive assessment of ***,SPTBs for life and health applications are comprehensively ***,electrochemical materials and their across-the-board applications for several types of SPTBs are introduced and compared with regard to disease prevention,diagnosis,precision therapy,and personalized health ***,the potential mechanisms for SPTBs for tissue repair promotion are ***,the prospective challenges are summarized and recommendations for future research are *** review elucidates on the significance and versatility of SPTBs for various medical applications.

关键词： electrochemical biomaterials self-powered implantable tissue batteries medical applications

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基于主成分分析的多重定量PCR荧光串扰校正

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光谱学与光谱分析 2024年第4期44卷 1151-1157页

作者：王鹏王振亚汪舜张杰张哲杨天航王弼陡罗刚银翁良飞张翀宇李原中国科学技术大学生物医学工程学院(苏州) 生命科学与医学部江苏苏州215163 中国科学院苏州生物医学工程技术研究所工程化研究中心江苏苏州215163 重庆国科医创科技发展有限公司分子诊断中心重庆400700

聚合酶链式反应(PCR)是分子生物学常用的检测手段,主要用于对生物的DNA或RNA进行检测。由于荧光光谱重叠和滤光片过滤带宽限制,检测时所获得的荧光数据通常会包含荧光通道之间的串扰,串扰的存在使PCR结果分析变得复杂,并可能影响最终的... 详细信息

聚合酶链式反应(PCR)是分子生物学常用的检测手段,主要用于对生物的DNA或RNA进行检测。由于荧光光谱重叠和滤光片过滤带宽限制,检测时所获得的荧光数据通常会包含荧光通道之间的串扰,串扰的存在使PCR结果分析变得复杂,并可能影响最终的检测结果。选择合适的光学元件,并确定通道间的补偿矩阵,可以降低甚至消除荧光串扰。目前荧光补偿矩阵大多通过迭代计算获得,还没有一种简单的方法可以从混合的多通道荧光数据中找到荧光补偿矩阵。为了快速获得荧光补偿矩阵,减小计算量,采用主成分分析法(PCA)中确定主成分的方式,基于搭建的测试平台进行单一染料实验,获得染料的荧光信号在各个检测通道的分布情况,计算得到荧光补偿矩阵。通过分析补偿矩阵,发现对于搭建的硬件系统,Cy5染料对Cy5.5通道串扰较大,串扰比例为8.76%,同时Cy5.5染料对Cy5通道串扰影响也相对较大,比例约为6.2%;其次是ROX染料对HEX通道串扰,比例约为2.68%;HEX染料对FAM通道串扰,比例约为1.58%;FAM染料对HEX通道串扰相对较小,比例约为0.25%,其余通道无明显串扰,与荧光光谱反映的结果一致。采用得到的荧光补偿矩阵对单一染料实验得到的原始荧光数据进行处理,有效去除了非目标通道的荧光串扰,实现了荧光通道数据的解耦,验证了方法的可行性。最后设计了染料颜色分辨实验,将不同浓度的多种染料进行组合测试,并采用所提出的方法将得到的数据进行荧光补偿。实验结果表明,荧光通道各自的线性相关性较高,五个荧光通道的线性相关系数r均大于0.99,该结果进一步验证了该补偿方法的有效性。

关键词：聚合酶链式反应(PCR)检测光谱分析主成分分析多重荧光检测荧光串扰荧光分离

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基于DIC及CPG技术的热冷循环后花岗岩Ⅰ型断裂特性

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煤炭学报 2024年第7期49卷 3102-3117页

作者：吴秋红夏宇浩赵延林翁磊王世鸣冯淦湖南科技大学南方煤矿瓦斯与顶板灾害预防控制安全生产重点实验室湖南湘潭411201 湖南科技大学资源环境与安全工程学院湖南湘潭411201 武汉大学土木建筑工程学院湖北武汉430072 湖南科技大学土木学院湖南湘潭411201 四川大学水利水电学院四川成都6100652

深部储层岩石的热力学特性,尤其是循环热冷作用下损伤破坏特性,对于增强型地热系统井壁稳定性分析及地热开采效率评估具有重要意义。针对中心直裂纹半圆盘(NSCB)花岗岩试样,首先进行不同热冷循环处理(加热温度400℃,最高循环次数13次),... 详细信息

深部储层岩石的热力学特性,尤其是循环热冷作用下损伤破坏特性,对于增强型地热系统井壁稳定性分析及地热开采效率评估具有重要意义。针对中心直裂纹半圆盘(NSCB)花岗岩试样,首先进行不同热冷循环处理(加热温度400℃,最高循环次数13次),然后开展3点弯Ⅰ型断裂韧度特性试验。基于裂纹扩展计(CPG)和数字图像相关(DIC)测试技术,研究了热冷循环作用下花岗岩Ⅰ型断裂韧度、断裂过程区(FPZ)、裂纹扩展速率及断裂轮廓特征的影响规律。试验结果表明:当热冷循环次数达到10次以上,花岗岩试样脆性明显减弱,而峰前软化特性和峰后延性增强;花岗岩的断裂过程区由裂缝尖端开始逐步孕育,断裂过程区长度随荷载增大呈先增大后减小的趋势,Ⅰ型断裂韧度、最大断裂过程区长度及裂纹平均扩展速度随热冷循环次数增大而指数减小,Ⅰ型断裂面随热冷循环次数增大越来越不平整。最后,基于X-ray衍射(XRD)和扫描电镜(SEM)等微观测试技术,研究了热冷循环作用对花岗岩矿物成分及微观结构的影响规律,结果表明花岗岩4种矿物成分的峰值衍射强度及矿物质量分数均随热冷循环次数增大而降低,而微裂纹大小及数量随热冷循环次数增大而增大。热冷循环作用下花岗岩的损伤劣化机理包含了多次高温热损伤、水冷冲击及水弱化等3方面的联合作用结果。

关键词：热冷循环断裂韧度断裂过程区裂纹扩展速度裂纹扩展计(CPG)技术数字图像相关(DIC)技术

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岩石结构面Grasselli二维粗糙度指标优化及其JRC估算

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岩土工程学报 2024年第6期46卷 1146-1154页

作者：洪陈杰翁寒倩王凯黄曼陶志刚杜时贵中国矿业大学(北京)隧道工程灾变防控与智能建养全国重点实验室北京100083 绍兴文理学院土木工程学院浙江绍兴312000 浙江省岩石力学与地质灾害重点实验室浙江绍兴312000 宁波大学土木与地理环境工程学院浙江宁波315000

采用只考虑迎剪侧表观倾角而忽略内部起伏角的Grasselli二维形貌参数θ_(G)来估算结构面粗糙度系数JRC仍有待改进。从θ_(G)的物理意义出发,发现爬坡区内部凸起高度对粗糙度的贡献可表示为其在总爬坡水平距离上的坡角,所有爬坡区提供的... 详细信息

采用只考虑迎剪侧表观倾角而忽略内部起伏角的Grasselli二维形貌参数θ_(G)来估算结构面粗糙度系数JRC仍有待改进。从θ_(G)的物理意义出发,发现爬坡区内部凸起高度对粗糙度的贡献可表示为其在总爬坡水平距离上的坡角,所有爬坡区提供的坡角之和定义为结构面内部起伏体粗糙贡献,将结构面迎剪侧表观平均倾角θ_(G)和爬坡区内部平均坡角θ_(H)叠加,提出岩石结构面粗糙度新指标θ_(C)。通过获取十条标准JRC剖面线的θ_(C),分析其与JRC之间的关系,建立基于θ_(C)的JRC估算式。计算不同采样间距和不同采样方向下的新指标θ_(C),结果显示θ_(C)具有分形特征且能够反映结构面形貌各向异性。进一步将JRC估算式应用于JRC-JCS模型,通过对比已有研究得到的试验结果以及不同抗剪强度模型的预测效果,验证基于新指标θ_(C)估算的JRC可以准确预测结构面峰值抗剪强度。最后,对二维指标θ_(C)进行三维拓展,提出三维粗糙度新指标(θ_(C))_(3D),并通过结构面形貌各向异性表征验证了其合理性。

关键词：岩石结构面粗糙度表观平均倾角内部平均坡角抗剪强度

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隐喻地图的基本理论问题

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地球信息科学学报 2024年第1期26卷 72-84页

作者：苏世亮王令琦杜清运张江玥亢孟军翁敏武汉大学资源与环境科学学院武汉310029

学术界关于隐喻地图的相关研究依然处于初级探索阶段。隐喻地图的合理概念范畴、生产机制、话语生产原理、设计框架等基本理论问题尚未得到解决。针对这些局限性,本研究以隐喻地图的生成机制和话语生产原理等基本理论问题为具体突破点,... 详细信息

学术界关于隐喻地图的相关研究依然处于初级探索阶段。隐喻地图的合理概念范畴、生产机制、话语生产原理、设计框架等基本理论问题尚未得到解决。针对这些局限性,本研究以隐喻地图的生成机制和话语生产原理等基本理论问题为具体突破点,首先定义符号学视角下“地图”的概念,并以此为基础从认知语言学相关理论入手,在阐释地图隐喻功能的基础上,界定了隐喻地图的基本概念及内涵,同时甄别出隐喻地图形象性和多义性两大基本特征;其次,通过厘清视觉隐喻发生的原理,解析了隐喻地图“相似性融合-相似性凸显-符号化”的生成机制;再次,引入语言符号学理论明晰了隐喻地图的话语生产原理,构建了基于“组合关系-聚合关系”的符号组构原理和“刺点生成”的语义传递法则;最后,以生成机制及话语生产原理为基础,提出了“明确主体-构建喻体-营造语境”的隐喻地图设计理论框架,并结合实际案例论证了其合理性和可操作性,以期为隐喻地图理论体系构建与实践应用提供参考。

关键词：隐喻地图视觉隐喻生成机制话语生产符号学地图学理论专题地图设计

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XELOX(capecitabine plus oxaliplatin)plus bevacizumab(anti-VEGF-A antibody)with or without adoptive cell immunotherapy in the treatment of patients with previously untreated metastatic colorectal cancer:a multicenter,open-label,randomized,controlled,phase 3 trial

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Signal Transduction and Targeted Therapy 2024年第5期9卷 2104-2113页

作者： Qiu-Zhong Pan Jing-Jing Zhao Liang Liu Dong-Sheng Zhang Li-Ping wang Wen-Wei Hu De-Sheng weng Xiang Xu Yi-Zhuo Li Yan Tang Wei-Hong Zhang Jie-Yao Li Xiao Zheng Qi-Jing wang Yong-Qiang Li Tong Xiang Li Zhou Shuang-Ning Yang Chen Wu Rong-Xing Huang Jia He Wei-Jiao Du Lu-Jun Chen Yue-Na Wu Bin Xu Qiong Shen Yi Zhang Jing-Ting Jiang Xiu-Bao Ren Jian-Chuan Xia State Key Laboratory of Oncology in South China Guangdong Provincial Clinical Research Center for CancerCollaborative Innovation Center for Cancer MedicineSun Yat-Sen University Cancer CenterGuangzhouGuangdong 510060PR China Department of Biotherapy Sun Yat-Sen University Cancer CenterGuangzhouGuangdong 510060PR China Tianjin Medical University Cancer Institute and Hospital National Clinical Research Center for CancerTianjin 300060PR China Key Laboratory of Cancer Immunology and Biotherapy Tianjin 300060PR China Department of Biotherapy/Immunology Tianjin Medical University Cancer Institute and HospitalTianjin 300060PR China Department of Medical Oncology Sun Yat-sen University Cancer CenterGuangzhou 510060PR China Department of Oncology the First Affiliated Hospital of Zhengzhou UniversityZhengzhou 450052PR China Department of Tumor Biological Treatment the Third Affiliated Hospital of Soochow UniversityChangzhouJiangsu 213003PR China Jiangsu Engineering Research Center for Tumor Immunotherapy ChangzhouJiangsu 213003PR China Institute for Cell Therapy of Soochow University ChangzhouJiangsu 213003PR China Department of Stem Cell&Regenerative Medicine State Key Laboratory of TraumaBurn and Combined InjuryDaping HospitalArmy Medical UniversityChongqing 400042PR China Imaging Diagnosis and Interventional Center Sun Yat-sen University Cancer CenterGuangzhouGuangdong 510060PR China

Fluoropyrimidine-based combination chemotherapy plus targeted therapy is the standard initial treatment for unresectable metastatic colorectal cancer(mCRC),but the prognosis remains *** phase 3 trial(***:NCT03950154)assessed the efficacy and adverse events(AEs)of the combination of PD-1 blockade-activated DC-CIK(PD1-T)cells with XELOX plus bevacizumab as a first-line therapy in patients with mCRC.A total of 202 participants were enrolled and randomly assigned in a 1:1 ratio to receive either first-line XELOX plus bevacizumab(the control group,n=102)or the same regimen plus autologous PD1-T cell immunotherapy(the immunotherapy group,n=100)every 21 days for up to 6 cycles,followed by maintenance treatment with capecitabine and *** main endpoint of the trial was progression-free survival(PFS).The median follow-up was 19.5 *** PFS was 14.8 months(95%CI,11.6-18.0)for the immunotherapy group compared with 9.9 months(8.0-11.8)for the control group(hazard ratio[HR],0.60[95%CI,0.40-0.88];p=0.009).Median overall survival(OS)was not reached for the immunotherapy group and 25.6 months(95%CI,18.3-32.8)for the control group(HR,0.57[95%CI,0.33-0.98];p=0.043).Grade 3 or higher AEs occurred in 20.0%of patients in the immunotherapy group and 23.5%in the control groups,with no toxicity-associated deaths *** addition of PD1-T cells to first-line XELOX plus bevacizumab demonstrates significant clinical improvement of PFS and OS with well tolerability in patients with previously untreated mCRC.

关键词： PD1 immunotherapy bevacizumab

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COVID-19 risk prediction scores for mortality:A validation study from the National Registry of COVID-19 in China

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Chinese Medical Journal 2024年第6期137卷 743-745页

作者： Sui Peng Kelvin KF Tsoi Jianfeng Wu Steve HL Yim Haibo wang Qian Zhou Han Xiao Zongpeng weng Bin Li Ming Kuang Jianyan Long Joseph JY Sung Haipeng Xiao Clinical Trials Unit The First Affiliated Hospital of Sun Yat-Sen UniversityGuangzhouGuangdong 510080China Stanley Ho Big Data Decision Analytics Research Centre The Chinese University of Hong KongHong Kong 999077China JC School of Public Health and Primary Care The Chinese University of Hong KongHong Kong 999077China Department of Critical Care Medicine The First Affiliated Hospital of Sun Yat-Sen UniversityGuangzhouGuangdong 510080China Department of Geography and Resource Management The Chinese University of Hong KongHong Kong 999077China Department of Medical Ultrasonics Institute of Diagnostic and Interventional UltrasoundThe First Affiliated Hospital of Sun Yat-Sen UniversityGuangzhouGuangdong 510080China Department of Liver Surgery The First Affiliated Hospital of Sun Yat-Sen UniversityGuangzhouGuangdong 510080China Department of Medicine and Therapeutics The Chinese University of Hong KongHong Kong 999077China Department of Endocrinology Precision Medicine InstituteThe First Affiliated Hospital of Sun Yat-Sen UniversityGuangzhouGuangdong 510080China

To the Editor:Coronavirus disease 2019(COVID-19)has evolved into a global pandemic,with over 700 million confirmed cases worldwide and still mounting.^([1])The clinical impact of this pandemic is immense,given the wide spectrum of disease manifestation,ranging from mild respiratory symptoms to severe pulmonary *** high-risk individuals,especially during their initial encounters in clinics and hospital emergency services,is crucial to provide timely effective ***,the timely risk stratification of COVID-19 patients in the emergency room can greatly benefit both infected individuals and healthcare professionals.^([2])This study aims to identify features of serious COVID-19 infection at presentation that may lead to mortality of the patients.

关键词： mortality respiratory prediction

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