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NIR-Ⅱ fluorescence/photoacoustic imaging of ovarian cancer and peritoneal metastasis

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Nano Research 2022年第10期15卷 9183-9191页

作者： Siyu Lu Liru Xue Meng Yang Jingjing wang Yang Li Yuxin Jiang xuechuan Hong Mingfu Wu Yuling Xiao State Key Laboratory of Virology Department GynecologyCancer Biology Research CenterTongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China Department of Cardiology Zhongnan Hospital of Wuhan UniversitySchool of Pharmaceutical SciencesWuhan UniversityWuhan 430071China Department of Ultrasound State Key Laboratory of Complex Severe and Rare DiseasesPeking Union Medical College HospitalChinese Academy of Medical Science and Peking Union Medical CollegeBeijing 100730China College of Science Research Center for EcologyLaboratory of Extreme Environmental Biological Resources and Adaptive EvolutionTibet UniversityLhasa 850000China Shenzhen Institute of Wuhan University Shenzhen 518057China

Ovarian cancer is a global problem,and is typically diagnosed in the middle or late stages,with a mysterious abdominal mass or atypical abdominal metastases due to the lack of specific initial diagnostic ***-modal near-infrared Ⅱ(NIR-Ⅱ,1,000–1,700 nm)fluorescence/photoacoustic imaging has great potential in early ovarian cancer diagnosis and image-guided surgery due to its high sensitivity and deep ***,we report a novel organic NIR-Ⅱ dye(H10)with excellent aggregation-induced-emission(AIE)characteristics(I/I0>1.6)utilizing a selenadiazolo-[3,4-f]benzo[c][1,2,5]thiadiazole(ST)-based building ***,water-soluble and biocompatible H10@follicle-stimulating hormone(H10@FSH)dots with superior optical/photoacoustic properties and a tenfold increase in ovarian-specific targeting ability were ***,for the first time,in vivo dual-mode NIR-Ⅱ fluorescent/photoacoustic(PA)imaging and image-guided surgery of patient-derived tumor xenograft(PDTX)and micro-metastatic abdominal ovarian cancer lesions were *** novel strategy will establish a new method for early detection of ovarian cancer and significantly improve the prognosis of ovarian cancer patients.

关键词： ovarian cancer peritoneal metastasis near-infraredⅡ(NIR-Ⅱ,1,000-1,700 nm)fluorescence/photoacoustic dual-modal imaging early detection

Wannier–Koopmans method calculations for transition metal oxide band gaps

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npj Computational Materials 2020年第1期6卷 1405-1412页

作者： Mouyi weng Feng Pan Lin-wang wang School of Advanced Materials Peking University Shenzhen Graduate School518055 ShenzhenPeople’s Republic of China Materials Science Division Lawrence Berkeley National LaboratoryBerkeleyCA 94720USA

The widely used density functional theory(DFT)has a major drawback of underestimating the band gaps of ***–Koopmans method(WKM)was recently developed for band gap calculations with accuracy on a par with more complicated *** has been tested for main group covalent semiconductors,alkali halides,2D materials,and organic *** we apply the WKM to another interesting type of material system:the transition metal(TM)oxides.

关键词： materials methods transition

Enhanced electrodeposition and separation of metallic Cr from soluble K2CrO4 on a liquid Zn cathode

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Journal of Energy Chemistry 2020年第1期29卷 204-211,I0007页

作者： Wei weng Zhi wang Zhancheng Guo Shuqiang Jiao Mingyong wang State Key Laboratory of Advanced Metallurgy University of Science and Technology BeijingBeijing 100083China School of Resource and Environmental Sciences Hubei International Scientific and Technological Cooperation Base of Sustainable Resource and EnergyWuhan UniversityWuhan 430072HubeiChina Key Laboratory of Green Process and Engineering National Engineering Laboratory for Hydrometallurgical Cleaner Production TechnologyInstitute of Process EngineeringChinese Academy of SciencesBeijing 100190China

Carbon contamination and the formation of low-valence oxides limit the preparation of refractory metals by molten salt *** this paper,a liquid Zn cathode is adopted for the electrochemical reduction of soluble K2CrO4 to metallic Cr in CaCl2-KCl molten *** is found that CrO4^2-can be directly electrochemically reduced to Cr via a six-electron-transfer step and low-valence Cr oxides is hardly *** reduction rate is obviously increased from 16.7 mgCrh^-1cm^-2 on the solid Mo cathode to58.7 mgCrh-1cm-2on liquid Zn *** electrodeposited Cr is distributed in liquid Zn *** contamination is effectively avoided due to the negligible solubility of carbon in the liquid Zn ***,Cr can be effectively separated and enriched to the bottom of liquid Zn under supergravity field,realizing the efficient acquisition of metallic Cr and recycling of liquid *** method herein provides a promising route for the preparation of refractory metals with high-purity by molten salt electrolysis.

关键词： Molten salt electrolysis Liquid Zn cathode Carbon contamination K2CrO4 Metallic Cr

Lagrangian surfaces with Legendrian boundary

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Science China Mathematics 2021年第7期64卷 1589-1598页

作者： Mingyan Li Guofang wang Liangjun weng School of Mathematics and Statistics Zhengzhou UniversityZhengzhou 450001China Mathematisches Institut Albert-Ludwigs-Universitat FreiburgFreiburg 79104Germany School of Mathematical Sciences University of Science and Technology of ChinaHefei 230026China

In this paper,we first introduce a boundary problem for Lagrangian submanifolds,analogous to the problem for free boundary hypersurfaces and capillary *** we present several interesting examples of Lagrangian submanifolds satisfying this boundary condition and we prove a Lagrangian version of the Nitsche(or Hopf)type *** problems are proposed at the end of this paper.

关键词： Lagrangian surface Legendrian capillary boundary Lagrangian catenoid contact angle

激光冲击和深冷处理对7050铝合金残余应力和力学性能的影响

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热加工工艺 2024年第16期53卷 39-44页

作者：翁泽钜王浩军郑建朋顾开选王俊杰中国科学院空间功热转换技术重点实验室北京100190 航空工业西安飞机工业(集团)有限责任公司陕西西安710089 北京航天控制仪器研究所北京100094 中国科学院大学北京100049

研究了不同激光冲击处理后进行深冷处理以及补充低温回火处理对7050铝合金残余应力和力学性能的影响及其规律。结果表明,激光冲击能够显著提高7050铝合金的表面压应力至-260 MPa,而增加深冷-低温回火处理后表面压应力减小约23%。但合理... 详细信息

研究了不同激光冲击处理后进行深冷处理以及补充低温回火处理对7050铝合金残余应力和力学性能的影响及其规律。结果表明,激光冲击能够显著提高7050铝合金的表面压应力至-260 MPa,而增加深冷-低温回火处理后表面压应力减小约23%。但合理调整激光冲击工艺参数,能够有效弥补深冷-补充低温回火处理对表面压应力的降低,其中,当激光冲击次数为3次时,增加深冷-补充低温回火后表面压应力可达-230 MPa。此外,与单一激光冲击处理相比,激光冲击-深冷-补充低温回火处理后铝合金基体、表面之间的硬度得到均匀化。深冷处理能够促使激光冲击后铝合金试样表面变形加剧,同时晶粒得到进一步细化并且亚晶界增多,使7050铝合金的强度提高。

关键词：激光冲击深冷处理铝合金残余应力 7050铝合金

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公石松多糖的提取、结构表征及生物活性研究

福建分析测试 2024年第3期33卷 1-5,11页

作者：张颖王长露翁文闽南师范大学化学化工与环境学院福建漳州363000 漳州城市职业学院福建漳州363000

以公石松为原料,通过水提醇沉法获得公石松多糖。利用高效凝胶渗透色谱、柱前衍生化HPLC法、紫外、红外光谱、刚果红实验等对公石松多糖的结构进行了表征,通过抗氧化实验评估公石松多糖的体外抗氧化活性,采用MTT法初步探讨了其对肝癌细... 详细信息

以公石松为原料,通过水提醇沉法获得公石松多糖。利用高效凝胶渗透色谱、柱前衍生化HPLC法、紫外、红外光谱、刚果红实验等对公石松多糖的结构进行了表征,通过抗氧化实验评估公石松多糖的体外抗氧化活性,采用MTT法初步探讨了其对肝癌细胞HepG2、肝细胞LO2的抑制效果。结果表明,公石松多糖的相对分子量分布于50325~115144 Da,由甘露糖、葡萄糖、半乳糖和阿拉伯糖组成,具有三螺旋结构。体外抗氧化活性测定显示,公石松多糖对DPPH、ABTS、羟基自由基表现出较强的清除能力。抗肿瘤实验表明,公石松多糖具有抑制HepG2增殖的能力。

关键词：公石松多糖结构表征抗氧化活性生物活性

不同秸秆还田技术模式对冬小麦强弱势粒灌浆特性的影响

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农业工程学报 2024年第12期40卷 128-137页

作者：陈翔唐志伟翁颖蔡洪梅黄伟祥王菲菲王睿郑宝强李金才安徽农业大学农学院/农业农村部华东地区作物栽培科学观测站合肥230036

为揭示砂姜黑土区不同秸秆还田技术模式对冬小麦籽粒灌浆进程的影响,该研究基于农业农村部华东地区作物栽培科学观测站15a的长期定位试验,设置单季小麦秸秆全量粉碎覆盖还田(T1)、小麦秸秆全量粉碎覆盖还田+玉米秸秆全量粉碎翻埋还田(T2... 详细信息

为揭示砂姜黑土区不同秸秆还田技术模式对冬小麦籽粒灌浆进程的影响,该研究基于农业农村部华东地区作物栽培科学观测站15a的长期定位试验,设置单季小麦秸秆全量粉碎覆盖还田(T1)、小麦秸秆全量粉碎覆盖还田+玉米秸秆全量粉碎翻埋还田(T2)、单季玉米秸秆全量粉碎翻埋还田(T3)和小麦玉米秸秆全年不还田(CK)4种不同秸秆还田技术模式,采用Richards方程模拟冬小麦籽粒灌浆过程,研究不同秸秆还田技术模式对冬小麦强弱势粒灌浆特征参数的调控效应。结果表明:1)相较于秸秆不还田,秸秆还田处理能提升冬小麦强、弱势粒的籽粒体积、千粒质量和产量,T1、T2、T3处理下强势粒千粒质量和籽粒产量较CK分别显著提升11.02%、10.63%、13.75%和16.28%、14.29%、13.94%,弱势粒千粒质量和籽粒产量较CK分别显著提升9.73%、6.64%、7.57%和19.24%、23.25%、11.50%。Richards方程能极显著模拟不同秸秆还田技术模式下冬小麦籽粒灌浆过程,拟合方程决定系数(R^(2))均在0.997以上。2)对冬小麦强势粒,秸秆还田可延长小麦强势粒灌浆时间,主要通过缩短灌浆渐增期持续时间和提高其灌浆速率,延长灌浆缓增期的持续时间来提升强势粒千粒质量。其中T1、T3处理下冬小麦强势粒灌浆持续时间较CK分别延长2.137 d和4.443 d,T1、T2处理下强势粒单粒最大灌浆速率较CK分别显著提高了7.81%和12.26%。3)对冬小麦弱势粒,T1处理下弱势粒灌浆持续时间较CK延长1.477 d,T1、T2、T3弱势粒单粒最大灌浆速率较CK分别显著提升16.46%、22.69%和17.13%。该研究表明秸秆全量还田可提升砂姜黑土区冬小麦籽粒库容和籽粒灌浆速率,最终增加粒质量。研究可为砂姜黑土区秸秆资源的高效利用提供理论指导和技术支撑。

关键词：秸秆还田冬小麦强、弱势粒灌浆特征参数 Richards模型产量

D-Cubicle:boosting data transfer dynamically for large-scale analytical queries in single-GPU systems

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Frontiers of Computer Science 2023年第4期17卷 141-153页

作者： Jialun wang Wenhao PANG Chuliang weng Aoying ZHOU School of Data Science and Engineering East China Normal UniversityShanghai 200062China

In analytical queries,a number of important operators like JOIN and GROUP BY are suitable for parallelization,and GPU is an ideal accelerator considering its power of parallel ***,when data size increases to hundreds of gigabytes,one GPU card becomes insufficient due to the small capacity of global memory and the slow data transfer between host and device.A straightforward solution is to equip more GPUs linked with high-bandwidth connectors,but the cost will be highly *** utilize unified memory(UM)produced by NVIDIA CUDA(Compute Unified Device Architecture)to make it possible to accelerate large-scale queries on just one GPU,but we notice that the transfer performance between host and UM,which happens before kernel execution,is often significantly slower than the theoretical *** important reason is that,in singleGPU environment,data processing systems usually invoke only one or a static number of threads for data copy,leading to an inefficient transfer which slows down the overall performance *** this paper,we present D-Cubicle,a runtime module to accelerate data transfer between host-managed memory and unified memory.D-Cubicle boosts the actual transfer speed dynamically through a self-adaptive *** our experiments,taking data transfer into account,D-Cubicle processes 200 GB of data on a single GPU with 32 GB of global memory,achieving 1.43x averagely and 2.09x maximally the performance of the baseline system.

关键词： data analytics GPU unified memory

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细胞紧密连接与鸡肠道疾病的互作关系

中国家禽 2024年第2期46卷 87-95页

作者：王小芬田二杰翁胜杰王宏伟周变华河南科技大学动物科技学院河南洛阳471000

紧密连接是肠道上皮屏障的重要结构基础,负责连接相邻肠道上皮细胞,建立物理屏障,调控物质经细胞旁路转运和维持细胞表面极性。紧密连接主要由咬合蛋白、闭合蛋白、连接黏附分子、闭锁小带蛋白和细胞骨架丝状肌动蛋白等成分组装而成,其... 详细信息

紧密连接是肠道上皮屏障的重要结构基础,负责连接相邻肠道上皮细胞,建立物理屏障,调控物质经细胞旁路转运和维持细胞表面极性。紧密连接主要由咬合蛋白、闭合蛋白、连接黏附分子、闭锁小带蛋白和细胞骨架丝状肌动蛋白等成分组装而成,其表达异常和功能紊乱与细菌、病毒、寄生虫或霉菌毒素等因素引起的鸡肠道疾病密切相关。文章就紧密连接相关蛋白的结构、功能及与鸡肠道疾病发生发展的互作关系进行综述,旨在为降低和修复病原微生物及霉菌毒素所引起的肠道屏障损伤提供理论依据。

关键词：紧密连接肠道上皮屏障通透性鸡肠道疾病