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Computers, Materials & Continua 2024年第8期80卷 3193-3219页

作者： linghong Kuang Wenlong Shi Jing Zhang School of Computer Science and Mathematics Fujian University of TechnologyFuzhou350118China Fujian Provincial Key Laboratory of Big Data Mining and Applications Fuzhou350118China

The Advanced Metering Infrastructure(AMI),as a crucial subsystem in the smart grid,is responsible for measuring user electricity consumption and plays a vital role in communication between providers and ***,with the advancement of information and communication technology,new security and privacy challenges have emerged for *** address these challenges and enhance the security and privacy of user data in the smart grid,a Hierarchical Privacy Protection Model in Advanced Metering Infrastructure based on Cloud and Fog Assistance(HPPM-AMICFA)is proposed in this *** proposed model integrates cloud and fog computing with hierarchical threshold encryption,offering a flexible and efficient privacy protection solution that significantly enhances data security in the smart *** methodology involves setting user protection levels by processing missing data and utilizing fuzzy comprehensive analysis to evaluate user importance,thereby assigning appropriate protection ***,a hierarchical threshold encryption algorithm is developed to provide differentiated protection strategies for fog nodes based on user IDs,ensuring secure aggregation and encryption of user *** results demonstrate that HPPM-AMICFA effectively resists various attack strategies while minimizing time costs,thereby safeguarding user data in the smart grid.

关键词： AMI cloud and fog assistance fuzzy comprehensive analysis hierarchical threshold encryption

Facile strategy for carbon foam fabrication with lignin as sole feedstock and its applications

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Frontiers of Chemical Science and Engineering 2023年第8期17卷 1051-1064页

作者： linghong Yin Zizhu Zhao Meng Han Wangda Qu Laboratory of Lignin-Based Materials College of Life SciencesQingdao Agricultural UniversityQingdao 266109China Shenzhen Institute of Advanced Electronic Materials Shenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhen 518055China

This research is a follow-up to our recent discovery of a facile strategy for directly converting lignin powder into carbon *** this work,we report that the thermal pretreatment parameters in air can remarkably influence the formation and properties of the derived carbon *** pretreatment parameters(heating rate,temperature,and residence time)were systematically investigated and a conversion mechanism into carbon foam was *** the thermal pretreatment,relatively low temperatures,low heating rates,and short residence time hindered the formation of smooth and well-connected structures in the carbon *** overall product yields were similar regardless of the thermal pretreatment *** densities of the different carbon foams ranged 0.27–0.83 g∙cm^(−3).The carbon foams with the highest compressive strengths(>10 MPa)were KLPC280-2-5,KLPC300-0-5,and ***280-2-5 exhibited a high iodine sorption value(182 mg∙g^(−1)).KLPC300-2-5 exhibited a specific capacitance of 158 F∙g^(−1) at a current density of 0.05 A∙g^(−1).The maximum evaporation rates in the solar vapor generation experiments were 1.05 and 1.38 kg∙m^(−2)∙h^(−1) under 100 and 150 mW∙cm^(−2) irradiation,*** good performances are attributed to the robust,porous,and continuous structure.

关键词： lignin carbon foam thermal pretreatment solar vapor generation

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pH-responsive vaccine delivery systems for improving cellular immunity

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Progress in Natural Science:Materials International 2020年第5期30卷 609-617页

作者： Zonghua Liu linghong Huang Wei Xue Key Laboratory of Biomaterials of Guangdong Higher Education Institutes Department of Biomedical Engineering Jinan University

Immune vaccination is a critically important strategy in disease prevention and treatment. In vaccination, efficient vaccine carriers are necessary to augment the immune response initiated by vaccines generally with weak immunogenecity. Nowadays, commercially available vaccine/carrier formulations induce effective humoral immunity but weak or none cellular immunity. However, in practice, cellular rather than humoral immunity plays the key role in treating some intractable diseases such as AIDS and cancers, in which the elicited cytotoxic T lymphocytes can directly kill HIV-infected or cancer cells. To trigger potent cellular immunity, the carriers should help antigens escape from endosomal/lysosomal degradation and release them directly into the cytosol of antigen presenting cells. To this aim, such kind of vaccine carriers should be rationally designed and prepared in terms of their structure and physiochemical properties. Here, we summarized the recent advances in p H-responsive vaccine carriers exclusively developed for improving cellular immunity.

关键词： Vaccination Vaccine delivery systems Cellular immunity pH-responsive

DEM study on effect of particle roundness on biaxial shearing of sand

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Underground Space 2021年第6期6卷 678-694页

作者： Mengmeng Wu linghong Xiong Jianfeng Wang Department of Architecture and Civil Engineering City University of Hong KongHong KongChina Shenzhen Research Institute of City University of Hong Kong ShenzhenChina

In this study,discrete element method(DEM)simulations of a biaxial test were used to examine the effect of particle roundness on the mechanical behavior of sands at both the macro and micro ***,a stack of microcomputed tomography images were binarized,segmented,and labeled using advanced image processing and analysis ***,a spherical harmonic(SH)analysis,which involves a complete set of orthogonal functions,was implemented to rebuild the natural particle ***,five templates of virtual particles were built in a DEM simulation,four of which were obtained from SH degrees of 3,8,12,and 15,and one template was an elementary sphere.A flexible membrane was numerically generated to allow the material to deform freely under a prescribed confining ***,the effect of particle roundness on the mechanical properties of granular materials was investigated and *** shear bands were found to intersect,forming an X shape in both the rotation and displacement ***,a lower particle roundness results in higher deviatoric stress and stronger dilation in the volumetric change.A decrease in particle roundness leads to less rotation of particles despite a higher displacement *** addition,a larger SH degree leads to smaller normalized contact forces of the *** implies that decreasing the roundness results in higher anisotropy of the contact forces.

关键词： Grain shape Roundness Flexible membrane Spherical harmonic analysis Discrete element method

A high pressure-ratio,energy-focused thermoacoustic heat engine with a tapered resonator

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Chinese Science Bulletin 2005年第3期50卷 284-286页

作者： LUOErcang linghong DAIWei ZHNAGYong TechnicalInstituteofPhysicsandChemistry ChineseAcademyof0SciencesBeijing100080China TechnicalInstituteofPhysicsandChemistry ChineseAcademyofSciencesBeijing100080China//GraduateSchoolofChineseAcademyofSciencesBeijing100039China

Heat energy with temperature difference may lead to self-excited acousticaloscillation under appropriate condition, which is called "thermoacoustic phenomenon". The physicalphenomenon was observed about two hundreds years ago. However, the research on high-energythermoacoustic devices was begun only about a decade ago. Thermoacoustic machines use inert gases asworking medium and have no moving mechanical parts; consequently they are reallyenvironment-friendly and highly reliable. The efficiencies of thermoacoustic machines are nowgreatly improved, close or even higher than that of conventional heat engines.

关键词：热能温度声学振动现象共鸣器

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Impacts of Microalloying Elements on the Hardening β"‑Phase in Automotive AlMgSi Alloys

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Acta Metallurgica Sinica(English Letters) 2023年第3期36卷 495-506页

作者： Zhaoqun Chen Yuxiang Lai linghong Liu Ziran Liu Jianghua Chen Center for High‑Resolution Electron Microscopy College of Materials Science&EngineeringHunan UniversityChangsha 410082HunanChina College of Science Central South University of Forestry and TechnologyChangsha 410004China Department of Physics and Key Laboratory for Low‑Dimensional Structures and Quantum Manipulation(Ministry of Education) Hunan Normal UniversityChangsha 410081China

Microalloying elements play a crucial role in mechanical properties and phase stability of metallic *** this work,we employ first-principles calculations and atomic-scale high-angle annular dark-field scanning transmission electron microscopy(HAADF-STEM)to find promising microalloying elements that will improve the stability and properties ofβ"/Al interface andβ"phase in Al–Mg-Si ***,we define a substitution energy for evaluating the stability ofβ"phase andβ"/Al interface with microalloying elements ***,experiments of HAADF-STEM imaging are carried out to verify the calculational ***,using the most stable structures doped with microalloying elements,the mechanical properties of theβ"bulk and theβ"/Al interface were calculated and *** last,we have figured out the effects of all considered microalloying elements and obtained a rule that the stable occupancy of solute atoms is related to their own radius and the radius of Mg,Si,and *** findings will provide some theoretical basis for future microalloying strategies of Al–Mg-Si alloys.

关键词： Al-Mg-Si alloy Microalloying Precipitate Crystal structure Elastic properties First-principles calculations

An injectable conductive hydrogel with dual responsive release of rosmarinic acid improves cardiac function and promotes repair after myocardial infarction

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Bioactive Materials 2023年第11期29卷 132-150页

作者： linghong Zhang Zhongwu Bei Tao Li Zhiyong Qian Department of Biotherapy Cancer Center and State Key Laboratory of BiotherapyWest China HospitalSichuan UniversityChengdu610041China Department of Pediatric Cardiac Surgery West China the Second HospitalSichuan UniversityChengdu610041China

Myocardial infarction (MI) causes irreversible damage to the heart muscle, seriously threatening the lives of patients. Injectable hydrogels have attracted extensive attention in the treatment of MI. By promoting the coupling of mechanical and electrical signals between cardiomyocytes, combined with synergistic therapeutic strategies targeting the pathological processes of inflammation, proliferation, and fibrotic remodeling after MI, it is expected to improve the therapeutic effect. In this study, a pH/ROS dual-responsive injectable hydrogel was developed by modifying xanthan gum and gelatin with reversible imine bond and boronic ester bond double crosslinking. By encapsulating polydopamine-rosmarinic acid nanoparticles to achieve on-demand drug release in response to the microenvironment of MI, thereby exerting anti-inflammatory, anti-apoptotic, and anti-fibrosis effects. By adding conductive composites to improve the conductivity and mechanical strength of the hydrogel, restore electrical signal transmission in the infarct area, promote synchronous contraction of cardiomyocytes, avoid induced arrhythmias, and induce angiogenesis. Furthermore, the multifunctional hydrogel promoted the expression of cardiac-specific markers to restore cardiac function after MI. The in vivo and in vitro results demonstrate the effectiveness of this synergistic comprehensive treatment strategy in MI treatment, showing great application potential to promote the repair of infarcted hearts.

关键词： Myocardial infarction Responsive hydrogel Rosmarinic acid Conductivity Combined treatment

Activation of leukotriene B_(4)receptor 1 is a prerequisite for complement receptor 3-mediated antifungal responses of neutrophils

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Cellular & Molecular Immunology 2024年第3期21卷 245-259页

作者： Yan Xin Sihan Xiong linghong Zhou Xin Lin Institute for Immunology and School of Medicine Tsinghua University100084BeijingChina Tsinghua University-Peking University Center for Life Sciences 100084BeijingChina Department of Infectious Diseases Shanghai Key Laboratory of Infectious Diseases and Biosafety Emergency ResponseNational Medical Center for Infectious DiseasesHuashan HospitalFudan UniversityShanghai200040China

Invasive fungal infections are life-threatening,and neutrophils are vital cells of the innate immune system that defend against *** role of LTA4H-LTB_(4)-BLT1 axis in regulation of neutrophil responses to fungal infection remains poorly ***,we demonstrated that the LTA4H-LTB_(4)-BLT1 axis protects the host against Candida albicans and Aspergillus fumigatus,but not Cryptococcus neoformans infection,by regulating the antifungal activity of *** results show that deleting Lta4h or Blt1 substantially impairs the fungal-specific phagocytic capacity of ***,defective activation of the spleen tyrosine kinase(Syk)and extracellular signal-related kinase(ERK1/2)pathways in neutrophils accompanies this ***,BLT1 regulates CR3-mediated,β-1,3-glucan-induced neutrophil phagocytosis,while a physical interaction with CR3 with slight influence on its dynamics is *** findings thus demonstrate that the LTA4H-LTB_(4)-BLT1 axis is essential for the phagocytic function of neutrophils in host antifungal immune response against Candida albicans and Aspergillus fumigatus.

关键词： LTA4H BLT1 Phagocytosis Complement receptor 3 Fungi

Antioxidant bisabolane-type sesquiterpenoids from algalderived fungus Aspergillus sydowii EN-434

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Journal of Oceanology and Limnology 2020年第5期38卷 1532-1536页

作者： HU Xueyi LI Xiaoming MENG linghong WANG Bingui Key Laboratory of Experimental Marine Biology Institute of OceanologyChinese Academy of Sciencesand Laboratory of Marine Biology and BiotechnologyQingdao National Laboratory for Marine Science and TechnologyQingdao 266071China College of Earth Science University of Chinese Academy of SciencesBeijing 100049China Center for Ocean Mega-Science Chinese Academy of SciencesQingdao 266071China

A new aromatic bisabolene-type sesquiterpenoid(7 S,8 S)-8-hydroxysydowic acid(1),together with a pair of new bisabolene derivative(±)-(7 R*,10 R*)-10-hydroxysydowic acid(2),as well as two known analogues hydroxysydonic acid(3)and sydowic acid(4)were isolated and identifi ed from the endophytic fungal strain Aspergillus sydowii EN-434 that was obtained from the marine red alga Symphyocladia *** structures were elucidated by nuclear magnetic resonance(NMR),high resolution electrospray ionization mass spectroscopy(HRESIMS),and quantum chemical electronic circular dichroism(ECD)calculations as well as comparison of the data with literature *** 1 exhibited potent DPPH free radical scavenging activity with IC 50 value of 113.5μmol/L.

关键词： Aspergillus sydowii algal-derived fungus bisabolene-type sesquiterpenoid antioxidant activity

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