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Effect of transverse static magnetic field on radial microstructure of hypereutectic aluminum alloy during directional solidification

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Journal of Materials Science & Technology 2021年第17期76卷 207-214页

作者： Shaodong Hu Long Hou Kang Wang Zhongmiao liao Wen Zhu Aihua Yi wenfang Li Yves Fautrelle Xi Li School of Materials Science and Engineering Dongguan University of TechnologyDongguan 523808China State Key Laboratory Advanced Special Steel Shanghai UniversityShanghai 200072China School of Materials Science and Engineering Xi'an Jiaotong UniversityXi'an710049China SIMAP-EPM-Madylam/G-INP/CNRS.PHELMA.38402 St Martin d'Heres Cedex.France

The effect of different scales thermoelectric magnetic convection(TEMC)on the radial solidification microstructure of hypereutectic Al alloy has been investigated under transverse static magnetic field during directional solidification,focusing on the formation of *** experimental and numerical simulation results indicate that the TEMC circulation at sample scale under transverse static magnetic field leads to the enrichment of solute Al on one side of the *** TEMC and the solute enrichment degree increase with the increase of magnetic field when the magnetic field increases to 0.5 *** enrichment degree of solute elements under magnetic field is affected by temperature gradient and growth *** non-uniform distribution of solute Al in the radial direction of the sample results in the non-uniform distribution of primary dendrite arm spacing(PDAS).Moreover,the applied magnetic field can lead to freckle formation and its number increases with the increase of magnetic *** change of freckle is consistent with the anisotropy TEMC caused by the anisotropy of primary dendrite or primary dendrite network under magnetic ***,the mechanism of synergism effect of the anisotropy TEMC,the distribution of solute Al and the PDAS on freckle formation and evolution is studied during directional solidification under magnetic field.

关键词： Static magnetic field Directional solidification Melt flow Radial solidification microstructure Freckle

Efficient desorption and reuse of collector from the flotation concentrate:A case study of scheelite

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International Journal of Minerals,Metallurgy and Materials 2024年第11期31卷 2435-2444页

作者： Liming Tao Jianjun Wang Dejin liao Wenkai Jia Zihan Zhao wenfang Che Zhongxu Qi Wei Sun Zhiyong Gao School of Minerals Processing and Bioengineering Key Laboratory of Hunan Province for Clean and Efficient Utilization of Strategic Calcium-containing Mineral ResourcesEngineering Research Center of Ministry of Education for Carbon Emission Reduction in Metal Resource Exploitation and UtilizationCentral South UniversityChangsha 410083China State Key Laboratory of Mineral Processing BGRIMM Technology GroupBeijing 102628China Mining Technology Research Center China Tungsten and Hightech Materials Co.Ltd.Chenzhou 423000China Luoyang Luanchuan molybdenum Group Co. Ltd.Luoyang 471500China Changsha Institute of Mining Research Co. Ltd.Changsha 410012China

Flotation is the most common method to obtain concentrate through the selective adsorption of collectors on target minerals to make them hydrophobic and *** the hydrometallurgy of concentrate,collectors adsorbed on concentrate can damage ion-exchange resin and increase the chemical oxygen demand(COD)value of *** this work,we proposed a new scheme,i.e.,desorbing the collectors from concentrate in ore dressing plant and reusing them in flotation *** nitrate and benzohydroxamic acid(Pb-BHA)complex is a common collector in scheelite *** this study,different physical(stirring or ultrasonic waves)and chemical(strong acid or alkali environment)methods for facilitating the desorption of Pb-BHA collector from scheelite concentrate were ***-mineral desorption tests showed that under the condition of pulp pH 13 and ultrasonic treatment for 15 min,the highest desorption rates of Pb and BHA from the scheelite concentrate were 90.48%and 63.75%,***-of-mine ore flotation tests revealed that the reuse of desorbed Pb and BHA reduced the collector dosage by 30%for BHA and 25%for *** strong alkali environment broke the chemical bonds between Pb and *** cavitation effect of ultrasonic waves effectively reduced the interaction intensity between Pb-BHA collector and scheelite *** method combining ultrasonic waves and strong alkali environment can effectively desorb the collectors from concentrate and provide“clean”scheelite concentrate for metallurgic plants;the reuse of desorbed collector in flotation flowsheet can reduce reagent cost for ore dressing plants.

关键词： scheelite concentrate collector desorption reuse flotation

采用Logistic模型分析钩虫感染率自然回升的变化规律

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实用寄生虫病杂志 2000年第1期8卷 40-40页

作者：廖文芳肖邦忠重庆市第二卫生防疫站重庆402160

logistic模型多用于发育、繁殖、动态率、剂量反应率以及人口等方面的研究[1],现将此模型试分析钩虫感染率自然回升的变化.

关键词： Logistic模型钩虫感染流行病学

A novel inactivated whole-cell Pseudomonas aeruginosa vaccine that acts through the cGAS-STING pathway

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Signal Transduction and Targeted Therapy 2021年第11期6卷 3256-3269页

作者： Cuicui Ma Xiao Ma Boguang Jiang Hailong Pan Xueyuan liao Li Zhang wenfang Li Yingjie Luo Zhixue Shen Xingjun Cheng Mao Lian Zhenling Wang State Key Laboratory of Biotherapy and Cancer Center West China HospitalSichuan Universityand Collaborative Innovation Center of BiotherapyChengdu610041China National Institutes for Food and Drug Control(NIFDC) Beijing100050China Department of Quality Management China National Biotec Group Company LimitedBeijing100020China

Pseudomonas aeruginosa infection continues to be a major threat to global public health,and new safe and efficacious vaccines are needed for prevention of infections caused by ***.X-ray irradiation has been used to prepare whole-cell inactivated vaccines against *** ***,the immunological mechanisms of X-ray-inactivated vaccines are still unclear and require further *** previous study found that an X-ray-inactivated whole-cell vaccine could provide protection against *** by boosting T *** aim of the present study was to further explore the immunological mechanisms of the ***,*** PAO1,a widely used laboratory strain,was utilized to prepare the vaccine,and we found nucleic acids and 8-hydroxyguanosine in the supernatant of X-ray-inactivated PAO1(XPa).By detecting CD86,CD80,and MHCII expression,we found that XPa fostered dentritic cell(DC)maturation by *** stimulated the cGAS-STING pathway as well as Toll-like receptors in DCs in vitro,and DC finally underwent apoptosis and pyroptosis after XPa *** addition,DC stimulated by XPa induced CD8+T-cell proliferation in vitro and generated immunologic memory in ***,XPa vaccination induced both Th1 and Th2 cytokine responses in mice and reduced the level of inflammatory factors during *** protected mice in pneumonia models from infection with PAO1 or multidrug-resistant clinical isolate *** obstructive pulmonary disease(COPD)mice immunized with XPa could resist PAO1 ***,a new mechanism of an X-ray-inactivated whole-cell vaccine against *** infection was discovered in this study.

关键词： vaccine prevention utilized

The essential role of N6-methyladenosine RNA methylation in complex eye diseases

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Genes & Diseases 2023年第2期10卷 505-520页

作者： Xiaohua Li Binyun Ma wenfang Zhang Zongming Song Xiaodan Zhang Mengyu liao Xue Li Xueru Zhao Mei Du Jinguo Yu Shikun He Hua Yan Henan Provincial People’s Hospital Henan Eye HospitalHenan Eye InstituteHenan Key Laboratory of Ophthalmology and Visual SciencePeople’s Hospital of Zhengzhou UniversityPeople’s Hospital of Henan UniversityZhengzhouHenan 450003China Department of Medicine/Hematology Keck School of Medicine of the University of Southern CaliforniaLos AngelesCA 90033USA Department of Ophthalmology Lanzhou University Second HospitalLanzhouGansu 730030China Department of Ophthalmology Tianjin Medical University General HospitalLaboratory of Molecular OphthalmologyTianjin Medical University. Department of Pharmacology and Tianjin Key Laboratory of Inflammation BiologySchool of Basic Medical SciencesTianjin Medical UniversityTianjin 300052China Department of Pathology and Ophthalmology USC Roski Eye InstituteKeck School of MedicineUniversity of Southern CaliforniaLos AngelesCA 90033USA

There are many complex eye diseases which are the leading causes of blindness,however,the pathogenesis of the complex eye diseases is not fully understood,especially the underlying molecular mechanisms of N6-methyladenosine(m6A)RNA methylation in the eye diseases have not been extensive *** review summarizes the latest advances in the studies of m6A modification in the pathogenesis of the complex eye diseases,including cornea disease,cataract,diabetic retinopathy,age-related macular degeneration,proliferative vitreoretinopathy,Graves’disease,uveal melanoma,retinoblastoma,and traumatic optic *** further discuss the possibility of developing m6A modification signatures as biomarkers for the diagnosis of the eye diseases,as well as potential therapeutic approaches.

关键词： Degeneration Eye diseases Fibrosis Inflammation m6A RNA methylation Tumor

Specific Regulation of m^(6)A by SRSF7 Promotes the Progression of Glioblastoma

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Genomics, Proteomics & Bioinformatics 2023年第4期21卷 707-728页

作者： Yixian Cun Sanqi An Haiqing Zheng Jing Lan wenfang Chen Wanjun Luo Chengguo Yao Xincheng Li Xiang Huang Xiang Sun Zehong Wu Yameng Hu Ziwen Li Shuxia Zhang Geyan Wu Meisongzhu Yang Miaoling Tang Ruyuan Yu Xinyi liao Guicheng Gao Wei Zhao Jinkai Wang Jun Li Department of Rehabilitation Medicine Key Laboratory of Liver Disease of Guangdong ProvinceThe Third Affiliated HospitalSun Yat-sen UniversityGuangzhou 510080China Department of Biochemistry Zhongshan School of MedicineSun Yat-sen UniversityGuangzhou 510080China Department of Medical Informatics Zhongshan School of MedicineSun Yat-sen UniversityGuangzhou 510080China Center for Stem Cell Biology and Tissue Engineering Key Laboratory for Stem Cells and Tissue EngineeringMinistry of EducationSun Yat-sen UniversityGuangzhou 510080China Biosafety Level-3 Laboratory Life Sciences InstituteGuangxi Medical UniversityNanning 530020China Department of Obstetrics and Gynecology The First Affiliated HospitalSun Yat-sen UniversityGuangzhou 510080China State Key Laboratory of Oncology in South China Cancer CenterSun Yat-sen UniversityGuangzhou 510080China RNA Biomedical Institute Sun Yat-sen Memorial HospitalSun Yat-sen UniversityGuangzhou 510080China

Serine/arginine-rich splicing factor 7(SRSF7),a known splicing factor,has been revealed to play oncogenic roles in multiple ***,the mechanisms underlying its oncogenic roles have not been well ***,based on N6-methyladenosine(m^(6)A)co-methylation network analysis across diverse cell lines,we find that the gene expression of SRSF7 is positively correlated with glioblastoma(GBM)cell-specific m^(6)A *** then indicate that SRSF7 is a novel m^(6)A regulator,which specifically facilitates the m^(6)A methylation near its binding sites on the mRNAs involved in cell proliferation and migration,through recruiting the methyltransferase ***,SRSF7 promotes the proliferation and migration of GBM cells largely dependent on the presence of the m^(6)A *** two m^(6)A sites on the mRNA for PDZ-binding kinase(PBK)are regulated by SRSF7 and partially mediate the effects of SRSF7 in GBM cells through recognition by insulin-like growth factor 2 mRNA-binding protein 2(IGF2BP2).Together,our discovery reveals a novel role of SRSF7 in regulating m^(6)A and validates the presence and functional importance of temporal-and spatial-specific regulation of m^(6)A mediated by RNA-binding proteins(RBPs).

关键词： m^(6)A Serine/arginine-rich splicing factor 7 Cell-specific regulation Glioblastoma PDZ-binding kinase

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基于CQPSO的LCL滤波器设计方法

安徽大学学报（自然科学版） 2016年第2期40卷 67-72页

作者：师文芳陈华廖俊勃新疆大学电气工程学院新疆乌鲁木齐830047

针对光伏并网逆变系统中LCL滤波器参数设计的困难,提出采用混沌量子粒子群算法对滤波器参数进行寻优.利用混沌优化方法具有的随机性、有界性、遍历性等特性,来扩大算法的搜索范围和提高收敛速度.对LCL滤波器进行分析后,确定约束条件,结... 详细信息

针对光伏并网逆变系统中LCL滤波器参数设计的困难,提出采用混沌量子粒子群算法对滤波器参数进行寻优.利用混沌优化方法具有的随机性、有界性、遍历性等特性,来扩大算法的搜索范围和提高收敛速度.对LCL滤波器进行分析后,确定约束条件,结合算法来对其参数进行优化设计.对三相光伏并网逆变器进行仿真实验,将混沌量子粒子群算法与自适应遗传算法进行比较,结果表明该算法比自适应遗传算法有更好的滤波效果,谐波畸变率也更小.

关键词：并网逆变器混沌量子粒子群 LCL滤波器

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抗肿瘤活性四氢异喹啉生物碱全合成研究进展

有机化学 2010年第3期30卷 317-329页

作者：廖祥伟董文芳刘伟陈世智刘站柱中国医学科学院北京协和医学院药物研究所北京100050

综述了近年来抗肿瘤活性四氢异喹啉生物碱Renieramycin,Ecteinascidin和Quinocarcin的全合成研究进展,对其构环顺序和方法进行了分析,对部分合成路线的优缺点进行了讨论.

关键词：四氢异喹啉生物碱 Renieramycins Ecteinascidins Quinocarcin 全合成

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手术联合复方倍他米松注射治疗耳廓瘢痕疙瘩

中华整形外科杂志 2014年第1期30卷 7-10页

作者：王芳杨红华廖怀伟李文芳刘伟南昌大学第一附属医院整形美容科330006

【摘要】目的探讨手术去核处理联合定期注射复方倍他米松（得宝松）治疗耳廓瘢痕疙瘩的临床效果。方法2008年1月至2012年1月，治疗186例耳廓瘢痕疙瘩患者，前期根据瘢痕疙瘩大小及患者意愿进行单纯手术（22例）或者单纯注射得宝松（34... 详细信息

【摘要】目的探讨手术去核处理联合定期注射复方倍他米松（得宝松）治疗耳廓瘢痕疙瘩的临床效果。方法2008年1月至2012年1月，治疗186例耳廓瘢痕疙瘩患者，前期根据瘢痕疙瘩大小及患者意愿进行单纯手术（22例）或者单纯注射得宝松（34例）治疗，后期开始进行手术去核处理后定期注射得宝松治疗（130例），所有疗程结束后回访1年，观察并评价3种治疗方法的疗效，将各组数据使用SPSS16．0软件作统计学处理和分析，并使用GraphPad检验方法进行检验。结果单纯手术治疗患者术后有效率仅为54．55％（12／22）；单纯得宝松注射组患者瘢痕疙瘩在治疗范围期间皆有所减小，各项临床症状都有所减轻，但停药后，逆转现象明显，有效率为55．88％（19／34）；手术去核处理后定期注射得宝松组患者治愈率高，复发病例仅为4例，有效率可高达96．92％（126／130），效果明显优于单纯手术或单纯得宝松注射（P〈0．01）。结论手术去核处理联合得宝松注射可以较好地治疗耳廓瘢痕疙瘩。

关键词：【关键词】瘢痕疙瘩耳廓外科手术复方倍他米松