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High-power, Joule-class, temporally shaped multi-pass ring laser amplifier with two Nd:glass laser heads

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High Power Laser Science and Engineering 2019年第1期7卷 60-67页

作者： Jiangtao Guo Jiangfeng Wang Hui Wei wenfa huang Tingrui huang Gang Xia Wei Fan Zunqi Lin Key Laboratory of High Power Laser and Physics Shanghai Institute of Optics and Fine Mechanics Chinese Academy of Sciences National Laboratory on High Power Laser and Physics Shanghai Institute of Optics and Fine Mechanics Chinese Academy of Sciences University of Chinese Academy of Sciences

A high-power, Joule-class, nanosecond temporally shaped multi-pass ring laser amplifier system with two neodymiumdoped phosphate glass(Nd:glass) laser heads is demonstrated. The laser amplifier system consists of three parts: an all-fiber structure seeder, a diode-pumped Nd:glass regenerative amplifier and a multi-pass ring amplifier, where the thermally induced depolarization of two laser heads is studied experimentally and theoretically. Following the injection of a square pulse with the pulse energy of 0.9 m J and pulse width of 6 ns, a 0.969-J high-energy laser pulse at 1 Hz was generated, which had the ability to change the waveform arbitrarily, based on the all-fiber structure front end. The experimental results show that the proposed laser system is promising to be adopted in the preamplifier of high-power laser facilities.

关键词： depolarization compensation laser amplifier neodymium laser ring laser

Progress of the injection laser system of SG-Ⅱ

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High Power Laser Science and Engineering 2018年第2期6卷 154-180页

作者： Wei Fan Youen Jiang Jiangfeng Wang Xiaochao Wang Dajie huang Xinghua Lu Hui Wei Guoyang Li Xue Pan Zhi Qiao Chao Wang He Cheng Peng Zhang wenfa huang Zhuli Xiao Shengjia Zhang Xuechun Li Jianqiang Zhu Zunqi Lin National Laboratory on High Power Laser and Physics Shanghai Institute of Optics and Fine MechanicsChinese Academy of SciencesShanghai 201800China

A high power laser system was used to drive the ignition of inertial confinement fusion(ICF), of which the high energy,the uniform focal spot, the accurate laser waveform, and the synchronization between the laser beams are key *** accomplish this, global laser characteristics control should be assured, which was the main purpose of the injection laser system. In this paper, the key technological progress involved in the improvement of the performance of the injection laser of SG-II is reported, including frequency domain control, time domain control, near-field spatial shaping, preamplifier technology, and the optical parametric chirped pulse amplification pump source.

关键词： amplifier injection laser pulse shaping spatial shaping synchronization

Efficacy of platinum in advanced triple-negative breast cancer with germline BRCA mutation determined by next generation sequencing

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Chinese Journal of Cancer Research 2020年第2期32卷 149-162页

作者： Nan Wang Kun Li wenfa huang Weiyao Kong Xiaoran Liu Weijie Shi Feng Xie Hanfang Jiang Guohong Song Lijun Di Quanren Wang Jianjun Yu Huiping Li Key Laboratory of Carcinogenesis and Translational Research(Ministry of Education/Beijing) Department of Breast OncologyPeking University Cancer Hospital and InstituteBeijing 100142China Huidu Shanghai Medical Sciences Shanghai 201499China Jiangsu Hengrui Medicine Shanghai 200120China

Objective:To compare the efficacy of platinum-and non-platinum-based regimens as first-line treatment for advanced triple-negative breast cancer(TNBC)and analyze the relationship between their efficacy and BRCA gene ***:Retrospectively analyze clinical data of 220 patients diagnosed pathologically with advanced TNBC and treated at the Department of Breast Oncology,Peking University Cancer Hospital from 2013 to 2018 and evaluate the efficacy of chemotherapy.A total of 114 patients had BRCA1/2 gene tested by next generation sequencing(NGS)using peripheral blood,and we analyzed the correlation between their efficacy and BRCA1/2 gene ***:Non-platinum-based chemotherapy(NPCT)was administered to 129 and platinum-based chemotherapy(PBCT)to 91 study *** clinical benefit rate(CBR)and median progression-free survival(PFS)were not statistically different between NPCT and PBCT *** median overall survival(OS)was 30.0 and 22.5 months for PBCT and NPCT group,respectively[P=0.090,hazard ratios(HR)=0.703].BRCA status was assessed in 114 patients,14 of whom had deleterious germline BRCA1/2(g BRCA)mutations(seven in each group).In PBCT group,the CBR was 85.7%and 35.1%for patients with and without deleterious g BRCA mutations,respectively(P=0.039).The median PFS were 14.9 and 5.3 months and median OS were 26.5 and 15.5 months for patients with and without deleterious g BRCA mutations,respectively(P=0.001,P=0.161,respectively).Patients in PBCT group had significantly greater rates of grade 3-4 anemia(5.5%vs.0%)and thrombocytopenia(8.8%vs.0%),whereas palmar-plantar erythrodysesthesia(12.4%vs.0%)and peripheral neuropathy(8.6%vs.1.1%)occurred more frequently in NPCT ***:Platinum-based regimens are more effective in patients with deleterious g BRCA mutations,but no difference in patients without BRCA gene mutations,so non-platinum is an option in patients without BRCA gene mutations considering the toxicity and side *** we recommend

关键词： Advanced breast cancer triple negative BRCA mutation next-generation sequencing platinum efficacy

A high energy nanosecond cryogenic cooled Yb:YAG active-mirror amplifier system

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High Power Laser Science and Engineering 2014年第3期2卷 46-49页

作者： Xiaojin Cheng Jianlei Wang Zhongguo Yang Jin Liu Lei Li Xiangchun Shi wenfa huang Jiangfeng Wang Weibiao Chen Shanghai Key Laboratory of All Solid-state Laser and Applied Techniques Shanghai Institute of Optics and Fine MechanicsChinese Academy of Sciences The Joint Laboratory for High Power Laser Physics Shanghai Institute of Optics and Fine MechanicsChinese Academy of Sciences

A diode-pumped master oscillator power amplifier system based on a cryogenic Yb:YAG active-mirror laser has been *** performances of the laser amplifier at low temperature and room temperature have been investigated theoretically and experimentally.A maximum output energy of 3.05 J with an optical-to-optical efficiency of 14.7% has been achieved by using the master amplifier system.

关键词： diode-pumped solid-state laser Yb:YAG

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康德与黑格尔崇高理论的比较分析

上海师范大学学报（哲学社会科学版） 2007年第6期36卷 12-19页

作者：朱立元黄文发复旦大学中文系上海200433

在概述康德、黑格尔崇高理论主要内容的基础上,对两者的异同,特别是差异从五个方面进行了深入分析,又对造成这种差异的原因,主要是两人对理论前驱思想的选择性接受和他们的基本哲学立场,进行了追根溯源的探讨。

关键词：康德黑格尔崇高理论关学

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基于PLC的一种密码锁控制系统设计

科技风 2019年第25期 5-5,10页

作者：黄文法贵州理工学院

随着社会的不断进步和科学技术的发展,智能控制技术逐渐应用于各个领域。采用PLC技术,触摸屏技术和组态软件技术设计了密码锁控制系统,通过PLC编程及人机界面组态,结合触摸屏技术,最后完成了一种可修改密码、操作简单、维修方便、可报... 详细信息

随着社会的不断进步和科学技术的发展,智能控制技术逐渐应用于各个领域。采用PLC技术,触摸屏技术和组态软件技术设计了密码锁控制系统,通过PLC编程及人机界面组态,结合触摸屏技术,最后完成了一种可修改密码、操作简单、维修方便、可报警、应用广泛的一种密码锁控制系统设计。

关键词： PLC 组态软件触摸屏密码锁

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基于三菱PLC的密码锁设计

科技风 2019年第26期 13-14页

作者：黄文法贵州理工学院

目前,自动化技术在工业、农业各个领域被广泛运用到一个很高的水平,电子密码锁与传统机械密码锁相比,既避免使用钥匙穿孔又提高安全性。基于PLC技术、触摸屏技术、组态软件技术设计一种具有修改密码功能、操作简单、维修方便、可报警、... 详细信息

目前,自动化技术在工业、农业各个领域被广泛运用到一个很高的水平,电子密码锁与传统机械密码锁相比,既避免使用钥匙穿孔又提高安全性。基于PLC技术、触摸屏技术、组态软件技术设计一种具有修改密码功能、操作简单、维修方便、可报警、应用广泛的一种密码锁控制系统。

关键词： PLC 触摸屏密码锁

基于边缘加热的气冷钕玻璃放大器热波前畸变补偿

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中国激光 2017年第1期44卷 152-158页

作者：黄文发王江峰卢兴华李学春中国科学院上海光学精密机械研究所上海201800

理论分析了基于边缘加热条件下气冷钕玻璃放大器的热致波前畸变,模拟计算了不同加热温度下钕玻璃片的温度分布和热波前畸变分布,并进行了实验验证。结果表明,数值模拟与实验结果能较好地吻合,在产热率为0.6 W/cm^3时,钕玻璃片产生的热... 详细信息

理论分析了基于边缘加热条件下气冷钕玻璃放大器的热致波前畸变,模拟计算了不同加热温度下钕玻璃片的温度分布和热波前畸变分布,并进行了实验验证。结果表明,数值模拟与实验结果能较好地吻合,在产热率为0.6 W/cm^3时,钕玻璃片产生的热波前畸变随着边缘温度的增加而减小,而当边缘温度达到90℃时,热波前畸变开始出现反转,随温度增加而增加。合理设计边缘加热结构和优化加热温度,能有效抑制气冷钕玻璃放大器的热波前畸变。

关键词：激光光学热畸变边缘加热钕玻璃氦气冷却激光放大器

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生态学中的点格局研究概况及其在国内的应用

生态学报 2017年第19期37卷 6624-6632页

作者：马志波肖文发黄清麟庄崇洋中国林业科学研究院森林生态环境与保护研究所北京100091 中国林业科学研究院资源信息研究所国家林业局林业遥感与信息技术重点实验室北京100091

点格局分析是研究生态学格局的工具之一,近年来在生态学中的应用越来越多。为深入了解点格局分析方法在国内的研究与应用情况,以所总结的研究进展、一般步骤和基本要点为背景,分析评述了1996—2015年期间以点格局为主题的国内中文核心... 详细信息

点格局分析是研究生态学格局的工具之一,近年来在生态学中的应用越来越多。为深入了解点格局分析方法在国内的研究与应用情况,以所总结的研究进展、一般步骤和基本要点为背景,分析评述了1996—2015年期间以点格局为主题的国内中文核心期刊文献。结果表明,在国内生态学格局研究中,应用研究占据主导地位,研究对象广泛,包括以树木为主的乔、灌、草等不同生活型的植物,甚至包括景观;基础研究,包括概括性统计量、零模型与点过程模型等方面,以及专用软件工具包的开发等研究薄弱。在应用中存在一定问题,主要表现为:概括性统计量使用单一,且以Ripley的K-函数及其变形为主;零模型(或点过程模型)是科学问题的统计表达,但是有一半以上的研究未明确给出零模型。建议在未来应用研究中重视多种统计量的组合使用和原假设的建立,在探讨热带、亚热带森林等具有复杂空间结构系统的多样性格局时,考虑对象的不同世代和系统的不同垂直层次,并加强多变量或三维概括性统计量的开发、点格局分析方法与动态过程模型的结合研究等工作。

关键词：格局生态学概括性统计量零模型群落物种多样性格局