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Cancer Biology & Medicine 2014年第1期11卷 56-63页

作者： winnie K.w.So Kai Chow Choi winnie P.Y.tang Paul C.w.Lee Ann t.Y.Shiu Simone S.M.Ho Helen Y.L.Chan wendy w.t.lam william B.Goggins Carmen w.H.Chan the Nethersole School of Nursing The Chinese University of Hong Kong Department of Community Medicine The University of Hong Kong the Jockey Club School of Public Health and Primary Care The Chinese University of Hong Kong

Objective: to investigate the uptake rate of prostate specific antigen(PSA) testing among Hong Kong Chinese males aged 50 or above, and identify factors associated with the likelihood of undergoing a PSA ***: A population-based telephone survey was conducted in Hong Kong in 2007. the survey covered demographic information, perceived health status, use of complementary therapy, cancer screening behavior, perceived susceptibility to cancer and family history of cancer. Descriptive statistics, percentages and logistic regression analysis were used for data ***: A total of 1,002 men aged 50 or above took part in the study(response rate =67%), and the uptake rate of PSA testing was found to be 10%. Employment status, use of complementary therapy, perceiving regular visits to a doctor as good for health and the recommendations of health professionals were significant factors associated with PSA ***: the uptake rate of PSA testing in the study population was very low. Among all the factors identified, recommendations from health professionals had the strongest association with the uptake of PSA testing, and they should therefore take an active role in educating this population about cancer prevention and detection.

关键词： Prostatic neoplasms early detection of cancer prostate-specific antigen (PSA) population-based survey

Highly enhanced UV absorption and light emission of monolayer wS_(2)through hybridization with ti_(2)N MXene quantum dots and g-C_(3)N_(4)quantum dots

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Opto-Electronic Advances 2024年第6期7卷 31-39页

作者： Anir S.Sharbirin Rebekah E.Kong wendy B.Mato trang thu tran Eunji Lee Jolene w.P.Khor Afrizal L.Fadli Jeongyong Kim Department of Energy Science Sungkyunkwan UniversitySuwon 16419Republic of Korea

two-dimensional(2D)transition metal dichalcogenides(tMD)are atomically thin semiconductors with promising optoelectronic applications across the visible ***,their intrinsically weak light absorption and the low photoluminescence quantum yield(PLQY)restrict their performance and potential use,especially in ultraviolet(UV)wavelength light *** dots(QD)derived from 2D materials(2D/QD)provide efficient light absorption and emission of which energy can be tuned for desirable light *** this study,we greatly enhanced the photon absorption and PLQY of monolayer(1L)tungsten disulfide(wS_(2))in the UV range via hybridization with 2D/QD,particularly titanium nitride MXene QD(ti_(2)N MQD)and graphitic carbon nitride QD(GCNQD).with the hybridization of MQD or GCNQD,1LwS_(2)showed a maximum PL enhancement by 15 times with 300 nm wavelength excitation,while no noticeable enhancement was observed when the excitation photon energy was less than the bandgap of the QD,indicating that UV absorption by the QD played a crucial role in enhancing the light emission of 1L-wS_(2)in our 0D/2D hybrid *** findings present a convenient method for enhancing the photo-response of 1L-wS_(2)to UV light and offer exciting possibilities for harvesting UV energy using 1L-tMD.

关键词： monolayer tMD wS_(2) 2D-derived quantum dots UV absorption energy transfer

A review of public health guidelines for postpartum physical activity and sedentary behavior from around the world

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Journal of Sport and Health Science 2024年第4期13卷 472-483,F0003页

作者： Kelly R.Evenson wendy J.Brown Alison K.Brinson Emily Budzynski-Seymour Melanie Hayman Department of Epidemiology Gillings School of Global Public HealthUniversity of North Carolina at Chapel HillChapel HillNC 27599-8050USA Faculty of Health Sciences and Medicine Bond UniversityGold CoastQLD 4226Australia School of Human Movement and Nutrition Sciences The University of QueenslandBrisbaneQLD 4072Australia Department of Anthropology University of North Carolina at Chapel HillChapel HillNC 27599-3115USA Carolina Population Center University of North Carolina at Chapel HillChapel HillNC 27599-8120USA Faculty of Sport Health and Social SciencesSolent UniversitySouthamptonSO140YNUK Appleton Institute School of HealthMedical and Applied SciencesCentral Queensland UniversityRockhamptonQLD 4701Australia

Background:the period following pregnancy is a critical time window when future habits with respect to physical activity(PA) and sedentary behavior(SB) are established;therefore,it warrants *** purpose of this scoping review was to summarize public health-oriented country-specific postpartum PA and SB guidelines ***:to identity guidelines published since 2010,we performed a(a) systematic search of 4 databases(CINAHL,Global Health,PubMed,and SPORtDiscus),(b) structured repeatable web-based search separately for 194 countries,and(c) separate web-based *** the most recent guideline was included for each ***:we identified 22 countries with public health-oriented postpartum guidelines for PA and 11 countries with SB *** continents with guidelines included Europe(n=12),Asia(n=5),Oceania(n=2),Africa(n=1),North America(n=1),and South America(n=1).the most common benefits recorded for PA included weight control/management(n=10),reducing the risk of postpartum depression or depressive symptoms(n=9),and improving mood/well-being(n=8).Postpartum guidelines specified exercises to engage in,including pelvic floor exercises(n=17);muscle strengthening,weight training,or resistance exercises(n=13);aerobics/general aerobic activity(n=13);walking(n=11);cycling(n=9);and swimming(n=9).Eleven guidelines remarked on the interaction between PA and breastfeeding;several guidelines stated that PA did not impact breast milk quantity(n=7),breast milk quality(n=6),or infant growth(n=3).For SB,suggestions included limiting long-term sitting and interrupting sitting with ***:Country-specific postpartum guidelines for PA and SB can help promote healthy behaviors using a culturally appropriate context while providing specific guidance to public health practitioners.

关键词： Breastfeeding Caesarean section Guidelines Postnatal Recommendations

Attenuated retinoic acid signaling is among the early responses in mouse uterus approaching embryo attachment

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Reproductive and Developmental Medicine 2024年第1期8卷 61-65页

作者： Honglu Diao Shuo Xiao tong Zhou taylor E.Martin wendy t.watford Xiaoqin Ye Department of Physiology and Pharmacology College of Veterinary MedicineUniversity of GeorgiaAthensGA 30602USA Interdisciplinary toxicology Program University of GeorgiaAthensGA 30602USA Department of Physiology and Cell Biology University of NevadaReno School of MedicineRenoNV 89557USA Department of Infectious Diseases College of Veterinary MedicineUniversity of GeorgiaAthensGA 30602USA

the uterus is transiently receptive for embryo *** remains to be understood why the uterus does not reject a semi-allogeneic embryo(to the biological mother)or an allogeneic embryo(to a surrogate)for *** gain insights,we examined uterine early response genes approaching embryo attachment on day 3 post coitum(D3)at 22 hours when blue dye reaction,an indication of embryo attachment,had not manifested in mice.C57BL/6 pseudo-pregnant(control)and pregnant mouse uteri were collected on D3 at 22 hours for microarray *** self-assembling-manifold(SAM)algorithm identified 21,858 unique *** component analysis indicated a clear separation between the pseudo-pregnant and pregnant *** were 106 upregulated and five downregulated protein-coding genes in the pregnant uterus with fold change(fc)>1.5 andq valuetology(GO)analysis of the 106 upregulated genes revealed 38 significant GO biological process(GOBP)terms(Pthem were associated with immune responses,with a dominant natural killer(NK)cell activation *** the top eight upregulated protein-coding genes,Cyp26a1 inactivates retinoic acid(RA)whileLrat promotes vitamin A storage,both of which are expected to attenuate RA bioavailability;Atp6v0d2 andGjb2 play roles in ion transport and transmembrane transport;Gzmb,Gzmc,andIl2rb are involved in immune responses;andtdo2 is important for kynurenine *** of these genes or their related pathways have functions in immune *** signaling has been implicated in immune tolerance and immune homeostasis,and uterine NK cells have been implicated in immunotolerance at the maternal-fetal interface in the *** mechanisms of immune responses approaching embryo attachment remain to be *** coordinated effects of the early response genes may hold the keys to the question of why the uterus does not reject an implanting embryo.

关键词： Embryo attachment Pseudo-pregnant uterus Pregnant uterus Natural killer cell activation signature Retinoic acid bioavailability transmembrane transport and ion transport

Predictors of survival in autoimmune liver disease overlap syndromes

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world Journal of Hepatology 2024年第9期16卷 1269-1277页

作者： Dujinthan Jayabalan Yi Huang Luis Calzadilla-Bertot Malik Janjua Bastiaan de Boer John Joseph wendy Cheng Simon Hazeldine Briohny w Smith Gerry C MacQuillan Michael C wallace George Garas Leon A Adams Gary P Jeffrey Medical School University of Western AustraliaNed-lands 6009Western AustraliaAustralia Department of Hepatology Sir Charles Gairdner HospitalNedlands 6009Western AustraliaAustralia Department of Anatomical Pathology PathWest Laboratory MedicineNedlands 6009Western AustraliaAustralia Department of Gastroenterology and Hepatology Royal Perth HospitalPerth 6000Western AustraliaAustralia Department of Gastroenterology and Hepatology Fiona Stanley HospitalMurdoch 6150Western AustraliaAustralia Medical School University of Western AustraliaNedl-ands 6009Western AustraliaAustralia

BACKGROUND Survival in patients with autoimmune liver disease overlap syndromes(AILDOS)compared to those with single autoimmune liver disease is *** to investigate the survival of patients with AILDOS and assess the accuracy of non-invasive serum models for predicting liver-related *** Patients with AILDOS were defined as either autoimmune hepatitis and primary biliary cholangitis overlap(AIH-PBC)or autoimmune hepatitis and primary sclerosing cholangitis overlap(AIH-PSC)and were identified from three tertiary centres for this cohort ***-related death or transplantation(liver-related mortality)was determined using a population-based data linkage *** scores for liver-related death were compared for accuracy[including liver outcome score(LOS),Hepascore,Mayo Score,model for end-stage liver disease(MELD)score and MELD incorporated with serum sodium(MELD-Na)score].RESULtS twenty-two AILDOS patients were followed for a median of 3.1 years(range,0.35-7.7).Fourteen were female,the median age was 46.7 years(range,17.8 to 82.1)and median Hepascore was 1(range,0.07-1).At five years post enrolment,57%of patients remained free from liver-related mortality(74%AIH-PBC,27%AIH-PSC).there was no significant difference in survival between AIH-PBC and *** was a significant predictor of liver-related mortality(Ptients with AIH-PBC(n=14)but not AIH-PSC(n=8).A LOS cut-point of 6 discriminated liver-related mortality in AIH-PBC patients(P=0.012,log-rank test,100%sensitivity,77.8%specificity)(Harrell's C-statistic 0.867).the MELD score,MELD-Na score and Mayo Score were not predictive of liver-related mortality in any *** Survival in the rare,AILDOS is *** current study supports the LOS as a predictor of liver-related mortality in AIH-PBC *** trials investigating predictors of survival in AILDOS are required.

关键词： Autoimmune liver disease overlap syndromes Liver outcome score Liver-related death Hepascore Autoimmune hepatitis Primary biliary cholangitis Primary sclerosing cholangitis

Signaling mechanisms regulating myelination in the central nervous system

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Neuroscience Bulletin 2013年第2期29卷 199-215页

作者： Jared t.Ahrendse wendy Macklin Cell and Developmental Biology University of Colorado School of Medicine

the precise and coordinated production of myelin is essential for proper development and function of the nervous system. Diseases that disrupt myelin, including multiple sclerosis, cause significant functional disability. Current treatment aims to reduce the inflammatory component of the disease, thereby preventing damage resulting from demyelination. However, therapies are not yet available to improve natural repair processes after damage has already occurred. A thorough understanding of the signaling mechanisms that regulate myelin generation will improve our ability to enhance repair. In this review, we summarize the positive and negative regulators of myelination, focusing primarily on central nervous system myelination. Axon-derived signals, extracellular signals from both diffusible factors and the extracellular matrix, and intracellular signaling pathways within myelinating oligodendrocytes are discussed. Much is known about the positive regulators that drive myelination, while less is known about the negative regulators that shift active myelination to myelin maintenance at the appropriate time. therefore, we also provide new data on potential negative regulators of CNS myelination.

关键词： myelination signaling oligodendrocyte Akt kinase

Multiple Antibiotic Resistance and Heavy Metal Resistance Profile of Bacteria Isolated from Giant Freshwater Prawn (Macrobrachium rosenbergii) Hatchery

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Agricultural Sciences in China 2009年第6期8卷 740-745页

作者： S w Lee M Najiah w wendy A Zahrol M Nadirah Department of Fishery and Aquaculture Faculty of Agrotechnology and Food Science Universiti Malaysia Terengganu

In this article, antibiogram and heavy metal resistance profile of bacteria isolated from giant freshwater prawn （Macrobrachium rosenbergii） hatchery in Malaysia are described. Although giant freshwater prawn was introduced into Malaysia since the 1980s, there was no database information on antibiogram and heavy metal resistance profile of bacteria from giant freshwater prawn （34. rosenbergii） hatchery in Malaysia. therefore, this study was carried out to determine the effectiveness of antibiotic and heavy metal resistance profile to control bacterial diseases in M. rosenbergii hatchery. the results can provide valuable information for local M. rosenbergii post-larval producer. Antibiotic sensitivity test was carried out by disk-diffusion method against 15 types of antibiotics as follows： oxolinic acid （2 μg）, ampicillin （10μg）, erythromycin （15μg）, furazolidone （15 μg）, lincomycin （15μg）, amoxicillin （25 μg）, colistin sulphate （25 μg）, doxycycline （30μg）, florfenicol （30 μg）, flumequine （30 lag）, nalidixic acid （30μg）, tetracycline （30μg）, oleandomycin （15μg）, fosfomycin （50μg）, and spiramycin （100 μg）, whereas heavy metal resistance profile of the present bacterial isolates was determined by 2-fold agar dilution technique. In this study, 5 types of bacteria were successfully isolated; they were Aeromonas spp. （n = 77）, Escherichia coli （n = 73）, Edwardsiella spp. （n = 62）, Salmonella spp. （n = 75）, and Vibrio spp. （n = 43）. the result showed that furazolidone was the most effective antibiotic to control the bacteria isolated in this study, approximately 89.7% of the bacterial isolates were sensitive to this antibiotic. Multiple antibiotic resistance （MAR） index indicated that the hatchery water source and M. rosenbergii post-larval and sediment tanks were at high-risk exposure to the tested antibiotic. Furthermore, all the tested heavy metals （Cd2＋, Cr6＋, Hg2＋, and Cu2＋） failed to inhibit the growth of the bacterial isolates. therefore, it indicated that the water

关键词： Macrobrachium rosenbergii hatchery antibiotic heavy metal MAR index

Antibiotic Resistance and Heavy Metals tolerance in Gram-Negative Bacteria from Diseased American Bullfrog (Rana catesbeiana) Cultured in Malaysia

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Agricultural Sciences in China 2009年第10期8卷 1270-1275页

作者： M Najiah S w Lee w wendy L w tee M Nadirah S H Faizah Department of Fisheries Science and Aquaculture Faculty of Agrotechnology and Food Science Universiti Malaysia Terengganu Institute of tropical Aquaculture Universiti Malaysia Terengganu Faculty of Agro Industry and Natural Resources Universiti Malaysia Kelantan

A total of 140 bacterial isolates have been successfully isolated from various organs of diseased American bullfrog （Rana catesbeiana） cultured in Malaysia. the most frequently isolated bacteria was Edwardsiella spp. （46 isolates） followed by Aeromonas spp. （33 isolates）, Flavobacterium spp. （31 isolates）, and Vibrio spp. （30 isolates）. Majority of the bacterial isolates were found sensitive to furazolidone （85.0%）, chloramphenicol （85.0%）, oxolinic acid （90.0%）, florfenicol （95.0%）, and flumequine （97.5%）. On the other hand, most of the bacterial isolates were resistant to oleandomycin （77.5%） and lincomycin （87.5%）. Nitrofurantoin and flumequine can be inhibited the growth of all of Vibrio spp. whereas all isolates of Edwardsiella spp. were found sensitive to florfenicol and flumequine. Multiple antibiotic resistance （MAR） index were in range of 0.30-0.40, indicating that bacterial isolates from cultured bullfrogs may have received high risk exposure to the tested antibiotics. In addition, 90-100% of the isolates were resistant to copper, cadmium, and chromium. these results provided insight information on tolerance level of bacterial isolates from cultured bullfrogs to 21 antibiotics as well as heavy metals.

关键词： Rana catesbeiana MAR index Edwardsiella Aeromonas Flavobaeterium Vibrio antibiotic resistance,heavy metal tolerance

Effect of grain size on iron-boride nanoglasses

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Journal of Materials Science & technology 2023年第10期141卷 116-123页

作者： Melody M.wang Mehrdad t.Kiani Abhinav Parakh Yue Jiang X.wendy Gu Department of Materials Science and Engineering Stanford UniversityStanfordCA 94305USA Department of Mechanical Engineering Stanford UniversityStanfordCA 94305USA

Metallic nanoglasses are made of amorphous grains that are separated by lower-density amorphous boundaries,which have been proposed to enhance plasticity through the deflection of cracks and shear bands at *** has been difficult to experimentally control grain size and interfacial structure to understand their roles in plastic ***,we fabricate bulk nanoglasses via compaction and sintering of colloidally synthesized amorphous iron-boride *** nanoglasses have amor-phous grains with diameters from 116 nm to 576 nm and were tested using nanoindentation and mi-cropillar *** nanoglass with a grain size of 576 nm shows the highest elastic modulus and hardness of 101 GPa and 7.4 GPa,*** electron microscopy reveals that nanocrys-tals form within the nanoglasses during *** nanocrystal density correlates with higher nanoparticle crystallization enthalpy,an increase in plasticity,and a decrease in yield *** strain of 5.0%,yield strength of 3.8 GPa,and ultimate compressive strength of 2.7-3.8 GPa were *** show that the compaction of colloidal metallic glass nanoparticles results in robust bulk samples,with mechanical properties similar to that of other iron-based bulk metallic glasses.

关键词： Colloidal Nanoparticles Interface Nanoindentation Micropillar Plasticity

A Registry-Based Observational Study on the Maternal and Fetal Outcomes of COVID-19 Patients in Hong Kong,China

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Maternal-Fetal Medicine 2024年第3期6卷 156-163页

作者： Hillary HY Leung teresa wL Ma Florrie NY Yu Meliza Cw Kong tsz Kin Lo Pauline PL So wing-Cheong Leung wendy Shu Ka wang Cheung Sakita Moungmaithong Chi Chiu wang Liona C.Poon Department of Obstetrics and Gynaecology The Chinese University of HongKongHong Kong 999077China Department of Obstetrics and Gynaecology Queen Elizabeth HospitalHong Kong 999077China Department of Obstetrics and Gynaecology United Christian HospitalHong Kong 999077China Department of Obstetrics and Gynaecology Princess Margaret HospitalHong Kong 999077China Department of Obstetrics and Gynaecology Tuen Mun HospitalHong Kong 999077China Department of Obstetrics and Gynaecology Kwong Wah HospitalHong Kong 999077China Department of Obstetrics and Gynaecology Pamela Youde Nethersole Eastern HospitalHong Kong 999077China Department of Obstetrics and Gynaecology Queen Mary HospitalHong Kong 999077China

Objective:to report the clinical maternal and fetal outcomes of pregnant women with coronavirus disease 2019(COVID-19),along with any associated pregnancy complications,in Hong Kong,China,and to assess the impact of COVID-19 vaccination on these ***:this prospective registry-based observational study included pregnant women who were recruited through convenient sampling and had a laboratory-confirmed severe acute respiratory syndrome coronavirus 2 infection with a cycle threshold(Ct)value result available on admission to eight local hospitals in Hong Kong,*** on clinical symptoms,laboratory results,medical treatments,delivery timing and mode,and pregnancy complications were extracted from the Hospital Authority’s electronic medical record ***,fetal,and pregnancy outcomes were compared between unvaccinated pregnant women with COVID-19 and those who had received at least one dose of COVID-19 vaccine before *** continuous variables and categorical variables were analyzed using the Mann-whitney U test and the Pearson’s chi-squared test respectively.A P value less than 0.05 was considered statistically ***:A total of 164 pregnant women were included,of whom 78(47.56%)were ***-19 was diagnosed before 28 weeks’gestation in 30(18.29%),while 134(81.71%)were diagnosed at or after 28 weeks’***-two(37.80%)women received at least one dose of COVID-19 *** were no significant differences between vaccinated and unvaccinated groups in the time interval between COVID-19 diagnosis and delivery,the Ct value,and the gestational age at infection onset or delivery(P>0.05).the majority of women were symptomatic at diagnosis regardless of vaccination status 55(88.71%)in vaccinated group vs.78(76.47%)in unvaccinated group(P=0.052).Symptoms did not significantly differ between groups except for cough(62.90%vs.47.06%,P=0.049).the overall rate of severe COVID-19 in pregnant women was *** t

关键词： COVID-19 Maternal outcomes Fetal outcomes Pregnancy complications Severe COVID-19