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Exploring alternative treatments for Helicobacter pylori infection

World Journal of Gastroenterology 2014年第6期20卷 1450-1469页

作者： Guadalupe Ayala wendy itzel escobedo-hinojosa Carlos Felipe de la Cruz-Herrera Irma Romero Centro de Investigación sobre Enfermedades Infecciosas Instituto Nacional de Salud Pública INSP Departamen-to de Bioquímica Facultad de Medicina Universidad Nacional Autónoma de México

Helicobacter pylori(H. pylori) is a successful pathogen that can persist in the stomach of an infected person for their entire life. It provokes chronic gastric inflammation that leads to the development of serious gastric diseases such as peptic ulcers, gastric cancer and Mucosa associated lymphoid tissue lymphoma. It is known that these ailments can be avoided if the infection by the bacteria can be prevented or eradicated. Currently, numerous antibiotic-based therapies are available. However, these therapies have several inherent problems, including the appearance of resistance to the antibiotics used and associated adverse effects, the risk of re-infection and the high cost of antibiotic therapy. The delay in developing a vaccine to prevent or eradicate the infection has furthered research into new therapeutic approaches. This review summarises the most relevant recent studies on vaccine development and new treatments using natural resources such as plants, probiotics and nutraceuticals. In addition, novel alternatives based on microorganisms, peptides, polysaccharides, and intragastric violet light irradiation are presented. Alternative therapies have not been effective in eradicating the bacteria but have been shown to maintain low bacterial levels. Nevertheless, some of them are useful in preventing the adverse effects of antibiotics, modulating the immune response, gastroprotection, and the general promotion of health. Therefore, those agents can be used as adjuvants of allopathic anti-H. pylori eradication therapy.

关键词： Helicobacter pylori Treatment Natural products Probiotics Nutraceuticals

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Building a Distributed Infrastructure for Scalable Triple Stores

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Journal of Computer Science & Technology 2009年第3期24卷 447-462页

作者：周菁 wendy Hall David De Roure School of Computer Science Communication University of China School of Electronics and Computer Science University of SouthamptonSouthamptonU.K.

Built specifically for the Semantic Web, triple stores are required to accommodate a large number of RDF triples and remain primarily centralized. As triple stores grow and evolve with time, there is a demanding need for scalable techniques to remove resource and performance bottlenecks in such systems. To this end, we propose a fully decentralized peer-to-peer architecture for large scale triple stores in which triples are maintained by individual stakeholders, and a semantics-directed search protocol, mediated by topology reorganization, for locating triples of interest. We test our design through simulations and the results show anticipated improvements over existing techniques for distributed triple stores. In addition to engineering future large scale triple stores, our work will in particular benefit the federation of stand-alone triple stores of today to achieve desired scalability.

关键词： peer-to-peer RDF data management semantics awareness scalability topology reorganization

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A note on the consistency of a behavioral play marker in piglets

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Journal of Animal Science and Biotechnology 2014年第2期5卷 245-250页

作者： wendy Mercedes Rauw Departamento de Mejora Genetica Animal Instituto Nacional de Investigaciony Tecnologia Agrariay AlimentariaCrtadela Corunakm 7.5Madrid 28040Spain

Background： Play behavior has been proposed as a new potential indicator of animal welfare. Animals play only if they are in a relaxed state. Play may improve adaptability to challenging environments which may be of interest in the breeding objective. Little information is available on play behavior in livestock species. The aim of the present study is to investigate whether play behavior in post-weaned piglets can be induced instantly in the presence of additional space and whether play markers are body weight, sex, and litter dependent, it is investigated whether playfulness is elicited by the moment or if this measure is consistent over different days. Methods： Thirty two piglets from four litters were released into a corridor and video recorded for eight min at 37, 41, 44 and 48 d of age. The first test was considered as an adjustment period and was not included in the analysis. In the second to the fourth test, joyful brusque movements （jumping, turning and running） were recorded with a camera and total number of movements （JOY#） and total time （JOYtime） were estimated individually. Animals were weighed at 41 d of age. Results： Females had higher scores of JOY# and JOYtime than males but this was significant only for JOY# at 41 d of age （P 〈 0.05）. The effect of age was highly significant both for JOY# and JOYtime （P 〈 0.01）. Animals with a higher JOY# and JOYtime also expressed a higher JOY# and JOYtime in the other tests, but this was significant only between 44 and 48 d of age （P〈 0.01）. Body weight at 41 d of age was not significantly related to JOY# and JQYtime in any of the tests. Conclusions： Locomotor play was induced instantly by the provision of increased space allowance. Litter origin had a significant effect on play behavior. In addition, locomotor play scores were consistent between two of the three tests.

关键词： Behavior Locomotor play Pigs Play marker Welfare

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Effectiveness of predicting tunneling-induced ground settlements using machine learning methods with small datasets

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Journal of Rock Mechanics and Geotechnical Engineering 2022年第4期14卷 1028-1041页

作者： Linan Liu wendy Zhou Marte Gutierrez Department of Geology and Geological Engineering Colorado School of MinesGoldenCO80401USA Department of Civil and Environmental Engineering Colorado School of MinesGoldenCO80401USA

Prediction of tunneling-induced ground settlements is an essential task,particularly for tunneling in urban *** settlements should be limited within a tolerable threshold to avoid damages to aboveground *** learning(ML)methods are becoming popular in many fields,including tunneling and underground excavations,as a powerful learning and predicting ***,the available datasets collected from a tunneling project are usually small from the perspective of applying ML *** ML algorithms effectively predict tunneling-induced ground settlements when the available datasets are small?In this study,seven ML methods are utilized to predict tunneling-induced ground settlement using 14 contributing factors measured before or during tunnel *** methods include multiple linear regression(MLR),decision tree(DT),random forest(RF),gradient boosting(GB),support vector regression(SVR),back-propagation neural network(BPNN),and permutation importancebased BPNN(PI-BPNN)*** methods except BPNN and PI-BPNN are shallow-structure ML *** effectiveness of these seven ML approaches on small datasets is evaluated using model accuracy and *** model accuracy is measured by the coefficient of determination(R2)of training and testing datasets,and the stability of a learning algorithm indicates robust predictive ***,the quantile error(QE)criterion is introduced to assess model predictive performance considering underpredictions and *** study reveals that the RF algorithm outperforms all the other models with the highest model prediction accuracy(0.9)and stability(3.0210^(-27)).Deep-structure ML models do not perform well for small datasets with relatively low model accuracy(0.59)and stability(5.76).The PI-BPNN architecture is proposed and designed for small datasets,showing better performance than typical *** important contributing factors of ground settlements are identified,including

关键词： Ground settlements Tunneling Machine learning Small dataset Model accuracy Model stability Feature importance

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Development of Integrative Medicine in Hong Kong,China

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Chinese Journal of Integrative Medicine 2017年第7期23卷 486-489页

作者： LEUNG Ting Hung wendy Wong School of Chinese Medicine The Chinese University of Hong Kong Hong Kong SAR China Hong Kong Institute of Integrative Medicine The Chinese University of Hong KongHong Kong SAR China

Upon reflection on the experience of integration of Chinese medicine（CM）and Western medicine（integrative medicine）in the China's Mainland in recent decades,this paper aims to review the recent developments of CM a... 详细信息

关键词： integrative Mainland collaboration disciplines challenging curriculum university heritage medicines deviation

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Anomalous pressure-dependence in surface-modified silicon-derived nanoparticles

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Nano Research 2021年第12期14卷 4748-4753页

作者： Qi Li Abhinav Parakh Rongchao Jin X.wendy Gu Department of Mechanical Engineering Stanford UniversityStanfordCA94305USA Department of Materials Science and Engineering Stanford UniversityStanfordCA94305USA Department of Chemistry Carnegie Mellon UniversityPittsburghPA15213USA

Surfaces can significantly alter the optical properties of nanomaterials,but they are difficult to control and their roles are hard to understand in highly reactive materials such as silicon *** this work,we investigate the role of the surface in controlling the optical transitions in highly luminescent silicon-derived *** combining high-pressure and low-temperature experiments,we experimentally correlate the anomalously intense and narrow transitions in the UV range with the surface oxides,while the visible transition and the photoluminescence(PL)are verified to originate from the Si-ligand charge transfer *** find that the high-pressure absorption and PL depends on the rigidity of the surface *** indicates that the surface plays a dominant role on the optical properties of these silicon-derived nanoparticles,and is different than other semiconductor nanomaterials,in which pressure-dependent optical transitions depend on lattice strain or phase *** work presents a comprehensive understanding of the optical transitions and the effect of surface ligands and surface oxidation in these highly luminescent Si-derived *** new insight into the oxidation-activated and ligand-mediated transitions,and the pressure-dependent PL may help with engineering the band structure of other highly-reactive optical nanomaterials.

关键词： silicon nanoparticles high pressure surface ligands surface oxidation diamond anvil cells

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Large anisotropic negative thermal expansion in Cu-TDPAT metalorganic framework:A combined in situ X-ray diffraction and DRIFTS study

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Nano Research 2021年第2期14卷 404-410页

作者： Mehrdad Asgari lia Kochetygov Hassan Abedini wendy L.Queen Institut des Sciences et Ingenierie Chimiques Ecole Polytechnique Federale de Lausanne(EPFL)-Valais WallisCH-1951 SionSwitzerland Gas Engineering Department Faculty of PetroleumPetroleum University of Technology(PUT)Ahwaz 61991-71183Iran

Cu-TDPAT(H_(6)TDPAT=2,4,6-tris(3,5-dicarboxylphenylamino)-1,3,5-triazine),a stable nanoporous metal-organic framework with rht topology,has sparked broad interest as an adsorbent for several chemical separation *** this work,in situ synchrotron diffraction experiments followed by sequential LeBail refinements reveal that Cu-TDPAT shows unusually large anisotropic negative thermal expansion(NTE).The PASCal crystallography tool,used to analyze the magnitude of the NTE,reveals an average volumetric thermal expansion coefficientαv=-20.3 MK^(-1).This value is significantly higher than the one reported for Cu-BTC(also known as HKUST-1),which contains the same Cu-paddlewheel building unit,αv=-12 MK^(-1).In situ synchrotron single crystal X-ray diffraction and in situ diffuse reflectance infrared Fourier transform spectroscopy(DRIFTS)were employed to shed light on the NTE *** these two methods,we were able to elucidate the three main structural motions that are responsible for the NTE *** more pronounced NTE behavior of Cu-TDPAT is attributed to the lower symmetry combined with the more complex ligand structure when compared to *** knowledge obtained in this work is important for understanding the behavior of the adsorbent under transient variable temperature conditions in fixed adsorption beds.

关键词： negative thermal expansion metal-organic frameworks Cu-TDPAT in situ diffraction in situ diffuse reflectance infrared Fourier transform spectroscopy(DRIFTS)

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Diversity scaling of human vaginal microbial communities

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Zoological Research 2019年第6期40卷 587-594页

作者： wendy Li Zhan-Shan(Sam) Ma Computational Biology and Medical Ecology Lab State Key Laboratory of Genetic Resources and EvolutionKunming Institute of ZoologyChinese Academy of SciencesKunming Yunnan 650223China Center for Excellence in Animal Evolution and Genetics Chinese Academy of SciencesKunming Yunnan 650223China Kunming College of Life Sciences University of Chinese Academy of SciencesKunming Yunnan 650223China

DEAR EDITOR,The composition and diversity of the human vaginal microbial community have been investigated intensively due to the diversity-stability relationship (DSR)-based hypothesis for bacterial vaginosis (BV) etiology, which was first proposed in the 1990s and has received renewed interest in recent years. Nevertheless, diversity changes (scaling) across individuals in a cohort or population have not yet been addressed, which is significant both theoretically and practically. Theoretically, biodiversity scaling is the core of biogeography, and practically, inter-subject heterogeneity is critical for understanding the etiology and epidemiology of human microbiome-associated diseases such as BV. Here we applied the diversity-area relationship (DAR), a recent extension to the classic species-area relationship (SAR), to study diversity scaling of the vaginal microbiome by reanalyzing reported data collected from 1 107 postpartum women. The model used here characterized the power-law (or its extension) relationships between accrued diversity and areas (numbers of individuals), upon which four biogeographic profiles were thus defined. Specifically, we established the DAR profile (relationship between diversity scaling parameter and so-termed diversity order (q)), similarly pair-wise diversity overlap (PDO) profile, maximal accrual diversity (MAD) profile, and ratio of individual-level to population-level diversity (RIP) profile. These four profiles offer valuable tools to assess and predict diversity scaling (changes) in the human vaginal microbiome across individuals, as well as to understand the dynamics of vaginal microbiomes in healthy women.

关键词： human vaginal microbial Diversity

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High-pressure storage of hydrogen fuel: ammonia borane and its related compounds

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Chinese Science Bulletin 2014年第36期59卷 5235-5240页

作者： Yu Lin wendy L.Mao Department of Geological and Environmental Sciences Stanford University Stanford CA 94305 USA Photon Science SLAC National Accelerator LaboratoryMenlo Park CA 94025 USA

As a promising candidate material for hydrogen storage, ammonia borane(NH3BH3) has attracted significant interest in recent years due to its remarkably high hydrogen content. Subjecting this material to high pressure not only enables the formation of novel phases and compounds with exotic properties, but also improves our basic understanding of material's behavior at different levels of atomic and molecular interactions. This review focuses on the perspective of high-pressure chemical hydrogen storage related to NH3BH3-based materials. Four main aspects are discussed: the structures and bonding of NH3BH3 over a wide pressure–temperature space, thermolysis of NH3BH3 at high pressure, the formation of a novel high-pressure H-rich compound as a result of storage of additional molecular H2 in NH3BH3, and the potential rehydrogenation of the thermally decomposed NH3BH3 under the extreme of pressure.

关键词：高压储存化合物硼烷氢燃料氨高压力相互作用分子间

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Evaluating Land Use and Emergency Management Plans for Natural Hazards as a Function of Good Governance:A Case Study from New Zealand

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International Journal of Disaster Risk Science 2015年第1期6卷 62-74页

作者： wendy Saunders Emily Grace James Beban David Johnston GNS Science School of Psychology Massey University Joint Centre of Disaster ResearchMassey University

Plan evaluation is of utmost importance as a function of good governance. It provides a means to improve the institutional basis for implementing land use controls, provides an important opportunity to improve future plans to reduce risk, and improves the vision for sustainable development and management. This article provides an overview of the methods and findings of a plan evaluation project undertaken in New Zealand. The project analyzed 99 operative plans, provided in-depth analysis of ten plans, and included a capability and capacity study of councils. This is the first time all operative plans in New Zealand have had their natural hazard provisions assessed in this manner. The information provides an important baseline for future policy improvements, and a basis for future research and policy directions. The project found that, while New Zealand land use plans appear to be improving over time, there are still opportunities for improvement. These include improving linkages between objectives, policies, and rules within land use plans; and strengthening the linkages between land use and emergency management plans. The largest challenge is the accessibility, understanding of, and updating of hazard information.

关键词： Emergency management plans Land use plans Natural hazards New Zealand Plan evaluation

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