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Benchmark Dose for Dioxin Based on Gestational Diabetes Mellitus Using Coexposure Statistical Methods and an Optimized Physiologically Based Toxicokinetic Model

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Environment & Health 2024年第9期2卷 661-671页

作者： Tao Ying Xin Liu Lei Zhang wencheng cao Sheng Wen Yongning Wu Gengsheng He Jingguang Li School of Public Health Key Laboratory of Public Health Safety of the Ministry of EducationFudan UniversityShanghai 200032China NHC Key Laboratory of Food Safety Risk Assessment Chinese Academy of Medical Science Research Unit(No.2019RU014)China National Center for Food Safety Risk AssessmentBeijing 100021China Key Laboratory for Deep Processing of Major Grain and Oil(The Chinese Ministry of Education) College of Food Science and EngineeringWuhan Polytechnic UniversityWuhan 430023China China Hubei Provincial Center for Disease Control and Prevention Hubei Provincial Academy of Preventive MedicineHubei 430023China

Dioxins are ubiquitous endocrine-disrupting substances,but determining the effects and benchmark doses in situations of coexposure is highly *** objective of this study was to assess the relationship between dioxin andgestational diabetes mellitus(GDM),calculate the benchmark dose(BMD)of dioxin in coexposure scenarios,and derive a daily exposure threshold using an optimized physiologically based toxicokinetic(PBTK)*** on a nested casecontrol study including 77 cases with GDM and 154 controls,serum levels of 29 dioxin-like compounds(DLCs)along with 10 perfluoroalkyl acids(PFAAs),seven polybrominated diphenyl ethers(PBDEs),and five non-dioxin-like polychlorinated biphenyls(ndl-PCBs)were measured at 9−16 weeks of *** machine kernel regression(BKMR)was employed to identify significant chemicals,and probit and logistic models were used to calculate BMD adjusted for significant chemicals.A physiologically based toxicokinetic(PBTK)model was optimized using polyfluorinated dibenzo-p-dioxins and dibenzofurans(PFDD/Fs)data by the Bayesian−Monte Carlo Markov chain method and was used to determine the daily dietary exposure *** median serum level of total dioxin toxic equivalent(TEQ)was 7.72 pg TEQ/g *** regression analysis revealed that individuals in the fifth quantile of total TEQ level had significantly higher odds of developing GDM compared to those in the first quantile(OR,8.87;95%CI 3.19,27.58).The BKMR analysis identified dioxin TEQ and BDE-153 as the compounds with the greatest *** binary logistic and probit models showed that the BMD10(benchmark dose corresponding to a 10%extra risk)and BMDL_(10)(lower bound on the BMD_(10))were 3.71 and 3.46 pg TEQ/g fat,respectively,when accounting for coexposure to BDE-153 up to the 80%*** the optimized PBTK model and modifying factor,it was estimated that daily exposure should be below 4.34 pg TEQ kg^(−1)bw week^(−1)in order to not reach a harmful serum concen

关键词： dioxin gestational diabetes mellitus coexposure benchmark dose physiologically based toxicokinetic model

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激光半主动制导中光斑对四象限探测器定位精度影响分析

火箭军工程大学学报

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火箭军工程大学学报 2024年第4期38卷 61-67页

作者：仲启媛刘峰曹纹诚冯梦豪火箭军工程大学

针对激光半主动制导中，光斑的实际位置、大小及能量分布等因素影响探测器定位精度的问题，基于四象限探测器的光斑位置检测原理，建立了探测器检测位置与光斑实际位置的关系模型，在控制背景光为定值的条件下，通过弹目距离的变化改变... 详细信息

针对激光半主动制导中，光斑的实际位置、大小及能量分布等因素影响探测器定位精度的问题，基于四象限探测器的光斑位置检测原理，建立了探测器检测位置与光斑实际位置的关系模型，在控制背景光为定值的条件下，通过弹目距离的变化改变光斑半径，仿真了激光传输距离和导引头光学系统焦距与定位误差之间的关系。仿真结果表明：激光远场传输条件下距离变化所引起的定位误差变化缓慢；在弹目距离一定时，短焦条件下焦距变化所引起的定位误差小于长焦条件下的焦距变化，且短焦条件下光斑的误差更容易控制在允许范围内。

关键词：激光半主动制导四象限探测器高斯光斑定位精度

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2022年湖北省猪肝中有机磷酸酯和多氯联苯污染水平与膳食暴露风险评估

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中国食品卫生杂志 2024年第7期36卷 858-863页

作者：刘小方刘潇周妍陈海川程青云曹文成闻胜国家卫生健康委员会食品安全风险评估与标准研制特色实验室湖北省疾病预防控制中心

目的调查湖北省猪肝中7种有机磷酸酯（OPEs）和6种指示性多氯联苯（PCBs）的污染水平，评估湖北省居民通过食用猪肝摄入OPEs和PCBs的暴露风险。方法 2022年在湖北采集51份猪肝样品，采用同位素稀释法，分别利用超高效液相色谱-串联质谱... 详细信息

目的调查湖北省猪肝中7种有机磷酸酯（OPEs）和6种指示性多氯联苯（PCBs）的污染水平，评估湖北省居民通过食用猪肝摄入OPEs和PCBs的暴露风险。方法 2022年在湖北采集51份猪肝样品，采用同位素稀释法，分别利用超高效液相色谱-串联质谱（UPLC-MS/MS）和高分辨气相色谱-高分辨磁质谱（HRGC-HRMS）测定猪肝样品中OPEs和PCBs的含量水平。通过分析其指纹特征，探索污染来源。根据湖北居民每日膳食摄入量（EDI）和危害指数（HI），评估居民通过食用猪肝摄入OPEs和PCBs的暴露风险。结果猪肝中7种OPEs（∑7OPEs）的浓度范围为15.6～262 ng/g，平均数为89.7 ng/g (P50=88.4 ng/g);6种PCBs（∑6PCBs）的浓度范围为3.67～19.5 pg/g，平均数为9.02 pg/g (P50=8.21 pg/g)。磷酸三（1,3-二氯-2-丙基）酯（TDCPP）和PCB 52分别为猪肝中OPEs和PCBs的主要特征污染物。部分OPEs之间呈正相关（r=0.278～0.841,P<0.05），不同PCBs之间均呈正相关（r=0.367～0.942,P<0.01）。湖北省居民通过食用猪肝摄入∑7OPEs和∑6PCBs的平均EDI值分别为2.76 ng/kg·BW/d(P95=5.83 ng/kg·BW/d)和0.28 pg/kg·BW/d(P95=0.58 pg/kg·BW/d)，通过与参考剂量值比较，HI值均远小于1。结论尽管OPEs和PCBs在猪肝中普遍检出，但污染水平较低。湖北省居民通过食用猪肝摄入OPEs和PCBs的暴露风险相对较低。

关键词：有机磷酸酯多氯联苯猪肝膳食暴露风险评估食品安全

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Zeros of Complete Symmetric Polynomials over Finite Fields

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Journal of Systems Science & Complexity 2024年第4期37卷 1772-1788页

作者： cao Wei School of Mathematics and Statistics Minnan Normal UniversityZhangzhou 363000China

Wan and Zhang(2021) obtained a nontrivial lower bound for the number of zeros of complete symmetric polynomials over finite fields,and proposed a problem whether their bound can be *** this paper,the author improves Wan-Zhang's bound from three *** proposed results are based on the estimates related to the number of certain permutations and the value sets of non-permutation polynomials associated to the complete symmetric *** the author believes that there are still possibilities to improve the bounds and hence Wan-Zhang's bound.

关键词： Complete symmetric polynomial finite field permutation polynomial value set

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Pt nanodendrites with a PtIr alloy surface structure exhibit excellent stability toward acidic hydrogen evolution reaction

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Nano Research 2024年第6期17卷 4844-4849页

作者： Chang Liu Zongnan Wei Minna cao Rong cao State Key Laboratory of Structural Chemistry Fujian Institute of Research on the Structure of MatterChinese Academy of SciencesFuzhou 350002China University of Chinese Academy of Sciences Beijing 100049China Fujian Science and Technology Innovation Laboratory for Optoelectronic Information of China Fuzhou 350108China

The development of effective and stable electrocatalysts for the hydrogen evolution reaction(HER)in acidic electrolytes is a significant *** this work,homogeneous Pt nanodendrites(Pt NDs)with a PtIr shell were successfully synthesized by a two-step wet chemical *** open three-dimensional(3D)dendritic structure exhibited exceptional electrocatalytic characteristics,exposing as many active sites as ***,by alloying Ir with Pt on the surface,catalytic activity was greatly enhanced while ensuring extremely high *** surface-enriched platinum nanodendritic catalysts(Pt@PtIr NDs)outperformed the control samples and the commercial *** acidic HER test,Pt@PtIr NDs had a lower overpotential(22 mV)than Pt NDs(26 mV)and commercial Pt/C(31 mV)at 10 mA/cm^(2),and the activity of Pt@PtIr NDs remained consistent even after undergoing a continuous durability test for at least 168 h,which was much superior to the performance of commercial Pt/C(10 h)under identical test *** study revealed that the application of 3D Pt dendritic metal alloys may offer a chance for the development of enhanced electrocatalysts in acidic HER.

关键词： Pt nanodendrites iridium high stability hydrogen evolution reaction alloy

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Quantitative phase imaging based on holography:trends and new perspectives

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Light(Science & Applications) 2024年第7期13卷 1235-1277页

作者： Zhengzhong Huang Liangcai cao Department of Precision Instrument Tsinghua UniversityBeijing 100084China

In 1948,Dennis Gabor proposed the concept of holography,providing a pioneering solution to a quantitative description of the optical *** 75 years of development,holographic imaging has become a powerful tool for optical wavefront measurement and quantitative phase *** emergence of this technology has given fresh energy to physics,biology,and materials *** holography(DH)possesses the quantitative advantages of wide-field,non-contact,precise,and dynamic measurement capability for *** has unique capabilities for the propagation of optical fields by measuring light scattering with phase *** offers quantitative visualization of the refractive index and thickness distribution of weak absorption samples,which plays a vital role in the pathophysiology of various diseases and the characterization of various *** provides a possibility to bridge the gap between the imaging and scattering *** propagation of wavefront is described by the complex *** complex-value in the complex-domain is reconstructed from the intensityvalue measurement by camera in the ***,we regard the process of holographic recording and reconstruction as a transformation between complex-domain and real-domain,and discuss the mathematics and physical principles of *** review the DH in underlying principles,technical approaches,and the breadth of *** conclude with emerging challenges and opportunities based on combining holographic imaging with other methodologies that expand the scope and utility of holographic imaging even *** multidisciplinary nature brings technology and application experts together in label-free cell biology,analytical chemistry,clinical sciences,wavefront sensing,and semiconductor production.

关键词： holographic phase precise

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Dynamic Setting Method of Assessment Indicators for Power Curves of Renewable Energy Sources Considering Scarcity of Reserve Resources

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Journal of Modern Power Systems and Clean Energy 2024年第1期12卷 101-114页

作者： Minghao cao Jilai Yu the Department of Electrical Engineering Harbin Institute of TechnologyHarbinChina

With the increasing proportion of renewable energy sources(RESs)in power grid,the reserve resource(RR)scarcity for correcting power deviation of RESs has become a potential ***,the power curve of RES needs to be more rigorously *** RR scarcity varies during different time periods,so the values of assessment indicators should be dynamically *** assessment indicators in this paper include two aspects,i.e.,deviation exemption ratio and penalty ***,this paper proposes a method for dynamically calculating the supply capacity and RR cost,primarily taking into account the operating status of thermal units,forecast information of RES,and load ***,after clarifying the logical relationship between the degree of RR scarcity and the values of assessment indicators,this paper establishes a mapping function between *** on this mapping function,a dynamic setting method for assessment indicators is *** the future,RES will generally be equipped with battery energy storage systems(BESSs).Reasonably utilizing BESSs to reduce the power deviation of RESs can increase the expected income of ***,this paper proposes a power curve optimization strategy for RESs considering self-owned *** case study demonstrates that the dynamic setting method of assessment indicators can increase the revenue of RESs while ensuring that the penalty fees paid by RESs to the grid are sufficient to cover the RR ***,the power curve optimization strategy can help RESs further increase income and fully utilize BESSs to reduce power deviation.

关键词： Renewable energy battery energy storage system(BESS) power curve assessment reserve service parameter setting

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Bioinspired Closed-loop CPG-based Control of a Robotic Manta for Autonomous Swimming

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Journal of Bionic Engineering 2024年第1期21卷 177-191页

作者： Yiwei Hao Yonghui cao Yingzhuo cao Xiong Mo Qiaogao Huang Lei Gong Guang Pan Yong cao School of Marine Science and Technology Northwestern Polytechnical UniversityXi'an 710072China Unmanned Vehicle Innovation Center Ningbo Institute of NPUNingbo 315103China Key Laboratory of Unmanned Underwater Vehicle Technology of Ministry of Industry and Information Technology Xi'an 710072China

Fish in nature exhibit a variety of swimming modes such as forward swimming,backward swimming,turning,pitching,etc.,enabling them to swim in complex scenes such as coral *** is still difficult for a robotic fish to swim autonomously in a confined area as a real ***,we develop an untethered robotic manta as an experimental platform,which consists of two flexible pectoral fins and a tail fin,with three infrared sensors installed on the front,left,and right sides of the head to sense the surrounding *** generate multiple swimming modes of the robotic manta and online switching of different modes,we design a closed-loop Central Pattern Generator(CPG)controller based on distance information and use a combination of phase difference and amplitude of the CPG model to achieve stable and rapid adjustment of yaw *** verify the autonomous swimming ability of the robotic manta in complex scenes,we design an experimental scenario with a concave *** experimental results show that the robotic manta can achieve forward swimming,backward swimming,in situ turning within the concave obstacle,and finally exit from the area safely while relying on the perception of external obstacles,which can provide insight into the autonomous exploration of complex scenes by the biomimetic robotic ***,the swimming ability of the robotic manta is verified by field tests.

关键词： Biomimetic robotic manta Central Pattern Generator Closed-loop control Backward swimming

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Multi-scenario land use prediction and layout optimization in Nanjing Metropolitan Area based on the PLUS model

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Journal of Geographical Sciences 2024年第7期34卷 1415-1436页

作者： cao Ji cao Weidong cao Yuhong WANG Xuewei ZHANG Yizhen MA Jinji School of Geography and Tourism Anhui Normal UniversityWuhuAnhui241002China School of Ecology and Environment Anhui Normal UniversityWuhuAnhui241002China

The metropolitan area is a crucial spatial element in promoting new urbanization in *** possesses theoretical and empirical value in the determination of the evolutionary patterns and development trends necessary for regional integration and high-quality *** study focused on Nanjing Metropolitan Area,the first national metropolitan area in China,and established three development scenarios by combining ecological–economic spatial conflict(EESC)zones and national key ecological functional *** scenarios simulate the spatial distribution of future land use and land cover change(LUCC)using the development zone planning function of the patch generation land use simulation(PLUS)*** results show that:(1)Between 2000 and 2020,the most prominent characteristics of land use change were largely the massive expansion of built-up land and the significant decline of farmland,while changes in the area of ecological land were less evident.(2)EESC areas experienced significant changes over the past 20 years,but the overall level of conflict was *** land was the main land use type in the lowest-conflict area,while built-up land was the main land use type in the highest-conflict area.(3)From 2030 to 2050,further expansion of built-up areas is expected,with continued decrease of *** regulation of these land use changes can be achieved through different development zone *** economic development scenario had the largest built-up land area,while the ecological protection scenario had the largest farmland *** study simulates the spatial pattern changes in the metropolitan area based on spatial conflict patterns and national main functional area planning process,providing a scientific reference for future spatial planning and management.

关键词： land use change spatial conflict patch-generating simulation land use prediction Nanjing Metropolitan Area

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Making the Complicated Simple:A Minimizing Carrier Strategy on Innovative Nanopesticides

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Nano-Micro Letters 2024年第10期16卷 31-46页

作者： Wenjie Shangguan Qiliang Huang Huiping Chen Yingying Zheng Pengyue Zhao Chong cao Manli Yu Yongsong cao Lidong cao State Key Laboratory for Biology of Plant Diseases and Insect Pests Institute of Plant ProtectionChinese Academy of Agricultural SciencesBeijing 100193People's Republic of China College of Plant Protection China Agricultural UniversityBeijing 100193People's Republic of China State Key Laboratory of Element-Organic Chemistry Department of Chemical BiologyCollege of ChemistryNankai UniversityTianjin 300071People's Republic of China

The flourishing progress in nanotechnology offers boundless opportunities for agriculture,particularly in the realm of nanopesticides research and ***,concerns have been raised regarding the human and environmental safety issues stemming from the unrestrained use of non-therapeutic nanomaterials in *** is also important to consider whether the current development strategy of nanopesticides based on nanocarriers can strike a balance between investment and return,and if the complex material composition genuinely improves the efficiency,safety,and circularity of ***,we introduced the concept of nanopesticides with minimizing carriers(NMC)prepared through prodrug design and molecular self-assembly emerging as practical tools to address the current limitations,and compared it with nanopesticides employing non-therapeutic nanomaterials as carriers(NNC).We further summarized the current development strategy of NMC and examined potential challenges in its preparation,performance,and ***,we asserted that the development of NMC systems can serve as the innovative driving force catalyzing a green and efficient revolution in nanopesticides,offering a way out of the current predicament.

关键词： Nanopesticides Green agrochemicals Self-assembly Nanomaterial safety Sustainable development strategies

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