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Starvation-Sensitized and Oxygenation-Promoted Tumor Sonodynamic Therapy by a Cascade Enzymatic Approach

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Research 2021年第1期2021卷 763-779页

作者： wencheng wu Yinying Pu Han Lin Heliang Yao Jianlin Shi The State Key Lab of High Performance Ceramics and Superfine Microstructures Shanghai Institute of CeramicsChinese Academy of SciencesShanghai 200050China Center of Materials Science and Optoelectronics Engineering University of Chinese Academy of SciencesBeijing 100049China Department of Medical Ultrasound Shanghai Tenth People’s HospitalUltrasound Research and Education InstituteTongji University School of MedicineShanghai 200072China Platform of Nanomedicine Translation Shanghai Tenth People’s Hospital of Tongji UniversityShanghai 200072China

The therapeutic outcomes of noninvasive sonodynamic therapy(SDT)are always compromised by tumor hypoxia,as well as inherent protective mechanisms of ***,we report a simple cascade enzymatic approach of the concurrent glucose depletion and intratumoral oxygenation for starvation-sensitized and oxygenation-amplified sonodynamic therapy using a dual enzyme and sonosensitizer-loaded nanomedicine designated as GOD/CAT@*** particular,glucose oxidase-(GOD-)catalyzed glycolysis would cut off glucose supply within the tumor,resulting in the production of tumor hydrogen peroxide(H_(2)O_(2))while causing tumor cells *** generated H_(2)O_(2)could subsequently be decomposed by catalase(CAT)to generate oxygen,which acts as reactants for the abundant singlet oxygen(^(1 O_(2))production by loaded sonosensitizer hematoporphyrin monomethyl ether(HMME)upon the US irradiation,performing largely elevated therapeutic outcomes of *** the meantime,the severe energy deprivation enabled by GOD-catalyzed glucose depletion would prevent tumor cells from executing protective mechanisms to defend themselves and make the tumor cells sensitized and succumbed to the cytotoxicity of^(1 O_(2)).Eventually,GOD/CAT@ZPF-Lips demonstrate the excellent tumoral therapeutic effect of SDT in vivo without significant side effect through the cascade enzymatic starvation and oxygenation,and encouragingly,the tumor xenografts have been found completely eradicated in around 4 days by the intravenous injection of the nanomedicine without reoccurrence for as long as 20 days.

关键词： protective dynamic loaded

Bacterial Metabolism-Initiated Nanocatalytic Tumor Immunotherapy

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Nano-Micro Letters 2022年第12期14卷 549-569页

作者： wencheng wu Yinying Pu Shuang Gao Yucui Shen Min Zhou Heliang Yao Jianlin Shi The State Key Lab of High Performance Ceramics and Superfine Microstructures Shanghai Institute of CeramicsChinese Academy of SciencesResearch Unit of Shanghai Nanocatalytic Medicine in Specific Therapy for Serious DiseaseChinese Academy of Medical Sciences(2021RU012)Shanghai 200050People’s Republic of China Department of Medical Ultrasound Shanghai Tenth People’s HospitalUltrasound Research and Education InstituteTongji University Cancer CenterTongji University School of MedicineShanghai 200072People’s Republic of China Digestive Endoscopy Center Shanghai Fourth People’s Hospital to Tongji UniversityShanghai 200081People’s Republic of China

The low immunogenicity of tumors remains one of the major limitations of cancer ***,we report a bacterial metabolisminitiated and photothermal-enhanced nanocatalytic therapy strategy to completely eradicate primary tumor by triggering highly effective antitumor immune ***,a microbiotic nanomedicine,designated as Cu_(2)O@ΔSt,has been constructed by conjugating PEGylated Cu_(2)O nanoparticles on the surface of an engineered Salmonella typhimurium strain(ΔSt).Owing to the natural hypoxia tropism ofΔSt,Cu_(2)O@ΔSt could selectively colonize hypoxic solid tumors,thus minimizing the adverse effects of the bacteria on normal *** bacterial metabolism within the tumor,Cu_(2)O@ΔSt generates H_(2)S gas and other acidic substances in the tumor microenvironment(TME),which will in situ trigger the sulfidation of Cu_(2)O to form CuS facilitating tumor-specific photothermal therapy(PTT)under local NIR laser irradiation on the one ***,the dissolved Cu+ions from Cu_(2)O into the acidified TME enables the nanocatalytic tumor therapy by catalyzing the Fenton-like reaction of decom-posing endogenous H_(2)O_(2) into cytotoxic hydroxyl radicals(·OH)on the other *** a bacterial metabolism-triggered PTT-enhanced nanocatalytic treatment could effectively destroy tumor cells and induce a massive release of tumor antigens and damage-associated molecular patterns,thereby sensitizing tumors to checkpoint blockade(ICB)*** combined nanocatalytic and ICB therapy results in the much-inhibited growth of distant and metastatic tumors,and more importantly,induces a powerful immunological memory effect after the primary tumor ablation.

关键词： Bacterial metabolism In situ nanocatalytic therapy Immunotherapy

Simultaneous removal of Cd(Ⅱ)and As(Ⅴ)by ferrihydrite-biochar composite:Enhanced effects of As(Ⅴ)on Cd(Ⅱ)adsorption

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Journal of Environmental Sciences 2024年第5期139卷 267-280页

作者： Wenjun Zeng Yang Lu Jingyan Zhou Jie Zhang Yuanxiao Duan Changxun Dong wencheng wu College of Sciences Nanjing Agricultural UniversityNanjing 210095China South China Institute of Environmental Sciences Ministry of Ecology and EnvironmentGuangzhou 510655China Guangdong Engineering&Technology Research Center for System Control of Livestock and Poultry breeding Pollution Guangzhou 510655China

The coexistence of cadmium(Cd(Ⅱ))and arsenate(As(Ⅴ))pollution has long been an environmental ***,a porous carbonaceous material with tunable functionality,has been used for the remediation of contaminated ***,it is still challenging for the dynamic quantification and mechanistic understanding of the simultaneous sequestration of multi-metals in biochar-engineered environment,especially in the presence of *** this study,ferrihydrite was coprecipitated with biochar to investigate how ferrihydritebiochar composite affects the fate of heavy metals,especially in the coexistence of Cd(Ⅱ)and As(Ⅴ).In the solution system containing both Cd(Ⅱ)and As(Ⅴ),the maximum adsorption capacities of ferrihydrite-biochar composite for Cd(Ⅱ)and As(Ⅴ)reached 82.03μmol/g and 531.53μmol/g,respectively,much higher than those of the pure biochar(26.90μmol/g for Cd(Ⅱ),and 40.24μmol/g for As(Ⅴ))and ferrihydrite(42.26μmol/g for Cd(Ⅱ),and 248.25μmol/g for As(Ⅴ)).Cd(Ⅱ)adsorption increased in the presence of As(Ⅴ),possibly due to the changes in composite surface charge in the presence of As(Ⅴ),and the increased dispersion of ferrihydrite by *** microscopic and mechanistic results showed that Cd(Ⅱ)complexed with both biochar and ferrihydrite,while As(Ⅴ)was mainly complexed by ferrihydrite in the Cd(Ⅱ)and As(Ⅴ)coexistence *** posed vital importance for the co-adsorption of Cd(Ⅱ)and As(Ⅴ).The different distribution patterns revealed by this study help to a deeper understanding of the behaviors of cations and anions in the natural environment.

关键词： Ferrihydrite Biochar Cadmium Arsenate Simultaneous sequestration Binding mechanisms

Research Progress on Remediation Technology Suitable for Farmland Soil Contaminated by Cd

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Meteorological and Environmental Research 2015年第2期6卷 29-32页

作者： Ren Lulu wu wencheng Cai Xinde Guangdong Vocational College of Environmental Protection Engineering South China Institute of Environmental Sciences Ministry of Environmental Protection

Cd contamination range of farmland soil in China is wide,which has constituted a major threat for food safety and residents＇ health. Via multi-year development,there are more remediation methods suitable for soil contaminated by Cd among the world,but some methods are only suitable for the contaminated sites and indoor research,and can not be applied in large-range contaminated farmland. We analyze the source of Cd in farmland soil. By combining farmland＇s characteristics,three remediation techniques（ low-absorption crops plantation,soil solidification and phytoremediation） and their effects are analyzed,and the existing problems and research prospects of the above techniques are explored. The research could provide reference for restoring farmland soil contaminated by Cd in China,recovering its production function and enhancing food safety standards.

关键词： Farmland Cd contamination Food safety Soil remediation China

Seroprevalence of neutralizing antibodies against HFMD associated enteroviruses among healthy individuals in Shanghai,China,2022

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Virologica Sinica 2024年第4期39卷 694-698页

作者： Jiayu Wang wencheng wu Wei Wang Jingyi Zhang Jianwei Xiao Mingyi Cai Jiaying Guo Run Li Shuangli Zhu Wanju Zhang Min Chen Zheng Teng Microbiology Department Shanghai Municipal Center for Disease Control and PreventionShanghai200336China Microbiology Department Yangpu Municipal Center for Disease Control and PreventionShanghai200090China Microbiology Department Jing’an Municipal Center for Disease Control and PreventionShanghai200070China Microbiology Department Changning Municipal Center for Disease Control and PreventionShanghai200050China WHO WPRO Regional Polio Reference Laboratory NHC Key Laboratory for BiosafetyNHC Key Laboratory for Medical VirologyNational Institute for Viral Disease Control and PreventionChinese Center for Disease Control and PreventionBeijing102206China

Dear Editor,Hand,foot and mouth disease(HFMD)is one of the most common infectious diseases,particularly in the Asia-Pacific *** the past two decades,HFMD rises to prominence for its heavy burden,with over one million cases reported *** 2013,enterovirus A71(EV-A71)and Coxsackievirus A16(CVA16)were the main pathogens leading to HFMD in the mainland of China(Yang et al.,2017).In recent years,non-EV-A71-non-CVA16 other enteroviruses,such as Coxsackievirus A6(CVA6),Coxsackievirus A10(CVA10)and Coxsackievirus A4(CVA4),were frequently reported and replaced EV-A71 and CVA16 becoming the major causative agents of HFMD(Zhou et al.,2021;Wang et al.,2022).

关键词： enterovirus HFMD

从扩散到竞争:规范研究纲领的问题转换与理论进步

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太平洋学报 2020年第9期28卷 27-39页

作者：吴文成外交学院《外交评论》北京100037

规范研究作为建构主义构建的指涉经验世界的科学研究纲领,在不断解决纲领内部的“反常”过程中,经历了从研究规范扩散,到规范衰退,再到关注规范竞争的内部问题转换。在这一历程中,研究纲领的硬核被重新理解,规范不再被视为意义稳定的“... 详细信息

规范研究作为建构主义构建的指涉经验世界的科学研究纲领,在不断解决纲领内部的“反常”过程中,经历了从研究规范扩散,到规范衰退,再到关注规范竞争的内部问题转换。在这一历程中,研究纲领的硬核被重新理解,规范不再被视为意义稳定的“事物”,而是被理解为处于不断变革的一种“进程”,规范硬核被重构为周期性“动态生成的事物”。在行为体对规范意义的持续竞争中,规范演进因而呈现扩散或衰退的双向发展可能。此外,随着研究问题从扩散转向竞争,学者们的分析层次下沉到单元,行为体之间的战略互动得到高度强调,“结果性逻辑”越来越被重视,成本—收益考量机制被吸纳进研究纲领。在这一问题转换过程中,单元的施动性逐渐得到充分体现,结构对行为体的单向建构被逆转,行为体建构体系层面的规范结构随之成为可能。概言之,规范研究的这一问题转换预测了规范演进方向的双向可能性、单元与结构的互构、行为体对理性选择机制的接纳这些新颖事实,并且在一定程度上得到经验验证,因此,规范研究纲领的问题转换呈现出进步特征。

关键词：规范研究纲领问题转换规范扩散规范衰退规范竞争

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学术共同体与中国外交变革

外交评论（外交学院学报） 2010年第4期27卷 94-104页

作者：吴文成外交学院国际关系研究所博士研究生北京100037

学术共同体是否影响了中国外交的变革,影响外交决策过程,影响程度如何,这是外交政策分析中的一个重要问题。本文从体系、国家和个体三个层次梳理了有关中国外交变革动力的现有研究,在此基础上提出了外交决策者的平行社会化问题。中国目... 详细信息

学术共同体是否影响了中国外交的变革,影响外交决策过程,影响程度如何,这是外交政策分析中的一个重要问题。本文从体系、国家和个体三个层次梳理了有关中国外交变革动力的现有研究,在此基础上提出了外交决策者的平行社会化问题。中国目前已初步形成了国际关系学术共同体,基本确立了学术专业分工,形成了一定的知识共识。但因为元理论的缺失、西方话语主导等因素,国际关系学术共同体作为一个整体,对中国外交变革的影响仍然有限。

关键词：中国外交变革国际关系学术共同体平行社会化

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全球大流行疫情下的地理教育担当

地理教学 2020年第9期 58-64页

作者：吴文成重庆市第一中学校重庆400030

在“全球大流行”疫情时期,地理学和地理教育应有重要的疫情职责担当,这种担当地位是由地理学本质和地理教育内涵所决定的,有充分的必要性和可行性。地理教育疫情担当主要体现在对受教育者地理价值观塑造、地理思维培养和地理技术掌握... 详细信息

在“全球大流行”疫情时期,地理学和地理教育应有重要的疫情职责担当,这种担当地位是由地理学本质和地理教育内涵所决定的,有充分的必要性和可行性。地理教育疫情担当主要体现在对受教育者地理价值观塑造、地理思维培养和地理技术掌握三个方面,这种担当精神和担当能力的培育既在疫情公共管理领域有重要地位,在民众个体防疫方面也有重要作用。

关键词：疫情地理教育担当价值观思维

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地理决策思维:基于预测的地理能力及培养

地理教学 2019年第15期 48-56页

作者：吴文成重庆市第一中学

地理决策思维是地理高阶思维的重要内容,也是地理学科的重要价值诉求。它是在地理科学预测基础上的与决策有关的思维集群,具有开放、区域、宏观、多面等方面的特质。广义决策思维是围绕决策全过程的思维集群;狭义决策思维包括科学决策... 详细信息

地理决策思维是地理高阶思维的重要内容,也是地理学科的重要价值诉求。它是在地理科学预测基础上的与决策有关的思维集群,具有开放、区域、宏观、多面等方面的特质。广义决策思维是围绕决策全过程的思维集群;狭义决策思维包括科学决策和民主决策两个思维主线。使用充要论证、swot、决策树、辩论等决策思维技术手段可以让地理决策更加科学合理。地理教学中应从实景化、复杂化、创新化等角度强调决策思维能力的培养。

关键词：地理预测地理决策思维创新决策地理论证