检索结果-南通市图书馆

Hypoxic microenvironment in cancer:molecular mechanisms and therapeutic interventions

在线全文

学校读者我要写书评

暂无评论

Signal Transduction and Targeted Therapy 2023年第3期8卷 1047-1069页

作者： zhou Chen Fangfang Han Yan Du Huaqing Shi wence zhou The First Clinical Medical College Lanzhou UniversityLanzhouGansuChina The First Hospital of Lanzhou University LanzhouGansuChina The Second Clinical Medical College Lanzhou UniversityLanzhouGansuChina Lanzhou University Sencond Hospital LanzhouGansuChina

Having a hypoxic microenvironment is a common and salient feature of most solid *** has a profound effect on the biological behavior and malignant phenotype of cancer cells,mediates the effects of cancer chemotherapy,radiotherapy,and immunotherapy through complex mechanisms,and is closely associated with poor prognosis in various cancer *** studies have demonstrated that through normalization of the tumor vasculature,nanoparticle carriers and biocarriers can effectively increase the oxygen concentration in the tumor microenvironment,improve drug delivery and the efficacy of *** also increase infiltration of innate and adaptive anti-tumor immune cells to enhance the efficacy of ***,drugs targeting key genes associated with hypoxia,including hypoxia tracers,hypoxia-activated prodrugs,and drugs targeting hypoxia-inducible factors and downstream targets,can be used for visualization and quantitative analysis of tumor hypoxia and antitumor ***,the relationship between hypoxia and cancer is an area of research that requires further ***,we investigated the potential factors in the development of hypoxia in cancer,changes in signaling pathways that occur in cancer cells to adapt to hypoxic environments,the mechanisms of hypoxia-induced cancer immune tolerance,chemotherapeutic tolerance,and enhanced radiation tolerance,as well as the insights and applications of hypoxia in cancer therapy.

关键词： drugs therapeutic microenvironment

Safety of high-carbohydrate fluid diet 2 h versus overnight fasting before non-emergency endoscopic retrograde cholangiopancreatography:A single-blind,multicenter,randomized controlled trial

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Medical Journal 2024年第12期137卷 1437-1446页

作者： Wenbo Meng Joseph W.Leung Zhenyu Wang Qiyong Li Leida Zhang Kai Zhang Xuefeng Wang Meng Wang Qi Wang Yingmei Shao Jijun Zhang Ping Yue Lei Zhang Kexiang Zhu Xiaoliang Zhu Hui Zhang Senlin Hou Kailin Cai Hao Sun Ping Xue Wei Liu Haiping Wang Li Zhang Songming Ding Zhiqing Yang Ming Zhang Hao Weng QingyuanWu Bendong Chen Tiemin Jiang Yingkai Wang Lichao Zhang Ke Wu Xue Yang Zilong Wen Chun Liu LongMiao Zhengfeng Wang Jiajia Li Xiaowen Yan Fangzhao Wang Lingen Zhang Mingzhen Bai Ningning Mi XianzhuoZhang wence zhou Jinqiu Yuan Azumi Suzuki Kiyohito Tanaka Jiankang Liu Ula Nur Elisabete Weiderpass Xun Li Department of General Surgery The First Hospital of Lanzhou UniversityLanzhouGansu 730000China Key Laboratory of Biological Therapy and Regenerative Medicine Transformation Gansu Province LanzhouGansu 730000China Division of Gastroenterology and Hepatology UC Davis Medical CenterSacramentoCA 95816USA Department of Minimally Invasive Surgery Tianjin Nankai HospitalTianjin 300100China Division of Hepatobiliary and Pancreatic Surgery Department of SurgeryShulan(Hangzhou)Hospital Affiliated to Zhejiang Shuren UniversityHangzhouZhejiang 310000China Department of Hepatobiliary Surgery Southwest HospitalArmy Medical UniversityChongqing 400000China Hepatobiliary Surgery Department Shandong Provincial Third HospitalJinanShandong 250000China Department of General Surgery Xinhua HospitalAffiliated to Shanghai Jiao Tong University School of MedicineShanghai Key Laboratory of Biliary Tract Disease ResearchShanghai 200000China Department of Hepatobiliary and Pancreatic Surgery The First Hospital of Jilin UniversityChangchunJilin 130000China Department of Hepatobiliary Surgery The General Hospital of Ningxia Medical UniversityYinchuanNingxia 750000China Department of Hepatobiliary&Hydatid Digestive and Vascular Surgery CenterXinjiang Key Laboratory of Echinococcosis and Liver Surgery ResearchThe First Affiliated Hospital of Xinjiang Medical UniversityUrumqiXinjiang 830000China Department of Hepatobiliary and Pancreatic Surgery The First Hospital of Shanxi Medical UniversityTaiyuanShanxi 030000China Department of General Surgery The Second Hospital of Lanzhou UniversityLanzhouGansu 730000China Department of Biliopancreatic Endoscopic Surgery The Second Hospital of Hebei Medical UniversityShijiazhuangHebei 050000China Gastrointestinal Surgery Department Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei 430000China Department of Hepatobiliary Surgery The First Affiliated Hospital of Xi’an Jiaotong UniversityXi’anShaanxi 710000China Depart

Background:Although overnight fasting is recommended prior to endoscopic retrograde cholangiopancreatography(ERCP),the benefits and safety of high-carbohydrate fluid diet(CFD)intake 2 h before ERCP remain *** study aimed to analyze whether high-CFD intake 2 h before ERCP can be safe and accelerate patients’***:This prospective,multicenter,randomized controlled trial involved 15 tertiary ERCP centers.A total of 1330 patients were randomized into CFD group(n=665)and fasting group(n=665).The CFD group received 400 mL of maltodextrin orally 2 h before ERCP,while the control group abstained from food/water overnight(>6 h)before *** ERCP procedures were performed using deep sedation with intravenous *** investigators were blinded but not the *** primary outcomes included postoperative fatigue and abdominal pain score,and the secondary outcomes included complications and changes in metabolic *** outcomes were analyzed according to a modified intention-to-treat ***:The post-ERCP fatigue scores were significantly lower at 4 h(4.1±2.6 vs.4.8±2.8,t=4.23,P<0.001)and 20 h(2.4±2.1 vs.3.4±2.4,t=7.94,P<0.001)in the CFD group,with least-squares mean differences of 0.48(95%confidence interval[CI]:0.26-0.71,P<0.001)and 0.76(95%CI:0.57-0.95,P<0.001),*** 4-h pain scores(2.1±1.7 vs.2.2±1.7,t=2.60,P=0.009,with a least-squares mean difference of 0.21[95%CI:0.05-0.37])and positive urine ketone levels(7.7%[39/509]vs.15.4%[82/533],χ^(2)=15.13,P<0.001)were lower in the CFD *** CFD group had significantly less cholangitis(2.1%[13/634]vs.4.0%[26/658],χ^(2)=3.99,P=0.046)but not pancreatitis(5.5%[35/634]vs.6.5%[43/658],χ^(2)=0.59,P=0.444).Subgroup analysis revealed that CFD reduced the incidence of complications in patients with native papilla(odds ratio[OR]:0.61,95%CI:0.39-0.95,P=0.028)in the multivariable ***:Ingesting 400 mL of CFD 2 h before ERCP is safe,with a reduction in post-ERCP fatigue,

关键词： Endoscopic retrograde cholangiopancreatography ERCP Carbohydrate Fasting Safety Complications Enhanced recovery after surgery Randomized controlled trial

Betulinic acid-mediating miRNA-365 inhibited the progression of pancreatic cancer

在线全文

学校读者我要写书评

暂无评论

Oncology Research 2023年第4期31卷 505-514页

作者： XIN LI WENKAI JIANG WANCHENG LI SHI DONG YAN DU HUI ZHANG wence zhou Department of General Surgery The Second Hospital of Lanzhou UniversityLanzhou730000China The First Clinical Medical College Lanzhou UniversityLanzhou730000China The Second Clinical Medical College Lanzhou UniversityLanzhou730000China

Background:The dilemma of pancreatic cancer treatment has become a global *** this reason,effective,feasible,and new medical methods are currently *** acid(BA)has been valued as a potential therapy for pancreatic ***,the mechanism by which BA exerts an inhibitory effect on the development of pancreatic cancer remains ***:A rat model and two cell models of pancreatic cancer were established,and the effect of BA on pancreatic cancer was verified in vivo and in vitro by using MTT,Transwell,flow cytometry,RT-PCR,Elisa and *** the same time,miR-365 inhibitors were introduced to test whether BA played a role in mediating ***:BA can significantly inhibit the proliferation and invasion of pancreatic cancer cells and promote *** vivo experiments,BA can significantly lower the number of cancer cells and tumor volume in the rat model of pancreatic *** vitro,it was found that BA inhibited the protein level and phosphorylation level of AKT/STAT3 by mediating the expression of miR365/BTG2/*** BA,miR-365 inhibitors also significantly inhibited cell viability and invasion ability,and inhibited the protein level and phosphorylation level of AKT/STAT3 by changing the expression of BTG2/IL-6,and their combination had a synergistic ***:BA inhibits AKT/STAT3 expression and phosphorylation by modulating miR-365/BTG2/IL-6 expression,and BA inhibits the progression of pancreatic cancer through the aforementioned mechanism.

关键词： Betulinic acid Pancreatic cancer miRNA-365 BTG2 IL-6

Preparation and properties of wheat gluten/silica composites

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Science China Chemistry 2009年第3期52卷 257-260页

作者： SONG YiHu ZHENG Qiang zhou wence Department of Polymer Science and Engineering Zhejiang UniversityHangzhou 310027China Key Laboratory of Macromolecular Synthesis and Functionalization of Ministry of Education Zhejiang UniversityHangzhou 310027China

Wheat gluten (WG)/silica (SiO2) hybrids were prepared through in-situ synthesis of SiO2 in WG disper-sion of aqueous ammonia. The hybrids with different SiO2 contents were mixed with glycerol plasticizer to form cohesive dough and the dough was compressively molded to form cross-linked sheets. Morphology, moisture absorption, protein solubility in water, tensile mechanical properties and dynamic rheological behavior of the WG/SiO2 composites were investigated in relation to SiO2 contents.

关键词： wheat gluten silica composites properties

胰腺癌微环境中的肿瘤相关巨噬细胞:潜在的治疗靶点

在线全文

学校读者我要写书评

暂无评论

中华肝胆外科杂志 2023年第12期29卷 955-960页

作者：董仕李昕杜岩周文策兰州大学第二临床医学院兰州730000 兰州大学第二医院普通外科兰州730000

胰腺癌是全球致命的消化道恶性肿瘤之一,尽管其治疗标准有所提高,但仍不足以有效改善患者的预后。肿瘤相关巨噬细胞(TAM)作为肿瘤微环境中的主要组成部分,在肿瘤发生发展、侵袭转移、血管生成、化疗耐药以及免疫逃逸中发挥重要作用,并... 详细信息

胰腺癌是全球致命的消化道恶性肿瘤之一,尽管其治疗标准有所提高,但仍不足以有效改善患者的预后。肿瘤相关巨噬细胞(TAM)作为肿瘤微环境中的主要组成部分,在肿瘤发生发展、侵袭转移、血管生成、化疗耐药以及免疫逃逸中发挥重要作用,并与患者预后不良密切相关。因此,深入探索TAM在胰腺癌免疫治疗中的作用机制可为胰腺癌微环境的调控提供新的见解。本文介绍了TAM在胰腺癌进展中的作用途径及机制,总结了针对TAM的胰腺癌治疗策略并提出进一步的优化方案,希望为基于TAM的胰腺癌免疫治疗提供参考。

关键词：胰腺肿瘤肿瘤相关巨噬细胞肿瘤免疫治疗肿瘤微环境

巨噬细胞浸润的胰腺癌患者预后分析及特征基因初筛

在线全文

学校读者我要写书评

暂无评论

中华肝胆外科杂志 2022年第9期28卷 683-688页

作者：李昕甘宇陈浩斐周文策兰州大学第一临床医学院兰州730010 兰州大学第一医院普外科兰州730010

目的分析巨噬细胞浸润与胰腺癌患者预后的相关性,并通过生物信息学分析胰腺癌患者M2型巨噬细胞浸润的相关基因。方法选择2015年6月至2018年12月兰州大学第一医院收治的32例胰腺癌患者为研究对象,其中男性19例,女性13例,年龄(61.8±2.8)... 详细信息

目的分析巨噬细胞浸润与胰腺癌患者预后的相关性,并通过生物信息学分析胰腺癌患者M2型巨噬细胞浸润的相关基因。方法选择2015年6月至2018年12月兰州大学第一医院收治的32例胰腺癌患者为研究对象,其中男性19例,女性13例,年龄(61.8±2.8)岁。收集患者癌组织和癌旁组织,以及相关临床资料,包括:血清糖类抗原19-9、肿瘤TNM分期、血管侵犯等。对样本行F4/80(巨噬细胞标志物)免疫组化染色。随访生存时间,并分析其与上述指标的相关性。使用癌症基因组图谱(TCGA)数据库胰腺癌数据行生物信息学分析。结果胰腺癌患者生存时间与癌组织巨噬细胞的浸润程度负相关(r=-0.522,P=0.002),与癌旁组织未见明显关系(r=0.168,P=0.358)。癌组织巨噬细胞浸润程度联合术前血清糖类抗原19-9、肿瘤TNM分期、血管侵犯对胰腺癌患者生存时间的解释度达到47.4%(R^(2)=0.474)。TCGA数据库等进行生物信息学分析得到胰腺癌中95个差异基因与M2型巨噬细胞浸润显著相关,其中主要为基因JPH3(正相关)和IL17REL(负相关)。结论癌组织巨噬细胞浸润程度可以作为胰腺癌患者预后预测因素,联合术前血清糖类抗原19-9、肿瘤TNM分期、血管侵犯预测预后更为准确。M2型巨噬细胞浸润的相关机制研究可以围绕JPH3和IL17REL等差异基因展开。

关键词：胰腺肿瘤巨噬细胞白细胞介素-17 亲联蛋白

在线全文

学校读者我要写书评

暂无评论

MELK在胰腺癌中的表达、功能及临床意义

中国肿瘤生物治疗杂志 2022年第11期29卷 1038-1044页

作者：姜文凯杜岩周永婕周文策兰州大学第二临床医学院甘肃兰州730000 兰州大学第一临床医学院甘肃兰州730000 兰州大学第二医院普通外科甘肃兰州730000

目的:探究母胚亮氨酸拉链激酶(MELK)在胰腺癌组织中的表达、功能及临床意义。方法:通过生物信息学方法分析MELK在胰腺癌中的表达情况并预测MELK在影响胰腺癌发生发展中可能的分子机制。回顾性分析45例在兰州大学第一医院接受手术治疗的... 详细信息

目的:探究母胚亮氨酸拉链激酶(MELK)在胰腺癌组织中的表达、功能及临床意义。方法:通过生物信息学方法分析MELK在胰腺癌中的表达情况并预测MELK在影响胰腺癌发生发展中可能的分子机制。回顾性分析45例在兰州大学第一医院接受手术治疗的胰腺癌患者的临床资料,采用免疫组化法检测胰腺癌组织和癌旁正常组织中的MELK表达水平,分析其与患者临床病理特征的关系;通过门诊就诊记录及电话随访收集患者的术后复发时间,探究MELK表达与术后复发时间的关系。结果:MELK的mRNA在胰腺癌组织中呈高表达并与患者总生存率和术后复发时间相关;多因素Cox分析结果表明MELK基因可作为胰腺癌患者的独立预后因素。功能分析表明MELK参与多个癌症相关功能通路,与胰腺癌致病分子正相关。免疫组化结果表明,MELK在胰腺癌组织中的表达明显高于癌旁正常组织。MELK在胰腺癌组织中的表达与肿瘤大小相关。结论:胰腺癌组织中MELK基因呈高表达且和预后相关,MELK在胰腺癌的进展中发挥作用,有望成为胰腺癌诊治的潜在生物标记物和治疗靶点。

关键词：胰腺癌母胚亮氨酸拉链激酶预后临床特征

在线全文

学校读者我要写书评

暂无评论

转移性胰腺癌的联合免疫治疗研究进展

实用医学杂志 2023年第6期39卷 655-659页

作者：张习杰李昕周文策兰州大学第二临床医学院兰州730000 兰州大学第一临床医学院兰州730000 兰州大学第二医院普通外科兰州730000

胰腺癌是恶性程度极高的消化系统肿瘤,特别是转移性胰腺癌在临床上表现为病程短、进展快、病死率高等特点。尽管吉西他滨已成为晚期胰腺癌的标准治疗方案,但治疗效果仍未达到预期。因此临床上逐渐开展以放化疗、免疫治疗、靶向治疗以及... 详细信息

胰腺癌是恶性程度极高的消化系统肿瘤,特别是转移性胰腺癌在临床上表现为病程短、进展快、病死率高等特点。尽管吉西他滨已成为晚期胰腺癌的标准治疗方案,但治疗效果仍未达到预期。因此临床上逐渐开展以放化疗、免疫治疗、靶向治疗以及纳米技术等多种治疗手段,但目前对于转移性胰腺癌单药治疗效果欠佳,研究人员考虑采用联合治疗不断探索新的治疗方案,在临床与基础研究方面进行了多项针对转移性胰腺癌的联合免疫治疗试验,但总体来讲该领域的治疗方案目前仍存在争议,本文就近年来转移性胰腺癌的联合免疫治疗研究进展作一综述。

关键词：转移性胰腺癌免疫治疗联合治疗

人工智能在胰腺疾病新型诊疗模式中的应用及进展

在线全文

学校读者我要写书评

暂无评论

中国医学物理学杂志 2022年第8期39卷 1049-1056页

作者：陈鑫龙叶凯周文策兰州大学第一临床医学院甘肃兰州730013 兰州大学第一医院普外科甘肃兰州730013 兰州大学信息科学与工程学院甘肃兰州730000 兰州大学第二医院普外科甘肃兰州730030

基于临床资料、医学影像学、基因组学的计算机诊疗辅助系统在鉴别胰腺囊性疾病、诊断胰腺癌等方面显现出优于传统诊疗方法的潜力。本文综述人工智能在胰腺各类疾病的诊断、预后、预测治疗反应和指导治疗方面的作用,并为胰腺疾病精准医... 详细信息

基于临床资料、医学影像学、基因组学的计算机诊疗辅助系统在鉴别胰腺囊性疾病、诊断胰腺癌等方面显现出优于传统诊疗方法的潜力。本文综述人工智能在胰腺各类疾病的诊断、预后、预测治疗反应和指导治疗方面的作用,并为胰腺疾病精准医疗、改良目前的临床诊疗模式提供新的思路及方法。

关键词：人工智能机器学习深度学习胰腺疾病胰腺炎胰腺癌精准医疗