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Acta Pharmaceutica Sinica B 2024年第8期14卷 3605-3623页

作者： Zehui Tan Ning Guo Zhi Cao Shuyu Liu Jiayu Zhang Deyi Ma Jiahao Zhang wencai lv Nan Jiang Linghe Zang Lihui Wang Xin Zhai Key Laboratory of Structure-Based Drug Design and Discovery Ministry of EducationShenyang Pharmaceutical UniversityShenyang 110016China Department of Pharmacology Shenyang Pharmaceutical UniversityShenyang 110016China

Recent research certified that DOT1L and its mutations represented by R231Q were potential targets for the treatment of lung ***,a series of adenosine-containing derivatives were identified with DOT1LR231Q inhibition through antiproliferation assay and Western blot analysis in the H460R231Q *** most promising compound 37 significantly reduced DOT1LR231Q mediated H3K79 methylation and effectively inhibited the proliferation,self-renewal,migration,and invasion of lung cancer cell lines at low micromolar *** cell permeability and cellular target engagement of 37 were verified by both CETSA and DARTS *** the H460R231Q OE cell-derived xenograft(CDX)model,37 displayed pronounced tumor growth inhibition after intraperitoneal administration at 20 mg/kg dose for 3 weeks(TGI=54.38%),without obvious toxicities.A pharmacokinetic study revealed that 37 possessed tolerable properties(t_(1/2)=1.93±0.91 h,F=97.2%)after intraperitoneal administration in *** study confirmed that 37 suppressed malignant phenotypes of lung cancer carrying R231Q gain-of-function mutation via the MAPK/ERK signaling ***,analysis of the binding modes between molecules and DOT1LWT/R231Q proteins put forward the“Induced-fit”allosteric model in favor to the discovery of potent DOT1L candidates.

关键词： DOT1L R231Q mutation Lung cancer Adenosine-containing inhibitors Epigenetics

单孔炭化室压力稳定系统(CPS系统)在新泰正大6.78 m捣固焦炉上的应用

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燃料与化工 2020年第4期51卷 10-13页

作者：崔义平张洪波刘宏吕文才新泰正大焦化有限公司新泰271212

新泰正大焦化有限公司新建6.78 m捣固焦炉是首个采用炭化室压力稳定系统(CPS系统)的超大型捣固焦炉。实际应用效果表明,CPS系统可以有效解决捣固焦炉装煤冒烟、炉门烟尘外逸等污染物治理问题,并能保证焦炉炭化室底部压力稳定,延长焦炉... 详细信息

新泰正大焦化有限公司新建6.78 m捣固焦炉是首个采用炭化室压力稳定系统(CPS系统)的超大型捣固焦炉。实际应用效果表明,CPS系统可以有效解决捣固焦炉装煤冒烟、炉门烟尘外逸等污染物治理问题,并能保证焦炉炭化室底部压力稳定,延长焦炉使用寿命。

关键词： CPS系统 6.78 m捣固焦炉单孔炭化室压力调节

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铁水智能调运系统的探索与应用

冶金信息导刊 2018年第4期55卷 7-9,35页

作者：吕安明邱成辉毕京辉吕文才李宝强山东钢铁集团日照有限公司生产部山东日照276805

日照公司铁水运输通过铁水智能调运系统,利用物联网＋技术、信息技术、无线通信、智能识别、自动跟踪等技术,实现短流程铁水的“一罐到底”智能调运,将高炉铁水的承接、运输、缓冲贮存、铁水预处理、转炉兑铁水等功能集为一体,取消了炼... 详细信息

日照公司铁水运输通过铁水智能调运系统,利用物联网＋技术、信息技术、无线通信、智能识别、自动跟踪等技术,实现短流程铁水的“一罐到底”智能调运,将高炉铁水的承接、运输、缓冲贮存、铁水预处理、转炉兑铁水等功能集为一体,取消了炼钢车间倒罐坑和铁水倒罐作业,缩短了工艺流程,有效减少铁水温降、铁损、烟尘排放,并大大降低了作业人员的工作强度.

关键词：铁水温降智能调运

Effect of rolling strain on microstructure and tensile properties of dual-phase Mg-8Li-3Al-2Zn-0.5Y alloy

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Journal of Materials Science & Technology 2018年第12期34卷 2256-2262页

作者： wencai Liu Shi Feng Zhongquan Li Jiong Zhao Guohua Wu Xianfei Wang lv Xiao Wenjiang Ding National Engineering Research Center of Light Alloy Net Forming and Key State Laboratory of Metal Matrix Composite School of Materials Science and EngineeringShanghai Jiao Tong UniversityShanghai 200240China Shanghai Spaceflight Precision Machinery Institute Shanghai 201600China

This study was conducted to discuss the effect of rolling strain on microstructure and tensile properties of dual-phase Mg-8Li-3Al-2Zn-0.5 Y（wt%） alloy, which was prepared by casting, and then homogenized and rolled at 200℃. The rolling process was conducted with 10% reduction per pass and five different accumulated strains, varying from 10% to 70%. The results indicate that the as-cast and as-rolled Mg-8Li-3Al-2Zn-0.5Y alloys are composed of α-Mg, β-Li, AlLi and Al;Y phases. After rolling process,anisotropic microstructure was observed. a-Mg phase got elongated in both rolling direction and transverse direction with the addition of rolling strain. Consequently, the strength of the alloy in both directions was notably improved whereas the elongation declined, mainly caused by strain hardening and dispersion strengthening. The tensile properties of the as-rolled alloys in the RD, no matter the YS, UTS or the elongation, are higher than those of the TD due to their larger deformation strain and significant anisotropy in the hcp α-Mg phase. In addition, the fracture and strengthening mechanism of the tested alloys were also investigated systematically.

关键词： Mg–8Li–3Al–2Zn–0.5Y Rolling Anisotropy Tensile properties Strain hardening

Effects of Ce-rich RE on microstructure and mechanical properties of as-cast Mg-8Li-3Al-2Zn-0.5Nd alloy with duplex structure

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Progress in Natural Science:Materials International 2019年第1期29卷 103-109页

作者： Xiang Peng Guohua Wu lv Xiao Hao Ji Jie Zhang Wenbing Zou Zhongquan Li wencai Liu National Engineering Research Center of Light Alloy Net Forming and State Key Laboratory of Metal Matrix Composites School of Materials Science and EngineeringShanghai Jiao Tong University Shanghai Spaceflight Precision Machinery Institute

The effects of Ce-rich RE on the microstructure and mechanical properties of as-cast Mg-8Li-3Al-2Zn-0.5Nd-x RE(x = 0, 1, 2, 3 wt%) alloys were investigated. The results indicated that the as-cast Mg-8Li-3Al-2Zn-0.5Nd alloy mainly consisted of α-Mg, β-Li, AlLi, MgLi2 Al and Al2 Nd phases. With the addition of Ce-rich RE in the alloy,Al3 RE and Al2 RE phases generated and gradually grew into net-like or block-like structure. With the addition of RE, Al-RE phases generated by consuming Al element and, thus, less Al element was dissolved in the matrix and less AlLi phase formed. Furthermore, less AlLi phase means that more Li element released to cause the increase ofβ-Li phase and refine the α-Mg phase. Under the influence of these factors, adding more RE led to higher elongation and lower tensile strength and hardness. With the addition of Ce-rich RE, the yield strength and ultimate tensile strength of the as-cast Mg-8Li-3Al-2Zn-0.5Nd alloy gradually decreased from 180 to 152 MPa and from 215 to 193 MPa, respectively, while the elongation was remarkably improved from 21.1% to 40.2%.

关键词： Mg-Li alloy Rare earth Ce Microstructure Mechanical property

LCD/OLED用紫外光固化胶粘剂研究进展

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化工新型材料 2008年第3期36卷 7-8,49页

作者：罗世永李东立吕勇许文才北京印刷学院印刷包装材料与技术北京市重点实验室北京102600

紫外光(UV)固化环氧丙烯酸胶粘剂粘结强度高、化学稳定性好、电学性能优良、耐热性好,特别适合LCD/OLED的封装。介绍了UV固化环氧丙烯酸胶粘剂的国内外生产、研究进展,提出了混杂固化、可循环使用和水性化是其发展趋势。

关键词：紫外光固化胶粘剂环氧丙烯酸 LCD/OLED

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无人机1∶500测图的应用与分析

北京测绘 2018年第7期32卷 827-830页

作者：李敏李存文吕国卿侯文才河南省基础地理信息中心河南郑州450003 河南省测绘工程院河南郑州450003

以桐柏县安鹏镇作为试验区,进行1∶500地形图航空摄影测量。本文介绍了无人机低空摄影测量在1∶500航测成图中的应用,包括本次实验使用无人机平台及传感器参数,像片控制点布设及空三加密等技术要求,并对此次试验精度进行分析。该方法有... 详细信息

以桐柏县安鹏镇作为试验区,进行1∶500地形图航空摄影测量。本文介绍了无人机低空摄影测量在1∶500航测成图中的应用,包括本次实验使用无人机平台及传感器参数,像片控制点布设及空三加密等技术要求,并对此次试验精度进行分析。该方法有效地解决了无人机航测在大比例尺成图中的关键问题,大大节省了工作时间和财力,有效地提高了工作效率,结果表明了该技术的可应用于大比例尺地形图测绘中,为无人机应用于大比例尺测图提供了好的借鉴经验。

关键词：无人机低空摄影测量精度分辨率大比例尺地形图

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抗菌剂在抗菌纸中的应用研究

北京印刷学院学报 2013年第2期21卷 14-18页

作者：尹彦娜刘全校许文才吕玉彬北京印刷学院印刷包装材料与技术重点实验室北京102600

从无机抗菌剂、有机抗菌剂、天然抗菌剂三方面阐述了抗菌剂在抗菌纸方面的应用,指出使用单一抗菌剂往往不能满足抗菌纸的某种要求,抗菌剂的使用向着改性和混合联用的方向发展。为了满足抗菌剂在抗菌纸中应用的需求,需要深入了解其所涉... 详细信息

从无机抗菌剂、有机抗菌剂、天然抗菌剂三方面阐述了抗菌剂在抗菌纸方面的应用,指出使用单一抗菌剂往往不能满足抗菌纸的某种要求,抗菌剂的使用向着改性和混合联用的方向发展。为了满足抗菌剂在抗菌纸中应用的需求,需要深入了解其所涉及的学科和领域,改进生产工艺,使其更适合大规模生产的需要,加大产、学、研合作的力度,完善相关的法规和规定。

关键词：抗菌纸抗菌剂应用

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高效能建筑应用技术概述

智能建筑电气技术 2010年第2期4卷 64-67页

作者：欧阳东张文才吕丽马名东中国建筑设计研究院北京100044

本文主要介绍了作者在日本技术考察期间了解到的一些新技术在建筑中的应用,其中节能减排已经成为日本智能建筑的一个新特点。例如:LED技术的应用、燃料电池应用对环境的作用、能源管理器对能源使用的整合和智能家居控制器对今后房屋居... 详细信息

本文主要介绍了作者在日本技术考察期间了解到的一些新技术在建筑中的应用,其中节能减排已经成为日本智能建筑的一个新特点。例如:LED技术的应用、燃料电池应用对环境的作用、能源管理器对能源使用的整合和智能家居控制器对今后房屋居住者的身体指标和环境指标的监控情况等各种新技术。

关键词：节能减排 LED 燃料电池节能控制智能家居