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Upconversion nano-photosensitizer targeting into mitochondria for cancer apoptosis induction and cyt c fluorescence monitoring

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Nano Research 2016年第11期9卷 3257-3266页

作者： Yanyan Liu Jiawen Zhang Changjing Zuo Zhen Zhang Dalong Ni Chen Zhang Jing Wang Hui Zhang Zhenwei Yao wenbo bu State Key Laboratory of High Performance Ceramics and Superfine Microstructures Shanghai Institute of Ceramics Chinese Academy o Sciences 1295 Dingxi Road Shanghai 200050 China Department of Radiology Huashan Hospital Fudan University 12 Urumqi Zhong Road Shanghai200040 China Department of Nuclear Medicine Changhai Hospital of Shanghai 168 Changhai Road Shanghai200433 China Cancer Research Institute Fudan University Shanghai Cancer Center 270 Dongan Road Shanghai200032 China Shanghai Key Laboratory of Green Chemistry and Chemical Processes School of Chemistry and Molecular Engineering East China Normal University 3663 Zhongshan North Road Shanghai200062 China

Disruption of mitochondrial reactive oxygen species （mitoROS） plays a major role in cancer cell apoptosis. Here, we designed a core/shell-structured mitochondriatargeting upconversion-based nano-photosensitizer （TPP-UC（PS）） with a lanthanidedoped upconversion nanoparticle （UCNP） core coated by a photosensitizer （PS）-incorporated dense silica shell. Following irradiation with external nearinfrared laser （NIR）, TPP-UC（PS） in mitochondria caused serious mitochondrial matrix swelling for the activated upconversion-based photodynamic therapy （UC-PDT）, and the mobilization of cytochrome c （cyt c） was amplified in response to the increased mitoROS. Specifically, this heme-containing cyt c could be monitored by varying TPP-UC（PS）＇s upconversion luminescence signal （UCL）, which may facilitate the in situ detection of cyt c for apoptosis research. As a proof of concept, our designed TPP-UC（PS） may provide significant opportunities for controlling cancer cell apoptosis under NIR stimulation and for studying apoptosis using the dynamic UCL, which is influenced by local cyt c.

关键词： mitochondrial reactiveoxygen species (mitoROS) upconversion-based photodynamic therapy(PDT) cytochrome c (cyt c) mitochondrial apoptosis

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Single W18O49 nanowires： A multifunctional nanoplatform for computed tomography imaging and photothermal/ photodynamic/radiation synergistic cancer therapy

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Nano Research 2015年第11期8卷 3580-3590页

作者： Jianjian Qiu Qingfeng Xiao Xiangpeng Zheng Libo Zhang Huaiyong Xing Dalong Ni Yanyan Liu Shengjian Zhang Qingguo Ren Yanqing Hua Kuaile Zhao wenbo bu Department of Radiation Oncology Fudan University Huadong Hospital Shanghai 200040 China State Key Laboratory of High performance Ceramics and Superfine Microstructures Shanghai Institute of Ceramics Chinese Academy of Sciences Shanghai 200050 China Department of Radiology Shanghai Cancer Hospital Fudan University Shanghai 200032 China Department of Radiology Fudan University Huadong Hospital Shanghai 200032 China Department of Radiation Oncology Shanghai Cancer Hospital Fudan University Shanghai 200032 China

Combination therapy is a promising cancer treatment strategy that is usually based on the utilization of complicated nanostructures with multiple components functioning as photo-thermal energy transducers, photo-sensitizers, or dose intensifiers for phototherma! therapy （PTT）, photodynamic therapy （PDT）, or radiation therapy （RT）. In this study, ultrathin tungsten oxide nanowires （W18O49） were synthesized using a solvothermal approach and examined as a multifunctional theranostic nanoplatform. In vitro and in vivo analyses demonstrated that these nanowires could induce extensive heat- and singlet oxygen-mediated damage to cancer cells under 980 nm near infrared （NIR）-laser excitation. They were also shown to function as radiation dose intensifying agents that enhance irradiative energy deposition locally and selectively during radiation therapy. Compared to NIR-induced PTT/PDT and RT alone, W18O49 - based synergistic tri-modal therapy eradicated xenograft tumors and no recurrence was observed within a 9-month follow up. Moreover, the strong X-ray attenuation ability of the tungsten element （Z = 74, 4.438 cm^2·g^-1, 100 KeV） qualified these nanowires as excellent contrast agents in X-ray-based imaging, such as diagnostic computed tomography （CT） and cone-beam CT for image-guided radiation therapy. Toxicity studies demonstrated minimal adverse effects on the hematologic system and major organs of mice within one month. In conclusion, these nanowires have shown significant potential for cancer therapy with inherent image guidance and synergistic effects from phototherapy and radiation therapy, which warrants further investigation.

关键词： photodynamic therapy photothermal therapy radiation therapy radiosensitization image guidance synergistic therapy

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Analgesic nanomedicines for the treatment of chronic pain

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BMEMat(BioMedical Engineering Materials) 2024年第1期2卷 76-87页

作者： Hao Liu Hongjun Zhuang Ya Wang Yuen Yee Cheng Feixiang Chen Jian Chen Xinglei Song Run Zhang Yanyan Liu wenbo bu State Key Laboratory of Molecular Engineering of Polymers Department of Materials ScienceFudan UniversityShanghaiChina Department of Rehabilitation Zhongshan HospitalFudan UniversityShanghaiChina Central Laboratory The First Affiliated Hospital of Xiamen UniversityXiamenChina Institute for Biomedical Materials&Devices(IBMD) Faculty of ScienceThe University of Technology SydneySydneyNew South WalesAustralia Department of Anatomy and Physiology Shanghai Jiao Tong University School of MedicineShanghaiChina Australian Institute for Bioengineering and Nanotechnology The University of QueenslandBrisbaneQueenslandAustralia

Chronic pain is a major cause of suffering that often accompanies diseases and therapies,affecting approximately 20%of individuals at some point in their ***,current treatment modalities,such as anesthetic and antipyretic analgesics,have limitations in terms of efficacy and side *** technology offers a promising avenue to overcome these challenges and introduce new therapeutic *** article reviews the recent research on nanomedicine analgesics,integrating analyses of neuroplasticity changes in neurons and pathways related to the transition from acute to chronic ***,it explores potential future strategies using nanomaterials,aiming to provide a roadmap for new analgesic development and improved clinical pain *** leveraging nanotechnology,these approaches hold the potential to revolutionize pain treatment by delivering targeted and effective relief while minimizing side effects.

关键词： analgesics chronic pain local anesthetics nanomedicine neuroplasticity

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AlN-SiC固溶体陶瓷研究进展

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材料导报 2000年第3期14卷 34-37页

作者：步文博徐洁南京化工大学材料科学与工程学院南京210009

评述了国内外AlN-SiC固体溶体陶瓷研究工作的最新进展。着重阐述了烧结工艺,包括粉体机械混合传统烧结工艺及化学活化烧结新工艺,并对其优缺点进行了评价。认为化学活化烧结新工艺是今后制备AlN-SiC固溶体陶瓷的发展趋势,介绍了该领域... 详细信息

评述了国内外AlN-SiC固体溶体陶瓷研究工作的最新进展。着重阐述了烧结工艺,包括粉体机械混合传统烧结工艺及化学活化烧结新工艺,并对其优缺点进行了评价。认为化学活化烧结新工艺是今后制备AlN-SiC固溶体陶瓷的发展趋势,介绍了该领域的最新发展动态。

关键词：固溶体复合超细粉末陶瓷氮化铝碳化硅

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Knowledge As Not Only Justified True Beliefs in Vision

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IEEE/CAA Journal of Automatica Sinica 2025年第2期12卷 297-299页

作者： wenbo Zheng Fei-Yue Wang IEEE School of Computer Science and Artificial Intelligence Wuhan University of Technology Sanya Science and Education Innovation Park of Wuhan University of Technology the State Key Laboratory for Management and Control of Complex Systems Institute of Automation Chinese Academy of Sciences

COMPUTATIONAL knowledge vision [1] is emphasized as a novel perspective or field in this paper. It first proposes the visual hierarchy and its connection to knowledge, stating that knowledge is a justified true belief. To further the previous research, we concisely summarize our recent works and suggest a new direction that knowledge is also a thought framework in vision.

关键词： Computational modeling Visualization Artificial intelligence Data models Visual perception Visual databases Training data

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Influence of introducing Zr,Ti,Nb and Ce elements on externally solidified crystals and mechanical properties of high-pressure die-casting Al–Si alloy

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International Journal of Minerals,Metallurgy and Materials 2025年第1期32卷 147-153页

作者： Junjie Li wenbo Yu Zhenyu Sun Weichen Zheng Liangwei Zhang Yanling Xue Wenning Liu Shoumei Xiong Center of Materials Science and Engineering School of Mechanical and Electronic Control EngineeringBeijing Jiaotong UniversityBeijing 100044China Traffic&Transportation Engineering Central South UniversityChangsha 410075China Shanghai Synchrotron Radiation Facility Shanghai Advanced Research InstituteChinese Academy of SciencesShanghai 201204China School of Materials Science and Engineering Tsinghua UniversityBeijing 100084China

High pressure die casting(HPDC)AlSi10Mn Mg alloy castings are widely used in the automobile *** can optimize the mechanical properties of castings through heat treatment,while the release of thermal stress arouses the deformation of large integrated ***,the development of non-heat treatment Al alloys is becoming the hot *** addition,HPDC contains externally solidified crystals(ESCs),which are detrimental to the mechanical properties of *** achieve high strength and toughness of non-heat treatment die-casting Al-Si alloy,we used AlSi9Mn alloy as matrix with the introduction of Zr,Ti,Nb,and *** influences on ESCs and mechanical properties were systematically investigated through three-dimensional reconstruction and thermodynamic *** results reveal that the addition of Ti increased ESCs'size and porosity,while the introduction of Nb refined ESCs and decreased ***,large-sized Al_3(Zr,Ti)phases formed and degraded the mechanical *** introduction of Ce resulted in the poisoning effect and reduced mechanical properties.

关键词： aluminium alloy high-pressure die-casting externally solidified crystals non-heat treatment

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艾拉光动力治疗仪在脓肿切开引流术后病人护理中的应用

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护理研究 2018年第6期32卷 971-972页

作者：姚建军布文博方杰中国医学科学院皮肤病医院

[目的]探讨艾拉光动力治疗仪(ALA-PDT)在脓肿切开引流术后病人护理中的应用效果。[方法]选取92例实施脓肿切开引流术后病人随机分为观察组和对照组各46例,观察组术后立刻使用ALA-PDT治疗仪,次日进行常规换药;对照组仅次日进行常规换药,... 详细信息

[目的]探讨艾拉光动力治疗仪(ALA-PDT)在脓肿切开引流术后病人护理中的应用效果。[方法]选取92例实施脓肿切开引流术后病人随机分为观察组和对照组各46例,观察组术后立刻使用ALA-PDT治疗仪,次日进行常规换药;对照组仅次日进行常规换药,比较两组病人的换药次数、创面愈合时间和疼痛程度。[结果]观察组疼痛程度低于对照组;换药次数和创面愈合时间低于对照组,差异有统计学意义(P<0.05)。[结论]脓肿切开引流术后病人立即采用ALA-PDT治疗,可有效减少换药次数,缩短病人切口愈合时间,减轻病人的疼痛。

关键词： ALAPDT治疗脓肿切开引流术换药疼痛

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A composite hydrogel with porous and homogeneous structure for efficient osmotic energy conversion

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Chinese Chemical Letters 2025年第2期36卷 234-238页

作者： Guilong Li wenbo Ma Jialing Zhou Caiqin Wu Chenling Yao Huan Zeng Jian Wang College of Materials and Chemistry & Chemical Engineering Chengdu University of Technology

With the impact of energy crisis and environmental problems, it is urgent to develop green sustainable energy. Osmotic energy stored in the salinity difference between seawater and river water is one of the sustainable, abundant, and renewable energy. However, the membranes used to capture osmotic energy by reverse electrodialysis （RED） always suffer from low ion selectivity, low stability and low *** with three-dimensional （3D） networks have shown great potential for ion transportation and energy conversion. In this work, based on the homogeneity and porosity characteristics of acrylamide（AM） hydrogel, as well as the remarkable stability and abundant negative charge of 3-sulfopropyl acrylate potassium salt （SPAK）, a high-performance AM/SPAK cation-selective hydrogel membrane was successfully developed for harvesting osmotic energy. Compared to AM hydrogels, utilizing AM/SPAK as a monomer mixture greatly facilitated the preparation of homogeneous polymers, exhibiting a porous structure, exceptional ion selectivity, and remarkable stability. A maximum output power density of 13.73 W/m2was achieved at a 50-fold NaCl concentration gradient, exceeding the commercial requirement of 5 W/m2. This work broadens the idea for the construction and application of composite hydrogel in high efficiency osmotic energy conversion.

关键词： Cation-selective membrane Osmotic energy Porous structure Power density Stability

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Bamboo-like MnO_(2)·Co_(3)O_(4):High-performance catalysts for the oxidative removal of toluene

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Journal of Environmental Sciences 2025年第1期147卷 617-629页

作者： Ali Rastegarpanah Jiguang Deng Yuxi Liu Lin Jing wenbo Pei Jia Wang Hongxing Dai Beijing Key Laboratory for Green Catalysis and Separation Key Laboratory of Beijing on Regional Air Pollution ControlKey Laboratory of Advanced Functional MaterialsEducation Ministry of ChinaLaboratory of Catalysis Chemistry and NanoscienceDepartment of Chemical EngineeringFaculty of Environment and LifeBeijing University of TechnologyBeijing 100124China

Themanganese-cobalt mixed oxide nanorodswere fabricated using a hydrothermalmethod with different metal precursors(KMnO_(4)and MnSO_(4)·H_(2)O for MnOx and Co(NO3)2>6H_(2)O and CoCl_(2)>6H_(2)O for Co_(3)O_(4)).Bamboo-like MnO_(2)>Co_(3)O_(4)(B-MnO_(2)>Co_(3)O_(4)(S))was derived from repeated hydrothermal treatments with Co_(3)O_(4)@MnO_(2)and MnSO_(4)>H_(2)O,whereas Co_(3)O_(4)@MnO_(2)nanorods were derived from hydrothermal treatment with Co_(3)O_(4)nanorods and KMnO_(4).The study shows that manganese oxide was tetragonal,while the cobalt oxide was found to be cubic in the crystalline *** surface ions were present in multiple oxidation states(e.g.,Mn^(4+)and Mn^(3+))and surface oxygen *** content of adsorbed oxygen species and reducibility at low temperature declined in the sequence of BMnO_(2)>Co_(3)O_(4)(S)>Co_(3)O_(4)@MnO_(2)>MnO_(2)>Co_(3)O_(4),matching the changing trend in *** all the samples,B-MnO_(2)>Co_(3)O_(4)(S)showed the preeminent catalytic performance for the oxidation of toluene(T10%=187℃,T50%=276℃,and T90%=339℃).In addition,the B-MnO_(2)>Co_(3)O_(4)(S)sample also exhibited good H_(2)O^(-),CO_(2)^(-),and SO_(2)^(-)resistant *** good catalytic performance of B-MnO_(2)>Co_(3)O_(4)(S)is due to the high concentration of adsorbed oxygen species and good reducibility at low *** oxidation over B-MnO_(2)>Co_(3)O_(4)(S)proceeds through the adsorption of O_(2)and toluene to form O∗,OH∗,and H_(2)C(C6H5)∗species,which then react to produce benzyl alcohol,benzoic acid,and benzaldehyde,ultimately converting to CO_(2)and H_(2)*** findings suggest that B-MnO_(2)>Co_(3)O_(4)(S)has promising potential for use as an effective catalyst in practical applications.

关键词： Manganese-cobalt mixed oxide Nanorod Bamboo-like morphology Hydrothermal method Toluene oxidation

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Tumor suffocation by non-toxic nanoparticles

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Science Foundation in China 2017年第2期25卷 9-9页

作者： Shi Jianlin (施剑林) bu wenbo (步文博) Shanghai Institute of Ceramics Chinese Academy of Sciences and East China Normal University

Subject Code:E02 With the support by the National Natural Science Foundation of China,recently,a study by the research group led by Shi Jianlin(施剑林)and bu wenbo(步文博)from Shanghai Institute of Ceramics,Chinese Ac... 详细信息

关键词： Tumor suffocation by non-toxic nanoparticles

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