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Bioactive Materials 2023年第4期22卷 47-59页

作者： Yanan Sun Bochen Lyu Chang Yang Bing He Hua Zhang Xueqing Wang Qiang Zhang wenbing Dai Beijing Key Laboratory of Molecular Pharmaceutics and New Drug Delivery Systems State Key Laboratory of Natural and Biomimetic DrugsSchool of Pharmaceutical SciencesPeking UniversityBeijing100191China Department of Pharmaceutics School of Pharmaceutical SciencesHebei Medical UniversityShijiazhuang050017China

Mild photothermal therapy combined with immune checkpoint blockade has received increasing attention for the treatment of advanced or metastatic cancers due to its good therapeutic ***,it remains a challenge to facilely integrate the two therapies and make it potential for clinical *** work designed a peptide-photosensitizer conjugate(PPC),which consisted of a PD-L1 antagonist peptide(CVRARTR),an MMP-2 specific cleavable sequence,a self-assembling motif,and the photosensitizer Purpurin *** single-component PPC can self-assemble into nanospheres which is suitable for intravenous *** PPC nanosphere is cleaved by MMP-2 when it accumulates in tumor sites,thereby initiating the cancer-specific release of the antagonist ***,the nanospheres gradually transform into co-assembled nanofibers,which promotes the retention of the remaining parts within the *** vivo studies demonstrated that PPC nanospheres under laser irradiation promote the infiltration of cytotoxic T lymphocytes and maturation of DCs,which sensitize 4T1 tumor cells to immune checkpoint blockade ***,PPC nanospheres inhibit tumor growth efficiently both in situ and distally and blocked the formation of lung *** present study provides a simple and efficient integrated strategy for breast cancer photoimmunotherapy.

关键词： Transformable nanomedicine Self-assembled peptide Immune checkpoint blockade Photothermal therapy Photoimmunotherapy

Application of Three Order Cumulants in Fault Diagnosis

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International Journal of Modern Nonlinear Theory and Application 2018年第4期7卷 97-105页

作者： wenbing Wu Department of Mathematics and Computer Science Nanchang Normal University Nanchang China

The three-order cumulants’ complex forms of different definitions include different coupling information of signals, and the information can be used to diagnose fault. In the experiment of pressure reducing valve’s fault diagnosis, through these different coupling information, the features of fault signals and normal signals were extracted by wavelet in different directions, then these features were inputted to diagnose the fault. The experiment shows that this method can achieve a satisfactory result.

关键词： Cumulants Coupling Wavelet Fault Diagnosis

Effects of Dietary Soybean Stachyose and Phytic Acid on Gene Expressions of Serine Proteases in Japanese Flounder(Paralichthys olivaceus)

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Journal of Ocean University of China 2011年第3期10卷 234-240页

作者： MI Haifeng MAI Kangsen ZHANG wenbing WU Chenglong CAI Yinghua The Key Laboratory of Mariculture Ministry of Education China Ocean University of China Qingdao 266003 P. R. China

Soybean stachyose (SBS) and phytic acid (PA) are anti-nutritional factors (ANF) which have deleterious effects on the growth and digestibility in fish. The present research studied the effects of dietary SBS and PA on the expression of three serine protease genes in the liver of Japanese flounder (Paralichthys olivaceus). These genes are trypsinogen 1 (poTRY), elastase 1 (poEL) and chymotrypsinogen 1 (poCTRY). Eight artificial diets with graded levels of supplemented ANFs were formulated to 4 levels of SBS (0.00, 0.40, 0.80 and 1.50%), 4 levels of PA (0.00, 0.20, 0.40 and 0.80), *** flounder (initial weight 2.45 g ± 0.01 g) were fed with these diets for 10 weeks with three replications per treatment. At the end of 10 weeks, supplementation of 0.40% of dietary SBS or PA significantly increased the gene expression of poTRY and poCTRY (P0.05). These results suggested that dietary SBS and dietary PA could directly affect the serine protease genes at the transcriptional level in Japanese flounder, and these genes'expression was more sensitive to dietary PA than to SBS under the current experimental conditions.

关键词： soybean stachyose phytic acid serine proteases gene expression Paralichthys olivaceus

Numerical analysis on the thermal regimes of thermosyphon embankment in snowy permafrost area

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Research in Cold and Arid Regions 2017年第6期9卷 668-674页

作者： Yan Lu Xin Yi wenbing Yu WeiBo Liu State Key Laboratory of Frozen Soil Engineering Northwest Institute of Eco-Environment and ResourcesChinese Academy of SciencesLanzhouGansu 730000China College of Civil Engineering Chongqing Jiaotong UniversityChongqing 400074China College of Civil Engineering Jiangxi University of Science and TechnologyGanzhouJiangxi 341000China University of Chinese Academy of Sciences Beijing 100049China

Snow covers the road embankments in winter in high latitude permafrost zones. The effect of snow cover on embankments was simulated based on field measurements of boundary conditions and initial ground temperature profile in Mohe,China. The effect of thermosyphons on the embankment warmed by snow cover was evaluated by numerical simulations as well. The results indicate that the difference of thermal regimes between non-thermosyphon and thermosyphon embankments reaches to 22 m in depth below the ground surface. It is much warmer in the non-thermosyphon embankment body in winter. Affected by the snow cover, heat flux gradually spreads into the deep ground of the subgrade over time. The permafrost table under the slope toe of a thermosyphon embankment is 1.2 m higher than that of a non-thermosyphon embankment in the 20 th year. In addition, the permafrost table at the slope toe of a thermosyphon embankment is 26 cm deeper over 20 years. These results indicate that thermosyphons can greatly weaken the warm effect of snow cover. However,thermosyphons cannot avoid the degradation of permafrost under the scenarios of snow cover. Therefore, composite measures need to be adopted to keep embankment stability in snowy permafrost zones.

关键词： snow cover permafrost embankment thaw settlement thermosyphon

Rearing in intermediate salinity enhances immunity and disease-resistance of turbot (Scophthalmus maximus L.)

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Acta Oceanologica Sinica 2011年第4期30卷 122-128页

作者： ZHANG Yanjiao MAI Kangsen MA Hongming AI Qinghui ZHANG wenbing XU Wei Key Laboratory of Mariculture Ministry of EducationOcean University of ChinaQingdao 266003China

Studies were conducted to investigate the non-specific immune responses and disease-resistance of juvenile turbot Scophthalmus maximus,cultured at four different salinities（8,20,32 and 40） . Three concentrations（3.75 × 10 7,3.75 × 10 8 and 3.75 × 10 9 CFU/ml） of Vibrio anguillarum suspension were employed at each salinity to determine the 4-day LD 50 . The serum lysozyme activity,the alternative complement pathway activity（ACH50） and the phagocytosis percentage of head kidney in turbot were tested at 24,48 and 72 h post-challenge of V. anguillarum（1.1 × 10 8 CFU/ml,0.1 ml） ,respectively,to evaluate the non-specific immune responses at the selected rearing salinities. Fish reared at salinity 20 had the lowest mortality,namely,the highest 4-day LD 50 value（8.88 ± 0.17） . Besides,the lysozyme activity,ACH50 and the phagocytosis of turbot were the highest at the salinity 20,but with the lowest at the salinity 40 treatment regardless of sampling time. In addition,the non-specific immune activities kept increasing within 72 h post-challenge of V. anguillarum,except that the lysozyme activity increased from 24 to 48 h,and then decreased from 48 to 72 h at 40 significantly. These results together indicate that rearing in intermediate salinity（20） was able to enhance the immunity and disease-resistance of turbot.

关键词： Scophthalmus maximus salinity immunity disease-resistance Vibrio anguillarum

Statistical potentials for 3D structure evaluation:From proteins to RNAs

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Chinese Physics B 2021年第2期30卷 103-115页

作者： Ya-Lan Tan Chen-Jie Feng Xunxun Wang wenbing Zhang Zhi-Jie Tan Department of Physics and Key Laboratory of Artificial Micro&Nano-structures of Education School of Physics and TechnologyWuhan UniversityWuhan 430072China

Structure evaluation is critical to in silico 3-dimensional structure predictions for biomacromolecules such as proteins and *** proteins,structure evaluation has been paid attention over three decades along with protein folding problem,and statistical potentials have been shown to be effective and efficient in protein structure prediction and *** recent two decades,RNA folding problem has attracted much attention and several statistical potentials have been developed for RNA structure evaluation,partially with the aid of the progress in protein structure *** this review,we will firstly give a brief overview on the existing statistical potentials for protein structure ***,we will introduce the recently developed statistical potentials for RNA structure ***,we will emphasize the perspective on developing new statistical potentials for RNAs in the near future.

关键词： statistical potential 3-dimensional structure evaluation RNA protein

Effects of Dietary Corn Gluten Meal on Growth Performance and Protein Metabolism in Relation to IGF-I and TOR Gene Expression of Juvenile Cobia (Rachycentron canadum)

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Journal of Ocean University of China 2013年第3期12卷 418-426页

作者： LUO Yiwen AI Qinghui MAI Kangsen ZHANG wenbing XU Wei ZHANG Yanjiao LIUFU Zhiguo Key Laboratory of Animal Nutrition and Feed Science Ministry of Agriculture of ChinaOcean University of China

A growth experiment was conducted on cobia(Rachycentron canadum,initial weight 108.2 g ± 3.0 g) to investigate the effects of dietary corn gluten meal(CGM) levels on the fish growth,whole body composition and protein metabolism in relation to specific gene *** isonitrogenous(crude protein 45%) and isoenergetic(gross energy 20 kJ g 1) practical diets were formulated by replacing 0%(the control),17.5%,35.0%,52.5%,and 70.0% of fish meal(FM) protein with CGM *** significant differences were observed in the survival,feed intake(FI),specific growth rate(SGR),feed efficiency(FE) and protein productive value(PPV) among fish fed diets with 0%,17.5%,35.0%,and 52.5% of CGM ***,these indices were significantly lower in fish fed the diet with 70.0% of CGM protein than those in fish fed the control diet(P < 0.05).The whole-body crude protein and lipid contents were significantly lower while the whole-body moisture content was significantly higher in fish fed the diet with 70.0% of CGM protein compared with the control group(P < 0.05).When 70.0% of FM protein was replaced by CGM,plasma total protein and cholesterol contents were significantly lower than those in the control group(P < 0.05).Fish fed the diet with 70.0% of CGM protein had significantly lower hepatic insulin-like growth factor I(IGF-I) expression levels than those in the control group(P < 0.05).However,no significant differences were observed in hepatic target of rapamycin(TOR),dorsal muscle IGF-I and TOR expression levels among dietary *** of the present study indicated that 52.5% of FM protein could be replaced by CGM in the diets without significant influences on the growth,feed utilization and protein metabolism of juvenile *** present results might be useful for developing cost effective and sustainable cobia dietary formulations.

关键词： Cobia corn gluten meal growth performance protein metabolism gene expression

Semisupervised Encrypted Traffic Identification Based on Auxiliary Classification Generative Adversarial Network

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Computer Systems Science & Engineering 2021年第12期39卷 373-390页

作者： Jiaming Mao Mingming Zhang Mu Chen Lu Chen Fei Xia Lei Fan ZiXuan Wang wenbing Zhao State Grid Jiangsu Electric Power Co. Ltd.Information and Telecommunication BranchNanJing210003China Institute of Information and Communication Global Energy Interconnection Research InstituteState Grid Key Laboratory of Information and Network SecurityNanjing210003China Engineering Research Center of Post Big Data Technology and Application of Jiangsu Province Research and Development Center of Post Industry Technology of the State Posts Bureau(Internet of Things Technology)Broadband Wireless Communication Technology Engineering Research Center of the Ministry of EducationNanjing University of Posts and TelecommunicationsNanjing210003China Department of Electrical Engineering and Computer Science Cleveland State UniversityCleveland44115USA

The rapidly increasing popularity of mobile devices has changed the methods with which people access various network services and increased net-work traffic *** the past few decades,network traffic identification has been a research hotspot in the field of network management and security ***,as more network services use encryption technology,network traffic identification faces many *** classic machine learning methods can solve many problems that cannot be solved by port-and payload-based methods,manually extract features that are frequently updated is time-consuming and *** learning has good automatic feature learning capabilities and is an ideal method for network traffic identification,particularly encrypted traffic identification;Existing recognition methods based on deep learning primarily use supervised learning methods and rely on many labeled ***,in real scenarios,labeled samples are often difficult to *** paper adjusts the structure of the auxiliary classification generation adversarial network(ACGAN)so that it can use unlabeled samples for training,and use the wasserstein distance instead of the original cross entropy as the loss function to achieve semisupervised *** results show that the identification accuracy of ISCX and USTC data sets using the proposed method yields markedly better performance when the number of labeled samples is small compared to that of convolutional neural network(CNN)based classifier.

关键词： Encrypted traffic recognition deep learning generative adversarial network traffic classification semisupervised learning

Effects of Dietary β-Glucan and Glycyrrhizin on Non-Specific Immunity and Disease Resistance of the Sea Cucumber (Apostichopus japonicus Selenka) Challenged with Vibrio splendidus

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Journal of Ocean University of China 2010年第4期9卷 389-394页

作者： CHANG Jie ZHANG wenbing MAI Kangsen MA Hongming XU Wei The Key Laboratory of Mariculture Ministry of Education of China Ocean University of China Qingdao 266003 P. R. China School of Animal Science and Technology Inner Mongolia University for the Nationalities Tongliao 028000 P.R. China

Sea cucumbers, Apostichopus japonicus Selenka, were fed diets containing non-immunostimulant (basal diet), 0.2% β-glucan and 0.02% glycyrrhizin in a recirculatory water system for 45 days, and subsequently challenged with Vibrio splendidus by injection at 1.0×108 cfu/sea cucumber for 15 *** capacity (PC), intracellular superoxide anion production (ISAP), ly-sozyme (LSZ) activity and superoxide dismutase (SOD) activity in the coelomic fluid were analyzed on the 0th, 5th, 10th and 15th days after *** showed that after the 45-day feeding period, PC, ISAP, LSZ activity and SOD activity in sea cucumbers fed with dietary β-glucan or glycyrrhizin were significantly higher than in those fed with the basal *** the 5th day after infection, all the immune parameters examined in the sea cucumbers injected with *** decreased in value *** the 15th day, PC, ISAP and LSZ activity returned to levels similar to those on the 0th *** the sea cucumbers injected with saline, there were no significant differences in all the immune parameters examined and in the cumulative morbidity during the 15-day challenging *** injecting with ***, the cumulative morbidity of sea cucumbers fed with the basal diet was significantly higher than those fed with dietary β-glucan or glycyrrhizin when challenged with *** challenged sea cucumber fed with the basal diet was significantly higher than those fed with dietary β-glucan or *** was no significant difference in cumulative morbidity between the dietary β-glucan and glycyrrhizin treatments over time.

关键词： β-Glucan Glycyrrhizin Apostichopus japonicus Selenka Immunity Vibrio splendidus

The Application of Cumulants Slices in Fault Diagnosis

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International Journal of Modern Nonlinear Theory and Application 2018年第3期7卷 89-96页

作者： wenbing Wu Department of Mathmatics and Computer Science Nanchang Normal University Nanchang China

Complex third-order cumulant has different definition forms. Different forms have different coupling properties, and the generated complex cumulants slices contain different coupling information of signals. In experiments, using the different definitions, the same coupling method is applied to both specific fault signals and normal signals. Furthermore, complex third-order cumulant slices spectrum is defined, and it is used to analyse the coupling features of normal signals and fault signals. Experiments indicate that the detection accuracy rate on the same fault is not the same with the different coupling method, thus, it provides an alternative method to diagnose the specific fault.

关键词： Third-Order Cumulant Slices Fault Diagnosis Spectrum of Slices