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An efficient metatranscriptomic approach for capturing RNA virome and its application to SARS-CoV-2

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Journal of Genetics and Genomics 2021年第9期48卷 860-862页

作者： Yao Meng Liwen Xiao wenbing chen Fangqing Zhao Xiang Zhao Beijing Institutes of Life Science Chinese Academy of SciencesBeijing 100101China Shaanxi Provincial Center for Disease Control and Prevention Xi'an 710054China University of Chinese Academy of Sciences Beijing 100101China State Key Laboratory for Manufacturing Systems Engineering Xi'an Jiaotong UniversityXi'an 710054China

Coronavirus disease 2019(COVID-19)is a new type of respiratory disease caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),which has caused severe social and economic costs and has become a great threat to public health because of the high mortality rate.Recent studies indicated that respiratory pathogens co-infection and secondary infection were critical risk factors for the severity and mortality rates of COVID-19(Zhou et al.,2020).

关键词： mortality respiratory

Simultaneous virus identification and characterization of severe unexplained pneumonia cases using a metagenomics sequencing technique

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Science China(Life Sciences) 2017年第3期60卷 279-286页

作者： Xiaohui Zou Guangpeng Tang Xiang Zhao Yan Huang Tao chen Mingyu Lei wenbing chen Lei Yang Wenfei Zhu Li Zhuang Jing Yang Zhaomin Feng Dayan Wang Dingming Wang Yuelong Shu National Institute for Viral Disease Control and Prevention Collaboration Innovation Center for Diagnosis and Treatment of Infectious Diseases Chinese Center for Disease Control and Prevention Key Laboratory for Medical Virology National Health and Family Planning Commission Beijing 102206 China Guizhou Provincial Center for Disease Control and Prevention Guiyang 550004 China

Many viruses can cause respiratory diseases in humans.Although great advances have been achieved in methods of diagnosis,it remains challenging to identify pathogens in unexplained pneumonia(UP) cases.In this study,we applied next-generation sequencing(NGS) technology and a metagenomic approach to detect and characterize respiratory viruses in UP cases from Guizhou Province,China.A total of 33 oropharyngeal swabs were obtained from hospitalized UP patients and subjected to NGS.An unbiased metagenomic analysis pipeline identified 13 virus species in 16 samples.Human rhinovirus C was the virus most frequently detected and was identified in seven samples.Human measles virus,adenovirus B 55 and coxsackievirus A10 were also identified.Metagenomic sequencing also provided virus genomic sequences,which enabled genotype characterization and phylogenetic analysis.For cases of multiple infection,metagenomic sequencing afforded information regarding the quantity of each virus in the sample,which could be used to evaluate each viruses' role in the disease.Our study highlights the potential of metagenomic sequencing for pathogen identification in UP cases.

关键词：基因型鉴定麻疹病毒宏基因组测序技术肺炎原因呼吸道疾病基因组序列

基于深度学习的高职院校在线开放课程设计策略研究

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顺德职业技术学院学报 2024年第2期22卷 39-43页

作者：陈文兵赵远芳仙桃职业学院科研处湖北仙桃433000

深度学习视角下高职院校在线开放课程具有知识整体性、深度参与性、课堂体验性、成果实用性等特征。明确高职院校在线开放课程设计的主线遵循,要坚持以学习者为中心的设计理念,聚焦学习者高阶能力与素质的培养,落实以问题解决为中心的... 详细信息

深度学习视角下高职院校在线开放课程具有知识整体性、深度参与性、课堂体验性、成果实用性等特征。明确高职院校在线开放课程设计的主线遵循,要坚持以学习者为中心的设计理念,聚焦学习者高阶能力与素质的培养,落实以问题解决为中心的设计导向,提供丰富的学习支持以促进深度交互。在此基础上,基于深度学习视角,从创新课程设计、梳理课程构成要素、变革教学方式、强化学习情境和交互、丰富评价方式等方面,提出高职院校在线开放课程设计的策略。

关键词：深度学习高职院校在线开放课程交互高阶能力

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一类三元极小线性码的构造

安庆师范大学学报（自然科学版） 2024年第2期30卷 20-25页

作者：王玉琦孙敏陈文兵安庆师范大学数理学院安徽安庆246133

极小线性码作为一类特殊的线性码,在秘密共享方案、安全多方计算等方面有着重要应用,因此构造有限域上极小线性码有着重要意义。本文基于指数和、Krawtchouk多项式和F3m中定义在特殊向量集上的函数,构造了一类新的不满足Ashikhmin-Barg... 详细信息

极小线性码作为一类特殊的线性码,在秘密共享方案、安全多方计算等方面有着重要应用,因此构造有限域上极小线性码有着重要意义。本文基于指数和、Krawtchouk多项式和F3m中定义在特殊向量集上的函数,构造了一类新的不满足Ashikhmin-Barg条件的三元极小线性码,并确定了它们的重量分布和完全重量计数。

关键词：线性码极小码汉明重量完全重量计数

Mutations associated with egg adaptation of influenza A(H1N1)pdm09 virus in laboratory based surveillance in China, 2009–2016

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Biosafety and Health 2019年第1期1卷 41-45页

作者： Lei Yang Yanhui cheng Xiang Zhao Hejiang Wei Minju Tan Xiyan Li Wenfei Zhu Weijuan Huang wenbing chen Jia Liu Zi Li Yuelong Shu Dayan Wang National Institute for Viral Disease Control and Prevention China CDCKey Laboratory for Medical VirologyNational Health CommissionBeijingPeople's Republic of China School of Public Health(Shenzhen) Sun Yat-sen UniversityGuangdongPeople's Republic of China

Mutations of influenza virus associated with adaptation occurring during passage in embryonated chicken eggs could result in antigenic change or reduced vaccine effectiveness.In this study,we investigated the mutations of influenza A(H1N1)pdm09 egg isolates from the Chinese National Influenza Surveillance Network between 2009 and 2016.Thirteen mutations were identified in the hemagglutinin(HA)protein from viruses passaged in eggs,in comparing to those in cells.After scanning public database,four mutations,D127E,L191I,D222G/N and Q223R in HA1,which may alter the receptor-binding specificity,were observed frequently.Although the A(H1N1)pdm09 virus has evolved in human for nearly ten years,most egg-cultured viruses acquired one or more further mutations.Using the egg isolates for influenza surveillance requires extra caution because of these selected mutations,and their impacts on antigenicity and receptor-binding property need further evaluation.Currently,most of the influenza vaccines are produced using egg isolates,particularly in China.Thus,there is an urge to promote the establishment of an alternative influenza vaccine production platform.

关键词： Influenza A(H1N1)pdm09 virus Surveillance Egg-adapted mutation

Topologically Correct Intersection Curves of Two Trimmed Quadrics with Tolerance Control

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Journal of Systems Science & Complexity 2024年第5期 2207-2239页

作者： SHAO wenbing chen Falai Department of Mathematics University of Science and Technology of China

Surface/surface intersection is a fundamental problem in Compute Aided Design and Geometric Modeling since it is essential to solid modeling, numerically controlled machining, feature recognition, computer animation, etc. In practical applications, quadric surfaces, which are the most basic type of surfaces, are typically bounded surfaces trimmed by a sequence of planes. In this paper,a robust algorithm is proposed for computing the intersection curve segments of two trimmed quadrics based on the parametric representation of the intersection curves of two quadrics. The proposed algorithm guarantees correct topology and ensures that the approximation errors of the end points of the intersection curve segments are less than a given tolerance. The error control is based on an effective solution to a set of polynomial inequality system using the root isolation technique. Some examples are presented to validate the robustness and effectiveness of the proposed algorithm.

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Synthesis of Ultra-High-Molecular-Weight Polyethylene by Transition-Metal-Catalyzed Precipitation Polymerization

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Precision Chemistry

Precision Chemistry 2024年第2期2卷 63-69页

作者： wenbing Wang Quan Wang chen Zou Changle chen Key Laboratory of Precision and Intelligent Chemistry Department of Polymer Science and EngineeringUniversity of Science and Technology of ChinaHefei 230026China

Ultra-high-molecular-weight polyethylene(UHMWPE)plays an important role in many important fields as engineering plastics.In this contribution,a precipitation polymerization strategy is developed by combination of highly active phosphino-phenolate nickel catalysts with polymer-insoluble solvent(heptane)to access UHMWPE(Mn up to 8.3×10^(6)g mol^(-1))with good product morphology,free-flowing characteristics,and great mechanical properties.Compared with the academically commonly used aromatic solvent(toluene),the utilization of heptane offers simultaneous enhancement in important parameters including activity,polymer molecular weight,and catalyst thermal stability.This system can also generate polar functionalized UHMWPE with molecular weight of up to 1.6×10^(6)g mol^(-1)in the copolymerization of ethylene with polar comonomers.More importantly,this precipitation polymerization strategy is generally applicable to several representative transition metal catalyst systems,leading to UHMWPE synthesis with good product morphology control.

关键词： transition metal catalysts polyolefin UHMWPE precipitation polymerization polar monomer

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多功能可重构电磁信号发射接收及处理技术

电子科技大学学报 2023年第2期52卷 214-223页

作者：陈显舟杨旭周琪吴翼虎陈文兵方海杨锋中国空间技术研究院西安分院西安710100 浙江臻镭科技股份有限公司杭州310000 中科芯集成电路有限公司江苏无锡214072 成都华芯天微科技有限公司成都610010 电子科技大学电子科学与工程学院成都611731

针对导航增强、通信、雷达探测、电子侦察和干扰综合多功能一体化载荷系统对硬件通用化、功能软件化和资源虚拟化的需求,实现最大限度资源复用与共享,提出了低剖面、超宽带宽角扫描、极化可重构的综合孔径技术,基于射频全链路可重构架... 详细信息

针对导航增强、通信、雷达探测、电子侦察和干扰综合多功能一体化载荷系统对硬件通用化、功能软件化和资源虚拟化的需求,实现最大限度资源复用与共享,提出了低剖面、超宽带宽角扫描、极化可重构的综合孔径技术,基于射频全链路可重构架构和三维异构集成的综合射频微系统技术;基于硬件进程实现超异构计算资源灵活调度和动态管理技术。该文提出的综合多功能一体化电磁信号发射接收处理架构和关键技术,为未来分布式多域智能网联电子系统的软件化、虚拟化和智能化提供技术基础。

关键词：异构资源虚拟化综合射频微系统多功能一体化软件化可重构超宽带综合孔径

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人类文明新形态的理论意蕴与学理解析

国际观察 2023年第2期 1-21页

作者：陈文兵王广大余丽方长平习近平外交思想研究中心北京100005 上海外国语大学上海201620 上海外国语大学中阿改革发展研究中心上海201620 郑州大学政治与公共管理学院郑州450001 中国人民大学国际关系学院北京100872

在习近平外交思想指引下,从世界意义上讲,创造人类文明新形态主要有五点意蕴:一是中国共产党人天下情怀的时代呈现,开辟了人类文明发展的新境界;二是坚持走和平发展道路的必然结果,为世界实现和平安宁作出重大贡献;三是彰显构建人类命... 详细信息

在习近平外交思想指引下,从世界意义上讲,创造人类文明新形态主要有五点意蕴:一是中国共产党人天下情怀的时代呈现,开辟了人类文明发展的新境界;二是坚持走和平发展道路的必然结果,为世界实现和平安宁作出重大贡献;三是彰显构建人类命运共同体理念的科学性和真理性,推动人类社会不断向前迈进;四是昭示了全人类共同价值的光明前景,为建设更加美好的世界提供了理念指引;五是马克思主义中国化在新时代实现新飞跃的重大成果,将不可避免地助推21世纪科学社会主义的发展。从学科层面上看,国家间文明互动是国际政治社会学研究的重要内容,国际政治社会学强调国际政治的社会内涵,突出政治权力的社会性,关注国际社会在演变过程中凸显的社会问题。从维护人类文明多样性视角出发,人类文明多样性的客观发展与国际政治社会学的守正创新交相辉映。因此,从世界意义和学科发展出发,全面、深刻理解“人类文明新形态”对全人类问题的重要价值,从战略高度把握对外讲好“人类文明新形态”故事具有四点重要的现实价值。第一,对于加强中国话语能力建设具有重要意义;第二,对于发展中国家现代化建设具有重要意义;第三,对于构建多元文明共生共荣、合作共赢的世界文明新秩序具有重要意义;第四,对于推动构建人类命运共同体具有重要意义。

关键词：人类文明新形态习近平外交思想文化国际主义国际政治社会学