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Mitochondrial translocator protein(TSPO),astrocytes and neuroinflammation

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Neural Regeneration Research 2016年第7期11卷 1056-1057页

作者： Olga V.Chechneva wenbin deng Department of Biochemistry and Molecular Medicine University of California Institute for Pediatric Regenerative Medicine Shriners Hospitals for Children

Mitochondrial translocator protein（TSPO）has been a somewhat mysterious player in searching for its true biological *** is involved in mitochondrial cholesterol transport and steroids biosynthesis and predominantly e... 详细信息

关键词： steroids predominantly somewhat synthesizing mitochondrial searching biosynthesis severity macrophages astrocyte

Vulnerability of premyelinating oligodendrocytes to white-matter damage in neonatal brain injury

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Neuroscience Bulletin 2013年第2期29卷 229-238页

作者： Xiao-Bo Liu Yan Shen Jennifer M.Plane wenbin deng Department of Biochemistry and Molecular Medicine Institute for Pediatric Regenerative MedicineSchool of MedicineUniversity of California at Davis

Premature birth is a significant economic and public health burden, and its incidence is rising. Periventricular leukomalacia （PVL） is the predominant form of brain injury in premature infants and the leading cause of cerebral palsy. PVL is characterized by selective white-matter damage with prominent oligodendroglial injury. The maturation-dependent vulnerability of developing and premyelinating oligodendrocytes to excitotoxic, oxidative, and inflammatory forms of injury is a major factor in the pathogenesis of PVL. Recent studies using mouse models of PVL reveal that synapses between axons and developing oligodendrocytes are quickly and profoundly damaged in immature white matter. Axon-glia synapses are highly vulnerable to white-matter injury in the developing brain, and the loss of synapses between axons and premyelinating oligodendrocytes occurs before any cellular loss in the immature white matter. Microglial activation and astrogliosis play important roles in triggering white-matter injury. Impairment of white-matter development and function in the neonatal period contributes critically to functional and behavioral deficits. Preservation of the integrity of the white matter is likely key in the treatment of PVL and subsequent neurological consequences and disabilities.

关键词： prematurity neonatal brain injury white matter oligodendrocyte myelin periventricular leukomalacia

Heterobifunctional PEG-grafted black phosphorus quantum dots: “Three-in-One”nano-platforms for mitochondria-targeted photothermal cancer therapy

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Asian Journal of Pharmaceutical Sciences 2021年第2期16卷 222-235页

作者： Junyang Qi Yue Xiong Ke Cheng Qi Huang Jingxiu Cao Fumei He Lin Mei Gan Liu wenbin deng School of Pharmaceutical Sciences(Shenzhen) Sun Yat-sen UniversityShenzhen 518107China Department of Chemistry City University of Hong KongHong KongChina School of Material Science and Engineering and Institute for Advanced Study Nanchang UniversityNanchang 330031China Department of Biochemistry and Molecular Medicine School of MedicineUniversity of California at DavisSacramento CA 95817USA

Black phosphorus(BP)nano-materials,especially BP quantum dots(BPQDs),performs outstanding photothermal antitumor effects,excellent biocompatibility and ***,there are several challenges to overcome before offering real benefits,such as poor stability,poor dispersibility as well as difficulty in tailoring other ***,a“three-in-one”mitochondria-targeted BP nano-platform,called as BPQD-PEG-TPP,was *** this nano-platform,BPQDs were covalently grafted with a heterobifunctional PEG,in which one end was an aryl diazo group capable of reacting with BPQDs to form a covalent bond and the other end was a mitochondria-targeted triphenylphosphine(TPP)*** addition to its excellent near-infrared photothermal properties,BPQD-PEG-TPP had much enhanced stability and dispersibility under physiological conditions,efficient mitochondria targeting and promoted ROS production through a photothermal *** in vitro and in vivo experiments demonstrated that BPQD-PEG-TPP performed much superior photothermal cytotoxicity than BPQDs and BPQD-PEG as the mitochondria targeted *** this“three-in-one”nanoplatform fabricated through polymer grafting,with excellent stability,dispersibility and negligible side effects,might be a promising strategy for mitochondria-targeted photothermal cancer therapy.

关键词： Mitochondria-target Black phosphorus quantum dots Photothermal therapy Heterobifunctional PEG Three-in-one

城市轨道交通对沿线住宅价值影响定量计算实例研究

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土木工程学报 2007年第4期40卷 98-103页

作者：梁青槐孔令洋邓文斌北京交通大学北京100044 北京市基础设施投资有限公司北京100086

城市轨道交通系统不仅改善了城市的交通状况,还极大地促进了沿线房地产业的发展。采用特征价格法,以北京地铁13号线沿线的70个住宅楼盘作为样本,以楼盘的均价为因变量,以楼盘建筑面积、装修精简、楼盘到CBD距离、到地铁车站距离、楼盘... 详细信息

城市轨道交通系统不仅改善了城市的交通状况,还极大地促进了沿线房地产业的发展。采用特征价格法,以北京地铁13号线沿线的70个住宅楼盘作为样本,以楼盘的均价为因变量,以楼盘建筑面积、装修精简、楼盘到CBD距离、到地铁车站距离、楼盘所在区域人均可支配收入等属性作为自变量,选用半对数模型,进行了回归分析计算。计算得出,地铁13号线对沿线2 km范围内住宅平均每建筑平方米增值267元,增值百分比为4.408%。研究从理论上验证北京地铁13号线的建设会给沿线住宅带来增值,且计算增值结果与经验值基本相符,说明特征价格法可以较精确地定量计算城市轨道交通对沿线住宅的价值影响。

关键词：城市轨道交通特征价格法住宅价值增值

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最小二乘配置下的新疆地区地壳形变动态分析

地质科学 2022年第3期57卷 958-974页

作者：邓文彬蓝敏王辉新疆大学建筑工程学院乌鲁木齐830017 中国地震局地震预测研究所北京100036

为了研究新疆地区地壳形变动态变化特征,本文搜集整理了国内外发表的多期中国大陆GPS观测资料,获取1992~2016年间新疆地区的4期GPS实测速度场,运用最小二乘配置法对实测速度场进行插值,构建研究区地壳运动模型和应变率场。结果表明:实... 详细信息

为了研究新疆地区地壳形变动态变化特征,本文搜集整理了国内外发表的多期中国大陆GPS观测资料,获取1992~2016年间新疆地区的4期GPS实测速度场,运用最小二乘配置法对实测速度场进行插值,构建研究区地壳运动模型和应变率场。结果表明:实测速度场中,平均的GPS最小站间距由1992~2001年间的84.7 km减小到1992~2016年间的28.6 km,点位覆盖密度增大了约3倍;利用最小二乘配置法插值后的地壳运动模型与实测速度场具有很好的一致性,并且地壳运动模型与应变率场反映出1992~2016年间构造运动与变形较稳定,是对区域长期构造运动与变形的继承。研究区内的乌恰地区和伊塞克湖附近的面应变和最大剪应变变化最大,应变高值区逐渐自西向东扩张,反映出帕米尔高原对天山造山带的持续推挤还在增强;而塔里木盆地、准噶尔盆地和哈萨克斯坦块体的应变量基本不发生变化,说明3大块体内部基本不发生变形,反映了其刚性的特征;研究区最大剪应变率和地震发生率的相关性研究表明二者相关性显著,说明应变积累和地震活动有较好的对应关系。

关键词：新疆地区最小二乘配置法地壳运动模型应变率场动态变化

TC11钛合金等轴组织热变形行为与组织演变

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稀有金属 2009年第2期33卷 147-152页

作者：陈慧琴邓文斌太原科技大学材料科学与工程学院山西太原030024

采用等温恒应变速率压缩试验研究了TC11钛合金等轴组织两相区980～800℃，应变速率0．001～0．1s^-1，变形程度50％条件下的变形行为，分析了变形参数对应力-应变曲线、微观组织演变机制和规律的影响，建立了该合金两相区变形的热加工... 详细信息

采用等温恒应变速率压缩试验研究了TC11钛合金等轴组织两相区980～800℃，应变速率0．001～0．1s^-1，变形程度50％条件下的变形行为，分析了变形参数对应力-应变曲线、微观组织演变机制和规律的影响，建立了该合金两相区变形的热加工图，并采用EBSD技术测试了热变形组织的晶界特征。结果表明：（1）980℃变形，B相是主要变形相，0．001—0．1s。之间的功率耗散效率值在动态回复和再结晶范围内；α相经历了变形促进下的溶解（高应变速率）和聚集粗化（低应变速率）的过程，即α晶粒尺寸和相含量随着应变速率的加快明显减小。（2）950～900℃变形，0．001～0．01s^-1之间的功率耗散效率值在超塑性变形范围内；变形主要是软基体的B相和界面的变形行为；变形过程中，α晶粒尺寸和相含量基本不变。（3）850～800℃变形，α相是主要变形相，发生了连续动态再结晶过程；β相起晶界协调变形的作用。

关键词： TC11钛合金热变形行为微观组织演变

Heterobifunctional PEG-modified Black Phosphorus Quantum Dots:“Three-in-One” Nanoplatforms for Mitochondria-targeted Photothermal Cancer Therapy

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Heterobifunctional PEG-modified Black Phosphorus Quantum Dot...

第十一届全国化学生物学学术会议

作者： Junyang Qi Yue Xiong Ke Cheng Qi Huang Jingxiu Cao Fumei He Gan Liu wenbin deng School of Pharmaceutical Sciences(Shenzhen) Sun Yat-sen University

Mitochondria-targeted black phosphorus(BP) nanomaterials are expected to achieve enhanced photothermal antitumor effects since mitochondria are more sensitive to hyperthermia and BP excellent optical ***,there are several challenges to overcome before offering real benefits,such as poor stability,poor dispersibility,and difficulty in achieving a real mitochondria ***,a "three-in-one" mitochondria-targeted BP nanoplatform,called as BPQD-PEG-TPP,was *** this nanoplatform,BP quantum dots(BPQDs) were covalently modified with a heterobifunctional PEG,in which one end was an aryl diazo group capable of reacting with BPQDs to form a covalent bond and the other end was a mitochondria-targeted triphenylphosphine(TPP) *** of its excellent near-infrared photothermal properties,BPQD-PEG-TPP had good dispersibility and much enhanced stability under physiological conditions,efficiently targeted mitochondria and promoted ROS production through a photothermal *** combination of targeting mitochondria and PTT resulted in an excellent ability to inhibit tumor cell growth both in vitro and in *** this "three-in-one" BP nanoplatform with enhanced photothermal efficacy and negligible toxicity on healthy tissues might be a promising strategy for mitochondria-targeted photothermal cancer therapy.

关键词： Mitochondria-targeted Black phosphorus quantum dots Photothermal therapy

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卫星重力梯度观测数据的时变信号影响分析

武汉大学学报（信息科学版） 2016年第1期41卷 72-78页

作者：邓文彬许闯阿力甫.努尔买买提武汉大学测绘学院湖北武汉430079 新疆大学建筑工程学院测绘工程系新疆乌鲁木齐830046 华中科技大学物理学院基本物理量测量教育部重点实验室湖北武汉430074

系统地讨论了时变重力中潮汐信号与非潮汐信号对GOCE卫星重力梯度观测数据的影响。结果表明:(1)时变改正的量级为0.1mE,比GOCE卫星设计精度(3.2mE)低,但其为有色噪声,在数据预处理中必须剔除;(2)潮汐影响(0.1mE)比非潮汐影响(0.01mE)要... 详细信息

系统地讨论了时变重力中潮汐信号与非潮汐信号对GOCE卫星重力梯度观测数据的影响。结果表明:(1)时变改正的量级为0.1mE,比GOCE卫星设计精度(3.2mE)低,但其为有色噪声,在数据预处理中必须剔除;(2)潮汐影响(0.1mE)比非潮汐影响(0.01mE)要高一个量级,决定着时变重力改正的精度。将本文计算结果与GOCE官方公布结果进行对比,二者具有较好一致性,验证了本文计算方法及结果的有效性。

关键词： GOCE 卫星重力梯度时变重力预处理潮汐非潮汐

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小波基选取对重力异常多尺度分解的影响

测绘科学 2018年第4期43卷 30-37页

作者：邓文彬尚海滨许闯新疆大学建筑工程学院测绘工程系乌鲁木齐830046 华中科技大学物理学院/固体地球物理研究所武汉430074

针对重力异常分离的有力工具——小波分析最优小波基获取的研究较少的现状,该文试图通过理论模型实验分析方法,深入探讨小波分解阶数、不同小波基、场源深度变化对重力异常分解的影响。实验结果表明,重力异常多尺度分离的最优小波基为D... 详细信息

针对重力异常分离的有力工具——小波分析最优小波基获取的研究较少的现状,该文试图通过理论模型实验分析方法,深入探讨小波分解阶数、不同小波基、场源深度变化对重力异常分解的影响。实验结果表明,重力异常多尺度分离的最优小波基为Dmey小波,最佳分解阶数为7阶;当场源深度发生变化时,最优小波基和分解阶数保持不变。

关键词：重力异常小波多尺度小波基分解