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Research progress on the mechanism of exercise against depression

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World Journal of Psychiatry 2024年第11期14卷 1611-1617页

作者： Ya-Lin Zhao Shu-Ya Sun Hao-Cheng Qin Yu-Lian Zhu zhi-wen luo Yuan Qian Shuo Chen School of Integrated Traditional Chinese and Western Medicine Nanjing University of Chinese MedicineNanjing 210006Jiangsu ProvinceChina Department of Sports Medicine Nanjing Hospital of Chinese Medicine Affiliated to Nanjing University of Chinese MedicineNanjing 210006Jiangsu ProvinceChina Department of Rehabilitation Medicine Huashan HospitalFudan UniversityShanghai 200433China Department of Sports Medicine Huashan HospitalFudan UniversityShanghai 200040China Department of Outpatient Nanjing Hospital of Chinese Medicine Affiliated to Nanjing University of Chinese MedicineNanjing 210006Jiangsu ProvinceChina

The substantial global health burden of depression encourages the development of innovative and broadly effective *** paper aimed to examine recent advancements by which exercise works as an antidepressant and recommends optimal types and quantity of exercise as supplemental therapies in treating *** behavior and low physical activity significantly influence the onset of *** an effective treatment option,exercise can significantly reduce depression *** exerts antidepressant effects as it modulates neurotransmitters,neuroplasticity,the immune system,and hormone *** exercise forms include yoga,strength training,and walking/*** exercise regimens that consider individual preferences and tolerability can improve *** exercise enhances general well-being and reduces depressive *** research is needed to understand the complex basis of exercise's effects on *** is a cost-effective and accessible intervention for depression management that needs additional ***,customized exercise programs,as per each patient’s needs,are essential for their successful implementation clinically.

关键词： Exercise Depression Dose-response relationship Glucocorticoid cortisol 5-hydroxy tryptamine Norepinephrine

Mechanism underlying the effects of exercise against type 2 diabetes:A review on research progress

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World Journal of Diabetes 2024年第8期15卷 1704-1711页

作者： Chen-Jian Peng Shuo Chen Su-Ying Yan Jian-Ning Zhao zhi-wen luo Yuan Qian Guo-Liang Zhao Department of Sports Medicine Nanjing Hospital of Chinese Medicine Affiliated to Nanjing University of Chinese MedicineNanjing 210022Jiangsu ProvinceChina Department of Sports Medicine Huashan HospitalFudan UniversityShanghai 200040China Department of Outpatient Nanjing Hospital of Chinese Medicine affiliated to Nanjing University of Chinese MedicineNanjing 210006Jiangsu ProvinceChina

Exercise has emerged as one of the important and effective non-drug therapies used for management of type 2 diabetes(T2D)in certain *** present report summarizes the latest findings from the research on the beneficial effect of exercise on *** objectives were to provide references for the theoretical study and the clinical practice of exercise-based management of T2D,in addition to identify the limitations of the existing literature,thereby provide direction for future research in this field.

关键词： Type 2 diabetes Diabetes Exercise Mechanism Inflammation

Long head of biceps tendon transposition for massive and irreparable rotator cuff tears:A systematic review and meta-analysis

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World Journal of Orthopedics 2023年第11期14卷 813-826页

作者： Ren-wen Wan zhi-wen luo Yi-Meng Yang Han-Li Zhang Jia-Ni Chen Shi-Yi Chen Xi-Liang Shang Department of Sports Medicine Huashan HospitalFudan UniversityShanghai 200040China

BACKGROUND Superior capsular reconstruction(SCR)with long head of biceps tendon(LHBT)transposition was developed to massive and irreparable rotator cuff tears(MIRCTs);however,the outcomes of this technique remain *** To perform a systematic review of biomechanical outcomes and a meta-analysis of clinical outcomes after LHBT transposition for *** We performed a systematic electronic database search on PubMed,EMBASE,and Cochrane *** of SCR with LHBT transposition were included according to the inclusion and exclusion *** studies were assessed for main results and *** clinical studies were evaluated for quality of *** including study characteristics,cohort demographics,and outcomes were extracted.A meta-analysis was conducted of the clinical *** According to our inclusion and exclusion criteria,a total of six biomechanical studies were identified and reported an overall improvement in subacromial contact pressures and prevention of superior humeral migration without limiting range of motion(ROM)after LHBT transposition for MIRCTs.A total of five clinical studies were included in the meta-analysis of LHBT transposition outcomes,consisting of 253 *** results indicated that compared to other surgical methods for MIRCTs,LHBT transposition had advantages of more significant improvement in ROM(forward flexion mean difference[MD]=6.54,95%confidence interval[CI]:3.07-10.01;external rotation[MD=5.15,95%CI:1.59-8.17];the acromiohumeral distance[AHD][MD=0.90,95%CI:0.21-1.59])and reducing retear rate(odds ratio=0.27,95%CI:0.15-0.48).No significant difference in American Shoulder and Elbow Surgeons score,visual analogue scale score,and University of California at Los Angles score was demonstrated between these two groups for *** In general,SCR with LHBT transposition was a reliable and economical technique for treating MIRCTs,both in terms of biomechanical and clinica

关键词： Massive and irreparable rotator cuff tears Long head of biceps tendon transposition Rotator cuff repair Superior capsular reconstruction

Physical exercise reverses immuno-cold tumor microenvironment via inhibiting SQLE in non-small cell lung cancer

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Military Medical Research 2024年第4期11卷 616-619页

作者： zhi-wen luo Ya-Ying Sun Wei Xia Jun-Ying Xu Dong-Jing Xie Chun-Meng Jiao Ji-Ze Dong Hui Chen Ren-wen Wan Shi-Yi Chen Jie Mei wen-Jun Mao Department of Sports Medicine Huashan Hospital Affiliated to Fudan UniversityShanghai 200040China Department of Sports Medicine Shanghai General HospitalShanghai 200080China Department of Critical Care Medicine the Affiliated Wuxi People’s Hospital of Nanjing Medical UniversityWuxi 214023JiangsuChina Department of Oncology the Affiliated Wuxi People’s Hospital of Nanjing Medical UniversityWuxi 214023JiangsuChina Guangdong Pharmaceutical University Guangzhou 510006China Institute of Acupuncture Research Institutes of Integrative MedicineFudan UniversityShanghai 200433China Department of Cardiothoracic Surgery the Affiliated Wuxi People’s Hospital of Nanjing Medical UniversityWuxi 214023JiangsuChina

Dear Editor,Physical exercise has been shown to be associated with reduced cancer incidence and cancer-associated mortality[1,2],but the underlying mechanisms are *** regulation has emerged as one of the most prominent mechanisms explaining the effects of exercise on cancer[1,2].Physical exercise primarily lowers blood cholesterol and triglycerides,and protects against cardiovascular diseases[3].However,whether physical exercise can modulate cholesterol metabolism in tumor cells is currently unknown.

关键词： Physical exercise Non-small cell lung cancer(NSCLC) Squalene epoxidase(SQLE) Tumor immune microenvironment(TIME)

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Interaction of Mouse Pem Protein and Cell Division Cycle 37 Homolog

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Acta Biochimica et Biophysica Sinica 2005年第11期37卷 784-787页

作者： Fen GUO Yue-Qin LI Shi-Qian LI zhi-wen luo Xin ZHANG Dong-Sheng TANG Tian-Hong ZHOU College of Life Science and Technology,Jinan University.Guangzhou 510632.China College of Life Science and Technology Jinan UniversityGuangzhou 510632 China

Mouse Pem,a homeobox gene,encodes a protein consisting of 210 amino acid *** the function of mouse Pem protein,we used the yeast two-hybrid system to screen the library of 7-daymouse embryo with full-length mouse Peru ***-two colonies were obtained after 1.57×10~8 colonieswere screened by nutrition limitation and β-galactosidase *** individual insert fragments wereobtained from the library,and three of them were identified,one of which was confirmed to be the celldivision cycle 37(Cdc37)homolog gene by *** interaction between mouse Pem and Cdc37homolog was then confirmed by glutathione S-transferase pull-down assay,and the possible interaction modelwas suggested.

关键词： mPem cell division cycle 37 homolog yeast two-hybrid system

Establishment of an adult zebrafish model of retinal neurodegeneration induced by NMDA

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International Journal of Ophthalmology(English edition) 2019年第8期12卷 1250-1261页

作者： zhi-wen luo Han-Tsing Wang Ning Wang Wei-Wei Sheng Ming Jin Ye Lu Yi-Jiang Bai Su-Qi Zou Yu-Lian Pang Hong Xu Xu Zhang Affiliated Eye Hospital of Nanchang University JiangxiResearch Institute of Ophthalmology&Visual Science Nanchang330006Jiangxi ProvinceChina Queen Mary School of Nanchang University Nanchang330031Jiangxi ProvinceChina Institute of Life Science Nanchang UniversityNanchang330031Jiangxi ProvinceChina Jiangxi Provincial Collaborative Innovation Center forCardiovascular Digestive and Neuropsychiatric DiseasesNanchang330031Jiangxi ProvinceChina

AIM: To establish a model of retinal neurodegeneration induced by N-Methyl-D-aspartic acid(NMDA) in adult ***: We compared the effects of three different NMDA delivery methods on retinal neurodegeneration in adult zebrafish: immersion(I.M.), intravitreal injection(I.V.), and intraperitoneal injection(I.P.), and examined retinal pathology and degeneration by hematoxylin and eosin and TUNEL staining in the treated zebrafish. Effects of the NMDA receptor antagonist MK-801 and the natural product resveratrol on NMDA-induced retinal neurodegeneration were also ***: The thickened inner retina was seen in histology with 100 μmol/L NMDA by I.M. administration. Significant apoptosis in the retinal ganglion cell layer and retinal thickness reduction occurred in 0.5 mol/L NMDA I.P. administration ***-like behavioral changes, but no retinal histological alteration occurred in 16 mg/kg NMDA I.P. administration group. Resveratrol and MK-801 prevented NMDA-induced retinal neurodegeneration in the zebrafish. CONCLUSION: Among the three drug administration methods, I.V. injection of NMDA is the most suitable for establishment of an acute retinal damage model inzebrafish. I.M. with NMDA is likely the best for use as a chronic retinal damage model. I.P. treatment with NMDA causes brain damage. Resveratrol and MK801 may be a clinically valuable treatment for retinal neurodegeneration.

关键词： zebrafish NMDA administration method retinal ganglion cell glaucomatous animal model resveratrol

Static shape control of a flat shell structure

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吉林大学学报(工学版) 2006年第S1期 1-3页

作者： Yao Guo-feng, Zhang Lin-wen, luo zhi-jiu (College of Mechanical Science and Engineering, Jilin University, Changchun 130022, China Jilin College of Traffic Profession Technique, Changchun 130021 ,China)

The eight-node and forty-DOF piezoelectric shell element were applied to shape control of a flat shell structure. By the direct and converse effects, a distributed piezoelectric sensor layer was used to monitor the shape deformation and a distributed actuator layer was used to suppresse the deflection. A finite element model was for static response of laminated shell with piezoelectric sensors/actuators was derived. The model was verified by calculating piezoelectric polymeric PVDF bimorph beam. The results are in good agreement with those obtained by theoretical analysis of Tzou and Hwang . A case study of the static shape control of a flat shell structure is presented.

关键词： piezoelectric shell element static shape control feedback control

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铝合金热挤压过程中界面摩擦的研究进展

中国有色金属学报 2017年第7期27卷 1311-1322页

作者：刘志文李落星张明李世康湖南大学汽车车身先进设计制造国家重点实验室长沙410082 湖南大学机械与运载工程学院长沙410082

在铝合金热挤压过程中,工件与模具界面的摩擦对模具磨损、挤压载荷、产品表面质量等具有重要的影响。摩擦也是挤压数值仿真中一个重要的边界条件,影响因素多,难以定量确定。为得到精确的仿真结果,需采用合理的摩擦模型。揭示铝合金热挤... 详细信息

在铝合金热挤压过程中,工件与模具界面的摩擦对模具磨损、挤压载荷、产品表面质量等具有重要的影响。摩擦也是挤压数值仿真中一个重要的边界条件,影响因素多,难以定量确定。为得到精确的仿真结果,需采用合理的摩擦模型。揭示铝合金热挤压过程中不同接触界面的摩擦学行为。分析工作带位置的摩擦磨损对型材表面质量的影响机理。综述模具材料的表面强化技术,并对各工艺作出评价。归纳总结铝合金热挤压过程中采用的摩擦理论模型及等效表征方法。最后指出热挤压过程中界面摩擦研究存在的主要问题。

关键词：铝合金热挤压界面摩擦摩擦学行为摩擦模型表征方法

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Cortico-striatal gamma oscillations are modulated by dopamine D3 receptors in dyskinetic rats

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Neural Regeneration Research 2025年第4期20卷 1164-1177页

作者： Pengfei Wang Yuewei Bi Min Li Jiazhi Chen Zhuyong Wang Huantao wen Ming Zhou Minjie luo Wangming Zhang Neurosurgery Center Department of Pediatric NeurosurgeryGuangdong Provincial Key Laboratory on Brain Function Repair and RegenerationZhujiang HospitalSouthern Medical UniversityGuangzhouGuangdong ProvinceChina

Long-term levodopa administration can lead to the development of levodopa-induced *** oscillations are a widely recognized hallmark of abnormal neural electrical activity in levodopa-induced ***,studies have reported increased oscillation power in cases of levodopa-induced ***,little is known about how the other electrophysiological parameters of gamma oscillations are altered in levodopa-induced ***,the role of the dopamine D3 receptor,which is implicated in levodopa-induced dyskinesia,in movement disorder-related changes in neural oscillations is *** found that the cortico-striatal functional connectivity of beta oscillations was enhanced in a model of Parkinson’s ***,levodopa application enhanced cortical gamma oscillations in cortico-striatal projections and cortical gamma aperiodic components,as well as bidirectional primary motor cortex(M1)↔dorsolateral striatum gamma *** of PD128907(a selective dopamine D3 receptor agonist)induced dyskinesia and excessive gamma oscillations with a bidirectional M1↔dorsolateral striatum ***,administration of PG01037(a selective dopamine D3 receptor antagonist)attenuated dyskinesia,suppressed gamma oscillations and cortical gamma aperiodic components,and decreased gamma causality in the M1→dorsolateral striatum *** findings suggest that the dopamine D3 receptor plays a role in dyskinesia-related oscillatory activity,and that it has potential as a therapeutic target for levodopa-induced dyskinesia.

关键词： aperiodic components dopamine D3 receptor dorsolateral striatum functional connectivity gamma oscillations levodopa-induced-dyskinesia local field potentials neuromodulation Parkinson’s disease primary motor cortex

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