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A Gas-Kinetic Unified Algorithm for Non-Equilibrium Polyatomic Gas Flows Covering Various Flow Regimes

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Communications in Computational Physics 2021年第6期30卷 144-189页

作者： wen-Qiang Hu zhi-Hui Li Ao-Ping Peng Xin-Yu jiang National Laboratory for Computational Fluid Dynamics Beijing University of Aeronautics and AstronauticsBeijing 100191China Hypervelocity Aerodynamics Institute China Aerodynamics Research and Development CenterMianyang 621000China

In this paper,a gas-kinetic unified algorithm(GKUA)is developed to investigate the non-equilibrium polyatomic gas flows covering various *** on the ellipsoidal statistical model with rotational energy excitation,the computable modelling equation is presented by unifying expressions on the molecular collision relaxing parameter and the local equilibrium distribution *** constructing the corresponding conservative discrete velocity ordinate method for this model,the conservative properties during the collision procedure are preserved at the discrete level by the numerical method,decreasing the computational storage and *** and implicit lower-upper symmetric Gauss-Seidel schemes are constructed to solve the discrete hyperbolic conservation equations *** the new GKUA,some numerical examples are simulated,including the Sod Riemann problem,homogeneous flow rotational relaxation,normal shock structure,Fourier and Couette flows,supersonic flows past a circular cylinder,and hypersonic flow around a plate placed *** results obtained by the analytic,experimental,direct simulation Monte Carlo method,and other measurements in references are compared with the GKUA results,which are in good agreement,demonstrating the high accuracy of the present ***,some polyatomic gas non-equilibrium phenomena are observed and analysed by solving the Boltzmann-type velocity distribution function equation covering various flow regimes.

关键词： Gas-kinetic unified algorithm polyatomic gas ellipsoidal statistical model conservative discrete velocity ordinate method implicit scheme

Mechanistic Analysis of AKT1 Regulation by the CBL-CIPK-PP2CA Interactions

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Molecular Plant 2011年第3期4卷 527-536页

作者： wen-zhi Lan Sung-Chul Lee Yu-Fen Che Yuan-Qing jiang Sheng Luan Department of Plant and Microbial Biology University of California Berkeley CA 94720 USA School of Biological Sciences (BK21 program) Chung-Ang University Seoul.156-756 Korea College of Food Science and Nutritional Engineering China Agricultural University Beijing 100083 China DBST-WCU Program Chonnam National University-Gwangju 500-757 Korea

Arabidopsis K＋ transporter I （AKT1） participates in K＋ uptake in roots, especially under Iow-K conditions. We recently identified a Ca2＋ signaling pathway consisting of multiple calcineurin B-like calcium sensors （CBLs） and multiple target kinases （CBL-interacting protein kinases or CIPKs） that phosphorylate and activate AKT1, whereas a specific PP2C-type phosphatase inactivates CIPK-dependent AKT1 activity. In this study, we analyzed the interactions between PP2Cs and the CBL-CIPK pathway and found previously unsuspected mechanisms underlying the CBL-CIPK-PP2C signaling processes. The interaction between the CIPKs and PP2Cs involves the kinase domain of the CIPK component, in addition to the protein phosphatase interacting motif （PPI） in the regulatory domain. Furthermore, specific CBLs physically interact with and inactivate PP2C phosphatases to recover the CIPK-dependent AKT1 channel activity. These findings provide fur- ther insights into the signaling network consisting of CBL-CIPK-PP2C interactions in the activation of the AKT1 channel.

关键词： Abscisic acid Arabidopsis environmental stress K+ uptake.

Prognostic values of interim and post-therapy ^(18)F-FDG PET/CT scanning in adult patients with Burkitt's lymphoma

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Chinese Journal of Cancer 2015年第12期34卷 608-613页

作者： wen-Xiao Wei Jia-Jia Huang wen-Yu Li Xu Zhang Yi Xia wen-Qi jiang Wei Fan zhi-Ming Li State Key Laboratory of Oncology in South China Collaborative Innovation Center for Cancer MedicineSun Yat-sen University Cancer Center Department of Medical Oncology Sun Yat-sen University Cancer Center Lymphoma Division Cancer CenterGuangdong General HospitalGuangdong Academy of Medical Sciences Department of Nuclear Medicine Sun Yat-sen University Cancer Center

Background:The prognostic values of interim and post-therapy fluorine-18-fluorodeoxyglucose(^(18)F-FDG) positron emission tomography(PET) and PET/computed tomography(CT) scanning have been confirmed in several subtypes of ***,its prognostic value in Burkitt's lymphoma has not been clearly *** aim of the present study was to assess the prognostic value of PET/CT scanning during different treatment processes of Burkitt's ***:A total of 29 adult patients with newly diagnosed Burkitt's lymphoma were retrospectively involved in this study;of them,23 patients underwent baseline PET/CT,15 patients underwent mid-therapy PET/CT after 1-4 cycles of chemotherapy,and 17 patients underwent post-therapy PET/CT after all planned first-line chemotherapy ***-therapy and post-therapy PET/CT results(positive ***) were visually interpreted according to the criteria of the International Harmonization *** reduction in the maximum standardizes uptake values(ASUVmax)of 25%,50%,and 75%were regarded as cutoff *** survival(OS) and progression-free survival(PFS) were regarded as the major ***:The median OS and PFS were 27.6 months(range 6.5-78.3 months) and 27.2 months(range 3.0-78.3 months),*** median SUVmax of the baseline PET/CT was 18.3(range 1.6-35.9),whereas the median SUVmax of the mid-therapy and post-therapy PET/CT decreased to 4.0(range 0-17.6) and 3.0(range 0-14.5),*** patients' Eastern Cooperative Oncology Group(ECOG) scores(<2 vs.≥2) were significantly associated with the baseline PET/CT *** mid-therapy and post-therapy PET/CT results(positive ***) showed no significant association with OS or *** optimal cutoff ASUVmax from the baseline to the post-therapy PET/CT that could predict a change in OS in patients with Burkitt's lymphoma was 50%(P = 0.019).Conclusions:^(18)F-FDG uptake was intense in Burkitt's lymphoma,and there was a significant reduction in SU

关键词： Burkitt's lymphoma, Mid-therapy PET/CT, Post-therapy PET/CT, Prognosis, Adult patients

Quantitative real-time RT-PCR detection for CEA, CK20 and CK19 mRNA in peripheral blood of colorectal cancer patients

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2006年第6期7卷 445-451页

作者： XU Dong LI Xu-fen ZHENG Shu jiang wen-zhi Cancer Institute the Second Affiliated Hospital School of Medicine Zhejiang University Hangzhou 310009 China

This study is aimed at establishing a sensitive approach to detect disseminated tumor cells in peripheral blood and evaluate its clinical significance. A total of 198 blood samples including 168 from colorectal carcinoma (CRC) patients and 30 from healthy volunteers were examined by quantitative real-time reverse transcription-polymerase chain reaction (RT-PCR) to evaluate the expression of carcinoembryonic antigen (CEA), cytokeratin 20 (CK20) and cytokeratin 19 (CK19) mRNA. CEA mRNA was detected in 35.8% of patients and 3.3% of controls, CK20 mRNA in 28.3% of patients and 6.7% of controls, and CK19 mRNA in 41.9% of patients and 3.3% of controls. CEA and CK20 mRNA positive ratio increased with the advancing Dukes stages, but there was no significant difference in positive ratio between any two stages (P>0.05). Also, relatively high positive ratio of CEA, CK20 and CK19 mRNA expression was observed in some CRC patients with earlier Dukes stages. A higher positive ratio was obtained when two or three detection markers were combined compared to a single marker. Our study indicates that quanti-tative real-time RT-PCR detection for CEA, CK20 and CK19 mRNA in peripheral blood is a valuable tool for monitoring early stage dissemination of CRC cells in blood circulation.

关键词： Colorectal carcinoma Real-time RT-PCR CEA mRNA CK20 mRNA CK19 mRNA

Small bowel diverticulum with enterolith causing intestinal obstruction: A case report

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World Journal of Gastrointestinal Surgery 2023年第6期15卷 1256-1261页

作者： Li-wen Wang Peng Chen jiang Liu zhi-Wei jiang Xin-Xin Liu Department of General Surgery Jiangsu Province Hospital of Chinese MedicineAffiliated Hospital of Nanjing University of Chinese MedicineNanjing 210000Jiangsu ProvinceChina

BACKGROUND Small bowel diverticula are rare in clinics,and small intestinal obstruction caused by coprolites is rarer and difficult to diagnose *** true incidence of these diverticula may be underestimated due to their clinical symptoms not differing from those of small bowel obstruction resulting from other *** is common in the elderly,although it can occur at any *** SUMMARY This is a case report of a 78-year-old man with epigastric pain for 5 *** treatment does not effectively relieve pain,inflammatory indicators are elevated,and computed tomography suggests jejunal intussusception and mild ischemic changes in the intestinal *** exploration showed that the left upper abdominal loop was slightly edematous,the jejunum mass at the near Flex ligament was palpable,the size was about 7 cm×8 cm,the local movement was slight,and the diverticulum was seen 10 cm downward,and the local small intestine was dilated and *** was *** the short parenteral nutrition after surgery,the fluid and enteral nutrition solution were pumped through the jejunostomy tube,and the patient was discharged after the treatment was stable,and the jejunostomy tube was removed in an outpatient clinic one month after the *** pathology:Jejunectomy specimen:(1)Small intestinal diverticulum with chronic inflammation,ulcer with full-thickness activity,and necrosis of the intestinal wall in some areas;(2)also see that the hard object is consistent with stone changes;and(3)the incision margin on both sides shows chronic inflammation of mucosal *** Clinically,the diagnosis of small bowel diverticulum is difficult to distinguish from jejunal *** with the patient’s condition,rule out other possibilities after a timely disease *** to the patient’s body tolerance adopt personalized surgical methods to achieve better recovery after surgery.

关键词： Small bowel diverticulum Surgery Complications Case report

Hydraulic experiment on mushroom head in bottom-blown smelting furnace

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Journal of Iron and Steel Research International 2017年第5期24卷 490-494页

作者： Fu-yong Su zhi wen School of Energy and Environmental Engineering University of Science and Technology Beijing Beijing 100083 China

There are many bottom-blown smelting furnaces in metallurgical industry. When oxygen or air sprays from the jet nozzle into the bottom of the furnace, the melting phase will be frozen and a hemispherical porous zone with a mushroom head shape will be formed around the nozzle. The mushroom head can pro- tect the jet nozzle and mitigate the liquid spray on the surface of melt. In order to analyze the formation process of a mushroom head in the bottom-blown smelting furnaces, a hydraulic experiment system was designed and the formation of the mushroom head was investigated by hydraulic experiment. The hydrau- lic experiment results show that the formation process is mainly divided into generating crushing genera- ting process and stable mushroom head generation process. The formation of stable mushroom head re- quires certain thermodynamic condition and water splash is more intense without a mushroom head than with a mushroom head. The size, porosity and diameter of the mushroom head are affected by the flow rate, temperature and heat capacity of the bottom-blowing gas and the temperature of the superheat and the physical parameters of the melt.

关键词： Bottom-blown smelting furnace Mushroom head Hydraulic experiment Thermal equilibrium Similarity criterion

The role of liver sinusoidal endothelial cells in liver remodeling after injury

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Hepatobiliary & Pancreatic Diseases International 2023年第1期22卷 22-27页

作者： zhi-wen Li Lin Wang Department of Hepatobiliary Surgery Xijing HospitalThe Fourth Military Medical UniversityXi’an 710032China

Liver transplantation is the optimal treatment for patients with end-stage liver disease,metabolic liver diseases,and hepatic malignancies that are not amenable to *** ischemia-reperfusion injury(IRI)is the main problem in liver transplantation and liver resection,leading to parenchymal cell injury and organ *** damage of liver sinusoidal endothelial cells(LSECs)is a critical event in *** work as an important regulating factor of liver regeneration after partial *** review primarily describes the mechanisms of LSECs injury in IRI and explores the roles of LSECs in liver regeneration,and briefly introduces the protective strategies targeting LSECs damaged in IRI.

关键词： Liver sinusoidal endothelial cells Liver transplantation Ischemia-reperfusion injury Liver regeneration

Regularized Methods for a Two-Stage Robust Production Planning Problem and its Sample Average Approximation

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Journal of the Operations Research Society of China 2023年第3期11卷 595-625页

作者： Jie jiang zhi-Ping Chen College of Mathematics and Statistics Chongqing UniversityChongqing401331China School of Mathematics and Statistics Xi'an Jiaotong UniversityCenter for Optimization Technique and Quantitative FinanceXi'an International Academy for Mathematics and Mathematical TechnologyXi'an 710049ShaanxiChina

In this paper,we consider a two-stage robust production planning model where the first stage problem determines the optimal production quantity upon considering the worst-case revenue generated by the uncertain future demand,and the second stage problem determines the possible demand of consumers by using a utility-based model given the production quantity and a realization of the random *** derive an equivalent single-stage reformulation of the two-stage ***,it fails the convergence analysis of the sample average approximation(SAA)approach for the reformulation *** we develop a regularized approximation of the second stage problem and derive its closed-form *** then present conditions under which the optimal value and the optimal solution set of the proposed SAA regularized approximation problem converge to those of the single-stage reformulation problem as the regularization parameter shrinks to zero and the sample size tends to ***,some preliminary numerical examples are presented to illustrate our theoretical results.

关键词： Production planning Utility function SAA Complementarity problem Regularized method

Mineralization and osteoblast behavior of multilayered films on TiO_2 nanotube surfaces assembled by the layer-by-layer technique

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Chinese Chemical Letters 2016年第7期27卷 1091-1096页

作者： Yan Zhang wen-Li Gao zhi-Yuan Liu Ya jiang Ke Duan Bo Feng Key Laboratory of Advanced Technologies of Materials Ministry of Education School of Materials Science and Engineering Southwest Jiaotong University School of Life Sciences and Engineering Southwest Jiaotong University

In this paper,the multilayer films of poly-L-lysine（PLL） and DNA were created on TiO2 nanotube surfaces using the layer-by-layer（LBL） self-assembly *** compositions of the assembled multilayered films were investigated by X-ray photoelectron *** properties of the multilayered films were evaluated by the biomimetic mineralization and osteoblast cell culture *** results indicated that PLL and DNA were successfully assembled onto TiO2 nanotube surfaces by electrostatic ***,the samples of assembled PLL or/and DNA had better bioactivity in inducing HA formation and promoting osteoblast cells adhesion,proliferation and early differentiation.

关键词： TiO2 nanotube Poly-L-lysine DNA Layer-by-layer Biological property